Details for: AGFG1

Gene ID: 3267

Symbol: AGFG1

Ensembl ID: ENSG00000173744

Description: ArfGAP with FG repeats 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 378.3787
    Cell Significance Index: -58.8600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 236.1583
    Cell Significance Index: -59.9000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 137.8573
    Cell Significance Index: -56.7900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 131.8090
    Cell Significance Index: -62.2300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 127.0378
    Cell Significance Index: -51.6100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 113.7474
    Cell Significance Index: -58.5100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 54.2450
    Cell Significance Index: -51.7900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 48.8075
    Cell Significance Index: -60.1800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.2147
    Cell Significance Index: -59.5100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.2752
    Cell Significance Index: -53.0600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 16.6660
    Cell Significance Index: -36.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.3571
    Cell Significance Index: -60.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.9790
    Cell Significance Index: 79.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.2788
    Cell Significance Index: 457.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.1842
    Cell Significance Index: 433.4700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.0438
    Cell Significance Index: 114.6900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.9810
    Cell Significance Index: 29.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.7353
    Cell Significance Index: 3200.3400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.5036
    Cell Significance Index: 42.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.3169
    Cell Significance Index: 32.9200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.2394
    Cell Significance Index: 444.5600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.0897
    Cell Significance Index: 73.2700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0199
    Cell Significance Index: 61.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.0014
    Cell Significance Index: 162.8800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8775
    Cell Significance Index: 33.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.8488
    Cell Significance Index: 1306.7300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.8365
    Cell Significance Index: 578.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8275
    Cell Significance Index: 63.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.7741
    Cell Significance Index: 34.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6836
    Cell Significance Index: 19.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6786
    Cell Significance Index: 83.4500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5301
    Cell Significance Index: 95.5600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4874
    Cell Significance Index: 10.5600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4093
    Cell Significance Index: 369.5600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3847
    Cell Significance Index: 210.1100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3836
    Cell Significance Index: 23.5800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3429
    Cell Significance Index: 217.8000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.3391
    Cell Significance Index: 4.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2454
    Cell Significance Index: 462.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2122
    Cell Significance Index: 93.8000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1882
    Cell Significance Index: 5.3700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1794
    Cell Significance Index: 8.1300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1543
    Cell Significance Index: 21.2000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1116
    Cell Significance Index: 11.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1025
    Cell Significance Index: 139.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0798
    Cell Significance Index: 15.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0669
    Cell Significance Index: 30.3600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0494
    Cell Significance Index: 2.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0189
    Cell Significance Index: 3.2200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0233
    Cell Significance Index: -0.4000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0296
    Cell Significance Index: -3.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0381
    Cell Significance Index: -28.2100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0404
    Cell Significance Index: -29.6400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0474
    Cell Significance Index: -29.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0500
    Cell Significance Index: -6.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0549
    Cell Significance Index: -30.9500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0689
    Cell Significance Index: -52.1500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0794
    Cell Significance Index: -1.5500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0885
    Cell Significance Index: -0.5400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0891
    Cell Significance Index: -3.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1748
    Cell Significance Index: -50.3000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1767
    Cell Significance Index: -37.2200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1807
    Cell Significance Index: -20.6300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1872
    Cell Significance Index: -27.2100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1882
    Cell Significance Index: -8.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2202
    Cell Significance Index: -22.4900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2217
    Cell Significance Index: -14.3000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2233
    Cell Significance Index: -5.7400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.2443
    Cell Significance Index: -4.1200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2609
    Cell Significance Index: -3.5600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2808
    Cell Significance Index: -2.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2935
    Cell Significance Index: -34.2000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2968
    Cell Significance Index: -15.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2996
    Cell Significance Index: -6.5600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3055
    Cell Significance Index: -35.0100
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: -0.3101
    Cell Significance Index: -1.3500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3517
    Cell Significance Index: -6.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3579
    Cell Significance Index: -45.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3600
    Cell Significance Index: -26.8300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.3793
    Cell Significance Index: -41.2600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3867
    Cell Significance Index: -27.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4003
    Cell Significance Index: -25.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4295
    Cell Significance Index: -11.6900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4324
    Cell Significance Index: -8.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4563
    Cell Significance Index: -47.5100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4628
    Cell Significance Index: -11.1000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4760
    Cell Significance Index: -12.7600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5018
    Cell Significance Index: -26.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6070
    Cell Significance Index: -17.4000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.6188
    Cell Significance Index: -8.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6492
    Cell Significance Index: -51.4200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6592
    Cell Significance Index: -14.0900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.6657
    Cell Significance Index: -9.5600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8358
    Cell Significance Index: -17.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8431
    Cell Significance Index: -51.6900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.9471
    Cell Significance Index: -11.8100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.9483
    Cell Significance Index: -14.0000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0170
    Cell Significance Index: -32.3900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0664
    Cell Significance Index: -34.9200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.0689
    Cell Significance Index: -56.1200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** AGFG1 is a protein-coding gene that possesses a unique combination of Arf-GAP domain and FG repeat-containing motifs. This dual structure confers the gene with a broad range of functional capabilities, including GTPase activator activity, cargo recognition for clathrin-mediated endocytosis, and protein binding. The gene's expression profile is characterized by its widespread distribution across various cell types, suggesting a multifaceted role in maintaining cellular homeostasis. **Pathways and Functions:** AGFG1 is intricately involved in several critical signaling pathways, including: 1. **Acrosome assembly:** AGFG1's involvement in acrosome assembly highlights its potential role in regulating sperm function and fertility. 2. **Cargo recognition for clathrin-mediated endocytosis:** This pathway underscores AGFG1's capacity to regulate membrane trafficking and cellular uptake of essential molecules. 3. **Clathrin-mediated endocytosis:** AGFG1's participation in this process underscores its importance in maintaining cellular homeostasis and regulating cellular growth. 4. **Cytoplasmic vesicle organization:** AGFG1's involvement in this pathway highlights its role in regulating cytoskeletal organization and membrane trafficking. 5. **Intracellular membrane-bounded organelle organization:** AGFG1's participation in this process underscores its capacity to regulate organelle dynamics and cellular homeostasis. AGFG1's functions can be broadly categorized into the following: 1. **Regulation of membrane trafficking:** AGFG1's involvement in clathrin-mediated endocytosis and cargo recognition highlights its role in regulating membrane trafficking and cellular uptake of essential molecules. 2. **Cytoskeletal organization:** AGFG1's participation in cytoplasmic vesicle organization underscores its capacity to regulate cytoskeletal organization and membrane trafficking. 3. **Cellular differentiation:** AGFG1's involvement in spermatid nucleus differentiation highlights its potential role in regulating cellular differentiation and development. **Clinical Significance:** The discovery of AGFG1 has significant implications for various diseases, including: 1. **Fertility disorders:** AGFG1's involvement in acrosome assembly suggests its potential role in regulating sperm function and fertility. 2. **Neurodegenerative disorders:** AGFG1's participation in cytoplasmic vesicle organization and cytoskeletal organization highlights its potential role in regulating cellular homeostasis and neurodegenerative disorders. 3. **Cancer:** AGFG1's involvement in membrane trafficking and cellular uptake of essential molecules suggests its potential role in regulating cellular growth and cancer progression. In conclusion, AGFG1 is a novel gene that has shed light on the intricate mechanisms of membrane trafficking, cytoskeletal organization, and cellular differentiation. Further research is necessary to fully elucidate the clinical significance of AGFG1 and its potential therapeutic applications.

Genular Protein ID: 1587137878

Symbol: AGFG1_HUMAN

Name: Arf-GAP domain and FG repeat-containing protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7634337

Title: Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins.

PubMed ID: 7634337

DOI: 10.1016/0092-8674(95)90437-9

PubMed ID: 7637788

Title: A human nucleoporin-like protein that specifically interacts with HIV Rev.

PubMed ID: 7637788

DOI: 10.1038/376530a0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10613896

Title: The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport.

PubMed ID: 10613896

DOI: 10.1083/jcb.147.7.1379

PubMed ID: 14701878

Title: hRIP, a cellular cofactor for Rev function, promotes release of HIV RNAs from the perinuclear region.

PubMed ID: 14701878

DOI: 10.1101/gad.1149704

PubMed ID: 15749819

Title: The cellular HIV-1 Rev cofactor hRIP is required for viral replication.

PubMed ID: 15749819

DOI: 10.1073/pnas.0408889102

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22484487

Title: Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning.

PubMed ID: 22484487

DOI: 10.1038/ncb2473

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 562
  • Mass: 58260
  • Checksum: 9A2242217F53B4D9
  • Sequence:
  • MAASAKRKQE EKHLKMLRDM TGLPHNRKCF DCDQRGPTYV NMTVGSFVCT SCSGSLRGLN 
    PPHRVKSISM TTFTQQEIEF LQKHGNEVCK QIWLGLFDDR SSAIPDFRDP QKVKEFLQEK 
    YEKKRWYVPP EQAKVVASVH ASISGSSASS TSSTPEVKPL KSLLGDSAPT LHLNKGTPSQ 
    SPVVGRSQGQ QQEKKQFDLL SDLGSDIFAA PAPQSTATAN FANFAHFNSH AAQNSANADF 
    ANFDAFGQSS GSSNFGGFPT ASHSPFQPQT TGGSAASVNA NFAHFDNFPK SSSADFGTFN 
    TSQSHQTASA VSKVSTNKAG LQTADKYAAL ANLDNIFSAG QGGDQGSGFG TTGKAPVGSV 
    VSVPSQSSAS SDKYAALAEL DSVFSSAATS SNAYTSTSNA SSNVFGTVPV VASAQTQPAS 
    SSVPAPFGAT PSTNPFVAAA GPSVASSTNP FQTNARGATA ATFGTASMSM PTGFGTPAPY 
    SLPTSFSGSF QQPAFPAQAA FPQQTAFSQQ PNGAGFAAFG QTKPVVTPFG QVAAAGVSSN 
    PFMTGAPTGQ FPTGSSSTNP FL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.