Gene HRAS - ENSG00000174775 | NCBI Gene ID: 3265

Details for: HRAS

Gene ID: 3265

Symbol: HRAS

Ensembl ID: ENSG00000174775

Description: HRas proto-oncogene, GTPase

Associated with

Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Adaptive immune system
(R-HSA-1280218)
Axon guidance
(R-HSA-422475)
C-type lectin receptors (clrs)
(R-HSA-5621481)
Cd209 (dc-sign) signaling
(R-HSA-5621575)
Cell surface interactions at the vascular wall
(R-HSA-202733)
Constitutive signaling by overexpressed erbb2
(R-HSA-9634285)
Cytokine signaling in immune system
(R-HSA-1280215)
Dap12 interactions
(R-HSA-2172127)
Dap12 signaling
(R-HSA-2424491)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signaling events of b cell receptor (bcr)
(R-HSA-1168372)
Downstream signal transduction
(R-HSA-186763)
Eph-ephrin signaling
(R-HSA-2682334)
Erythropoietin activates ras
(R-HSA-9027284)
Esr-mediated signaling
(R-HSA-8939211)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Fc epsilon receptor (fceri) signaling
(R-HSA-2454202)
Fceri mediated mapk activation
(R-HSA-2871796)
Flt3 signaling
(R-HSA-9607240)
Flt3 signaling in disease
(R-HSA-9682385)
G alpha (q) signalling events
(R-HSA-416476)
Gpcr downstream signalling
(R-HSA-388396)
Grb2 events in egfr signaling
(R-HSA-179812)
Grb2 events in erbb2 signaling
(R-HSA-1963640)
Hemostasis
(R-HSA-109582)
Igf1r signaling cascade
(R-HSA-2428924)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Insulin receptor signalling cascade
(R-HSA-74751)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Met activates ras signaling
(R-HSA-8851805)
Ncam signaling for neurite out-growth
(R-HSA-375165)
Nervous system development
(R-HSA-9675108)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Oncogenic mapk signaling
(R-HSA-6802957)
Paradoxical activation of raf signaling by kinase inactive braf
(R-HSA-6802955)
Ptk6 regulates rho gtpases, ras gtpase and map kinases
(R-HSA-8849471)
Raf/map kinase cascade
(R-HSA-5673001)
Ras signaling downstream of nf1 loss-of-function variants
(R-HSA-6802953)
Shc1 events in egfr signaling
(R-HSA-180336)
Shc1 events in erbb2 signaling
(R-HSA-1250196)
Shc1 events in erbb4 signaling
(R-HSA-1250347)
Signaling by braf and raf1 fusions
(R-HSA-6802952)
Signaling by egfr
(R-HSA-177929)
Signaling by egfr in cancer
(R-HSA-1643713)
Signaling by egfrviii in cancer
(R-HSA-5637812)
Signaling by erbb2
(R-HSA-1227986)
Signaling by erbb2 ecd mutants
(R-HSA-9665348)
Signaling by erbb2 in cancer
(R-HSA-1227990)
Signaling by erbb2 kd mutants
(R-HSA-9664565)
Signaling by erbb2 tmd/jmd mutants
(R-HSA-9665686)
Signaling by erbb4
(R-HSA-1236394)
Signaling by erythropoietin
(R-HSA-9006335)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr1 in disease
(R-HSA-5655302)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr3 in disease
(R-HSA-5655332)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by fgfr4 in disease
(R-HSA-5655291)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by flt3 fusion proteins
(R-HSA-9703465)
Signaling by flt3 itd and tkd mutants
(R-HSA-9703648)
Signaling by gpcr
(R-HSA-372790)
Signaling by high-kinase activity braf mutants
(R-HSA-6802948)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by kit in disease
(R-HSA-9669938)
Signaling by ligand-responsive egfr variants in cancer
(R-HSA-5637815)
Signaling by met
(R-HSA-6806834)
Signaling by moderate kinase activity braf mutants
(R-HSA-6802946)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrk2 (trkb)
(R-HSA-9006115)
Signaling by ntrk3 (trkc)
(R-HSA-9034015)
Signaling by ntrks
(R-HSA-166520)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by pdgf
(R-HSA-186797)
Signaling by pdgfra extracellular domain mutants
(R-HSA-9673770)
Signaling by pdgfra transmembrane, juxtamembrane and kinase domain mutants
(R-HSA-9673767)
Signaling by pdgfr in disease
(R-HSA-9671555)
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain kit mutants
(R-HSA-9670439)
Signaling by ptk6
(R-HSA-8848021)
Signaling by raf1 mutants
(R-HSA-9656223)
Signaling by ras mutants
(R-HSA-6802949)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by scf-kit
(R-HSA-1433557)
Signaling by the b cell receptor (bcr)
(R-HSA-983705)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Signaling by vegf
(R-HSA-194138)
Signal transduction
(R-HSA-162582)
Tie2 signaling
(R-HSA-210993)
Transmission across chemical synapses
(R-HSA-112315)
Vegfa-vegfr2 pathway
(R-HSA-4420097)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.87
Marker Score: 2755
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.73
Marker Score: 6409
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 1.7
Marker Score: 14667
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.68
Marker Score: 3423
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 1.57
Marker Score: 12297.5
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.56
Marker Score: 1755
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.42
Marker Score: 1491
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.41
Marker Score: 5554
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 1.39
Marker Score: 1093.5
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 1.32
Marker Score: 442
Cell Name: stem cell of epidermis (CL1000428)
Fold Change: 1.22
Marker Score: 414
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 1.2
Marker Score: 2529
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 1.19
Marker Score: 8867
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 1.15
Marker Score: 566
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.12
Marker Score: 2813
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.11
Marker Score: 2716
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.1
Marker Score: 38237
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 1.1
Marker Score: 1821
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 1.06
Marker Score: 375
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.05
Marker Score: 1159
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 1.03
Marker Score: 1245
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 1
Marker Score: 373
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71712
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47937
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.98
Marker Score: 8535
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30396
Cell Name: basal cell (CL0000646)
Fold Change: 0.98
Marker Score: 1265
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.97
Marker Score: 2605
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 0.97
Marker Score: 914
Cell Name: proerythroblast (CL0000547)
Fold Change: 0.97
Marker Score: 657
Cell Name: PP cell (CL0000696)
Fold Change: 0.97
Marker Score: 218
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.95
Marker Score: 4657.5
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.94
Marker Score: 980
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2397
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 0.94
Marker Score: 949
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.93
Marker Score: 1051
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.93
Marker Score: 478
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.92
Marker Score: 434
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.9
Marker Score: 2698
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 0.9
Marker Score: 9297
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.89
Marker Score: 744
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.86
Marker Score: 5236
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.86
Marker Score: 812.5
Cell Name: pancreatic stellate cell (CL0002410)
Fold Change: 0.86
Marker Score: 544
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.86
Marker Score: 3044
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.86
Marker Score: 308
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 0.86
Marker Score: 685
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 0.85
Marker Score: 438
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.84
Marker Score: 251
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.84
Marker Score: 4800
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.83
Marker Score: 3186
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 0.83
Marker Score: 390
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.82
Marker Score: 867
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 0.81
Marker Score: 196
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 0.81
Marker Score: 1147
Cell Name: motor neuron (CL0000100)
Fold Change: 0.81
Marker Score: 479
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.81
Marker Score: 1429
Cell Name: male germ cell (CL0000015)
Fold Change: 0.8
Marker Score: 230
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.79
Marker Score: 227
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.78
Marker Score: 8779
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1264
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.78
Marker Score: 428
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.77
Marker Score: 1758
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.77
Marker Score: 765
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.76
Marker Score: 580.5
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.76
Marker Score: 304.5
Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 0.74
Marker Score: 432
Cell Name: neural cell (CL0002319)
Fold Change: 0.73
Marker Score: 352
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.72
Marker Score: 373
Cell Name: peptic cell (CL0000155)
Fold Change: 0.72
Marker Score: 300
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 0.72
Marker Score: 230
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 0.71
Marker Score: 1942
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.7
Marker Score: 1339
Cell Name: enterocyte (CL0000584)
Fold Change: 0.7
Marker Score: 3376
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.69
Marker Score: 444
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 0.69
Marker Score: 228
Cell Name: brush cell (CL0002204)
Fold Change: 0.69
Marker Score: 629
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.69
Marker Score: 437
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.69
Marker Score: 2878.5
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 0.68
Marker Score: 640
Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 0.68
Marker Score: 416
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 0.68
Marker Score: 481
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 0.67
Marker Score: 423
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 0.67
Marker Score: 1344
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.67
Marker Score: 1062
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.67
Marker Score: 171
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.67
Marker Score: 1570
Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.66
Marker Score: 344
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.66
Marker Score: 4228
Cell Name: enteric neuron (CL0007011)
Fold Change: 0.66
Marker Score: 352.5
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.66
Marker Score: 6674
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.66
Marker Score: 212
Cell Name: muscle cell (CL0000187)
Fold Change: 0.65
Marker Score: 185
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.65
Marker Score: 1533
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.65
Marker Score: 1062
Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.65
Marker Score: 223
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 0.64
Marker Score: 281
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.64
Marker Score: 6419
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.64
Marker Score: 433
Cell Name: supporting cell (CL0000630)
Fold Change: 0.64
Marker Score: 1194

Hover over a box to see details here...

**Key characteristics:** - HRAS is a GTPase, meaning it can act as a protein kinase. - It is a proto-oncogene, meaning it is a precursor to a full-length protein. - HRAS is highly expressed in a variety of cell types, including immune cells, epithelial cells, and neurons. - It is known to be a tumor suppressor gene in many cancer types. **Pathways and functions:** - HRAS proto-oncogene is involved in the adaptive immune system, where it is expressed in immune cells. - It is also involved in cell surface interactions at the vascular wall, where it regulates the growth of endothelial cells. - HRAS proto-oncogene is also involved in cytokine signaling, where it is a key regulator of immune responses. - It is involved in developmental biology, where it is expressed in developing tissues and organs. - It is also involved in disease, including cancer and cardiovascular diseases. **Clinical significance:** - Mutations in HRAS proto-oncogene have been linked to the development of various cancers, including lung cancer, breast cancer, and colon cancer. - Inhibition of HRAS has shown to be effective in treating cancer cells. - HRAS is a promising target for cancer immunotherapy.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

GTPase HRas

Genular Protein ID: 1178990467

Symbol: RASH_HUMAN

Name: GTPase HRas

UniProtKB Accession Codes:

P01112 B5BUA0 Q14080 Q6FHV9 Q9BR65 Q9UCE2

Database IDs:

Citations:

PubMed ID: 6298635

Title: Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue.

PubMed ID: 6298635

DOI: 10.1038/302033a0

PubMed ID: 6844927

Title: Nucleotide sequence analysis of the T24 human bladder carcinoma oncogene.

PubMed ID: 6844927

DOI: 10.1126/science.6844927

PubMed ID: 6087347

Title: Molecular cloning and the total nucleotide sequence of the human c-Ha-ras-1 gene activated in a melanoma from a Japanese patient.

PubMed ID: 6087347

DOI: 10.1073/pnas.81.15.4771

PubMed ID: 14500341

Title: Alternative splicing of the human proto-oncogene c-H-ras renders a new Ras family protein that trafficks to cytoplasm and nucleus.

PubMed ID: 14500341

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6290897

Title: Mechanism of activation of a human oncogene.

PubMed ID: 6290897

DOI: 10.1038/300143a0

PubMed ID: 3670300

Title: Identification of the principal promoter sequence of the c-H-ras transforming oncogene: deletion analysis of the 5'-flanking region by focus formation assay.

PubMed ID: 3670300

DOI: 10.1128/mcb.7.8.2933-2940.1987

PubMed ID: 8393791

Title: Affinity labeling of c-H-ras p21 consensus elements with periodate-oxidized GDP and GTP.

PubMed ID: 8393791

DOI: 10.1111/j.1432-1033.1993.tb18056.x

PubMed ID: 3088563

Title: Isolation of ras GTP-binding mutants using an in situ colony-binding assay.

PubMed ID: 3088563

DOI: 10.1073/pnas.83.13.4607

PubMed ID: 3011420

Title: Deletion mutants of Harvey ras p21 protein reveal the absolute requirement of at least two distant regions for GTP-binding and transforming activities.

PubMed ID: 3011420

DOI: 10.1002/j.1460-2075.1986.tb04267.x

PubMed ID: 2661017

Title: All ras proteins are polyisoprenylated but only some are palmitoylated.

PubMed ID: 2661017

DOI: 10.1016/0092-8674(89)90054-8

PubMed ID: 8626586

Title: Ras, Rap, and Rac small GTP-binding proteins are targets for Clostridium sordellii lethal toxin glucosylation.

PubMed ID: 8626586

DOI: 10.1074/jbc.271.17.10217

PubMed ID: 8626575

Title: Inactivation of Ras by Clostridium sordellii lethal toxin-catalyzed glucosylation.

PubMed ID: 8626575

DOI: 10.1074/jbc.271.17.10149

PubMed ID: 8626715

Title: Palmitoylation of Ha-Ras facilitates membrane binding, activation of downstream effectors, and meiotic maturation in Xenopus oocytes.

PubMed ID: 8626715

DOI: 10.1074/jbc.271.19.11541

PubMed ID: 9020151

Title: A molecular redox switch on p21(ras). Structural basis for the nitric oxide-p21(ras) interaction.

PubMed ID: 9020151

DOI: 10.1074/jbc.272.7.4323

PubMed ID: 9632667

Title: Functional consequences of monoglucosylation of Ha-Ras at effector domain amino acid threonine 35.

PubMed ID: 9632667

DOI: 10.1074/jbc.273.26.16134

PubMed ID: 10369681

Title: Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization.

PubMed ID: 10369681

DOI: 10.1093/emboj/18.12.3419

PubMed ID: 10608844

Title: RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans.

PubMed ID: 10608844

DOI: 10.1074/jbc.274.53.37815

PubMed ID: 11022048

Title: Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras.

PubMed ID: 11022048

DOI: 10.1074/jbc.m008324200

PubMed ID: 11598133

Title: Nedd4 regulates ubiquitination and stability of the guanine-nucleotide exchange factor CNrasGEF.

PubMed ID: 11598133

DOI: 10.1074/jbc.m108373200

PubMed ID: 11257115

Title: Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism.

PubMed ID: 11257115

DOI: 10.1083/jcb.152.6.1135

PubMed ID: 11980706

Title: The complex of Arl2-GTP and PDE delta: from structure to function.

PubMed ID: 11980706

DOI: 10.1093/emboj/21.9.2095

PubMed ID: 12684535

Title: The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras.

PubMed ID: 12684535

DOI: 10.1073/pnas.0735842100

PubMed ID: 22821884

Title: A novel HRAS substitution (c.266C>G; p.S89C) resulting in decreased downstream signaling suggests a new dimension of RAS pathway dysregulation in human development.

PubMed ID: 22821884

DOI: 10.1002/ajmg.a.35449

PubMed ID: 15546861

Title: Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease.

PubMed ID: 15546861

DOI: 10.1074/jbc.m410775200

PubMed ID: 16000296

Title: DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras.

PubMed ID: 16000296

DOI: 10.1074/jbc.m504113200

PubMed ID: 15705808

Title: An acylation cycle regulates localization and activity of palmitoylated Ras isoforms.

PubMed ID: 15705808

DOI: 10.1126/science.1105654

PubMed ID: 17230191

Title: Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin.

PubMed ID: 17230191

DOI: 10.1038/nature05476

PubMed ID: 19744486

Title: Distinct kinetics of (H/K/N)Ras glucosylation and Rac1 glucosylation catalysed by Clostridium sordellii lethal toxin.

PubMed ID: 19744486

DOI: 10.1016/j.febslet.2009.09.006

PubMed ID: 29239724

Title: SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a.

PubMed ID: 29239724

DOI: 10.7554/elife.32436

PubMed ID: 30442762

Title: Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination.

PubMed ID: 30442762

DOI: 10.1126/science.aap7607

PubMed ID: 2448879

Title: Three-dimensional structure of an oncogene protein: catalytic domain of human c-H-ras p21.

PubMed ID: 2448879

DOI: 10.1126/science.2448879

PubMed ID: 2476675

Title: Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation.

PubMed ID: 2476675

DOI: 10.1038/341209a0

PubMed ID: 2196171

Title: Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35-A resolution: implications for the mechanism of GTP hydrolysis.

PubMed ID: 2196171

DOI: 10.1002/j.1460-2075.1990.tb07409.x

PubMed ID: 1899707

Title: Crystal structures at 2.2-A resolution of the catalytic domains of normal ras protein and an oncogenic mutant complexed with GDP.

PubMed ID: 1899707

DOI: 10.1016/0022-2836(91)90753-s

PubMed ID: 8142349

Title: Solution structure and dynamics of ras p21.GDP determined by heteronuclear three- and four-dimensional NMR spectroscopy.

PubMed ID: 8142349

DOI: 10.1021/bi00178a008

PubMed ID: 9219684

Title: The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants.

PubMed ID: 9219684

DOI: 10.1126/science.277.5324.333

PubMed ID: 10574788

Title: The pre-hydrolysis state of p21(ras) in complex with GTP: new insights into the role of water molecules in the GTP hydrolysis reaction of ras-like proteins.

PubMed ID: 10574788

DOI: 10.1016/s0969-2126(00)80021-0

PubMed ID: 12213964

Title: The structural basis for the transition from Ras-GTP to Ras-GDP.

PubMed ID: 12213964

DOI: 10.1073/pnas.192453199

PubMed ID: 12740440

Title: Structural and biochemical studies of p21Ras S-nitrosylation and nitric oxide-mediated guanine nucleotide exchange.

PubMed ID: 12740440

DOI: 10.1073/pnas.1037299100

PubMed ID: 16698776

Title: A newly designed microspectrofluorometer for kinetic studies on protein crystals in combination with x-ray diffraction.

PubMed ID: 16698776

DOI: 10.1529/biophysj.105.078931

PubMed ID: 18073111

Title: Transformation efficiency of RasQ61 mutants linked to structural features of the switch regions in the presence of Raf.

PubMed ID: 18073111

DOI: 10.1016/j.str.2007.10.011

PubMed ID: 18596699

Title: Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II.

PubMed ID: 18596699

DOI: 10.1038/emboj.2008.125

PubMed ID: 1459726

Title: The p53 tumor-suppressor gene and ras oncogene mutations in oral squamous-cell carcinoma.

PubMed ID: 1459726

DOI: 10.1002/ijc.2910520606

PubMed ID: 12727991

Title: RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma.

PubMed ID: 12727991

DOI: 10.1210/jc.2002-021907

PubMed ID: 16170316

Title: Germline mutations in HRAS proto-oncogene cause Costello syndrome.

PubMed ID: 16170316

DOI: 10.1038/ng1641

PubMed ID: 16329078

Title: HRAS mutation analysis in Costello syndrome: genotype and phenotype correlation.

PubMed ID: 16329078

DOI: 10.1002/ajmg.a.31047

PubMed ID: 16443854

Title: Genotype-phenotype correlation in Costello syndrome: HRAS mutation analysis in 43 cases.

PubMed ID: 16443854

DOI: 10.1136/jmg.2005.040352

PubMed ID: 17054105

Title: Diversity, parental germline origin, and phenotypic spectrum of de novo HRAS missense changes in Costello syndrome.

PubMed ID: 17054105

DOI: 10.1002/humu.20431

PubMed ID: 17412879

Title: Myopathy caused by HRAS germline mutations: implications for disturbed myogenic differentiation in the presence of constitutive HRas activation.

PubMed ID: 17412879

DOI: 10.1136/jmg.2007.049270

PubMed ID: 18247425

Title: Costello syndrome associated with novel germline HRAS mutations: an attenuated phenotype?

PubMed ID: 18247425

DOI: 10.1002/ajmg.a.32227

PubMed ID: 18039947

Title: Severe neonatal manifestations of Costello syndrome.

PubMed ID: 18039947

DOI: 10.1136/jmg.2007.054411

PubMed ID: 19995790

Title: Duplication of Glu37 in the switch I region of HRAS impairs effector/GAP binding and underlies Costello syndrome by promoting enhanced growth factor-dependent MAPK and AKT activation.

PubMed ID: 19995790

DOI: 10.1093/hmg/ddp548

PubMed ID: 22683711

Title: Postzygotic HRAS and KRAS mutations cause nevus sebaceous and Schimmelpenning syndrome.

PubMed ID: 22683711

DOI: 10.1038/ng.2316

Sequence Information:

Length: 189
Mass: 21298
Checksum: EE6DC2D933E2856A
Sequence:

MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG 
QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHQYREQI KRVKDSDDVP MVLVGNKCDL 
AARTVESRQA QDLARSYGIP YIETSAKTRQ GVEDAFYTLV REIRQHKLRK LNPPDESGPG 
CMSCKCVLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: HRAS

Associated with

Cells (max top 100)

Other Information

Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue. PubMed ID: 6298635

Nucleotide sequence analysis of the T24 human bladder carcinoma oncogene. PubMed ID: 6844927

Molecular cloning and the total nucleotide sequence of the human c-Ha-ras-1 gene activated in a melanoma from a Japanese patient. PubMed ID: 6087347

Alternative splicing of the human proto-oncogene c-H-ras renders a new Ras family protein that trafficks to cytoplasm and nucleus. PubMed ID: 14500341

Human protein factory for converting the transcriptome into an in vitro-expressed proteome. PubMed ID: 19054851

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mechanism of activation of a human oncogene. PubMed ID: 6290897

Identification of the principal promoter sequence of the c-H-ras transforming oncogene: deletion analysis of the 5'-flanking region by focus formation assay. PubMed ID: 3670300

Affinity labeling of c-H-ras p21 consensus elements with periodate-oxidized GDP and GTP. PubMed ID: 8393791

Isolation of ras GTP-binding mutants using an in situ colony-binding assay. PubMed ID: 3088563

Deletion mutants of Harvey ras p21 protein reveal the absolute requirement of at least two distant regions for GTP-binding and transforming activities. PubMed ID: 3011420

All ras proteins are polyisoprenylated but only some are palmitoylated. PubMed ID: 2661017

Ras, Rap, and Rac small GTP-binding proteins are targets for Clostridium sordellii lethal toxin glucosylation. PubMed ID: 8626586

Inactivation of Ras by Clostridium sordellii lethal toxin-catalyzed glucosylation. PubMed ID: 8626575

Palmitoylation of Ha-Ras facilitates membrane binding, activation of downstream effectors, and meiotic maturation in Xenopus oocytes. PubMed ID: 8626715

A molecular redox switch on p21(ras). Structural basis for the nitric oxide-p21(ras) interaction. PubMed ID: 9020151

Functional consequences of monoglucosylation of Ha-Ras at effector domain amino acid threonine 35. PubMed ID: 9632667

Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization. PubMed ID: 10369681

RA-GEF, a novel Rap1A guanine nucleotide exchange factor containing a Ras/Rap1A-associating domain, is conserved between nematode and humans. PubMed ID: 10608844

Regulation of a novel human phospholipase C, PLCepsilon, through membrane targeting by Ras. PubMed ID: 11022048

Nedd4 regulates ubiquitination and stability of the guanine-nucleotide exchange factor CNrasGEF. PubMed ID: 11598133

Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism. PubMed ID: 11257115

The complex of Arl2-GTP and PDE delta: from structure to function. PubMed ID: 11980706

The cyclopentenone 15-deoxy-delta 12,14-prostaglandin J2 binds to and activates H-Ras. PubMed ID: 12684535

A novel HRAS substitution (c.266C&gt;G; p.S89C) resulting in decreased downstream signaling suggests a new dimension of RAS pathway dysregulation in human development. PubMed ID: 22821884

Dephosphorylation of tau by protein phosphatase 5: impairment in Alzheimer's disease. PubMed ID: 15546861

DHHC9 and GCP16 constitute a human protein fatty acyltransferase with specificity for H- and N-Ras. PubMed ID: 16000296

An acylation cycle regulates localization and activity of palmitoylated Ras isoforms. PubMed ID: 15705808

Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin. PubMed ID: 17230191

Distinct kinetics of (H/K/N)Ras glucosylation and Rac1 glucosylation catalysed by Clostridium sordellii lethal toxin. PubMed ID: 19744486

SIRT2 and lysine fatty acylation regulate the transforming activity of K-Ras4a. PubMed ID: 29239724

Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination. PubMed ID: 30442762

Three-dimensional structure of an oncogene protein: catalytic domain of human c-H-ras p21. PubMed ID: 2448879

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation. PubMed ID: 2476675

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35-A resolution: implications for the mechanism of GTP hydrolysis. PubMed ID: 2196171

Crystal structures at 2.2-A resolution of the catalytic domains of normal ras protein and an oncogenic mutant complexed with GDP. PubMed ID: 1899707

Solution structure and dynamics of ras p21.GDP determined by heteronuclear three- and four-dimensional NMR spectroscopy. PubMed ID: 8142349

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. PubMed ID: 9219684

The pre-hydrolysis state of p21(ras) in complex with GTP: new insights into the role of water molecules in the GTP hydrolysis reaction of ras-like proteins. PubMed ID: 10574788

The structural basis for the transition from Ras-GTP to Ras-GDP. PubMed ID: 12213964

Structural and biochemical studies of p21Ras S-nitrosylation and nitric oxide-mediated guanine nucleotide exchange. PubMed ID: 12740440

A newly designed microspectrofluorometer for kinetic studies on protein crystals in combination with x-ray diffraction. PubMed ID: 16698776

Transformation efficiency of RasQ61 mutants linked to structural features of the switch regions in the presence of Raf. PubMed ID: 18073111

Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II. PubMed ID: 18596699

The p53 tumor-suppressor gene and ras oncogene mutations in oral squamous-cell carcinoma. PubMed ID: 1459726

RAS point mutations and PAX8-PPAR gamma rearrangement in thyroid tumors: evidence for distinct molecular pathways in thyroid follicular carcinoma. PubMed ID: 12727991

Germline mutations in HRAS proto-oncogene cause Costello syndrome. PubMed ID: 16170316

HRAS mutation analysis in Costello syndrome: genotype and phenotype correlation. PubMed ID: 16329078

Genotype-phenotype correlation in Costello syndrome: HRAS mutation analysis in 43 cases. PubMed ID: 16443854

Diversity, parental germline origin, and phenotypic spectrum of de novo HRAS missense changes in Costello syndrome. PubMed ID: 17054105

Myopathy caused by HRAS germline mutations: implications for disturbed myogenic differentiation in the presence of constitutive HRas activation. PubMed ID: 17412879

Costello syndrome associated with novel germline HRAS mutations: an attenuated phenotype? PubMed ID: 18247425

Severe neonatal manifestations of Costello syndrome. PubMed ID: 18039947

Duplication of Glu37 in the switch I region of HRAS impairs effector/GAP binding and underlies Costello syndrome by promoting enhanced growth factor-dependent MAPK and AKT activation. PubMed ID: 19995790

Postzygotic HRAS and KRAS mutations cause nevus sebaceous and Schimmelpenning syndrome. PubMed ID: 22683711