Details for: HNRNPL
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 291.8765
Cell Significance Index: -45.4000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 180.4108
Cell Significance Index: -45.7600 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 97.3201
Cell Significance Index: -50.0600 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 75.7054
Cell Significance Index: -50.8000 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 40.1393
Cell Significance Index: -49.4900 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 16.9027
Cell Significance Index: -45.2800 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 13.0655
Cell Significance Index: -40.1300 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 12.8027
Cell Significance Index: -50.5200 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 9.6820
Cell Significance Index: -21.1900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 2.9009
Cell Significance Index: 81.0700 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 2.5706
Cell Significance Index: 418.0900 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.8769
Cell Significance Index: 34.6900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.8712
Cell Significance Index: 25.5300 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 1.7581
Cell Significance Index: 22.5200 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.3091
Cell Significance Index: 34.9600 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.2791
Cell Significance Index: 18.8800 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.2523
Cell Significance Index: 80.8000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.2192
Cell Significance Index: 1100.8600 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.1647
Cell Significance Index: 209.9600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.1115
Cell Significance Index: 222.9700 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.9826
Cell Significance Index: 434.4200 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.9593
Cell Significance Index: 117.9600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.8400
Cell Significance Index: 166.7000 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.8082
Cell Significance Index: 95.3200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.7980
Cell Significance Index: 36.1700 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.7727
Cell Significance Index: 106.1100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.7511
Cell Significance Index: 269.4100 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7506
Cell Significance Index: 21.6300 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.7132
Cell Significance Index: 20.4500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.6650
Cell Significance Index: 18.1000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.6530
Cell Significance Index: 48.6700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.6498
Cell Significance Index: 354.8600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4747
Cell Significance Index: 32.8300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.4587
Cell Significance Index: 28.9100 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4171
Cell Significance Index: 41.2600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.4151
Cell Significance Index: 19.5100 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.4032
Cell Significance Index: 52.0900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.3745
Cell Significance Index: 28.7400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.3686
Cell Significance Index: 26.0700 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.3680
Cell Significance Index: 17.1600 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.3320
Cell Significance Index: 42.5600 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2524
Cell Significance Index: 13.1100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.2416
Cell Significance Index: 13.5600 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.2325
Cell Significance Index: 11.7500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1505
Cell Significance Index: 3.2600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1132
Cell Significance Index: 21.5500 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.1108
Cell Significance Index: 3.8500 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0599
Cell Significance Index: 2.1100 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.0581
Cell Significance Index: 3.0500 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: 0.0573
Cell Significance Index: 1.2000 - Cell Name: granulosa cell (CL0000501)
Fold Change: 0.0555
Cell Significance Index: 1.4600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0521
Cell Significance Index: 98.0600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0372
Cell Significance Index: 57.2900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0255
Cell Significance Index: 46.9900 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.0247
Cell Significance Index: 0.3700 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0228
Cell Significance Index: 14.5100 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0138
Cell Significance Index: 2.3600 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0056
Cell Significance Index: 7.6700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0017
Cell Significance Index: 0.7500 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.0247
Cell Significance Index: -0.1900 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0305
Cell Significance Index: -22.3900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0323
Cell Significance Index: -1.4300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0329
Cell Significance Index: -24.9100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0421
Cell Significance Index: -31.1500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0787
Cell Significance Index: -8.0400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0787
Cell Significance Index: -44.4000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1435
Cell Significance Index: -3.8500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1514
Cell Significance Index: -43.5500 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1653
Cell Significance Index: -24.0300 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1681
Cell Significance Index: -19.5900 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1788
Cell Significance Index: -6.7700 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.1839
Cell Significance Index: -5.4000 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.2498
Cell Significance Index: -4.4200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2551
Cell Significance Index: -53.7400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2669
Cell Significance Index: -30.5800 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.2803
Cell Significance Index: -5.9700 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.2862
Cell Significance Index: -4.7900 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4014
Cell Significance Index: -12.8600 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4168
Cell Significance Index: -43.4000 - Cell Name: skeletal muscle myoblast (CL0000515)
Fold Change: -0.4940
Cell Significance Index: -5.3700 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.5013
Cell Significance Index: -10.7200 - Cell Name: peg cell (CL4033014)
Fold Change: -0.5281
Cell Significance Index: -12.2000 - Cell Name: Sertoli cell (CL0000216)
Fold Change: -0.5532
Cell Significance Index: -7.7600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5552
Cell Significance Index: -43.9700 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.6256
Cell Significance Index: -12.2100 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.6542
Cell Significance Index: -11.0200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: -0.6799
Cell Significance Index: -40.8200 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.7205
Cell Significance Index: -44.1800 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: -0.7229
Cell Significance Index: -9.2700 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: -0.7792
Cell Significance Index: -5.0800 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.8487
Cell Significance Index: -7.8200 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.8689
Cell Significance Index: -5.2500 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.8777
Cell Significance Index: -22.5600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.8781
Cell Significance Index: -21.9500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.9333
Cell Significance Index: -29.7300 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.9418
Cell Significance Index: -22.9800 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.9575
Cell Significance Index: -31.3500 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.9644
Cell Significance Index: -39.5200 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.9716
Cell Significance Index: -24.8200 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.9925
Cell Significance Index: -34.7700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2779626072
Symbol: HNRPL_HUMAN
Name: Heterogeneous nuclear ribonucleoprotein L
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11280764
Title: Molecular basis of T cell-mediated recognition of pancreatic cancer cells.
PubMed ID: 11280764
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 2687284
Title: A novel heterogeneous nuclear RNP protein with a unique distribution on nascent transcripts.
PubMed ID: 2687284
PubMed ID: 1286667
Title: Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.
PubMed ID: 1286667
PubMed ID: 11809897
Title: Human AP-endonuclease 1 and hnRNP-L interact with a nCaRE-like repressor element in the AP-endonuclease 1 promoter.
PubMed ID: 11809897
DOI: 10.1093/nar/30.3.823
PubMed ID: 17289661
Title: Molecular composition of IMP1 ribonucleoprotein granules.
PubMed ID: 17289661
PubMed ID: 18161049
Title: Natural antisense transcript stabilizes inducible nitric oxide synthase messenger RNA in rat hepatocytes.
PubMed ID: 18161049
DOI: 10.1002/hep.22036
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 18669861
Title: Regulation of CD45 alternative splicing by heterogeneous ribonucleoprotein, hnRNPLL.
PubMed ID: 18669861
PubMed ID: 19332550
Title: Heterogeneous nuclear ribonucleoprotein L is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo.
PubMed ID: 19332550
PubMed ID: 19124611
Title: Auto- and cross-regulation of the hnRNP L proteins by alternative splicing.
PubMed ID: 19124611
DOI: 10.1128/mcb.01689-08
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22570490
Title: A conserved serine of heterogeneous nuclear ribonucleoprotein L (hnRNP L) mediates depolarization-regulated alternative splicing of potassium channels.
PubMed ID: 22570490
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 24164894
Title: Transcriptome-wide RNA interaction profiling reveals physical and functional targets of hnRNP L in human T cells.
PubMed ID: 24164894
DOI: 10.1128/mcb.00740-13
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 25623890
Title: hnRNP L inhibits CD44 V10 exon splicing through interacting with its upstream intron.
PubMed ID: 25623890
PubMed ID: 25772364
Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
PubMed ID: 25772364
PubMed ID: 26051023
Title: The signature of the five-stranded vRRM fold defined by functional, structural and computational analysis of the hnRNP L protein.
PubMed ID: 26051023
PubMed ID: 25755297
Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
PubMed ID: 25755297
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 33174841
Title: circZNF827 nucleates a transcription inhibitory complex to balance neuronal differentiation.
PubMed ID: 33174841
DOI: 10.7554/elife.58478
PubMed ID: 36537238
Title: CHD8 suppression impacts on histone H3 lysine 36 trimethylation and alters RNA alternative splicing.
PubMed ID: 36537238
DOI: 10.1093/nar/gkac1134
PubMed ID: 23782695
Title: Crystal structures and RNA-binding properties of the RNA recognition motifs of heterogeneous nuclear ribonucleoprotein L: insights into its roles in alternative splicing regulation.
PubMed ID: 23782695
Sequence Information:
- Length: 589
- Mass: 64133
- Checksum: 31EEB51AF1C65F83
- Sequence:
MSRRLLPRAE KRRRRLEQRQ QPDEQRRRSG AMVKMAAAGG GGGGGRYYGG GSEGGRAPKR LKTDNAGDQH GGGGGGGGGA GAAGGGGGGE NYDDPHKTPA SPVVHIRGLI DGVVEADLVE ALQEFGPISY VVVMPKKRQA LVEFEDVLGA CNAVNYAADN QIYIAGHPAF VNYSTSQKIS RPGDSDDSRS VNSVLLFTIL NPIYSITTDV LYTICNPCGP VQRIVIFRKN GVQAMVEFDS VQSAQRAKAS LNGADIYSGC CTLKIEYAKP TRLNVFKNDQ DTWDYTNPNL SGQGDPGSNP NKRQRQPPLL GDHPAEYGGP HGGYHSHYHD EGYGPPPPHY EGRRMGPPVG GHRRGPSRYG PQYGHPPPPP PPPEYGPHAD SPVLMVYGLD QSKMNCDRVF NVFCLYGNVE KVKFMKSKPG AAMVEMADGY AVDRAITHLN NNFMFGQKLN VCVSKQPAIM PGQSYGLEDG SCSYKDFSES RNNRFSTPEQ AAKNRIQHPS NVLHFFNAPL EVTEENFFEI CDELGVKRPS SVKVFSGKSE RSSSGLLEWE SKSDALETLG FLNHYQMKNP NGPYPYTLKL CFSTAQHAS
Genular Protein ID: 708121467
Symbol: Q6NTA2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 572
- Mass: 61927
- Checksum: 5E5EB8F6773DC522
- Sequence:
QRQQPDEQRR RSGAMVKMAA AGGGGGGGRY YGGGSEGGRA PKRLKTDNAG DQHGGGGGGG GGAGAAGGGG GGENYDDPHK TPASPVVHIR GLIDGVVEAD LVEALQEFGP ISYVVVMPKK RQALVEFEDV LGACNAVNYA ADNQIYIAGH PAFVNYSTSQ KISRPGDSDD SRSVNSVLLF TILNPIYSIT TDVLYTICNP CGPVQRIVIF RKNGVQAMVE FDSVQSAQRA KASLNGADIY SGCCTLKIEY AKPTRLNVFK NDQDTWDYTN PNLSGQGDPG SNPNKRQRQP PLLGDHPAEY GGPHGGYHSH YHDEGYGPPP PHYEGRRMGP PVGGHRRGPS RYGPQYGHPP PPPPPPEYGP HADSPVLMVY GLDQSKMNCD RVFNVFCLYG NVEKVKFMKS KPGAAMVEMA DGYAVDRAIT HLNNNFMFGQ KLNVCVSKQP AIMPGQSYGL EDGSCSYKDF SESRNNRFST PEQAAKNRIQ HPSNVLHFFN APLEVTEENF FEICDELGVK RPSSVKVFSG KSERSSSGLL EWESKSDALE TLGFLNHYQM KNPNGPYPYT LKLCFSTAQH AS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.