Details for: ONECUT1

Gene ID: 3175

Symbol: ONECUT1

Ensembl ID: ENSG00000169856

Description: one cut homeobox 1

Associated with

  • Developmental biology
    (R-HSA-1266738)
  • Regulation of beta-cell development
    (R-HSA-186712)
  • Regulation of gene expression in early pancreatic precursor cells
    (R-HSA-210747)
  • Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
    (R-HSA-210744)
  • Anatomical structure morphogenesis
    (GO:0009653)
  • B cell differentiation
    (GO:0030183)
  • Cell fate commitment
    (GO:0045165)
  • Cell migration
    (GO:0016477)
  • Chromatin
    (GO:0000785)
  • Chromatin binding
    (GO:0003682)
  • Cilium assembly
    (GO:0060271)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Endoderm development
    (GO:0007492)
  • Epithelial cell development
    (GO:0002064)
  • Glucose metabolic process
    (GO:0006006)
  • Liver development
    (GO:0001889)
  • Negative regulation of transforming growth factor beta receptor signaling pathway
    (GO:0030512)
  • Notch signaling pathway
    (GO:0007219)
  • Nucleus
    (GO:0005634)
  • Pancreatic a cell differentiation
    (GO:0003310)
  • Pancreatic d cell differentiation
    (GO:0003311)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Regulation of cell-matrix adhesion
    (GO:0001952)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Spleen development
    (GO:0048536)
  • Transforming growth factor beta receptor signaling pathway
    (GO:0007179)
  • Type b pancreatic cell differentiation
    (GO:0003309)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 3.2897
    Cell Significance Index: 12.3900
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 2.9927
    Cell Significance Index: 37.5900
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 2.7110
    Cell Significance Index: 28.2400
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.4306
    Cell Significance Index: 18.8900
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.1089
    Cell Significance Index: 29.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7568
    Cell Significance Index: 348.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.5609
    Cell Significance Index: 87.5900
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 1.3325
    Cell Significance Index: 13.7900
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.8761
    Cell Significance Index: 4.9800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.7136
    Cell Significance Index: 5.8900
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.5100
    Cell Significance Index: 4.1800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.4891
    Cell Significance Index: 8.3600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.4256
    Cell Significance Index: 7.1700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.3705
    Cell Significance Index: 5.4000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.2590
    Cell Significance Index: 3.2300
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.1513
    Cell Significance Index: 1.1000
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.1450
    Cell Significance Index: 1.8200
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.1308
    Cell Significance Index: 1.2900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.1188
    Cell Significance Index: 1.5000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0559
    Cell Significance Index: 0.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0467
    Cell Significance Index: 7.9700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0084
    Cell Significance Index: 0.4400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0080
    Cell Significance Index: 5.5200
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.0057
    Cell Significance Index: 0.0500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0011
    Cell Significance Index: -1.6500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0017
    Cell Significance Index: -3.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0019
    Cell Significance Index: -3.6200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0020
    Cell Significance Index: -0.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0023
    Cell Significance Index: -0.4600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0030
    Cell Significance Index: -4.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0044
    Cell Significance Index: -1.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0052
    Cell Significance Index: -2.9400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0062
    Cell Significance Index: -4.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0063
    Cell Significance Index: -3.9800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0063
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0078
    Cell Significance Index: -4.8400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0079
    Cell Significance Index: -4.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0089
    Cell Significance Index: -2.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0093
    Cell Significance Index: -4.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0137
    Cell Significance Index: -1.6000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0190
    Cell Significance Index: -0.2800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0211
    Cell Significance Index: -1.0600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0226
    Cell Significance Index: -4.7500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0230
    Cell Significance Index: -0.9400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0233
    Cell Significance Index: -0.5700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0251
    Cell Significance Index: -4.5300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0270
    Cell Significance Index: -0.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0285
    Cell Significance Index: -4.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0334
    Cell Significance Index: -4.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0371
    Cell Significance Index: -4.5700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0412
    Cell Significance Index: -1.0600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0444
    Cell Significance Index: -1.2400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0491
    Cell Significance Index: -5.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0644
    Cell Significance Index: -4.9500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0677
    Cell Significance Index: -3.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0684
    Cell Significance Index: -4.6000
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: -0.0721
    Cell Significance Index: -0.6500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0747
    Cell Significance Index: -1.2100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0773
    Cell Significance Index: -1.3000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0794
    Cell Significance Index: -2.1600
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0813
    Cell Significance Index: -1.1400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0844
    Cell Significance Index: -2.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0865
    Cell Significance Index: -4.0400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0927
    Cell Significance Index: -4.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1034
    Cell Significance Index: -4.8600
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1044
    Cell Significance Index: -0.9900
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: -0.1051
    Cell Significance Index: -0.6100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1054
    Cell Significance Index: -4.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1218
    Cell Significance Index: -4.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1235
    Cell Significance Index: -4.0500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1260
    Cell Significance Index: -4.7700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1348
    Cell Significance Index: -2.3100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1382
    Cell Significance Index: -4.3700
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.1400
    Cell Significance Index: -1.4500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1404
    Cell Significance Index: -4.4700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1409
    Cell Significance Index: -2.9500
  • Cell Name: H1 horizontal cell (CL0004217)
    Fold Change: -0.1416
    Cell Significance Index: -1.7800
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.1457
    Cell Significance Index: -1.2600
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.1461
    Cell Significance Index: -1.6900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1485
    Cell Significance Index: -4.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1500
    Cell Significance Index: -4.0200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.1556
    Cell Significance Index: -1.3800
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1574
    Cell Significance Index: -4.0100
  • Cell Name: ON parasol ganglion cell (CL4033052)
    Fold Change: -0.1597
    Cell Significance Index: -1.9900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1607
    Cell Significance Index: -1.8300
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1611
    Cell Significance Index: -2.1100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1626
    Cell Significance Index: -4.6400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1630
    Cell Significance Index: -4.0700
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1633
    Cell Significance Index: -1.7900
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.1637
    Cell Significance Index: -1.4800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1650
    Cell Significance Index: -4.8600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1708
    Cell Significance Index: -4.4900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1720
    Cell Significance Index: -4.3000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1734
    Cell Significance Index: -4.9700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1746
    Cell Significance Index: -2.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1763
    Cell Significance Index: -3.8200
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1766
    Cell Significance Index: -4.3100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.1771
    Cell Significance Index: -1.2000
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1847
    Cell Significance Index: -2.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1858
    Cell Significance Index: -4.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transcriptional Regulation:** ONECUT1 acts as a transcriptional regulator, influencing the expression of genes involved in cellular differentiation, proliferation, and survival. 2. **Cell Fate Commitment:** The gene plays a critical role in committing cells to specific fates, such as pancreatic acinar cell differentiation or intestinal goblet cell development. 3. **Cell Migration:** ONECUT1 regulates cell migration, which is essential for tissue development, wound healing, and immune cell trafficking. 4. **Chromatin Binding:** The gene binds to chromatin, influencing the accessibility of DNA to transcription factors and other regulatory proteins. 5. **Interactions with Other Genes:** ONECUT1 interacts with various transcription factors, including HNF6, to regulate the expression of target genes. **Pathways and Functions:** 1. **Pancreatic Development:** ONECUT1 is essential for pancreatic development, particularly in regulating the expression of pancreatic cell-specific genes. 2. **Immune Cell Fate:** The gene influences the development and function of immune cells, including innate lymphoid cells and retinal ganglion cells. 3. **Cell-Matrix Adhesion:** ONECUT1 regulates cell-matrix adhesion, which is critical for tissue development and immune cell migration. 4. **Notch Signaling Pathway:** The gene interacts with the Notch signaling pathway, influencing cell fate commitment and differentiation. 5. **Chromatin Remodeling:** ONECUT1 regulates chromatin remodeling, which is essential for gene expression and cellular differentiation. **Clinical Significance:** 1. **Pancreatic Cancer:** Aberrant expression of ONECUT1 has been linked to pancreatic cancer, highlighting its potential as a diagnostic biomarker or therapeutic target. 2. **Immune-Mediated Diseases:** Dysregulation of ONECUT1 has been implicated in immune-mediated diseases, such as autoimmune diabetes and inflammatory bowel disease. 3. **Neurological Disorders:** The gene's involvement in regulating retinal ganglion cell development and function makes it a potential therapeutic target for neurological disorders, such as glaucoma. 4. **Regenerative Medicine:** ONECUT1's role in regulating cell fate commitment and differentiation makes it a promising tool for regenerative medicine applications, such as tissue engineering and organ transplantation. In conclusion, the ONECUT1 gene plays a critical role in regulating pancreatic development, immune cell fate, and cellular processes. Further research is necessary to fully understand the gene's functions and clinical implications, but its significance in these areas is clear.

Genular Protein ID: 950555477

Symbol: HNF6_HUMAN

Name: Hepatocyte nuclear factor 6

UniProtKB Accession Codes:

Q9UBC0 B2RTV4 Q99744 Q9UMR6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 28 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10491763

Title: Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion.

PubMed ID: 10491763

DOI: 10.1007/s001250051261

Sequence Information:

  • Length: 465
  • Mass: 51023
  • Checksum: F47F78957A6ECFC2
  • Sequence:
    • MNAQLTMEAI GELHGVSHEP VPAPADLLGG SPHARSSVAH RGSHLPPAHP RSMGMASLLD 
GGSGGGDYHH HHRAPEHSLA GPLHPTMTMA CETPPGMSMP TTYTTLTPLQ PLPPISTVSD 
KFPHHHHHHH HHHHPHHHQR LAGNVSGSFT LMRDERGLAS MNNLYTPYHK DVAGMGQSLS 
PLSSSGLGSI HNSQQGLPHY AHPGAAMPTD KMLTPNGFEA HHPAMLGRHG EQHLTPTSAG 
MVPINGLPPH HPHAHLNAQG HGQLLGTARE PNPSVTGAQV SNGSNSGQME EINTKEVAQR 
ITTELKRYSI PQAIFAQRVL CRSQGTLSDL LRNPKPWSKL KSGRETFRRM WKWLQEPEFQ 
RMSALRLAAC KRKEQEHGKD RGNTPKKPRL VFTDVQRRTL HAIFKENKRP SKELQITISQ 
QLGLELSTVS NFFMNARRRS LDKWQDEGSS NSGNSSSSSS TCTKA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.