Details for: SLC29A2

Gene ID: 3177

Symbol: SLC29A2

Ensembl ID: ENSG00000174669

Description: solute carrier family 29 member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 49.3104
    Cell Significance Index: -7.6700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 27.0853
    Cell Significance Index: -6.8700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 17.0089
    Cell Significance Index: -6.9100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 7.2480
    Cell Significance Index: -6.9200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 6.2289
    Cell Significance Index: -7.6800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.0834
    Cell Significance Index: -8.2600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.9521
    Cell Significance Index: 47.6300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 1.5259
    Cell Significance Index: 24.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.3729
    Cell Significance Index: 261.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1236
    Cell Significance Index: 111.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8867
    Cell Significance Index: 40.1900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7034
    Cell Significance Index: 635.1400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6277
    Cell Significance Index: 68.2800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5928
    Cell Significance Index: 96.4100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5877
    Cell Significance Index: 35.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5843
    Cell Significance Index: 16.8400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.5828
    Cell Significance Index: 14.9800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5263
    Cell Significance Index: 104.4500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4995
    Cell Significance Index: 38.3300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3537
    Cell Significance Index: 5.3000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.3419
    Cell Significance Index: 4.9000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3264
    Cell Significance Index: 8.7500
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.2940
    Cell Significance Index: 1.2800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2723
    Cell Significance Index: 5.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2625
    Cell Significance Index: 52.6500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2593
    Cell Significance Index: 8.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2412
    Cell Significance Index: 16.6800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2333
    Cell Significance Index: 12.1200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2031
    Cell Significance Index: 2.8500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1850
    Cell Significance Index: 5.1700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1769
    Cell Significance Index: 3.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1730
    Cell Significance Index: 94.5000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1485
    Cell Significance Index: 2.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1403
    Cell Significance Index: 3.8200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1381
    Cell Significance Index: 49.5400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1376
    Cell Significance Index: 8.6700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1367
    Cell Significance Index: 4.7500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1049
    Cell Significance Index: 72.5700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1027
    Cell Significance Index: 0.8200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.1003
    Cell Significance Index: 1.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0915
    Cell Significance Index: 2.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0813
    Cell Significance Index: 14.6600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0761
    Cell Significance Index: 1.6200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0715
    Cell Significance Index: 10.3900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0637
    Cell Significance Index: 0.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0601
    Cell Significance Index: 2.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0577
    Cell Significance Index: 2.6900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0544
    Cell Significance Index: 1.9100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0436
    Cell Significance Index: 67.1800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0420
    Cell Significance Index: 1.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0385
    Cell Significance Index: 70.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0279
    Cell Significance Index: 3.6100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0272
    Cell Significance Index: 3.3500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0232
    Cell Significance Index: 0.2400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0194
    Cell Significance Index: 8.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0180
    Cell Significance Index: 33.9100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0089
    Cell Significance Index: 6.7700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0064
    Cell Significance Index: 0.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0063
    Cell Significance Index: 8.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0046
    Cell Significance Index: 2.9500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0004
    Cell Significance Index: -0.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0038
    Cell Significance Index: -2.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0039
    Cell Significance Index: -0.2900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0071
    Cell Significance Index: -0.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0080
    Cell Significance Index: -0.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0086
    Cell Significance Index: -6.3500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0088
    Cell Significance Index: -4.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0091
    Cell Significance Index: -0.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0115
    Cell Significance Index: -6.4600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0136
    Cell Significance Index: -8.5200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0190
    Cell Significance Index: -0.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0192
    Cell Significance Index: -0.8500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0198
    Cell Significance Index: -1.0400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0200
    Cell Significance Index: -5.7500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0212
    Cell Significance Index: -1.5000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0256
    Cell Significance Index: -2.9300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0331
    Cell Significance Index: -4.2400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0333
    Cell Significance Index: -0.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0374
    Cell Significance Index: -3.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0387
    Cell Significance Index: -8.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0442
    Cell Significance Index: -5.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0463
    Cell Significance Index: -3.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0484
    Cell Significance Index: -6.6500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0512
    Cell Significance Index: -0.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0531
    Cell Significance Index: -5.5300
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0542
    Cell Significance Index: -0.6300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0547
    Cell Significance Index: -1.6100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0547
    Cell Significance Index: -3.3600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0582
    Cell Significance Index: -6.8600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0654
    Cell Significance Index: -4.2200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0702
    Cell Significance Index: -1.0100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0718
    Cell Significance Index: -0.6100
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0812
    Cell Significance Index: -0.6700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0874
    Cell Significance Index: -1.0900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0908
    Cell Significance Index: -7.1900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0933
    Cell Significance Index: -4.8600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0938
    Cell Significance Index: -1.9900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1141
    Cell Significance Index: -1.7200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1236
    Cell Significance Index: -1.5600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1237
    Cell Significance Index: -2.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Nucleoside Transporter Protein**: SLC29A2 is a member of the solute carrier family 29, which is characterized by its ability to transport nucleosides across cellular membranes. 2. **Widespread Tissue Expression**: The SLC29A2 gene is expressed in various tissues, including the brain, heart, placenta, and immune cells. 3. **Multiple Transport Pathways**: The SLC29A2 protein is involved in the transport of multiple nucleosides, including adenine, guanine, cytidine, and uracil. 4. **Hydrophobic Nucleolar Protein**: The SLC29A2 protein is a 36 kDa hydrophobic nucleolar protein, suggesting its involvement in nucleolar function and regulation of nucleoside metabolism. **Pathways and Functions** 1. **Nucleoside Metabolism**: The SLC29A2 protein plays a crucial role in the regulation of nucleoside metabolism, including the transport of nucleosides across cellular membranes. 2. **Energy Production**: The SLC29A2 protein is involved in the transport of nucleosides that are required for energy production, including ATP and NAD+. 3. **Neurotransmission**: The SLC29A2 protein is expressed in the brain and is involved in the transport of neurotransmitters, such as GABA, across the blood-brain barrier. 4. **Immune Response**: The SLC29A2 protein is expressed in immune cells, such as macrophages and T cells, and is involved in the transport of nucleosides that are required for immune function. **Clinical Significance** 1. **Disease Association**: The SLC29A2 gene has been associated with several diseases, including adrenoleukodystrophy, a neurodegenerative disorder characterized by the accumulation of very long-chain fatty acids in the brain. 2. **Therapeutic Target**: The SLC29A2 protein is an attractive target for the development of novel therapeutic agents, particularly in the treatment of diseases related to nucleoside metabolism. 3. **Cancer Therapy**: The SLC29A2 protein is overexpressed in certain types of cancer, including glioblastoma and leukemia, making it a potential target for cancer therapy. 4. **Neurological Disorders**: The SLC29A2 protein is involved in the transport of neurotransmitters across the blood-brain barrier, making it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, the SLC29A2 gene encodes a nucleoside transporter protein that plays a crucial role in the regulation of nucleoside metabolism, energy production, and neurotransmission. Its widespread tissue expression and involvement in multiple transport pathways make it an attractive target for the development of novel therapeutic agents, particularly in the treatment of diseases related to nucleoside metabolism.

Genular Protein ID: 4131810547

Symbol: S29A2_HUMAN

Name: Hydrophobic nucleolar protein, 36 kDa

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7639753

Title: A mammalian delayed-early response gene encodes HNP36, a novel, conserved nucleolar protein.

PubMed ID: 7639753

DOI: 10.1006/bbrc.1995.2133

PubMed ID: 9396714

Title: Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placenta.

PubMed ID: 9396714

DOI: 10.1042/bj3280739

PubMed ID: 9478986

Title: Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line.

PubMed ID: 9478986

DOI: 10.1074/jbc.273.9.5288

PubMed ID: 12527552

Title: Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells.

PubMed ID: 12527552

DOI: 10.1152/ajprenal.00215.2002

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10722669

Title: Kinetic and pharmacological properties of cloned human equilibrative nucleoside transporters, ENT1 and ENT2, stably expressed in nucleoside transporter-deficient PK15 cells. Ent2 exhibits a low affinity for guanosine and cytidine but a high affinity for inosine.

PubMed ID: 10722669

DOI: 10.1074/jbc.275.12.8375

PubMed ID: 12590919

Title: Functional analysis of site-directed glycosylation mutants of the human equilibrative nucleoside transporter-2.

PubMed ID: 12590919

DOI: 10.1016/s0003-9861(02)00718-x

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21795683

Title: Nucleobase transport by human equilibrative nucleoside transporter 1 (hENT1).

PubMed ID: 21795683

DOI: 10.1074/jbc.m111.236117

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23639800

Title: Basolateral uptake of nucleosides by Sertoli cells is mediated primarily by equilibrative nucleoside transporter 1.

PubMed ID: 23639800

DOI: 10.1124/jpet.113.203265

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 27271752

Title: Novel nuclear hENT2 isoforms regulate cell cycle progression via controlling nucleoside transport and nuclear reservoir.

PubMed ID: 27271752

DOI: 10.1007/s00018-016-2288-9

PubMed ID: 16214850

Title: Functional characterization and haplotype analysis of polymorphisms in the human equilibrative nucleoside transporter, ENT2.

PubMed ID: 16214850

DOI: 10.1124/dmd.105.006270

Sequence Information:

  • Length: 456
  • Mass: 50113
  • Checksum: ABCBD244306708E1
  • Sequence:
  • MARGDAPRDS YHLVGISFFI LGLGTLLPWN FFITAIPYFQ ARLAGAGNST ARILSTNHTG 
    PEDAFNFNNW VTLLSQLPLL LFTLLNSFLY QCVPETVRIL GSLLAILLLF ALTAALVKVD 
    MSPGPFFSIT MASVCFINSF SAVLQGSLFG QLGTMPSTYS TLFLSGQGLA GIFAALAMLL 
    SMASGVDAET SALGYFITPC VGILMSIVCY LSLPHLKFAR YYLANKSSQA QAQELETKAE 
    LLQSDENGIP SSPQKVALTL DLDLEKEPES EPDEPQKPGK PSVFTVFQKI WLTALCLVLV 
    FTVTLSVFPA ITAMVTSSTS PGKWSQFFNP ICCFLLFNIM DWLGRSLTSY FLWPDEDSRL 
    LPLLVCLRFL FVPLFMLCHV PQRSRLPILF PQDAYFITFM LLFAVSNGYL VSLTMCLAPR 
    QVLPHEREVA GALMTFFLAL GLSCGASLSF LFKALL

Genular Protein ID: 2123172917

Symbol: Q96FB2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 361
  • Mass: 38765
  • Checksum: 26CF176AF0A8ED08
  • Sequence:
  • MARGDAPRDS YHLVGISFFI LGLGTLLPWN FFITAIPYFQ ARLAGAGNST ARILSTNHTG 
    PEDAFNFNHW VTLLSQLPLL LFTLLNSFLY QCVPETVRIL GSLLAILLLF ALTAALVKVD 
    MSPGPFFSIT MASVCFINSF SAVLQGSLFG QLGTMPSTYS TLFLSGQGLA GIFAALAMLL 
    AMASGVDAET SALGYFITPC VGILMSIVCY LSLPHLKFAR YYLANKSSQA QAQELETKAE 
    LLQSDLADSA VPCVGLHSHP VRLPRHHSHG DQLHQSWEVE SVLQPHLLLP PLQHHGLAGT 
    EPDLLLPVAR RGQPAAAPAG LPAVPVRAPL HAVPRAPEVP AAHPLPTGCL LHHLHAALCR 
    F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.