Details for: HSF1

Gene ID: 3297

Symbol: HSF1

Ensembl ID: ENSG00000185122

Description: heat shock transcription factor 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 5.66
    Marker Score: 75255.5
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.91
    Marker Score: 2599
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.35
    Marker Score: 8364
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.29
    Marker Score: 51106
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 2
    Marker Score: 1211
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.91
    Marker Score: 1348
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.79
    Marker Score: 3777
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 1.63
    Marker Score: 538
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.62
    Marker Score: 16297
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.54
    Marker Score: 1630
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.53
    Marker Score: 1024.5
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.51
    Marker Score: 4120
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.5
    Marker Score: 5789
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.43
    Marker Score: 970
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.42
    Marker Score: 417
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.42
    Marker Score: 1504
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.4
    Marker Score: 681
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.4
    Marker Score: 5492
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.39
    Marker Score: 1493
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.36
    Marker Score: 5884
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.31
    Marker Score: 1931
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.3
    Marker Score: 2637
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.3
    Marker Score: 2151
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.29
    Marker Score: 3156.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.29
    Marker Score: 2118
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.28
    Marker Score: 7567
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.27
    Marker Score: 367
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.27
    Marker Score: 710
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.26
    Marker Score: 1584.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.26
    Marker Score: 4666
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.26
    Marker Score: 1822
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.25
    Marker Score: 3355
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.25
    Marker Score: 1506
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.25
    Marker Score: 16755
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.25
    Marker Score: 663
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.24
    Marker Score: 599
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.24
    Marker Score: 8049
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.23
    Marker Score: 1243
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.23
    Marker Score: 2082
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.22
    Marker Score: 3631
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.21
    Marker Score: 957
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.2
    Marker Score: 1134
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.19
    Marker Score: 7640
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.19
    Marker Score: 864
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.18
    Marker Score: 1003
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.17
    Marker Score: 1412
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.17
    Marker Score: 3229
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.15
    Marker Score: 1295
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.15
    Marker Score: 2397
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.14
    Marker Score: 630
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.14
    Marker Score: 1222
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.14
    Marker Score: 1074
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.14
    Marker Score: 398
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.13
    Marker Score: 1060
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.12
    Marker Score: 359
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.12
    Marker Score: 814
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.11
    Marker Score: 2536
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.11
    Marker Score: 1159.5
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.1
    Marker Score: 1924
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.09
    Marker Score: 2131
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.09
    Marker Score: 727
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.09
    Marker Score: 4671
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.09
    Marker Score: 1563
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.07
    Marker Score: 2520
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.06
    Marker Score: 1809.5
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.06
    Marker Score: 371
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.06
    Marker Score: 412
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.06
    Marker Score: 10708
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.06
    Marker Score: 355
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.05
    Marker Score: 986
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.05
    Marker Score: 1966
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.04
    Marker Score: 696
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.04
    Marker Score: 256
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.03
    Marker Score: 1080
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.03
    Marker Score: 2609
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.02
    Marker Score: 600
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.02
    Marker Score: 240
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.02
    Marker Score: 34671
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.02
    Marker Score: 53810
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.01
    Marker Score: 2021
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.01
    Marker Score: 497
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 1.01
    Marker Score: 911
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.01
    Marker Score: 1065
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1
    Marker Score: 4110
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.99
    Marker Score: 2698.5
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.98
    Marker Score: 401
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.98
    Marker Score: 2334
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.98
    Marker Score: 737
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.98
    Marker Score: 448
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30371
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.98
    Marker Score: 12906
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.98
    Marker Score: 297
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.98
    Marker Score: 54578
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.97
    Marker Score: 1550
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.97
    Marker Score: 1724
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.97
    Marker Score: 475
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.97
    Marker Score: 1368
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.97
    Marker Score: 4011
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.96
    Marker Score: 4702
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.95
    Marker Score: 228

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Other Information

**Key characteristics:** * HSF1 is a member of the heat shock family of transcription factors. * It is a highly conserved protein with a conserved structure and function. * HSF1 is a key regulator of the expression of many heat shock genes. * It is also involved in the regulation of apoptosis. **Pathways and functions:** * HSF1 is involved in a variety of cellular pathways, including the aggregation of misfolded proteins, the activation of the unfolded protein response (UPR), and the regulation of autophagy. * It is also involved in the regulation of inflammation and apoptosis. * HSF1 is a key regulator of the heat shock response. * It is involved in the regulation of the expression of many heat shock genes, including those that encode chaperones, proteins that help to protect proteins from damage by heat. * HSF1 also plays a role in the regulation of apoptosis. **Clinical significance:** * Mutations in HSF1 have been linked to a number of human diseases, including heat stroke, myocardial infarction, and cancer. * HSF1 is a potential target for the treatment of these diseases. **Additional information:** * HSF1 is a highly conserved protein with a molecular weight of approximately 42 kDa. * It is expressed in a variety of cell types, including cardiac muscle cells, endothelial cells, and immune cells. * HSF1 is a key regulator of the heat shock response. * It is activated by heat shock proteins (HSPs) and is involved in the induction of HSP expression. * HSF1 is also involved in the regulation of inflammation and apoptosis.

Genular Protein ID: 928567285

Symbol: HSF1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q00613 A8K4L0 A8MW26 Q53XT4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 6 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 80 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 8 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 5 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1871105

Title: Molecular cloning and expression of a human heat shock factor, HSF1.

PubMed ID: 1871105

DOI: 10.1073/pnas.88.16.6906

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1871106

Title: Isolation of a cDNA for HSF2: evidence for two heat shock factor genes in humans.

PubMed ID: 1871106

DOI: 10.1073/pnas.88.16.6911

PubMed ID: 11447121

Title: Phosphorylation of serine 230 promotes inducible transcriptional activity of heat shock factor 1.

PubMed ID: 11447121

DOI: 10.1093/emboj/20.14.3800

PubMed ID: 1986252

Title: Heat shock-induced interactions of heat shock transcription factor and the human hsp70 promoter examined by in vivo footprinting.

PubMed ID: 1986252

DOI: 10.1128/mcb.11.1.586-592.1991

PubMed ID: 8455624

Title: Activation of human heat shock genes is accompanied by oligomerization, modification, and rapid translocation of heat shock transcription factor HSF1.

PubMed ID: 8455624

DOI: 10.1128/mcb.13.4.2486-2496.1993

PubMed ID: 7935376

Title: Interaction between heat shock factor and hsp70 is insufficient to suppress induction of DNA-binding activity in vivo.

PubMed ID: 7935376

DOI: 10.1128/mcb.14.10.6552-6560.1994

PubMed ID: 7935471

Title: Activation of the DNA-binding ability of human heat shock transcription factor 1 may involve the transition from an intramolecular to an intermolecular triple-stranded coiled-coil structure.

PubMed ID: 7935471

DOI: 10.1128/mcb.14.11.7557-7568.1994

PubMed ID: 7760831

Title: A heat shock-responsive domain of human HSF1 that regulates transcription activation domain function.

PubMed ID: 7760831

DOI: 10.1128/mcb.15.6.3354

PubMed ID: 7623826

Title: Multiple layers of regulation of human heat shock transcription factor 1.

PubMed ID: 7623826

DOI: 10.1128/mcb.15.8.4319

PubMed ID: 9222587

Title: Evidence for a role of Hsp70 in the regulation of the heat shock response in mammalian cells.

PubMed ID: 9222587

DOI: 10.1379/1466-1268(1996)001<0033:efaroh>2.3.co;2

PubMed ID: 8946918

Title: Repression of human heat shock factor 1 activity at control temperature by phosphorylation.

PubMed ID: 8946918

DOI: 10.1101/gad.10.21.2782

PubMed ID: 8940068

Title: Sequential phosphorylation by mitogen-activated protein kinase and glycogen synthase kinase 3 represses transcriptional activation by heat shock factor-1.

PubMed ID: 8940068

DOI: 10.1074/jbc.271.48.30847

PubMed ID: 9341107

Title: Heat shock factor 1 represses Ras-induced transcriptional activation of the c-fos gene.

PubMed ID: 9341107

DOI: 10.1074/jbc.272.43.26803

PubMed ID: 9121459

Title: Repression of the heat shock factor 1 transcriptional activation domain is modulated by constitutive phosphorylation.

PubMed ID: 9121459

DOI: 10.1128/mcb.17.4.2107

PubMed ID: 9727490

Title: Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1.

PubMed ID: 9727490

DOI: 10.1016/s0092-8674(00)81588-3

PubMed ID: 9499401

Title: Molecular chaperones as HSF1-specific transcriptional repressors.

PubMed ID: 9499401

DOI: 10.1101/gad.12.5.654

PubMed ID: 9535852

Title: Transcriptional activation of heat shock factor HSF1 probed by phosphopeptide analysis of factor 32P-labeled in vivo.

PubMed ID: 9535852

DOI: 10.1074/jbc.273.15.8749

PubMed ID: 10413683

Title: Human heat shock factor 1 is predominantly a nuclear protein before and after heat stress.

PubMed ID: 10413683

DOI: 10.1242/jcs.112.16.2765

PubMed ID: 10359787

Title: Rapid and reversible relocalization of heat shock factor 1 within seconds to nuclear stress granules.

PubMed ID: 10359787

DOI: 10.1073/pnas.96.12.6769

PubMed ID: 11005381

Title: Potential targets for HSF1 within the preinitiation complex.

PubMed ID: 11005381

DOI: 10.1379/1466-1268(2000)005<0229:ptfhwt>2.0.co;2

PubMed ID: 10747973

Title: c-Jun NH2-terminal kinase targeting and phosphorylation of heat shock factor-1 suppress its transcriptional activity.

PubMed ID: 10747973

DOI: 10.1074/jbc.m000958200

PubMed ID: 11514557

Title: Regulation of heat shock transcription factor 1 by stress-induced SUMO-1 modification.

PubMed ID: 11514557

DOI: 10.1074/jbc.m104714200

PubMed ID: 11583998

Title: Evidence for a mechanism of repression of heat shock factor 1 transcriptional activity by a multichaperone complex.

PubMed ID: 11583998

DOI: 10.1074/jbc.m105931200

PubMed ID: 12646186

Title: Insights into the regulation of heat shock transcription factor 1 SUMO-1 modification.

PubMed ID: 12646186

DOI: 10.1016/s0006-291x(03)00312-7

PubMed ID: 12659875

Title: Transcriptional activity and DNA binding of heat shock factor-1 involve phosphorylation on threonine 142 by CK2.

PubMed ID: 12659875

DOI: 10.1016/s0006-291x(03)00398-x

PubMed ID: 12665592

Title: Phosphorylation of serine 303 is a prerequisite for the stress-inducible SUMO modification of heat shock factor 1.

PubMed ID: 12665592

DOI: 10.1128/mcb.23.8.2953-2968.2003

PubMed ID: 12917326

Title: Regulation of molecular chaperone gene transcription involves the serine phosphorylation, 14-3-3 epsilon binding, and cytoplasmic sequestration of heat shock factor 1.

PubMed ID: 12917326

DOI: 10.1128/mcb.23.17.6013-6026.2003

PubMed ID: 14707147

Title: HSF1 modulation of Hsp70 mRNA polyadenylation via interaction with symplekin.

PubMed ID: 14707147

DOI: 10.1074/jbc.m311719200

PubMed ID: 15016915

Title: DAXX interacts with heat shock factor 1 during stress activation and enhances its transcriptional activity.

PubMed ID: 15016915

DOI: 10.1073/pnas.0304768101

PubMed ID: 15760475

Title: Analysis of phosphorylation of human heat shock factor 1 in cells experiencing a stress.

PubMed ID: 15760475

DOI: 10.1186/1471-2091-6-4

PubMed ID: 15661742

Title: Polo-like kinase 1 phosphorylates heat shock transcription factor 1 and mediates its nuclear translocation during heat stress.

PubMed ID: 15661742

DOI: 10.1074/jbc.m411908200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16278218

Title: Phosphorylation of HSF1 by MAPK-activated protein kinase 2 on serine 121, inhibits transcriptional activity and promotes HSP90 binding.

PubMed ID: 16278218

DOI: 10.1074/jbc.m505822200

PubMed ID: 16371476

Title: PDSM, a motif for phosphorylation-dependent SUMO modification.

PubMed ID: 16371476

DOI: 10.1073/pnas.0503698102

PubMed ID: 16554823

Title: RNA-mediated response to heat shock in mammalian cells.

PubMed ID: 16554823

DOI: 10.1038/nature04518

PubMed ID: 17467953

Title: Nine-amino-acid transactivation domain: establishment and prediction utilities.

PubMed ID: 17467953

DOI: 10.1016/j.ygeno.2007.02.003

PubMed ID: 17897941

Title: HSF1-TPR interaction facilitates export of stress-induced HSP70 mRNA.

PubMed ID: 17897941

DOI: 10.1074/jbc.m704054200

PubMed ID: 18794143

Title: HSF1 as a mitotic regulator: phosphorylation of HSF1 by Plk1 is essential for mitotic progression.

PubMed ID: 18794143

DOI: 10.1158/0008-5472.can-08-0129

PubMed ID: 18451878

Title: A transcription cofactor required for the heat-shock response.

PubMed ID: 18451878

DOI: 10.1038/embor.2008.70

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19229036

Title: Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1.

PubMed ID: 19229036

DOI: 10.1126/science.1165946

PubMed ID: 21085490

Title: Protein kinase A binds and activates heat shock factor 1.

PubMed ID: 21085490

DOI: 10.1371/journal.pone.0013830

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21597468

Title: Transformation of eEF1Bdelta into heat-shock response transcription factor by alternative splicing.

PubMed ID: 21597468

DOI: 10.1038/embor.2011.82

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24581496

Title: Interplay of acetyltransferase EP300 and the proteasome system in regulating heat shock transcription factor 1.

PubMed ID: 24581496

DOI: 10.1016/j.cell.2014.01.055

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 26159920

Title: BAG3 affects the nucleocytoplasmic shuttling of HSF1 upon heat stress.

PubMed ID: 26159920

DOI: 10.1016/j.bbrc.2015.07.006

PubMed ID: 25816751

Title: HSF1 transcriptional activity is modulated by IER5 and PP2A/B55.

PubMed ID: 25816751

DOI: 10.1016/j.febslet.2015.03.019

PubMed ID: 26496226

Title: Immediate-early response 5 (IER5) interacts with protein phosphatase 2A and regulates the phosphorylation of ribosomal protein S6 kinase and heat shock factor 1.

PubMed ID: 26496226

DOI: 10.1016/j.febslet.2015.10.013

PubMed ID: 25963659

Title: Uncoupling stress-inducible phosphorylation of heat shock factor 1 from its activation.

PubMed ID: 25963659

DOI: 10.1128/mcb.00816-14

PubMed ID: 26359349

Title: Heat shock factor 1, an inhibitor of non-homologous end joining repair.

PubMed ID: 26359349

DOI: 10.18632/oncotarget.5073

PubMed ID: 26517842

Title: Client proteins and small molecule inhibitors display distinct binding preferences for constitutive and stress-induced HSP90 isoforms and their conformationally restricted mutants.

PubMed ID: 26517842

DOI: 10.1371/journal.pone.0141786

PubMed ID: 27354066

Title: Heat shock factor 1 is a substrate for p38 mitogen-activated protein kinases.

PubMed ID: 27354066

DOI: 10.1128/mcb.00292-16

PubMed ID: 26754925

Title: IER5 generates a novel hypo-phosphorylated active form of HSF1 and contributes to tumorigenesis.

PubMed ID: 26754925

DOI: 10.1038/srep19174

PubMed ID: 27189267

Title: Heat shock factor 1 mediates latent HIV reactivation.

PubMed ID: 27189267

DOI: 10.1038/srep26294

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 34723967

Title: FOXR1 regulates stress response pathways and is necessary for proper brain development.

PubMed ID: 34723967

DOI: 10.1371/journal.pgen.1009854

PubMed ID: 26727489

Title: Structure of human heat-shock transcription factor 1 in complex with DNA.

PubMed ID: 26727489

DOI: 10.1038/nsmb.3149

Sequence Information:

  • Length: 529
  • Mass: 57260
  • Checksum: 735074507C954365
  • Sequence:
    • MDLPVGPGAA GPSNVPAFLT KLWTLVSDPD TDALICWSPS GNSFHVFDQG QFAKEVLPKY 
FKHNNMASFV RQLNMYGFRK VVHIEQGGLV KPERDDTEFQ HPCFLRGQEQ LLENIKRKVT 
SVSTLKSEDI KIRQDSVTKL LTDVQLMKGK QECMDSKLLA MKHENEALWR EVASLRQKHA 
QQQKVVNKLI QFLISLVQSN RILGVKRKIP LMLNDSGSAH SMPKYSRQFS LEHVHGSGPY 
SAPSPAYSSS SLYAPDAVAS SGPIISDITE LAPASPMASP GGSIDERPLS SSPLVRVKEE 
PPSPPQSPRV EEASPGRPSS VDTLLSPTAL IDSILRESEP APASVTALTD ARGHTDTEGR 
PPSPPPTSTP EKCLSVACLD KNELSDHLDA MDSNLDNLQT MLSSHGFSVD TSALLDLFSP 
SVTVPDMSLP DLDSSLASIQ ELLSPQEPPR PPEAENSSPD SGKQLVHYTA QPLFLLDPGS 
VDTGSNDLPV LFELGEGSYF SEGDGFAEDP TISLLTGSEP PKAKDPTVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.