Details for: ICA1

Gene ID: 3382

Symbol: ICA1

Ensembl ID: ENSG00000003147

Description: islet cell autoantigen 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 210.9354
    Cell Significance Index: -32.8100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 113.7424
    Cell Significance Index: -28.8500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 67.0142
    Cell Significance Index: -27.2300
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 51.4886
    Cell Significance Index: -34.5500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 28.4632
    Cell Significance Index: -27.1800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.9004
    Cell Significance Index: -34.4000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.0798
    Cell Significance Index: -32.3600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.1120
    Cell Significance Index: -34.1300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.4497
    Cell Significance Index: -22.8700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.9127
    Cell Significance Index: -35.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.6487
    Cell Significance Index: 189.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.4665
    Cell Significance Index: 109.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.3884
    Cell Significance Index: 183.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.3770
    Cell Significance Index: 476.8200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.2191
    Cell Significance Index: 84.0300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.9746
    Cell Significance Index: 28.4000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.7864
    Cell Significance Index: 16.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.5835
    Cell Significance Index: 567.9900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.3936
    Cell Significance Index: 34.8400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.2913
    Cell Significance Index: 86.8300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.2093
    Cell Significance Index: 18.1200
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.1719
    Cell Significance Index: 7.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1083
    Cell Significance Index: 51.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1029
    Cell Significance Index: 198.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.9418
    Cell Significance Index: 42.6900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9081
    Cell Significance Index: 628.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8858
    Cell Significance Index: 19.1900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7496
    Cell Significance Index: 74.1500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7376
    Cell Significance Index: 90.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.7069
    Cell Significance Index: 120.7000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6650
    Cell Significance Index: 19.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6335
    Cell Significance Index: 43.8100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.6077
    Cell Significance Index: 45.2900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.5833
    Cell Significance Index: 3.5900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.5473
    Cell Significance Index: 70.7100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5457
    Cell Significance Index: 33.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5121
    Cell Significance Index: 24.0700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5064
    Cell Significance Index: 11.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4626
    Cell Significance Index: 91.8100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4510
    Cell Significance Index: 12.8700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.4326
    Cell Significance Index: 5.9000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4264
    Cell Significance Index: 232.8400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4239
    Cell Significance Index: 80.6700
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 0.3925
    Cell Significance Index: 3.9600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.3861
    Cell Significance Index: 5.7000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.3224
    Cell Significance Index: 11.3300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.3164
    Cell Significance Index: 2.5800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3107
    Cell Significance Index: 50.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.3080
    Cell Significance Index: 16.0500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2830
    Cell Significance Index: 4.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1774
    Cell Significance Index: 12.5500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1564
    Cell Significance Index: 3.3300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1097
    Cell Significance Index: 2.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1059
    Cell Significance Index: 46.8100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0948
    Cell Significance Index: 85.6200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.0385
    Cell Significance Index: 0.4800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.0116
    Cell Significance Index: 0.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0046
    Cell Significance Index: 3.4900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0085
    Cell Significance Index: -6.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0095
    Cell Significance Index: -6.9500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0122
    Cell Significance Index: -0.3900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0152
    Cell Significance Index: -28.6700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0182
    Cell Significance Index: -33.6200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0215
    Cell Significance Index: -33.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0250
    Cell Significance Index: -34.0500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0260
    Cell Significance Index: -16.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0312
    Cell Significance Index: -17.5900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0450
    Cell Significance Index: -28.6100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0586
    Cell Significance Index: -12.3400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0629
    Cell Significance Index: -28.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0696
    Cell Significance Index: -7.1100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0787
    Cell Significance Index: -1.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0997
    Cell Significance Index: -28.7000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1213
    Cell Significance Index: -1.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1448
    Cell Significance Index: -16.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1559
    Cell Significance Index: -17.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1801
    Cell Significance Index: -26.1800
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1828
    Cell Significance Index: -2.3700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1879
    Cell Significance Index: -22.1600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1942
    Cell Significance Index: -3.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1989
    Cell Significance Index: -27.3200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2149
    Cell Significance Index: -24.5300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2184
    Cell Significance Index: -3.8600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2357
    Cell Significance Index: -3.3700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2651
    Cell Significance Index: -33.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2673
    Cell Significance Index: -7.4700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2777
    Cell Significance Index: -6.0000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3336
    Cell Significance Index: -26.4200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3409
    Cell Significance Index: -35.5000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3534
    Cell Significance Index: -4.4600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3711
    Cell Significance Index: -11.8200
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.3764
    Cell Significance Index: -3.9000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3775
    Cell Significance Index: -23.1500
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -0.3862
    Cell Significance Index: -4.0000
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.3897
    Cell Significance Index: -3.9000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4108
    Cell Significance Index: -21.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4152
    Cell Significance Index: -23.3000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4197
    Cell Significance Index: -13.7400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.4343
    Cell Significance Index: -9.5100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4388
    Cell Significance Index: -8.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Expression:** ICA1 is expressed in a diverse range of cell types, including cardiac myocytes, chromaffin cells, and neurons. This widespread expression suggests a potential role in maintaining tissue homeostasis and regulating cellular processes. 2. **Protein Structure:** The ICA69 protein, encoded by ICA1, is a small, secreted protein with no known enzymatic activity. Its structure and function remain poorly understood, but it is thought to play a role in protein-protein interactions. 3. **Cellular Localization:** ICA69 is primarily localized to the Golgi apparatus and secretory granules, suggesting its involvement in protein secretion and transport. **Pathways and Functions:** 1. **Neurotransmitter Transport:** ICA69 has been implicated in neurotransmitter transport, specifically in the regulation of GABAergic neurotransmission. Its expression in GABAergic cortical interneurons suggests a role in modulating neuronal excitability. 2. **Protein Binding:** ICA69 interacts with various proteins, including those involved in protein transport and secretion. These interactions may play a crucial role in maintaining cellular homeostasis and regulating cellular processes. 3. **Regulation of Transport:** ICA69 may influence the regulation of transport processes, including protein secretion and neurotransmitter uptake. Its involvement in these pathways could have significant implications for cellular function and disease. **Clinical Significance:** 1. **Autoimmune Diseases:** ICA1 has been implicated in autoimmune diseases, particularly type 1 diabetes. Autoantibodies against ICA69 have been detected in patients with type 1 diabetes, suggesting a potential role in the disease's pathogenesis. 2. **Neurological Disorders:** The expression of ICA69 in neurons and its involvement in neurotransmitter transport suggest a potential role in neurological disorders, including epilepsy and Parkinson's disease. 3. **Cardiac Function:** ICA1's expression in cardiac myocytes and its involvement in protein binding and transport suggest a potential role in cardiac function and disease. In conclusion, ICA1 is a gene of significant immunological interest, with a complex role in cellular processes and a potential link to autoimmune diseases and neurological disorders. Further research is needed to fully elucidate the functions of ICA1 and its encoded protein, ICA69, and to explore their implications for human health and disease.

Genular Protein ID: 1903386032

Symbol: ICA69_HUMAN

Name: Islet cell autoantigen 1

UniProtKB Accession Codes:

Q05084 A8K7U1 B3FTQ2 P78506 Q13824 Q96HG3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 24 Ensembl 5 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 15 SIGNOR 1 SMART 2 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8326004

Title: Islet cell autoantigen 69 kD (ICA69). Molecular cloning and characterization of a novel diabetes-associated autoantigen.

PubMed ID: 8326004

DOI: 10.1172/jci116574

PubMed ID: 7918678

Title: Cloning of human and rat p69 cDNA, a candidate autoimmune target in type 1 diabetes.

PubMed ID: 7918678

DOI: 10.1016/0925-4439(94)90113-9

PubMed ID: 8975715

Title: Genomic organization and transcript analysis of ICAp69, a target antigen in diabetic autoimmunity.

PubMed ID: 8975715

DOI: 10.1006/geno.1996.0641

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12682071

Title: Islet cell autoantigen of 69 kDa is an arfaptin-related protein associated with the Golgi complex of insulinoma INS-1 cells.

PubMed ID: 12682071

DOI: 10.1074/jbc.m213222200

Sequence Information:

  • Length: 483
  • Mass: 54645
  • Checksum: 1696F928EE7454C9
  • Sequence:
    • MSGHKCSYPW DLQDRYAQDK SVVNKMQQKY WETKQAFIKA TGKKEDEHVV ASDADLDAKL 
ELFHSIQRTC LDLSKAIVLY QKRICFLSQE ENELGKFLRS QGFQDKTRAG KMMQATGKAL 
CFSSQQRLAL RNPLCRFHQE VETFRHRAIS DTWLTVNRME QCRTEYRGAL LWMKDVSQEL 
DPDLYKQMEK FRKVQTQVRL AKKNFDKLKM DVCQKVDLLG ASRCNLLSHM LATYQTTLLH 
FWEKTSHTMA AIHESFKGYQ PYEFTTLKSL QDPMKKLVEK EEKKKINQQE STDAAVQEPS 
QLISLEEENQ RKESSSFKTE DGKSILSALD KGSTHTACSG PIDELLDMKS EEGACLGPVA 
GTPEPEGADK DDLLLLSEIF NASSLEEGEF SKEWAAVFGD GQVKEPVPTM ALGEPDPKAQ 
TGSGFLPSQL LDQNMKDLQA SLQEPAKAAS DLTAWFSLFA DLDPLSNPDA VGKTDKEHEL 
LNA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.