Details for: HOXB2

Gene ID: 3212

Symbol: HOXB2

Ensembl ID: ENSG00000173917

Description: homeobox B2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 93.8634
    Cell Significance Index: -14.6000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 60.0055
    Cell Significance Index: -15.2200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 33.6247
    Cell Significance Index: -15.8800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.5771
    Cell Significance Index: -16.7400
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 5.4956
    Cell Significance Index: 34.0000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.4374
    Cell Significance Index: -17.5100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.7912
    Cell Significance Index: 30.2700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.4418
    Cell Significance Index: -9.2200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 3.1310
    Cell Significance Index: 26.3000
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 2.9881
    Cell Significance Index: 16.9900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.4957
    Cell Significance Index: 62.3900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.3341
    Cell Significance Index: 81.1100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.0257
    Cell Significance Index: 46.8000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 1.8591
    Cell Significance Index: -5.7100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.7490
    Cell Significance Index: 36.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.5211
    Cell Significance Index: 32.9600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3682
    Cell Significance Index: 747.1900
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.0828
    Cell Significance Index: 5.7000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.8829
    Cell Significance Index: 13.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8576
    Cell Significance Index: 22.9800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7151
    Cell Significance Index: 32.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7011
    Cell Significance Index: 81.7100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.5262
    Cell Significance Index: 5.7200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5052
    Cell Significance Index: 37.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3774
    Cell Significance Index: 46.4000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3453
    Cell Significance Index: 311.8100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2538
    Cell Significance Index: 45.7500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2156
    Cell Significance Index: 35.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2051
    Cell Significance Index: 6.5700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1920
    Cell Significance Index: 36.5400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1898
    Cell Significance Index: 18.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1300
    Cell Significance Index: 14.1500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1144
    Cell Significance Index: 3.2800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1076
    Cell Significance Index: 3.1600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0834
    Cell Significance Index: 1.4000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0747
    Cell Significance Index: 3.7800
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.0653
    Cell Significance Index: 0.2500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0462
    Cell Significance Index: 28.8700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0435
    Cell Significance Index: 1.1900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0391
    Cell Significance Index: 0.3600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0266
    Cell Significance Index: 19.5100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0219
    Cell Significance Index: 1.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0064
    Cell Significance Index: 0.8800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0061
    Cell Significance Index: 0.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0054
    Cell Significance Index: 0.1500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0021
    Cell Significance Index: 0.0600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0002
    Cell Significance Index: 0.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0011
    Cell Significance Index: -0.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0018
    Cell Significance Index: -0.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0018
    Cell Significance Index: -1.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0089
    Cell Significance Index: -16.7900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0136
    Cell Significance Index: -0.6400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0158
    Cell Significance Index: -8.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0162
    Cell Significance Index: -2.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0193
    Cell Significance Index: -1.9700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0209
    Cell Significance Index: -15.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0247
    Cell Significance Index: -15.7100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0285
    Cell Significance Index: -1.7100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0310
    Cell Significance Index: -14.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0363
    Cell Significance Index: -7.6400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0374
    Cell Significance Index: -4.8000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0375
    Cell Significance Index: -1.0000
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0482
    Cell Significance Index: -0.6900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0565
    Cell Significance Index: -16.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0663
    Cell Significance Index: -7.6000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0731
    Cell Significance Index: -5.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0790
    Cell Significance Index: -10.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0795
    Cell Significance Index: -15.7700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0853
    Cell Significance Index: -17.1100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0974
    Cell Significance Index: -5.0600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1081
    Cell Significance Index: -15.7100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1195
    Cell Significance Index: -3.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1266
    Cell Significance Index: -14.9300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1320
    Cell Significance Index: -5.4100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1345
    Cell Significance Index: -2.7900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1644
    Cell Significance Index: -17.1200
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1682
    Cell Significance Index: -1.4300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2002
    Cell Significance Index: -5.3600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2087
    Cell Significance Index: -5.3700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2112
    Cell Significance Index: -3.6400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2264
    Cell Significance Index: -17.3700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2309
    Cell Significance Index: -4.0800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2349
    Cell Significance Index: -7.6900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2507
    Cell Significance Index: -16.1800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2597
    Cell Significance Index: -17.4600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2638
    Cell Significance Index: -4.5200
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2688
    Cell Significance Index: -5.6100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2709
    Cell Significance Index: -6.9200
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.3011
    Cell Significance Index: -2.3400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3024
    Cell Significance Index: -11.1000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3111
    Cell Significance Index: -7.7600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.3246
    Cell Significance Index: -2.1600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3258
    Cell Significance Index: -18.2800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.3299
    Cell Significance Index: -2.0300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3358
    Cell Significance Index: -5.0600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3489
    Cell Significance Index: -6.8100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3521
    Cell Significance Index: -4.0000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3760
    Cell Significance Index: -17.5300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3925
    Cell Significance Index: -7.7600
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.4293
    Cell Significance Index: -2.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Anterior-Posterior Pattern Specification:** HOXB2 is involved in the regulation of anterior-posterior pattern specification during embryonic development, particularly in the hindbrain. 2. **Dorsal/Ventral Pattern Formation:** HOXB2 also plays a role in dorsal/ventral pattern formation, which is critical for the development of the nervous system. 3. **Chromatin Modification:** HOXB2 interacts with chromatin to regulate gene expression, influencing the transcriptional landscape of target genes. 4. **DNA Binding and Transcriptional Activation:** HOXB2 exhibits sequence-specific DNA binding and transcriptional activation capabilities, enabling it to regulate the expression of target genes. 5. **Cellular Context:** HOXB2 is specifically expressed in various cell types, including pulmonary interstitial fibroblasts, respiratory basal cells, and neural crest cells. **Pathways and Functions:** 1. **Activation of Anterior Hox Genes:** HOXB2 activates the expression of anterior hox genes, which are essential for the development of the hindbrain. 2. **Activation of Hox Genes during Differentiation:** HOXB2 also regulates the expression of hox genes during differentiation, ensuring proper patterning and morphogenesis. 3. **Anterior/Posterior Pattern Specification:** HOXB2 is involved in the regulation of anterior-posterior pattern specification, which is critical for the development of the nervous system. 4. **Dorsal/Ventral Pattern Formation:** HOXB2 plays a role in dorsal/ventral pattern formation, influencing the development of the nervous system. 5. **Morphogenesis of Epithelial Sheets:** HOXB2 is involved in the morphogenesis of epithelial sheets, which is essential for the development of various tissues. **Clinical Significance:** 1. **Neurological Disorders:** Alterations in HOXB2 expression have been implicated in various neurological disorders, including autism spectrum disorder and schizophrenia. 2. **Cancer:** Aberrant expression of HOXB2 has been observed in various types of cancer, including leukemia and lymphoma. 3. **Developmental Abnormalities:** HOXB2 dysregulation has been linked to developmental abnormalities, including craniofacial defects and neural tube defects. 4. **Regenerative Medicine:** HOXB2 has been explored as a potential target for regenerative medicine, particularly in the context of neural tissue repair and replacement. In conclusion, HOXB2 plays a complex and multifaceted role in developmental biology, influencing anterior-posterior pattern specification, dorsal/ventral pattern formation, and chromatin modification. Its dysregulation has been implicated in various neurological disorders, cancer, and developmental abnormalities. Further research is necessary to fully elucidate the mechanisms underlying HOXB2 function and to explore its potential therapeutic applications.

Genular Protein ID: 387850814

Symbol: HXB2_HUMAN

Name: Homeobox protein Hox-B2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2574852

Title: The human HOX gene family.

PubMed ID: 2574852

DOI: 10.1093/nar/17.24.10385

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2570724

Title: Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system.

PubMed ID: 2570724

DOI: 10.1111/j.1432-0436.1989.tb00598.x

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

PubMed ID: 2901346

Title: Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages.

PubMed ID: 2901346

DOI: 10.1002/j.1460-2075.1988.tb03052.x

PubMed ID: 7876223

Title: Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells.

PubMed ID: 7876223

DOI: 10.1074/jbc.270.9.4544

PubMed ID: 10595394

Title: The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation.

PubMed ID: 10595394

DOI: 10.1089/104454999314809

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 356
  • Mass: 37914
  • Checksum: D7ACA0E3D5BEBFB9
  • Sequence:
  • MNFEFEREIG FINSQPSLAE CLTSFPAVLE TFQTSSIKES TLIPPPPPFE QTFPSLQPGA 
    STLQRPRSQK RAEDGPALPP PPPPPLPAAP PAPEFPWMKE KKSAKKPSQS ATSPSPAASA 
    VPASGVGSPA DGLGLPEAGG GGARRLRTAY TNTQLLELEK EFHFNKYLCR PRRVEIAALL 
    DLTERQVKVW FQNRRMKHKR QTQHREPPDG EPACPGALED ICDPAEEPAA SPGGPSASRA 
    AWEACCHPPE VVPGALSADP RPLAVRLEGA GASSPGCALR GAGGLEPGPL PEDVFSGRQD 
    SPFLPDLNFF AADSCLQLSG GLSPSLQGSL DSPVPFSEEE LDFFTSTLCA IDLQFP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.