Details for: HSF1

Gene ID: 3297

Symbol: HSF1

Ensembl ID: ENSG00000185122

Description: heat shock transcription factor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 154.2960
    Cell Significance Index: -24.0000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 131.6415
    Cell Significance Index: -33.3900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 86.1031
    Cell Significance Index: -34.9800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 80.9218
    Cell Significance Index: -41.6300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.1933
    Cell Significance Index: -35.5100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 28.7034
    Cell Significance Index: -35.3900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.4456
    Cell Significance Index: -33.3400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.6856
    Cell Significance Index: -38.2200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.4748
    Cell Significance Index: -26.0300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 3.9713
    Cell Significance Index: 58.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9892
    Cell Significance Index: 54.1500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.9658
    Cell Significance Index: 229.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.5947
    Cell Significance Index: 1439.8800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.0736
    Cell Significance Index: 56.3700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0241
    Cell Significance Index: 61.4800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9983
    Cell Significance Index: 13.6200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9548
    Cell Significance Index: 71.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.8663
    Cell Significance Index: 66.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.8578
    Cell Significance Index: 110.8300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.8002
    Cell Significance Index: 14.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7948
    Cell Significance Index: 157.7300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7348
    Cell Significance Index: 38.1700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7263
    Cell Significance Index: 85.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6800
    Cell Significance Index: 129.4000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6280
    Cell Significance Index: 32.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.5718
    Cell Significance Index: 15.0400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5700
    Cell Significance Index: 39.4200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5690
    Cell Significance Index: 26.5300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5631
    Cell Significance Index: 36.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5621
    Cell Significance Index: 15.7100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5574
    Cell Significance Index: 111.8100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5310
    Cell Significance Index: 72.9200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.5040
    Cell Significance Index: 10.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4913
    Cell Significance Index: 60.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4816
    Cell Significance Index: 21.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4602
    Cell Significance Index: 21.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4448
    Cell Significance Index: 242.9100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.4305
    Cell Significance Index: 4.6800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4266
    Cell Significance Index: 12.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4044
    Cell Significance Index: 72.9000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3651
    Cell Significance Index: 62.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3577
    Cell Significance Index: 7.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3195
    Cell Significance Index: 9.2100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3124
    Cell Significance Index: 216.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.3100
    Cell Significance Index: 7.7500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2936
    Cell Significance Index: 105.3100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2852
    Cell Significance Index: 126.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2483
    Cell Significance Index: 31.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2080
    Cell Significance Index: 20.5800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0986
    Cell Significance Index: 1.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0973
    Cell Significance Index: 3.4200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0851
    Cell Significance Index: 4.3000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0530
    Cell Significance Index: 99.7600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0447
    Cell Significance Index: 3.1600
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.0260
    Cell Significance Index: 0.3500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0259
    Cell Significance Index: 0.9000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0255
    Cell Significance Index: 18.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0064
    Cell Significance Index: 0.1700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0044
    Cell Significance Index: 8.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0023
    Cell Significance Index: 3.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0065
    Cell Significance Index: -2.9600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0147
    Cell Significance Index: -9.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0149
    Cell Significance Index: -20.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0233
    Cell Significance Index: -17.6600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0277
    Cell Significance Index: -2.8300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0325
    Cell Significance Index: -2.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0442
    Cell Significance Index: -32.7400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0505
    Cell Significance Index: -0.8500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0563
    Cell Significance Index: -31.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0596
    Cell Significance Index: -8.6600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0758
    Cell Significance Index: -47.3300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0843
    Cell Significance Index: -2.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1116
    Cell Significance Index: -12.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1409
    Cell Significance Index: -40.5300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1692
    Cell Significance Index: -4.8500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1699
    Cell Significance Index: -2.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1997
    Cell Significance Index: -42.0600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2428
    Cell Significance Index: -3.1100
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.2702
    Cell Significance Index: -3.7900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2748
    Cell Significance Index: -5.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3142
    Cell Significance Index: -32.7200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3143
    Cell Significance Index: -8.0300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3226
    Cell Significance Index: -6.8700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.3229
    Cell Significance Index: -4.1400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3235
    Cell Significance Index: -25.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3409
    Cell Significance Index: -19.1300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4211
    Cell Significance Index: -6.3100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4253
    Cell Significance Index: -5.0700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.4750
    Cell Significance Index: -3.9900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4803
    Cell Significance Index: -12.3500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.4994
    Cell Significance Index: -30.6200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5703
    Cell Significance Index: -10.5400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5740
    Cell Significance Index: -23.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5820
    Cell Significance Index: -25.7500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.6000
    Cell Significance Index: -14.6400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6401
    Cell Significance Index: -10.9700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.6960
    Cell Significance Index: -5.3700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7233
    Cell Significance Index: -27.3900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.7433
    Cell Significance Index: -7.7000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7547
    Cell Significance Index: -4.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** HSF1 is a transcription factor that belongs to the basic leucine zipper (bZIP) family of proteins. It is activated by heat shock, oxidative stress, and other forms of cellular stress, leading to the regulation of gene expression involved in stress response, cell survival, and apoptosis. Some of the key characteristics of HSF1 include: * High specificity for heat shock proteins (HSPs) promoter sequences * Ability to activate transcription of HSP genes * Role in regulating cellular responses to stress, inflammation, and tissue damage * Interaction with other transcription factors and signaling pathways, including MAPK and NF-κB **Pathways and Functions** HSF1 is involved in various cellular pathways and functions, including: * Heat shock response: HSF1 regulates the expression of HSPs, which protect cells against protein misfolding and aggregation * Autophagy: HSF1 modulates autophagy, a cellular process involved in protein degradation and cellular renewal * Apoptosis: HSF1 regulates apoptosis, a form of programmed cell death, in response to cellular stress * Inflammation: HSF1 is involved in regulating inflammatory responses, including the expression of pro-inflammatory genes * Cell survival: HSF1 promotes cell survival by regulating the expression of anti-apoptotic genes **Clinical Significance** Dysregulation of HSF1 has been implicated in various diseases, including: * Cancer: HSF1 overexpression is associated with cancer progression and metastasis * Neurodegenerative disorders: HSF1 is involved in the regulation of protein misfolding and aggregation in neurodegenerative diseases, such as Alzheimer's and Parkinson's * Cardiovascular diseases: HSF1 regulates the expression of genes involved in cardiovascular disease, including hypertension and atherosclerosis * Inflammatory disorders: HSF1 modulates inflammatory responses, which are involved in various inflammatory disorders, including rheumatoid arthritis and inflammatory bowel disease In conclusion, HSF1 is a critical transcription factor that plays a pivotal role in regulating cellular responses to stress, inflammation, and tissue damage. Its dysregulation has been implicated in various diseases, highlighting the importance of HSF1 in maintaining cellular homeostasis and preventing disease. Further research is needed to fully elucidate the mechanisms by which HSF1 regulates cellular responses and to develop therapeutic strategies targeting HSF1 for the treatment of various diseases.

Genular Protein ID: 928567285

Symbol: HSF1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q00613 A8K4L0 A8MW26 Q53XT4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 81 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1871105

Title: Molecular cloning and expression of a human heat shock factor, HSF1.

PubMed ID: 1871105

DOI: 10.1073/pnas.88.16.6906

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1871106

Title: Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans.

PubMed ID: 1871106

DOI: 10.1073/pnas.88.16.6911

PubMed ID: 11447121

Title: Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1.

PubMed ID: 11447121

DOI: 10.1093/emboj/20.14.3800

PubMed ID: 1986252

Title: Heat shock-induced interactions of heat shock transcription factor and the human hsp70 promoter examined by in vivo footprinting.

PubMed ID: 1986252

DOI: 10.1128/mcb.11.1.586-592.1991

PubMed ID: 8455624

Title: Activation of human heat shock genes is accompanied by oligomerization, modification, and rapid translocation of heat shock transcription factor HSF1.

PubMed ID: 8455624

DOI: 10.1128/mcb.13.4.2486-2496.1993

PubMed ID: 7935376

Title: Interaction between heat shock factor and hsp70 is insufficient to suppress induction of DNA-binding activity in vivo.

PubMed ID: 7935376

DOI: 10.1128/mcb.14.10.6552-6560.1994

PubMed ID: 7935471

Title: Activation of the DNA-binding ability of human heat shock transcription factor 1 may involve the transition from an intramolecular to an intermolecular triple-stranded coiled-coil structure.

PubMed ID: 7935471

DOI: 10.1128/mcb.14.11.7557-7568.1994

PubMed ID: 7760831

Title: A heat shock-responsive domain of human HSF1 that regulates transcription activation domain function.

PubMed ID: 7760831

DOI: 10.1128/mcb.15.6.3354

PubMed ID: 7623826

Title: Multiple layers of regulation of human heat shock transcription factor 1.

PubMed ID: 7623826

DOI: 10.1128/mcb.15.8.4319

PubMed ID: 9222587

Title: Evidence for a role of Hsp70 in the regulation of the heat shock response in mammalian cells.

PubMed ID: 9222587

DOI: 10.1379/1466-1268(1996)001<0033:efaroh>2.3.co;2

PubMed ID: 8946918

Title: Repression of human heat shock factor 1 activity at control temperature by phosphorylation.

PubMed ID: 8946918

DOI: 10.1101/gad.10.21.2782

PubMed ID: 8940068

Title: Sequential phosphorylation by mitogen-activated protein kinase and glycogen synthase kinase 3 represses transcriptional activation by heat shock factor-1.

PubMed ID: 8940068

DOI: 10.1074/jbc.271.48.30847

PubMed ID: 9341107

Title: Heat shock factor 1 represses Ras-induced transcriptional activation of the c-fos gene.

PubMed ID: 9341107

DOI: 10.1074/jbc.272.43.26803

PubMed ID: 9121459

Title: Repression of the heat shock factor 1 transcriptional activation domain is modulated by constitutive phosphorylation.

PubMed ID: 9121459

DOI: 10.1128/mcb.17.4.2107

PubMed ID: 9727490

Title: Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1.

PubMed ID: 9727490

DOI: 10.1016/s0092-8674(00)81588-3

PubMed ID: 9499401

Title: Molecular chaperones as HSF1-specific transcriptional repressors.

PubMed ID: 9499401

DOI: 10.1101/gad.12.5.654

PubMed ID: 9535852

Title: Transcriptional activation of heat shock factor HSF1 probed by phosphopeptide analysis of factor 32P-labeled in vivo.

PubMed ID: 9535852

DOI: 10.1074/jbc.273.15.8749

PubMed ID: 10413683

Title: Human heat shock factor 1 is predominantly a nuclear protein before and after heat stress.

PubMed ID: 10413683

DOI: 10.1242/jcs.112.16.2765

PubMed ID: 10359787

Title: Rapid and reversible relocalization of heat shock factor 1 within seconds to nuclear stress granules.

PubMed ID: 10359787

DOI: 10.1073/pnas.96.12.6769

PubMed ID: 11005381

Title: Potential targets for HSF1 within the preinitiation complex.

PubMed ID: 11005381

DOI: 10.1379/1466-1268(2000)005<0229:ptfhwt>2.0.co;2

PubMed ID: 10747973

Title: c-Jun NH2-terminal kinase targeting and phosphorylation of heat shock factor-1 suppress its transcriptional activity.

PubMed ID: 10747973

DOI: 10.1074/jbc.m000958200

PubMed ID: 11514557

Title: Regulation of heat shock transcription factor 1 by stress-induced SUMO-1 modification.

PubMed ID: 11514557

DOI: 10.1074/jbc.m104714200

PubMed ID: 11583998

Title: Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex.

PubMed ID: 11583998

DOI: 10.1074/jbc.m105931200

PubMed ID: 12646186

Title: Insights into the regulation of heat shock transcription factor 1 SUMO-1 modification.

PubMed ID: 12646186

DOI: 10.1016/s0006-291x(03)00312-7

PubMed ID: 12659875

Title: Transcriptional activity and DNA binding of heat shock factor-1 involve phosphorylation on threonine 142 by CK2.

PubMed ID: 12659875

DOI: 10.1016/s0006-291x(03)00398-x

PubMed ID: 12665592

Title: Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1.

PubMed ID: 12665592

DOI: 10.1128/mcb.23.8.2953-2968.2003

PubMed ID: 12917326

Title: Regulation of molecular chaperone gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmic sequestration of heat shock factor 1.

PubMed ID: 12917326

DOI: 10.1128/mcb.23.17.6013-6026.2003

PubMed ID: 14707147

Title: HSF1 modulation of Hsp70 mRNA polyadenylation via interaction with symplekin.

PubMed ID: 14707147

DOI: 10.1074/jbc.m311719200

PubMed ID: 15016915

Title: DAXX interacts with heat shock factor 1 during stress activation and enhances its transcriptional activity.

PubMed ID: 15016915

DOI: 10.1073/pnas.0304768101

PubMed ID: 15760475

Title: Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress.

PubMed ID: 15760475

DOI: 10.1186/1471-2091-6-4

PubMed ID: 15661742

Title: Polo-like kinase 1 phosphorylates heat shock transcription factor 1 and mediates its nuclear translocation during heat stress.

PubMed ID: 15661742

DOI: 10.1074/jbc.m411908200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16278218

Title: Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding.

PubMed ID: 16278218

DOI: 10.1074/jbc.m505822200

PubMed ID: 16371476

Title: PDSM, a motif for phosphorylation-dependent SUMO modification.

PubMed ID: 16371476

DOI: 10.1073/pnas.0503698102

PubMed ID: 16554823

Title: RNA-mediated response to heat shock in mammalian cells.

PubMed ID: 16554823

DOI: 10.1038/nature04518

PubMed ID: 17467953

Title: Nine-amino-acid transactivation domain: establishment and prediction utilities.

PubMed ID: 17467953

DOI: 10.1016/j.ygeno.2007.02.003

PubMed ID: 17897941

Title: HSF1-TPR interaction facilitates export of stress-induced HSP70 mRNA.

PubMed ID: 17897941

DOI: 10.1074/jbc.m704054200

PubMed ID: 18794143

Title: HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression.

PubMed ID: 18794143

DOI: 10.1158/0008-5472.can-08-0129

PubMed ID: 18451878

Title: A transcription cofactor required for the heat-shock response.

PubMed ID: 18451878

DOI: 10.1038/embor.2008.70

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19229036

Title: Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1.

PubMed ID: 19229036

DOI: 10.1126/science.1165946

PubMed ID: 21085490

Title: Protein kinase A binds and activates heat shock factor 1.

PubMed ID: 21085490

DOI: 10.1371/journal.pone.0013830

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21597468

Title: Transformation of eEF1Bdelta into heat-shock response transcription factor by alternative splicing.

PubMed ID: 21597468

DOI: 10.1038/embor.2011.82

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24581496

Title: Interplay of acetyltransferase EP300 and the proteasome system in regulating heat shock transcription factor 1.

PubMed ID: 24581496

DOI: 10.1016/j.cell.2014.01.055

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26159920

Title: BAG3 affects the nucleocytoplasmic shuttling of HSF1 upon heat stress.

PubMed ID: 26159920

DOI: 10.1016/j.bbrc.2015.07.006

PubMed ID: 25816751

Title: HSF1 transcriptional activity is modulated by IER5 and PP2A/B55.

PubMed ID: 25816751

DOI: 10.1016/j.febslet.2015.03.019

PubMed ID: 26496226

Title: Immediate-early response 5 (IER5) interacts with protein phosphatase 2A and regulates the phosphorylation of ribosomal protein S6 kinase and heat shock factor 1.

PubMed ID: 26496226

DOI: 10.1016/j.febslet.2015.10.013

PubMed ID: 25963659

Title: Uncoupling stress-inducible phosphorylation of heat shock factor 1 from its activation.

PubMed ID: 25963659

DOI: 10.1128/mcb.00816-14

PubMed ID: 26359349

Title: Heat shock factor 1, an inhibitor of non-homologous end joining repair.

PubMed ID: 26359349

DOI: 10.18632/oncotarget.5073

PubMed ID: 26517842

Title: Client proteins and small molecule inhibitors display distinct binding preferences for constitutive and stress-induced HSP90 isoforms and their conformationally restricted mutants.

PubMed ID: 26517842

DOI: 10.1371/journal.pone.0141786

PubMed ID: 27354066

Title: Heat shock factor 1 is a substrate for p38 mitogen-activated protein kinases.

PubMed ID: 27354066

DOI: 10.1128/mcb.00292-16

PubMed ID: 26754925

Title: IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.

PubMed ID: 26754925

DOI: 10.1038/srep19174

PubMed ID: 27189267

Title: Heat shock factor 1 mediates latent HIV reactivation.

PubMed ID: 27189267

DOI: 10.1038/srep26294

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 34723967

Title: FOXR1 regulates stress response pathways and is necessary for proper brain development.

PubMed ID: 34723967

DOI: 10.1371/journal.pgen.1009854

PubMed ID: 26727489

Title: Structure of human heat-shock transcription factor 1 in complex with DNA.

PubMed ID: 26727489

DOI: 10.1038/nsmb.3149

Sequence Information:

  • Length: 529
  • Mass: 57260
  • Checksum: 735074507C954365
  • Sequence:
    • MDLPVGPGAA GPSNVPAFLT KLWTLVSDPD TDALICWSPS GNSFHVFDQG QFAKEVLPKY 
FKHNNMASFV RQLNMYGFRK VVHIEQGGLV KPERDDTEFQ HPCFLRGQEQ LLENIKRKVT 
SVSTLKSEDI KIRQDSVTKL LTDVQLMKGK QECMDSKLLA MKHENEALWR EVASLRQKHA 
QQQKVVNKLI QFLISLVQSN RILGVKRKIP LMLNDSGSAH SMPKYSRQFS LEHVHGSGPY 
SAPSPAYSSS SLYAPDAVAS SGPIISDITE LAPASPMASP GGSIDERPLS SSPLVRVKEE 
PPSPPQSPRV EEASPGRPSS VDTLLSPTAL IDSILRESEP APASVTALTD ARGHTDTEGR 
PPSPPPTSTP EKCLSVACLD KNELSDHLDA MDSNLDNLQT MLSSHGFSVD TSALLDLFSP 
SVTVPDMSLP DLDSSLASIQ ELLSPQEPPR PPEAENSSPD SGKQLVHYTA QPLFLLDPGS 
VDTGSNDLPV LFELGEGSYF SEGDGFAEDP TISLLTGSEP PKAKDPTVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.