Details for: HSPA4

Gene ID: 3308

Symbol: HSPA4

Ensembl ID: ENSG00000170606

Description: heat shock protein family A (Hsp70) member 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 317.8497
    Cell Significance Index: -49.4400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 200.7937
    Cell Significance Index: -50.9300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 143.5013
    Cell Significance Index: -59.1200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 118.6344
    Cell Significance Index: -56.0100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 114.1149
    Cell Significance Index: -46.3600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 103.1328
    Cell Significance Index: -53.0500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 83.5442
    Cell Significance Index: -56.0600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 48.8404
    Cell Significance Index: -46.6300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 43.8377
    Cell Significance Index: -54.0500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.9446
    Cell Significance Index: -50.7500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 13.9532
    Cell Significance Index: -55.0600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.6129
    Cell Significance Index: -38.7400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.4849
    Cell Significance Index: -18.5700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.2398
    Cell Significance Index: 38.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.3129
    Cell Significance Index: 145.7800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.7674
    Cell Significance Index: 16.2800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.6602
    Cell Significance Index: 44.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6367
    Cell Significance Index: 178.0300
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.6277
    Cell Significance Index: 12.2900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.6275
    Cell Significance Index: 322.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.5805
    Cell Significance Index: 194.3400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3670
    Cell Significance Index: 37.2100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.3225
    Cell Significance Index: 238.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.1755
    Cell Significance Index: 235.8100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.1241
    Cell Significance Index: 132.5700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8473
    Cell Significance Index: 44.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7838
    Cell Significance Index: 428.0400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7695
    Cell Significance Index: 532.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7311
    Cell Significance Index: 262.2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7123
    Cell Significance Index: 643.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6817
    Cell Significance Index: 19.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6080
    Cell Significance Index: 268.7900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4667
    Cell Significance Index: 24.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4000
    Cell Significance Index: 54.9300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3785
    Cell Significance Index: 17.7900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3777
    Cell Significance Index: 6.9800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3690
    Cell Significance Index: 26.1000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3616
    Cell Significance Index: 35.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3413
    Cell Significance Index: 8.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3406
    Cell Significance Index: 7.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.3398
    Cell Significance Index: 212.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3017
    Cell Significance Index: 19.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2482
    Cell Significance Index: 42.3900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2078
    Cell Significance Index: 9.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2013
    Cell Significance Index: 15.4500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1820
    Cell Significance Index: 5.2500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0910
    Cell Significance Index: 2.6100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0896
    Cell Significance Index: 5.0300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0826
    Cell Significance Index: 5.0800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0649
    Cell Significance Index: 10.5600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0501
    Cell Significance Index: 94.4000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0385
    Cell Significance Index: 24.4800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0369
    Cell Significance Index: 4.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0276
    Cell Significance Index: 1.2500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0239
    Cell Significance Index: 32.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0149
    Cell Significance Index: 1.9300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0116
    Cell Significance Index: 17.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0053
    Cell Significance Index: 9.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0056
    Cell Significance Index: -4.1300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0289
    Cell Significance Index: -21.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0383
    Cell Significance Index: -28.9600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0427
    Cell Significance Index: -19.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0455
    Cell Significance Index: -1.6000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0502
    Cell Significance Index: -9.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0578
    Cell Significance Index: -5.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0611
    Cell Significance Index: -4.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0643
    Cell Significance Index: -36.2600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1080
    Cell Significance Index: -2.9000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1339
    Cell Significance Index: -9.9800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1485
    Cell Significance Index: -31.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1564
    Cell Significance Index: -3.3300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1603
    Cell Significance Index: -46.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1665
    Cell Significance Index: -19.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2038
    Cell Significance Index: -29.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2119
    Cell Significance Index: -24.2800
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2166
    Cell Significance Index: -3.2900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2584
    Cell Significance Index: -5.9700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.2808
    Cell Significance Index: -2.2900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3235
    Cell Significance Index: -11.2400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3254
    Cell Significance Index: -6.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3423
    Cell Significance Index: -17.9700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3522
    Cell Significance Index: -10.0500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3621
    Cell Significance Index: -4.9400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3705
    Cell Significance Index: -10.8800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4078
    Cell Significance Index: -46.5500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4379
    Cell Significance Index: -19.3700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4499
    Cell Significance Index: -7.5300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4883
    Cell Significance Index: -50.8400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4914
    Cell Significance Index: -12.6300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5139
    Cell Significance Index: -40.7000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5686
    Cell Significance Index: -12.4500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5694
    Cell Significance Index: -21.5600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5754
    Cell Significance Index: -12.3000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.6261
    Cell Significance Index: -10.7300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.6349
    Cell Significance Index: -13.2900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.6687
    Cell Significance Index: -4.0400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7110
    Cell Significance Index: -19.0200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7997
    Cell Significance Index: -20.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9017
    Cell Significance Index: -55.2800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.9029
    Cell Significance Index: -22.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Chaperone Activity:** HSPA4 is an ATP-dependent protein folding chaperone, capable of binding and folding proteins into their native conformation, thereby preventing protein aggregation and promoting cellular homeostasis. 2. **Heat Shock Response:** HSPA4 is involved in the regulation of the heat shock response, a cellular response to heat stress that helps protect cells against protein denaturation and aggregation. 3. **Protein Insertion into Mitochondria:** HSPA4 is also responsible for the insertion of proteins into the mitochondrial outer membrane, a critical process for maintaining mitochondrial function and preventing mitochondrial dysfunction. 4. **Regulation of HSF1-Mediated Heat Shock Response:** HSPA4 interacts with heat shock transcription factor 1 (HSF1) to regulate the heat shock response, ensuring that the expression of heat shock proteins is tightly controlled and coordinated. **Pathways and Functions:** 1. **Adenyl-nucleotide Exchange Factor Activity:** HSPA4 participates in the adenyl-nucleotide exchange factor activity, a process that is essential for the folding of proteins into their native conformation. 2. **ATP Binding:** HSPA4 binds to ATP, which is required for its chaperone activity and protein folding functions. 3. **Protein Binding:** HSPA4 binds to various proteins, including unfolded proteins, to prevent protein aggregation and promote protein homeostasis. 4. **Chaperone-Mediated Protein Complex Assembly:** HSPA4 is involved in the assembly of protein complexes, including those involved in protein folding and quality control. **Clinical Significance:** 1. **Heat Stress and Disease:** Dysregulation of HSPA4 has been implicated in various heat-related diseases, including heat shock-induced cell death and heat stress-related disorders. 2. **Protein Aggregation Diseases:** HSPA4 has been linked to protein aggregation diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 3. **Cancer and Immune Response:** HSPA4 has been shown to play a role in cancer development and immune response, highlighting its potential as a therapeutic target. 4. **Neurodegenerative Diseases:** HSPA4 has been implicated in neurodegenerative diseases, including Huntington's disease and spinocerebellar ataxia. In conclusion, HSPA4 is a multifaceted protein that plays a critical role in maintaining protein homeostasis, responding to cellular stress, and regulating the heat shock response. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms of HSPA4 and its potential as a therapeutic target.

Genular Protein ID: 1603149383

Symbol: HSP74_HUMAN

Name: Heat shock 70 kDa protein 4

UniProtKB Accession Codes:

P34932 O95756 Q2TAL4 Q9BUK9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 8 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8335910

Title: Molecular cloning of a novel human hsp70 from a B cell line and its assignment to chromosome 5.

PubMed ID: 8335910

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18663603

Title: Guidelines for the nomenclature of the human heat shock proteins.

PubMed ID: 18663603

DOI: 10.1007/s12192-008-0068-7

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

  • Length: 840
  • Mass: 94331
  • Checksum: 8B690A52A0729C2A
  • Sequence:
    • MSVVGIDLGF QSCYVAVARA GGIETIANEY SDRCTPACIS FGPKNRSIGA AAKSQVISNA 
KNTVQGFKRF HGRAFSDPFV EAEKSNLAYD IVQLPTGLTG IKVTYMEEER NFTTEQVTAM 
LLSKLKETAE SVLKKPVVDC VVSVPCFYTD AERRSVMDAT QIAGLNCLRL MNETTAVALA 
YGIYKQDLPA LEEKPRNVVF VDMGHSAYQV SVCAFNRGKL KVLATAFDTT LGGRKFDEVL 
VNHFCEEFGK KYKLDIKSKI RALLRLSQEC EKLKKLMSAN ASDLPLSIEC FMNDVDVSGT 
MNRGKFLEMC NDLLARVEPP LRSVLEQTKL KKEDIYAVEI VGGATRIPAV KEKISKFFGK 
ELSTTLNADE AVTRGCALQC AILSPAFKVR EFSITDVVPY PISLRWNSPA EEGSSDCEVF 
SKNHAAPFSK VLTFYRKEPF TLEAYYSSPQ DLPYPDPAIA QFSVQKVTPQ SDGSSSKVKV 
KVRVNVHGIF SVSSASLVEV HKSEENEEPM ETDQNAKEEE KMQVDQEEPH VEEQQQQTPA 
ENKAESEEME TSQAGSKDKK MDQPPQAKKA KVKTSTVDLP IENQLLWQID REMLNLYIEN 
EGKMIMQDKL EKERNDAKNA VEEYVYEMRD KLSGEYEKFV SEDDRNSFTL KLEDTENWLY 
EDGEDQPKQV YVDKLAELKN LGQPIKIRFQ ESEERPKLFE ELGKQIQQYM KIISSFKNKE 
DQYDHLDAAD MTKVEKSTNE AMEWMNNKLN LQNKQSLTMD PVVKSKEIEA KIKELTSTCS 
PIISKPKPKV EPPKEEQKNA EQNGPVDGQG DNPGPQAAEQ GTDTAVPSDS DKKLPEMDID

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.