Details for: HSPA4

Gene ID: 3308

Symbol: HSPA4

Ensembl ID: ENSG00000170606

Description: heat shock protein family A (Hsp70) member 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.28
    Marker Score: 3281
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.15
    Marker Score: 641
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.01
    Marker Score: 112526
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.99
    Marker Score: 1698
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.97
    Marker Score: 5633
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.88
    Marker Score: 464
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.82
    Marker Score: 1945
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.78
    Marker Score: 513
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.73
    Marker Score: 3010
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.68
    Marker Score: 1648
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.67
    Marker Score: 1137
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.63
    Marker Score: 2396
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.63
    Marker Score: 2301
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.62
    Marker Score: 2028
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.57
    Marker Score: 16263
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.57
    Marker Score: 5829
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.57
    Marker Score: 1883.5
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.55
    Marker Score: 4587
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.54
    Marker Score: 1624
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.52
    Marker Score: 531
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.52
    Marker Score: 5209
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.51
    Marker Score: 743
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.48
    Marker Score: 1786
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.46
    Marker Score: 5928
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.45
    Marker Score: 89276
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.45
    Marker Score: 1537
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 165945
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.43
    Marker Score: 12300
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.42
    Marker Score: 1074
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.41
    Marker Score: 16395
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.4
    Marker Score: 2734
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.39
    Marker Score: 3387
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.37
    Marker Score: 1381
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.37
    Marker Score: 926
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.36
    Marker Score: 12904
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.36
    Marker Score: 46145
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.35
    Marker Score: 895
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.34
    Marker Score: 3650
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.34
    Marker Score: 5248
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.32
    Marker Score: 70047
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.32
    Marker Score: 2041
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.32
    Marker Score: 548
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.31
    Marker Score: 1384
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.31
    Marker Score: 1130
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.3
    Marker Score: 644
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.3
    Marker Score: 12204
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.29
    Marker Score: 44621.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.28
    Marker Score: 47375
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.28
    Marker Score: 1380
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.28
    Marker Score: 2099.5
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.28
    Marker Score: 280
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.28
    Marker Score: 1174
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.27
    Marker Score: 851
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.27
    Marker Score: 845.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.27
    Marker Score: 48200
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.27
    Marker Score: 4903
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.27
    Marker Score: 10917
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.26
    Marker Score: 302
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.25
    Marker Score: 853.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.24
    Marker Score: 3123
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.23
    Marker Score: 340
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.23
    Marker Score: 821
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.23
    Marker Score: 501
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.23
    Marker Score: 2574
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.22
    Marker Score: 716
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.22
    Marker Score: 1205
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.22
    Marker Score: 3005
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.22
    Marker Score: 1178
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.22
    Marker Score: 2545
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.22
    Marker Score: 3316
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.22
    Marker Score: 1017
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.21
    Marker Score: 627
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.21
    Marker Score: 4687
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 1.21
    Marker Score: 609
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.2
    Marker Score: 12106.5
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.2
    Marker Score: 7133
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.2
    Marker Score: 1550
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.19
    Marker Score: 1065
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 1.19
    Marker Score: 580
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.18
    Marker Score: 681
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.18
    Marker Score: 569
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.18
    Marker Score: 10227
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.17
    Marker Score: 2926
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.17
    Marker Score: 740
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.17
    Marker Score: 3693
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.17
    Marker Score: 17430
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.16
    Marker Score: 349
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.16
    Marker Score: 846
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.16
    Marker Score: 1398
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.16
    Marker Score: 466
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.16
    Marker Score: 604
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.15
    Marker Score: 695
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.15
    Marker Score: 1157
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.15
    Marker Score: 1267
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.14
    Marker Score: 2605
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.14
    Marker Score: 1337
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.14
    Marker Score: 361
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.14
    Marker Score: 567
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.14
    Marker Score: 4038
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.14
    Marker Score: 709

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Other Information

**Key characteristics:** * HSPA4 is a large protein (70 kDa) that is expressed in high levels in cells that are exposed to heat stress. * It is a member of the HSP70 family of heat shock proteins. * HSPA4 is a chaperone protein that helps to protect other proteins from denaturation and aggregation. * It is involved in the folding of proteins, as well as in the assembly of protein complexes. * It is also involved in the regulation of the heat shock response. **Pathways and functions:** * HSPA4 is involved in the heat shock response, which is a protective mechanism that is triggered by high temperatures. * It helps to prevent the aggregation of misfolded proteins, which can lead to cell death. * It also helps to fold other proteins that are required for the proper functioning of cells. * HSPA4 is involved in the assembly of mitochondrial outer membrane proteins. * It is also involved in the regulation of the activity of the heat shock factor 1 (hsf1). **Clinical significance:** * Mutations in HSPA4 have been linked to a number of human diseases, including amyotrophic lateral sclerosis, heat-related illnesses, and cancer. * HSPA4 is a potential therapeutic target for these diseases. * By understanding the role of HSPA4 in the heat shock response, it may be possible to develop new treatments for these diseases.

Genular Protein ID: 1603149383

Symbol: HSP74_HUMAN

Name: Heat shock 70 kDa protein 4

UniProtKB Accession Codes:

P34932 O95756 Q2TAL4 Q9BUK9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 1 EMBL 8 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8335910

Title: Molecular cloning of a novel human hsp70 from a B cell line and its assignment to chromosome 5.

PubMed ID: 8335910

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

  • Length: 840
  • Mass: 94331
  • Checksum: 8B690A52A0729C2A
  • Sequence:
    • MSVVGIDLGF QSCYVAVARA GGIETIANEY SDRCTPACIS FGPKNRSIGA AAKSQVISNA 
KNTVQGFKRF HGRAFSDPFV EAEKSNLAYD IVQLPTGLTG IKVTYMEEER NFTTEQVTAM 
LLSKLKETAE SVLKKPVVDC VVSVPCFYTD AERRSVMDAT QIAGLNCLRL MNETTAVALA 
YGIYKQDLPA LEEKPRNVVF VDMGHSAYQV SVCAFNRGKL KVLATAFDTT LGGRKFDEVL 
VNHFCEEFGK KYKLDIKSKI RALLRLSQEC EKLKKLMSAN ASDLPLSIEC FMNDVDVSGT 
MNRGKFLEMC NDLLARVEPP LRSVLEQTKL KKEDIYAVEI VGGATRIPAV KEKISKFFGK 
ELSTTLNADE AVTRGCALQC AILSPAFKVR EFSITDVVPY PISLRWNSPA EEGSSDCEVF 
SKNHAAPFSK VLTFYRKEPF TLEAYYSSPQ DLPYPDPAIA QFSVQKVTPQ SDGSSSKVKV 
KVRVNVHGIF SVSSASLVEV HKSEENEEPM ETDQNAKEEE KMQVDQEEPH VEEQQQQTPA 
ENKAESEEME TSQAGSKDKK MDQPPQAKKA KVKTSTVDLP IENQLLWQID REMLNLYIEN 
EGKMIMQDKL EKERNDAKNA VEEYVYEMRD KLSGEYEKFV SEDDRNSFTL KLEDTENWLY 
EDGEDQPKQV YVDKLAELKN LGQPIKIRFQ ESEERPKLFE ELGKQIQQYM KIISSFKNKE 
DQYDHLDAAD MTKVEKSTNE AMEWMNNKLN LQNKQSLTMD PVVKSKEIEA KIKELTSTCS 
PIISKPKPKV EPPKEEQKNA EQNGPVDGQG DNPGPQAAEQ GTDTAVPSDS DKKLPEMDID

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.