Details for: ONECUT1

Gene ID: 3175

Symbol: ONECUT1

Ensembl ID: ENSG00000169856

Description: one cut homeobox 1

Associated with

  • Developmental biology
    (R-HSA-1266738)
  • Regulation of beta-cell development
    (R-HSA-186712)
  • Regulation of gene expression in early pancreatic precursor cells
    (R-HSA-210747)
  • Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells
    (R-HSA-210744)
  • Anatomical structure morphogenesis
    (GO:0009653)
  • B cell differentiation
    (GO:0030183)
  • Cell fate commitment
    (GO:0045165)
  • Cell migration
    (GO:0016477)
  • Chromatin
    (GO:0000785)
  • Chromatin binding
    (GO:0003682)
  • Cilium assembly
    (GO:0060271)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Endoderm development
    (GO:0007492)
  • Epithelial cell development
    (GO:0002064)
  • Glucose metabolic process
    (GO:0006006)
  • Liver development
    (GO:0001889)
  • Negative regulation of transforming growth factor beta receptor signaling pathway
    (GO:0030512)
  • Notch signaling pathway
    (GO:0007219)
  • Nucleus
    (GO:0005634)
  • Pancreatic a cell differentiation
    (GO:0003310)
  • Pancreatic d cell differentiation
    (GO:0003311)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Regulation of cell-matrix adhesion
    (GO:0001952)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Spleen development
    (GO:0048536)
  • Transforming growth factor beta receptor signaling pathway
    (GO:0007179)
  • Type b pancreatic cell differentiation
    (GO:0003309)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: acinar cell (CL0000622)
    Fold Change: 2.45
    Marker Score: 1729
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1998
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.94
    Marker Score: 6350
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1173
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.5
    Marker Score: 1556
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.41
    Marker Score: 590
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.39
    Marker Score: 381
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.36
    Marker Score: 2584
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 858
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.26
    Marker Score: 2558
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 1.2
    Marker Score: 1154
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.2
    Marker Score: 7727
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 489
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7649
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4817
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.11
    Marker Score: 650
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 505
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.02
    Marker Score: 4393
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.01
    Marker Score: 574
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71827
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48050
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1
    Marker Score: 5354
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 511
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.95
    Marker Score: 1312
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 376
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5350
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 328
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.88
    Marker Score: 13755
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.81
    Marker Score: 1686.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 399
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 465
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.72
    Marker Score: 417
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.71
    Marker Score: 428
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.66
    Marker Score: 450
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.63
    Marker Score: 200
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.62
    Marker Score: 329
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.62
    Marker Score: 962
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.61
    Marker Score: 486
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.57
    Marker Score: 184
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.56
    Marker Score: 178
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 176
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.55
    Marker Score: 417
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.54
    Marker Score: 2094
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.51
    Marker Score: 191
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.49
    Marker Score: 232
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.48
    Marker Score: 254
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 279
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.43
    Marker Score: 686
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.4
    Marker Score: 429.5
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.39
    Marker Score: 137.5
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.39
    Marker Score: 485
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.38
    Marker Score: 469
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.38
    Marker Score: 797
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.37
    Marker Score: 371
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.37
    Marker Score: 162
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.36
    Marker Score: 278
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.36
    Marker Score: 135
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.33
    Marker Score: 101
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.32
    Marker Score: 133
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.31
    Marker Score: 317
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.27
    Marker Score: 269
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.27
    Marker Score: 154
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.26
    Marker Score: 746
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.26
    Marker Score: 609
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.25
    Marker Score: 1046
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.24
    Marker Score: 72
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.22
    Marker Score: 246
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.21
    Marker Score: 47
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.21
    Marker Score: 138
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.2
    Marker Score: 74
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.19
    Marker Score: 177
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.18
    Marker Score: 74
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.16
    Marker Score: 60
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.16
    Marker Score: 304
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.15
    Marker Score: 93
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.14
    Marker Score: 65
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.14
    Marker Score: 77
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.13
    Marker Score: 84
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.13
    Marker Score: 61
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.13
    Marker Score: 34
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.13
    Marker Score: 112
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.12
    Marker Score: 109
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.11
    Marker Score: 6864
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.11
    Marker Score: 450
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.11
    Marker Score: 118
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.1
    Marker Score: 172
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.1
    Marker Score: 65
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.1
    Marker Score: 119

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Other Information

**Key characteristics:** * ONECUT1 is a homeobox gene, which are a family of transcription factors that are involved in a variety of cellular processes, including development, differentiation, and proliferation. * ONECUT1 is a key regulator of pancreatic development. * It is expressed in a variety of cell types throughout the developing embryo, including the pancreas, liver, and gut. * ONECUT1 is a key regulator of pancreatic cell differentiation. * It is involved in the regulation of beta-cell development, as well as the regulation of cell-matrix adhesion and the Notch signaling pathway. **Pathways and functions:** * ONECUT1 is involved in the regulation of pancreatic cell differentiation. * It is a key regulator of beta-cell development. * It is involved in the regulation of cell-matrix adhesion and the Notch signaling pathway. * ONECUT1 also plays a role in the regulation of the glucose metabolic process, liver development, and the development of the pancreas. **Clinical significance:** * Mutations in the ONECUT1 gene have been linked to a number of human diseases, including diabetes, cancer, and heart disease. * ONECUT1 is a promising target for the treatment of these diseases. * Studies of ONECUT1 have shown that it can be used to inhibit pancreatic cancer growth in animal models. **Additional information:** * The ONECUT1 gene is located on chromosome 17q21. * It is a large gene, with a transcript length of approximately 2.2 kb. * There are 11 exons and 13 introns in the ONECUT1 gene. * ONECUT1 is a highly conserved gene, with a similar gene found in mammals, birds, and fish.

Genular Protein ID: 950555477

Symbol: HNF6_HUMAN

Name: Hepatocyte nuclear factor 6

UniProtKB Accession Codes:

Q9UBC0 B2RTV4 Q99744 Q9UMR6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 28 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10491763

Title: Hepatocyte nuclear factor-6: associations between genetic variability and type II diabetes and between genetic variability and estimates of insulin secretion.

PubMed ID: 10491763

DOI: 10.1007/s001250051261

Sequence Information:

  • Length: 465
  • Mass: 51023
  • Checksum: F47F78957A6ECFC2
  • Sequence:
    • MNAQLTMEAI GELHGVSHEP VPAPADLLGG SPHARSSVAH RGSHLPPAHP RSMGMASLLD 
GGSGGGDYHH HHRAPEHSLA GPLHPTMTMA CETPPGMSMP TTYTTLTPLQ PLPPISTVSD 
KFPHHHHHHH HHHHPHHHQR LAGNVSGSFT LMRDERGLAS MNNLYTPYHK DVAGMGQSLS 
PLSSSGLGSI HNSQQGLPHY AHPGAAMPTD KMLTPNGFEA HHPAMLGRHG EQHLTPTSAG 
MVPINGLPPH HPHAHLNAQG HGQLLGTARE PNPSVTGAQV SNGSNSGQME EINTKEVAQR 
ITTELKRYSI PQAIFAQRVL CRSQGTLSDL LRNPKPWSKL KSGRETFRRM WKWLQEPEFQ 
RMSALRLAAC KRKEQEHGKD RGNTPKKPRL VFTDVQRRTL HAIFKENKRP SKELQITISQ 
QLGLELSTVS NFFMNARRRS LDKWQDEGSS NSGNSSSSSS TCTKA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.