Details for: HNRNPL

Gene ID: 3191

Symbol: HNRNPL

Ensembl ID: ENSG00000104824

Description: heterogeneous nuclear ribonucleoprotein L

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 3.83
    Marker Score: 3066
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.79
    Marker Score: 155836
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.07
    Marker Score: 109268
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.04
    Marker Score: 2316
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.02
    Marker Score: 13156
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.99
    Marker Score: 5575
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.97
    Marker Score: 6212
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.95
    Marker Score: 5320
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.91
    Marker Score: 2027
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.74
    Marker Score: 1875
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.71
    Marker Score: 17214
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.67
    Marker Score: 56813
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.63
    Marker Score: 496
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.62
    Marker Score: 9625
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.62
    Marker Score: 21397
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.57
    Marker Score: 3294
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.56
    Marker Score: 15835
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.53
    Marker Score: 11411.5
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.49
    Marker Score: 1863
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.48
    Marker Score: 983.5
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.48
    Marker Score: 1160
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.46
    Marker Score: 1064
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.46
    Marker Score: 1437
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.44
    Marker Score: 503
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.44
    Marker Score: 21537
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.44
    Marker Score: 620
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.42
    Marker Score: 340
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.42
    Marker Score: 2994
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.41
    Marker Score: 1190
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.4
    Marker Score: 773
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.39
    Marker Score: 1634
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.39
    Marker Score: 2279
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.38
    Marker Score: 833.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.36
    Marker Score: 5052.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.36
    Marker Score: 1457
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.36
    Marker Score: 659
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.34
    Marker Score: 1785
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.34
    Marker Score: 562
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.34
    Marker Score: 1455
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.33
    Marker Score: 903
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.32
    Marker Score: 651
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.31
    Marker Score: 1860
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.31
    Marker Score: 5055.5
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.31
    Marker Score: 527
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.3
    Marker Score: 531
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.3
    Marker Score: 475
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3
    Marker Score: 79814
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.3
    Marker Score: 9943
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.29
    Marker Score: 3841
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.28
    Marker Score: 454
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.28
    Marker Score: 2498
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.28
    Marker Score: 397
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.28
    Marker Score: 280
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.28
    Marker Score: 47151
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.28
    Marker Score: 400
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.28
    Marker Score: 409
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 1.27
    Marker Score: 535
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.27
    Marker Score: 410
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.27
    Marker Score: 403
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.27
    Marker Score: 334
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.27
    Marker Score: 1165
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.27
    Marker Score: 1099
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.27
    Marker Score: 4887
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.27
    Marker Score: 1866
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.26
    Marker Score: 25145
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.26
    Marker Score: 1320
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.26
    Marker Score: 789
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.26
    Marker Score: 362
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.25
    Marker Score: 852
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.25
    Marker Score: 1792.5
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.24
    Marker Score: 430
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.24
    Marker Score: 312
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.24
    Marker Score: 930
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.24
    Marker Score: 3371
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.24
    Marker Score: 47032
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.24
    Marker Score: 1157
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.23
    Marker Score: 700
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.23
    Marker Score: 1251
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.23
    Marker Score: 765
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.22
    Marker Score: 835
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.22
    Marker Score: 1229
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.22
    Marker Score: 607.5
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.22
    Marker Score: 5215
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.21
    Marker Score: 1284
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.21
    Marker Score: 11526.5
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.21
    Marker Score: 456
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.21
    Marker Score: 10368
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.21
    Marker Score: 2137.5
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.2
    Marker Score: 562
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.2
    Marker Score: 1207
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.2
    Marker Score: 295
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.2
    Marker Score: 812
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.19
    Marker Score: 1645
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.19
    Marker Score: 2708.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.19
    Marker Score: 2797
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.19
    Marker Score: 11751
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.19
    Marker Score: 258
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.19
    Marker Score: 682
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.18
    Marker Score: 271
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.18
    Marker Score: 352

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Other Information

**Key characteristics:** - HNRNPL is a nuclear protein with a molecular weight of approximately 500 kDa. - It is a key component of the spliceosome, an RNA-protein complex responsible for mRNA splicing. - HNRNPL is a negative regulator of DNA-templated transcription. - It is involved in the regulation of alternative mRNA splicing by binding to the pre-mrna and facilitating its inclusion or exclusion in the mature mRNA. **Pathways and functions:** - HNRNPL is involved in the regulation of alternative mRNA splicing through its interaction with the spliceosome. - It helps to control the inclusion or exclusion of exons in the mature mRNA. - It plays a role in the development and maintenance of tissue identity and differentiation. - It is also involved in the regulation of cell proliferation, differentiation, and apoptosis. **Clinical significance:** - Mutations in HNRNPL have been linked to several human diseases, including cancer and neurodegenerative disorders. - Dysregulation of HNRNPL has been implicated in the pathogenesis of these diseases. - Therefore, understanding the role of HNRNPL in mRNA splicing could lead to the development of novel therapeutic strategies for these diseases.

Genular Protein ID: 2779626072

Symbol: HNRPL_HUMAN

Name: Heterogeneous nuclear ribonucleoprotein L

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11280764

Title: Molecular basis of T cell-mediated recognition of pancreatic cancer cells.

PubMed ID: 11280764

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 2687284

Title: A novel heterogeneous nuclear RNP protein with a unique distribution on nascent transcripts.

PubMed ID: 2687284

DOI: 10.1083/jcb.109.6.2575

PubMed ID: 1286667

Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.

PubMed ID: 1286667

DOI: 10.1002/elps.11501301199

PubMed ID: 11809897

Title: Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter.

PubMed ID: 11809897

DOI: 10.1093/nar/30.3.823

PubMed ID: 17289661

Title: Molecular composition of IMP1 ribonucleoprotein granules.

PubMed ID: 17289661

DOI: 10.1074/mcp.m600346-mcp200

PubMed ID: 18161049

Title: Natural antisense transcript stabilizes inducible nitric oxide synthase messenger RNA in rat hepatocytes.

PubMed ID: 18161049

DOI: 10.1002/hep.22036

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18669861

Title: Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL.

PubMed ID: 18669861

DOI: 10.1126/science.1157610

PubMed ID: 19332550

Title: Heterogeneous nuclear ribonucleoprotein L is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo.

PubMed ID: 19332550

DOI: 10.1074/jbc.m808431200

PubMed ID: 19124611

Title: Auto- and cross-regulation of the hnRNP L proteins by alternative splicing.

PubMed ID: 19124611

DOI: 10.1128/mcb.01689-08

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22570490

Title: A conserved serine of heterogeneous nuclear ribonucleoprotein L (hnRNP L) mediates depolarization-regulated alternative splicing of potassium channels.

PubMed ID: 22570490

DOI: 10.1074/jbc.m112.357343

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24164894

Title: Transcriptome-wide RNA interaction profiling reveals physical and functional targets of hnRNP L in human T cells.

PubMed ID: 24164894

DOI: 10.1128/mcb.00740-13

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25623890

Title: hnRNP L inhibits CD44 V10 exon splicing through interacting with its upstream intron.

PubMed ID: 25623890

DOI: 10.1016/j.bbagrm.2015.01.004

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 26051023

Title: The signature of the five-stranded vRRM fold defined by functional, structural and computational analysis of the hnRNP L protein.

PubMed ID: 26051023

DOI: 10.1016/j.jmb.2015.05.020

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 33174841

Title: circZNF827 nucleates a transcription inhibitory complex to balance neuronal differentiation.

PubMed ID: 33174841

DOI: 10.7554/elife.58478

PubMed ID: 36537238

Title: CHD8 suppression impacts on histone H3 lysine 36 trimethylation and alters RNA alternative splicing.

PubMed ID: 36537238

DOI: 10.1093/nar/gkac1134

PubMed ID: 23782695

Title: Crystal structures and RNA-binding properties of the RNA recognition motifs of heterogeneous nuclear ribonucleoprotein L: insights into its roles in alternative splicing regulation.

PubMed ID: 23782695

DOI: 10.1074/jbc.m113.463901

Sequence Information:

  • Length: 589
  • Mass: 64133
  • Checksum: 31EEB51AF1C65F83
  • Sequence:
  • MSRRLLPRAE KRRRRLEQRQ QPDEQRRRSG AMVKMAAAGG GGGGGRYYGG GSEGGRAPKR 
    LKTDNAGDQH GGGGGGGGGA GAAGGGGGGE NYDDPHKTPA SPVVHIRGLI DGVVEADLVE 
    ALQEFGPISY VVVMPKKRQA LVEFEDVLGA CNAVNYAADN QIYIAGHPAF VNYSTSQKIS 
    RPGDSDDSRS VNSVLLFTIL NPIYSITTDV LYTICNPCGP VQRIVIFRKN GVQAMVEFDS 
    VQSAQRAKAS LNGADIYSGC CTLKIEYAKP TRLNVFKNDQ DTWDYTNPNL SGQGDPGSNP 
    NKRQRQPPLL GDHPAEYGGP HGGYHSHYHD EGYGPPPPHY EGRRMGPPVG GHRRGPSRYG 
    PQYGHPPPPP PPPEYGPHAD SPVLMVYGLD QSKMNCDRVF NVFCLYGNVE KVKFMKSKPG 
    AAMVEMADGY AVDRAITHLN NNFMFGQKLN VCVSKQPAIM PGQSYGLEDG SCSYKDFSES 
    RNNRFSTPEQ AAKNRIQHPS NVLHFFNAPL EVTEENFFEI CDELGVKRPS SVKVFSGKSE 
    RSSSGLLEWE SKSDALETLG FLNHYQMKNP NGPYPYTLKL CFSTAQHAS

Genular Protein ID: 708121467

Symbol: Q6NTA2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 572
  • Mass: 61927
  • Checksum: 5E5EB8F6773DC522
  • Sequence:
  • QRQQPDEQRR RSGAMVKMAA AGGGGGGGRY YGGGSEGGRA PKRLKTDNAG DQHGGGGGGG 
    GGAGAAGGGG GGENYDDPHK TPASPVVHIR GLIDGVVEAD LVEALQEFGP ISYVVVMPKK 
    RQALVEFEDV LGACNAVNYA ADNQIYIAGH PAFVNYSTSQ KISRPGDSDD SRSVNSVLLF 
    TILNPIYSIT TDVLYTICNP CGPVQRIVIF RKNGVQAMVE FDSVQSAQRA KASLNGADIY 
    SGCCTLKIEY AKPTRLNVFK NDQDTWDYTN PNLSGQGDPG SNPNKRQRQP PLLGDHPAEY 
    GGPHGGYHSH YHDEGYGPPP PHYEGRRMGP PVGGHRRGPS RYGPQYGHPP PPPPPPEYGP 
    HADSPVLMVY GLDQSKMNCD RVFNVFCLYG NVEKVKFMKS KPGAAMVEMA DGYAVDRAIT 
    HLNNNFMFGQ KLNVCVSKQP AIMPGQSYGL EDGSCSYKDF SESRNNRFST PEQAAKNRIQ 
    HPSNVLHFFN APLEVTEENF FEICDELGVK RPSSVKVFSG KSERSSSGLL EWESKSDALE 
    TLGFLNHYQM KNPNGPYPYT LKLCFSTAQH AS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.