Details for: HOXB2

Gene ID: 3212

Symbol: HOXB2

Ensembl ID: ENSG00000173917

Description: homeobox B2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 4.08
    Marker Score: 3269
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 2.62
    Marker Score: 3763.5
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.22
    Marker Score: 2493
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.15
    Marker Score: 28415
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.03
    Marker Score: 2167
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.99
    Marker Score: 1871
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.95
    Marker Score: 1226
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.95
    Marker Score: 1943
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.83
    Marker Score: 63289
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.79
    Marker Score: 1063
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.76
    Marker Score: 3683
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.69
    Marker Score: 568
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.55
    Marker Score: 3651
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.54
    Marker Score: 729
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.48
    Marker Score: 347
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.37
    Marker Score: 914
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.33
    Marker Score: 3362
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.33
    Marker Score: 2320
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.2
    Marker Score: 3221
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.2
    Marker Score: 415
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.19
    Marker Score: 2919
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.18
    Marker Score: 1959
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.13
    Marker Score: 4753
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.08
    Marker Score: 211.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71757
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47982
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.98
    Marker Score: 310
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.96
    Marker Score: 363
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 486
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 440
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.91
    Marker Score: 470
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5182
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2717
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.9
    Marker Score: 289
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.9
    Marker Score: 1269
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.89
    Marker Score: 947.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.89
    Marker Score: 355
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.89
    Marker Score: 407
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.88
    Marker Score: 831
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5257
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.86
    Marker Score: 908
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.85
    Marker Score: 862
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.83
    Marker Score: 1140
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.82
    Marker Score: 583
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.78
    Marker Score: 221
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.76
    Marker Score: 153.5
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.76
    Marker Score: 167
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.75
    Marker Score: 1223
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 572.5
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.73
    Marker Score: 391
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 377
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.73
    Marker Score: 282
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.71
    Marker Score: 882
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.71
    Marker Score: 448
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.71
    Marker Score: 414
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 645
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.7
    Marker Score: 1840
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.69
    Marker Score: 195
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.69
    Marker Score: 2171
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.68
    Marker Score: 2617.5
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.67
    Marker Score: 1263.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.67
    Marker Score: 643
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.65
    Marker Score: 351.5
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.65
    Marker Score: 158
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.64
    Marker Score: 189
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.64
    Marker Score: 630
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.64
    Marker Score: 266
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.63
    Marker Score: 599
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.63
    Marker Score: 785
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.63
    Marker Score: 196
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.63
    Marker Score: 151
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.63
    Marker Score: 453
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.62
    Marker Score: 1812
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.62
    Marker Score: 408
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.62
    Marker Score: 298
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.61
    Marker Score: 32334
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.6
    Marker Score: 375
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.59
    Marker Score: 20026
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.57
    Marker Score: 129
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.56
    Marker Score: 1116
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.56
    Marker Score: 619
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.55
    Marker Score: 129
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.55
    Marker Score: 612
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.55
    Marker Score: 787
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.54
    Marker Score: 193
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.53
    Marker Score: 301
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.52
    Marker Score: 133
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.52
    Marker Score: 445
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.51
    Marker Score: 1813
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.5
    Marker Score: 341
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.5
    Marker Score: 888
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5
    Marker Score: 360
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.49
    Marker Score: 1942
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.49
    Marker Score: 438
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.49
    Marker Score: 231

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Other Information

**Key characteristics** * HOXB2 is a homeobox gene, which are a family of transcription factors that are involved in the development of the body. * It is expressed in a variety of cell types, including pulmonary interstitial fibroblast, respiratory basal cell, peripheral nervous system neuron, mesodermal cell, neural crest cell, and migratory enteric neural crest cell. * It is involved in the development of the anterior/posterior axis of the human body, the development of the facial nerve, and the development of the embryonic skeleton. **Pathways and functions** * HOXB2 is involved in the activation of anterior hox genes in hindbrain development. * It is involved in the activation of hox genes during differentiation. * It is involved in the specification of the anterior/posterior axis of the human body. * It is involved in chromatin remodeling and the regulation of gene expression. * It is involved in the development of the facial nerve. * It is involved in the development of the embryonic skeleton. **Clinical significance** HOXB2 mutations have been linked to a number of human diseases, including craniosynostosis, which is a condition that is characterized by the formation of multiple eyes. HOXB2 mutations can also be linked to the development of various types of cancer.

Genular Protein ID: 387850814

Symbol: HXB2_HUMAN

Name: Homeobox protein Hox-B2

UniProtKB Accession Codes:

P14652 P10913 P17485

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 6 Ensembl 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2574852

Title: The human HOX gene family.

PubMed ID: 2574852

DOI: 10.1093/nar/17.24.10385

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2570724

Title: Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system.

PubMed ID: 2570724

DOI: 10.1111/j.1432-0436.1989.tb00598.x

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

PubMed ID: 2901346

Title: Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages.

PubMed ID: 2901346

DOI: 10.1002/j.1460-2075.1988.tb03052.x

PubMed ID: 7876223

Title: Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells.

PubMed ID: 7876223

DOI: 10.1074/jbc.270.9.4544

PubMed ID: 10595394

Title: The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation.

PubMed ID: 10595394

DOI: 10.1089/104454999314809

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 356
  • Mass: 37914
  • Checksum: D7ACA0E3D5BEBFB9
  • Sequence:
    • MNFEFEREIG FINSQPSLAE CLTSFPAVLE TFQTSSIKES TLIPPPPPFE QTFPSLQPGA 
STLQRPRSQK RAEDGPALPP PPPPPLPAAP PAPEFPWMKE KKSAKKPSQS ATSPSPAASA 
VPASGVGSPA DGLGLPEAGG GGARRLRTAY TNTQLLELEK EFHFNKYLCR PRRVEIAALL 
DLTERQVKVW FQNRRMKHKR QTQHREPPDG EPACPGALED ICDPAEEPAA SPGGPSASRA 
AWEACCHPPE VVPGALSADP RPLAVRLEGA GASSPGCALR GAGGLEPGPL PEDVFSGRQD 
SPFLPDLNFF AADSCLQLSG GLSPSLQGSL DSPVPFSEEE LDFFTSTLCA IDLQFP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.