Details for: SLC29A2

Gene ID: 3177

Symbol: SLC29A2

Ensembl ID: ENSG00000174669

Description: solute carrier family 29 member 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.11
    Marker Score: 537
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1
    Marker Score: 4342
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.09
    Marker Score: 17124
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.02
    Marker Score: 1939
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71818
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48043
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.97
    Marker Score: 3439
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 0.97
    Marker Score: 353
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5184
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.79
    Marker Score: 17600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 578.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 303
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 683
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.75
    Marker Score: 1154
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.72
    Marker Score: 541
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.68
    Marker Score: 826
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.68
    Marker Score: 160
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.68
    Marker Score: 911
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.66
    Marker Score: 6824
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.63
    Marker Score: 579
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.6
    Marker Score: 1509
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.6
    Marker Score: 1223
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.58
    Marker Score: 245
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 442
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.52
    Marker Score: 249
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.5
    Marker Score: 1272
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.5
    Marker Score: 293
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.49
    Marker Score: 293
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.48
    Marker Score: 132
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.48
    Marker Score: 414
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.47
    Marker Score: 17435
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.47
    Marker Score: 259
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.45
    Marker Score: 291
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.45
    Marker Score: 716
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.44
    Marker Score: 451
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.44
    Marker Score: 1053
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.44
    Marker Score: 26958
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.44
    Marker Score: 183
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.43
    Marker Score: 263
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.42
    Marker Score: 321.5
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.42
    Marker Score: 3967
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.41
    Marker Score: 281
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.41
    Marker Score: 1668
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.4
    Marker Score: 15320
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.39
    Marker Score: 3353
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.38
    Marker Score: 256
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.38
    Marker Score: 292
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.37
    Marker Score: 3520
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.36
    Marker Score: 1405
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.36
    Marker Score: 752
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.36
    Marker Score: 1126
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.36
    Marker Score: 1475
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.35
    Marker Score: 939
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.35
    Marker Score: 302
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.35
    Marker Score: 2278
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.35
    Marker Score: 577
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.35
    Marker Score: 68
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.35
    Marker Score: 345.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.34
    Marker Score: 477
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.33
    Marker Score: 352
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.33
    Marker Score: 104
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.33
    Marker Score: 217
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.33
    Marker Score: 136
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.33
    Marker Score: 185
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.33
    Marker Score: 6938
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.32
    Marker Score: 1358
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.32
    Marker Score: 11236
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.32
    Marker Score: 348.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.32
    Marker Score: 141
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.29
    Marker Score: 172
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.29
    Marker Score: 508
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.29
    Marker Score: 301
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.28
    Marker Score: 5613
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.28
    Marker Score: 148
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.28
    Marker Score: 74
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.28
    Marker Score: 2125
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.28
    Marker Score: 154
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.26
    Marker Score: 1952
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.26
    Marker Score: 3860
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.26
    Marker Score: 4116
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.25
    Marker Score: 304.5
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.25
    Marker Score: 78
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.24
    Marker Score: 87
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.24
    Marker Score: 162
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.24
    Marker Score: 169
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.24
    Marker Score: 196
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.23
    Marker Score: 1474
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.23
    Marker Score: 151
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.23
    Marker Score: 226

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Other Information

**Key characteristics:** - The protein is a hydrophilic protein with a molecular weight of approximately 36 kDa. - It is a member of the SLC29 family of solute carriers, which are responsible for the transport of various molecules across the plasma membrane. - It is expressed in cells that are involved in energy metabolism, ion transport, and signaling. **Pathways and functions:** - SLC29A2 is involved in a variety of cellular processes, including energy metabolism, ion transport, and signaling. - It is expressed in cells that are involved in the uptake and transport of nucleosides and free purine and pyrimidine bases. - It is also expressed in cells that are involved in the transport of small molecules and nutrients across the plasma membrane. - It is involved in the regulation of cardiac function and blood pressure. **Clinical significance:** - Mutations in SLC29A2 have been linked to a number of human diseases, including hyperlipidemia, diabetes, and obesity. - SLC29A2 is a potential target for the treatment of these diseases. **Conclusion:** SLC29A2 is an important protein that plays a key role in maintaining cellular function and homeostasis. Its mutations can lead to a number of human diseases, highlighting its importance in human health.

Genular Protein ID: 4131810547

Symbol: S29A2_HUMAN

Name: Hydrophobic nucleolar protein, 36 kDa

UniProtKB Accession Codes:

Q14542 B3KPY7 G5E943 O43530 Q52M84 Q96R00 Q9UPE0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChEBI 11 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 10 EMBL 10 EPD 1 Ensembl 7 ExpressionAtlas 1 GO 33 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 5 Rhea 33 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7639753

Title: A mammalian delayed-early response gene encodes HNP36, a novel, conserved nucleolar protein.

PubMed ID: 7639753

DOI: 10.1006/bbrc.1995.2133

PubMed ID: 9396714

Title: Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placenta.

PubMed ID: 9396714

DOI: 10.1042/bj3280739

PubMed ID: 9478986

Title: Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line.

PubMed ID: 9478986

DOI: 10.1074/jbc.273.9.5288

PubMed ID: 12527552

Title: Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells.

PubMed ID: 12527552

DOI: 10.1152/ajprenal.00215.2002

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10722669

Title: Kinetic and pharmacological properties of cloned human equilibrative nucleoside transporters, ENT1 and ENT2, stably expressed in nucleoside transporter-deficient PK15 cells. Ent2 exhibits a low affinity for guanosine and cytidine but a high affinity for inosine.

PubMed ID: 10722669

DOI: 10.1074/jbc.275.12.8375

PubMed ID: 12590919

Title: Functional analysis of site-directed glycosylation mutants of the human equilibrative nucleoside transporter-2.

PubMed ID: 12590919

DOI: 10.1016/s0003-9861(02)00718-x

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21795683

Title: Nucleobase transport by human equilibrative nucleoside transporter 1 (hENT1).

PubMed ID: 21795683

DOI: 10.1074/jbc.m111.236117

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23639800

Title: Basolateral uptake of nucleosides by Sertoli cells is mediated primarily by equilibrative nucleoside transporter 1.

PubMed ID: 23639800

DOI: 10.1124/jpet.113.203265

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 27271752

Title: Novel nuclear hENT2 isoforms regulate cell cycle progression via controlling nucleoside transport and nuclear reservoir.

PubMed ID: 27271752

DOI: 10.1007/s00018-016-2288-9

PubMed ID: 16214850

Title: Functional characterization and haplotype analysis of polymorphisms in the human equilibrative nucleoside transporter, ENT2.

PubMed ID: 16214850

DOI: 10.1124/dmd.105.006270

Sequence Information:

  • Length: 456
  • Mass: 50113
  • Checksum: ABCBD244306708E1
  • Sequence:
    • MARGDAPRDS YHLVGISFFI LGLGTLLPWN FFITAIPYFQ ARLAGAGNST ARILSTNHTG 
PEDAFNFNNW VTLLSQLPLL LFTLLNSFLY QCVPETVRIL GSLLAILLLF ALTAALVKVD 
MSPGPFFSIT MASVCFINSF SAVLQGSLFG QLGTMPSTYS TLFLSGQGLA GIFAALAMLL 
SMASGVDAET SALGYFITPC VGILMSIVCY LSLPHLKFAR YYLANKSSQA QAQELETKAE 
LLQSDENGIP SSPQKVALTL DLDLEKEPES EPDEPQKPGK PSVFTVFQKI WLTALCLVLV 
FTVTLSVFPA ITAMVTSSTS PGKWSQFFNP ICCFLLFNIM DWLGRSLTSY FLWPDEDSRL 
LPLLVCLRFL FVPLFMLCHV PQRSRLPILF PQDAYFITFM LLFAVSNGYL VSLTMCLAPR 
QVLPHEREVA GALMTFFLAL GLSCGASLSF LFKALL

Genular Protein ID: 2123172917

Symbol: Q96FB2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96FB2

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 2 Genevisible 1 GenomeRNAi 1 IntAct 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 2 SAM 1 SMR 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 361
  • Mass: 38765
  • Checksum: 26CF176AF0A8ED08
  • Sequence:
    • MARGDAPRDS YHLVGISFFI LGLGTLLPWN FFITAIPYFQ ARLAGAGNST ARILSTNHTG 
PEDAFNFNHW VTLLSQLPLL LFTLLNSFLY QCVPETVRIL GSLLAILLLF ALTAALVKVD 
MSPGPFFSIT MASVCFINSF SAVLQGSLFG QLGTMPSTYS TLFLSGQGLA GIFAALAMLL 
AMASGVDAET SALGYFITPC VGILMSIVCY LSLPHLKFAR YYLANKSSQA QAQELETKAE 
LLQSDLADSA VPCVGLHSHP VRLPRHHSHG DQLHQSWEVE SVLQPHLLLP PLQHHGLAGT 
EPDLLLPVAR RGQPAAAPAG LPAVPVRAPL HAVPRAPEVP AAHPLPTGCL LHHLHAALCR 
F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.