Details for: AGFG1

Gene ID: 3267

Symbol: AGFG1

Ensembl ID: ENSG00000173744

Description: ArfGAP with FG repeats 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 4.3
    Marker Score: 5779
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.35
    Marker Score: 4060
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.66
    Marker Score: 1587
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.43
    Marker Score: 2592
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 2.32
    Marker Score: 849
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.22
    Marker Score: 649
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.2
    Marker Score: 2315.5
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.03
    Marker Score: 1132
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 2.01
    Marker Score: 1650
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.96
    Marker Score: 8201
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.89
    Marker Score: 69744
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.89
    Marker Score: 7690
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.89
    Marker Score: 2083
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.88
    Marker Score: 2168
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.84
    Marker Score: 113421
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.78
    Marker Score: 67704
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.78
    Marker Score: 744
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.77
    Marker Score: 35165
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.76
    Marker Score: 16765
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.76
    Marker Score: 1024
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.75
    Marker Score: 7243
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.71
    Marker Score: 25571
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.71
    Marker Score: 14687
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.71
    Marker Score: 16079
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.71
    Marker Score: 6599
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.69
    Marker Score: 3715
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.69
    Marker Score: 36114
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.69
    Marker Score: 1914
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.69
    Marker Score: 4040
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.69
    Marker Score: 486
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.69
    Marker Score: 17400
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.66
    Marker Score: 12745
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.59
    Marker Score: 3908
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.57
    Marker Score: 53108
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.55
    Marker Score: 907
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.51
    Marker Score: 2325
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.45
    Marker Score: 703
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.45
    Marker Score: 1790
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.41
    Marker Score: 1524
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.4
    Marker Score: 2702
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.38
    Marker Score: 35320
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.35
    Marker Score: 1166
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.34
    Marker Score: 21558
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.34
    Marker Score: 1034
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.34
    Marker Score: 1328
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.32
    Marker Score: 450
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.32
    Marker Score: 360
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.31
    Marker Score: 664
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.31
    Marker Score: 73134
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.29
    Marker Score: 677
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.28
    Marker Score: 1294
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.27
    Marker Score: 5860
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.26
    Marker Score: 703
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.26
    Marker Score: 22285
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.25
    Marker Score: 1433
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.25
    Marker Score: 3557
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.23
    Marker Score: 1536
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.22
    Marker Score: 442.5
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.22
    Marker Score: 847
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.2
    Marker Score: 1705
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.18
    Marker Score: 588
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.18
    Marker Score: 428
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.18
    Marker Score: 440
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.17
    Marker Score: 2071
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.17
    Marker Score: 307.5
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.15
    Marker Score: 4802.5
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.15
    Marker Score: 363.5
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.14
    Marker Score: 1088
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.12
    Marker Score: 1655
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.11
    Marker Score: 759
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.1
    Marker Score: 349
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.1
    Marker Score: 957
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.1
    Marker Score: 1601
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.1
    Marker Score: 2655
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.1
    Marker Score: 7067
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.1
    Marker Score: 543
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.1
    Marker Score: 405
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.09
    Marker Score: 1319
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.09
    Marker Score: 964
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.08
    Marker Score: 4480
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.07
    Marker Score: 36531
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.07
    Marker Score: 1146
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.07
    Marker Score: 1796
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.06
    Marker Score: 4570
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.06
    Marker Score: 399
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.05
    Marker Score: 1471
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.04
    Marker Score: 1045
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.04
    Marker Score: 956.5
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 1.04
    Marker Score: 448
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.03
    Marker Score: 1328
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.02
    Marker Score: 1081.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.01
    Marker Score: 2063.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71639
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47864
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.99
    Marker Score: 22152
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.99
    Marker Score: 537
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.99
    Marker Score: 1097
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.98
    Marker Score: 15358
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30380
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.98
    Marker Score: 249

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - The AGFG1 gene is located on chromosome 19q21.1. - It is a large gene with a total length of approximately 12.5 kb. - The protein encoded by AGFG1 is a transmembrane protein with a predicted molecular weight of approximately 170 kDa. - It contains an arf-gap domain and FG repeat-containing motifs. **Pathways and functions:** - AGFG1 is involved in the assembly of the arf-gap complex. - The arf-gap complex is a large multi-subunit protein that is responsible for the internalization of clathrin-coated vesicles. - The complex is composed of a pair of immunoglobulin heavy chains and a pair of immunoglobulin light chains. - The complex is anchored to the cytoplasmic surface of endosomes and lysosomes and is required for the internalization of clathrin-coated vesicles. - The arf-gap complex is also involved in the sorting and transport of vesicles within the cell. **Clinical significance:** - Mutations in the AGFG1 gene have been linked to several eye diseases, including cataracts and glaucoma. - The expression of AGFG1 is often upregulated in cancer cells, suggesting that it may play a role in tumor growth and metastasis. - Targeting AGFG1 has been investigated as a potential therapeutic strategy for cancer and other diseases that are characterized by abnormal endocytic function.

Genular Protein ID: 1587137878

Symbol: AGFG1_HUMAN

Name: Arf-GAP domain and FG repeat-containing protein 1

UniProtKB Accession Codes:

P52594 B3KUL1 E9PHX7 Q15277 Q4VAS0 Q4VAS1 Q4VAS3 Q53QT8 Q53R11

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 10 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7634337

Title: Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins.

PubMed ID: 7634337

DOI: 10.1016/0092-8674(95)90437-9

PubMed ID: 7637788

Title: A human nucleoporin-like protein that specifically interacts with HIV Rev.

PubMed ID: 7637788

DOI: 10.1038/376530a0

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10613896

Title: The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport.

PubMed ID: 10613896

DOI: 10.1083/jcb.147.7.1379

PubMed ID: 14701878

Title: hRIP, a cellular cofactor for Rev function, promotes release of HIV RNAs from the perinuclear region.

PubMed ID: 14701878

DOI: 10.1101/gad.1149704

PubMed ID: 15749819

Title: The cellular HIV-1 Rev cofactor hRIP is required for viral replication.

PubMed ID: 15749819

DOI: 10.1073/pnas.0408889102

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22484487

Title: Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning.

PubMed ID: 22484487

DOI: 10.1038/ncb2473

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 562
  • Mass: 58260
  • Checksum: 9A2242217F53B4D9
  • Sequence:
    • MAASAKRKQE EKHLKMLRDM TGLPHNRKCF DCDQRGPTYV NMTVGSFVCT SCSGSLRGLN 
PPHRVKSISM TTFTQQEIEF LQKHGNEVCK QIWLGLFDDR SSAIPDFRDP QKVKEFLQEK 
YEKKRWYVPP EQAKVVASVH ASISGSSASS TSSTPEVKPL KSLLGDSAPT LHLNKGTPSQ 
SPVVGRSQGQ QQEKKQFDLL SDLGSDIFAA PAPQSTATAN FANFAHFNSH AAQNSANADF 
ANFDAFGQSS GSSNFGGFPT ASHSPFQPQT TGGSAASVNA NFAHFDNFPK SSSADFGTFN 
TSQSHQTASA VSKVSTNKAG LQTADKYAAL ANLDNIFSAG QGGDQGSGFG TTGKAPVGSV 
VSVPSQSSAS SDKYAALAEL DSVFSSAATS SNAYTSTSNA SSNVFGTVPV VASAQTQPAS 
SSVPAPFGAT PSTNPFVAAA GPSVASSTNP FQTNARGATA ATFGTASMSM PTGFGTPAPY 
SLPTSFSGSF QQPAFPAQAA FPQQTAFSQQ PNGAGFAAFG QTKPVVTPFG QVAAAGVSSN 
PFMTGAPTGQ FPTGSSSTNP FL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.