Details for: ID4

Gene ID: 3400

Symbol: ID4

Ensembl ID: ENSG00000172201

Description: inhibitor of DNA binding 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 200.8332
    Cell Significance Index: -50.9400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 119.1171
    Cell Significance Index: -49.0700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 104.2526
    Cell Significance Index: -49.2200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 99.8875
    Cell Significance Index: -40.5800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 42.5193
    Cell Significance Index: -40.6000
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 15.9757
    Cell Significance Index: 169.7400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.7621
    Cell Significance Index: -50.3600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 9.5090
    Cell Significance Index: 219.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.5683
    Cell Significance Index: 124.3500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.9944
    Cell Significance Index: 383.8600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.6538
    Cell Significance Index: 92.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.8131
    Cell Significance Index: 248.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.8031
    Cell Significance Index: 325.0400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.6327
    Cell Significance Index: 721.8600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3494
    Cell Significance Index: 736.9200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3473
    Cell Significance Index: 165.6600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.3095
    Cell Significance Index: 28.3700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.2086
    Cell Significance Index: 11.1300
  • Cell Name: glioblast (CL0000030)
    Fold Change: 1.2071
    Cell Significance Index: 7.5800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1800
    Cell Significance Index: 61.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1019
    Cell Significance Index: 49.9500
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 1.0591
    Cell Significance Index: 4.8900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.0358
    Cell Significance Index: 8.2700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9087
    Cell Significance Index: 89.8900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9036
    Cell Significance Index: 26.0400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7733
    Cell Significance Index: 698.2500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7232
    Cell Significance Index: 20.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6584
    Cell Significance Index: 30.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.5133
    Cell Significance Index: 31.5500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4453
    Cell Significance Index: 48.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.4266
    Cell Significance Index: 23.9400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.3631
    Cell Significance Index: 7.6000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2485
    Cell Significance Index: 11.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2227
    Cell Significance Index: 28.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1348
    Cell Significance Index: 9.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1019
    Cell Significance Index: 3.5800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.0522
    Cell Significance Index: 0.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0141
    Cell Significance Index: 10.6800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0123
    Cell Significance Index: 2.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0007
    Cell Significance Index: 0.5100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0048
    Cell Significance Index: -0.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0080
    Cell Significance Index: -10.9300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0159
    Cell Significance Index: -30.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0160
    Cell Significance Index: -24.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0189
    Cell Significance Index: -14.0000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0238
    Cell Significance Index: -4.7200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0332
    Cell Significance Index: -61.2900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0376
    Cell Significance Index: -23.4800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0415
    Cell Significance Index: -26.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0440
    Cell Significance Index: -0.6000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0581
    Cell Significance Index: -32.7700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0587
    Cell Significance Index: -0.8800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0699
    Cell Significance Index: -1.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0741
    Cell Significance Index: -1.2400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0744
    Cell Significance Index: -51.4700
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0851
    Cell Significance Index: -1.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1064
    Cell Significance Index: -48.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1071
    Cell Significance Index: -12.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1095
    Cell Significance Index: -31.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1141
    Cell Significance Index: -40.9100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1178
    Cell Significance Index: -20.1100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1507
    Cell Significance Index: -30.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1628
    Cell Significance Index: -34.3000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1660
    Cell Significance Index: -19.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2339
    Cell Significance Index: -6.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2374
    Cell Significance Index: -34.5100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2587
    Cell Significance Index: -29.5300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2712
    Cell Significance Index: -27.7000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4133
    Cell Significance Index: -29.2300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4140
    Cell Significance Index: -48.8200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4144
    Cell Significance Index: -10.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4179
    Cell Significance Index: -13.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4681
    Cell Significance Index: -48.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4784
    Cell Significance Index: -13.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4976
    Cell Significance Index: -39.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5122
    Cell Significance Index: -38.1800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6071
    Cell Significance Index: -37.2200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6565
    Cell Significance Index: -34.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.7338
    Cell Significance Index: -56.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7497
    Cell Significance Index: -50.4100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7743
    Cell Significance Index: -48.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8114
    Cell Significance Index: -42.6000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8173
    Cell Significance Index: -36.1500
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.8456
    Cell Significance Index: -14.6200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.8722
    Cell Significance Index: -22.4200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.8746
    Cell Significance Index: -5.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.9599
    Cell Significance Index: -25.6300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.9600
    Cell Significance Index: -16.9700
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -0.9697
    Cell Significance Index: -7.0500
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.9854
    Cell Significance Index: -23.8700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.0120
    Cell Significance Index: -37.1500
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -1.0576
    Cell Significance Index: -4.8900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.0745
    Cell Significance Index: -40.6900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -1.0837
    Cell Significance Index: -25.9900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.0980
    Cell Significance Index: -28.0500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.1232
    Cell Significance Index: -23.9200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.2331
    Cell Significance Index: -36.3200
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -1.3063
    Cell Significance Index: -10.0500
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -1.3172
    Cell Significance Index: -32.9000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.4765
    Cell Significance Index: -51.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ID4 is a member of the inhibitor of DNA binding (ID) family, which consists of four closely related proteins. ID4 is specifically characterized by its ability to inhibit the activity of transcription factors, thereby suppressing the expression of target genes. This function is mediated through the interaction of ID4 with specific transcription factors, such as E2F1, E2F3, and NF-κB, which are involved in regulating cell cycle progression, differentiation, and survival. **Pathways and Functions:** ID4 is involved in a wide range of cellular processes, including: 1. **Cell differentiation**: ID4 regulates the expression of genes involved in cell fate determination, such as neurogenesis, adipogenesis, and osteogenesis. 2. **Cell proliferation**: ID4 modulates the cell cycle by inhibiting the expression of genes involved in G1/S transition, thereby regulating cell growth and proliferation. 3. **Transcription regulation**: ID4 interacts with various transcription factors, including E2F1, E2F3, and NF-κB, to regulate the expression of target genes. 4. **Neurodevelopment**: ID4 is involved in the regulation of neuroblast proliferation, neuronal differentiation, and the formation of the cerebral cortex. 5. **Cancer**: ID4 has been implicated in the regulation of cancer cell proliferation, survival, and metastasis. **Clinical Significance:** Dysregulation of ID4 has been implicated in various diseases, including: 1. **Cancer**: ID4 is often downregulated in cancer cells, leading to increased cell proliferation and tumorigenesis. 2. **Cardiovascular disorders**: ID4 has been linked to the development of cardiovascular diseases, including atherosclerosis and cardiac hypertrophy. 3. **Neurological conditions**: ID4 dysregulation has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. 4. **Developmental disorders**: ID4 mutations have been associated with developmental abnormalities, including neural tube defects and congenital heart defects. In conclusion, ID4 is a multifaceted regulator of cellular differentiation and development, playing a crucial role in regulating cell fate determination, cell proliferation, and transcriptional programs. Its dysregulation has been implicated in various diseases, highlighting the importance of ID4 in maintaining tissue homeostasis and preventing disease. Further research is needed to elucidate the molecular mechanisms underlying ID4 function and to explore its therapeutic potential in diseases characterized by ID4 dysregulation.

Genular Protein ID: 1933721824

Symbol: ID4_HUMAN

Name: DNA-binding protein inhibitor ID-4

UniProtKB Accession Codes:

P47928 Q13005

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9872455

Title: cDNA cloning, tissue distribution and chromosomal localization of the human ID4 gene.

PubMed ID: 9872455

DOI: 10.1093/dnares/5.5.309

PubMed ID: 7665172

Title: Molecular cloning of ID4, a novel dominant negative helix-loop-helix human gene on chromosome 6p21.3-p22.

PubMed ID: 7665172

DOI: 10.1006/geno.1995.1026

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 161
  • Mass: 16622
  • Checksum: 5B14847AE7337339
  • Sequence:
    • MKAVSPVRPS GRKAPSGCGG GELALRCLAE HGHSLGGSAA AAAAAAAARC KAAEAAADEP 
ALCLQCDMND CYSRLRRLVP TIPPNKKVSK VEILQHVIDY ILDLQLALET HPALLRQPPP 
PAPPHHPAGT CPAAPPRTPL TALNTDPAGA VNKQGDSILC R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.