Gene ID4 - ENSG00000172201 | NCBI Gene ID: 3400

Details for: ID4

Gene ID: 3400

Symbol: ID4

Ensembl ID: ENSG00000172201

Description: inhibitor of DNA binding 4

Associated with

Developmental biology
(R-HSA-1266738)
Formation of the nephric duct
(R-HSA-9830364)
Kidney development
(R-HSA-9830369)
Ngf-stimulated transcription
(R-HSA-9031628)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Astrocyte differentiation
(GO:0048708)
Cell differentiation
(GO:0030154)
Central nervous system myelination
(GO:0022010)
Cerebral cortex neuron differentiation
(GO:0021895)
Circadian regulation of gene expression
(GO:0032922)
Cytoplasm
(GO:0005737)
Fat cell differentiation
(GO:0045444)
G1/s transition of mitotic cell cycle
(GO:0000082)
Hippocampus development
(GO:0021766)
Negative regulation of astrocyte differentiation
(GO:0048712)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of fat cell differentiation
(GO:0045599)
Negative regulation of neuron differentiation
(GO:0045665)
Negative regulation of oligodendrocyte differentiation
(GO:0048715)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neuroblast proliferation
(GO:0007405)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Osteoblast differentiation
(GO:0001649)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of neuroblast proliferation
(GO:0002052)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Prostate gland epithelium morphogenesis
(GO:0060740)
Prostate gland stromal morphogenesis
(GO:0060741)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Protein localization
(GO:0008104)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Seminal vesicle morphogenesis
(GO:0061682)
Transcription regulator activity
(GO:0140110)
Transcription regulator inhibitor activity
(GO:0140416)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 3.37
Marker Score: 2640
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 2.31
Marker Score: 741
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 2.24
Marker Score: 848
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.24
Marker Score: 25192
Cell Name: supporting cell (CL0000630)
Fold Change: 2.02
Marker Score: 3795
Cell Name: decidual cell (CL2000002)
Fold Change: 2.02
Marker Score: 8698.5
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 1.92
Marker Score: 988
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.91
Marker Score: 40786
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: 1.89
Marker Score: 1184
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 1.77
Marker Score: 1990
Cell Name: Mueller cell (CL0000636)
Fold Change: 1.76
Marker Score: 2444
Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
Fold Change: 1.75
Marker Score: 1489
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.74
Marker Score: 1807
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 1.71
Marker Score: 501
Cell Name: cell in vitro (CL0001034)
Fold Change: 1.7
Marker Score: 58733
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.68
Marker Score: 2470
Cell Name: male germ cell (CL0000015)
Fold Change: 1.66
Marker Score: 478
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 1.65
Marker Score: 8099
Cell Name: ovarian surface epithelial cell (CL2000064)
Fold Change: 1.64
Marker Score: 4452
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 1.62
Marker Score: 1066
Cell Name: muscle cell (CL0000187)
Fold Change: 1.53
Marker Score: 432
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.52
Marker Score: 3466
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 1.52
Marker Score: 1081
Cell Name: neural crest cell (CL0011012)
Fold Change: 1.51
Marker Score: 1619
Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167773
Cell Name: astrocyte (CL0000127)
Fold Change: 1.46
Marker Score: 1263
Cell Name: kidney cell (CL1000497)
Fold Change: 1.45
Marker Score: 968
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.44
Marker Score: 1539
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.4
Marker Score: 3529
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 1.39
Marker Score: 1475
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 1.38
Marker Score: 5106
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.38
Marker Score: 350
Cell Name: serous secreting cell (CL0000313)
Fold Change: 1.34
Marker Score: 536
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 1.33
Marker Score: 1255
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.33
Marker Score: 845
Cell Name: type I pneumocyte (CL0002062)
Fold Change: 1.31
Marker Score: 1576
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 1.29
Marker Score: 44022
Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 1.28
Marker Score: 704
Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 1.27
Marker Score: 1215
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 1.22
Marker Score: 2541.5
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 1.21
Marker Score: 299
Cell Name: blood vessel smooth muscle cell (CL0019018)
Fold Change: 1.19
Marker Score: 312
Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
Fold Change: 1.18
Marker Score: 492
Cell Name: motor neuron (CL0000100)
Fold Change: 1.16
Marker Score: 690.5
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.15
Marker Score: 331
Cell Name: granulosa cell (CL0000501)
Fold Change: 1.15
Marker Score: 11529
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 1.14
Marker Score: 1491
Cell Name: primordial germ cell (CL0000670)
Fold Change: 1.14
Marker Score: 1433
Cell Name: mature astrocyte (CL0002627)
Fold Change: 1.14
Marker Score: 750
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 1.13
Marker Score: 462
Cell Name: pneumocyte (CL0000322)
Fold Change: 1.13
Marker Score: 1814
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 1.12
Marker Score: 7316
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.12
Marker Score: 2737
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 1.1
Marker Score: 347
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 1.06
Marker Score: 477
Cell Name: mammary gland epithelial cell (CL0002327)
Fold Change: 1.06
Marker Score: 375
Cell Name: taste receptor cell (CL0000209)
Fold Change: 1.05
Marker Score: 911
Cell Name: nephron tubule epithelial cell (CL1000494)
Fold Change: 1.01
Marker Score: 238
Cell Name: inflammatory cell (CL0009002)
Fold Change: 1
Marker Score: 432
Cell Name: PP cell (CL0000696)
Fold Change: 1
Marker Score: 225
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71731
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47955.5
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.99
Marker Score: 464.5
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.99
Marker Score: 1685
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.99
Marker Score: 486
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30400.5
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.96
Marker Score: 495
Cell Name: kidney collecting duct cell (CL1001225)
Fold Change: 0.96
Marker Score: 188
Cell Name: pericyte (CL0000669)
Fold Change: 0.96
Marker Score: 559
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.95
Marker Score: 2249
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.95
Marker Score: 450
Cell Name: vascular associated smooth muscle cell (CL0000359)
Fold Change: 0.95
Marker Score: 435
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2406
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 0.94
Marker Score: 2470
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 0.94
Marker Score: 317
Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.92
Marker Score: 234
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2735
Cell Name: type A enteroendocrine cell (CL0002067)
Fold Change: 0.91
Marker Score: 366
Cell Name: keratinocyte (CL0000312)
Fold Change: 0.91
Marker Score: 757
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 0.9
Marker Score: 1105
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.89
Marker Score: 5107
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.89
Marker Score: 7689
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.89
Marker Score: 1413
Cell Name: basal cell (CL0000646)
Fold Change: 0.89
Marker Score: 1146
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.88
Marker Score: 318
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.87
Marker Score: 325
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 0.87
Marker Score: 1341
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.87
Marker Score: 2049
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5250
Cell Name: mucous neck cell (CL0000651)
Fold Change: 0.86
Marker Score: 1949.5
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.85
Marker Score: 899
Cell Name: cardiac mesenchymal cell (CL0000569)
Fold Change: 0.85
Marker Score: 209
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.83
Marker Score: 12993
Cell Name: inhibitory motor neuron (CL0008015)
Fold Change: 0.83
Marker Score: 392
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 0.83
Marker Score: 5386.5
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.82
Marker Score: 623
Cell Name: fibroblast of connective tissue of prostate (CL1000299)
Fold Change: 0.81
Marker Score: 201
Cell Name: prostate stromal cell (CL0002622)
Fold Change: 0.8
Marker Score: 201
Cell Name: Unknown (CL0002371)
Fold Change: 0.8
Marker Score: 850
Cell Name: enteric neuron (CL0007011)
Fold Change: 0.8
Marker Score: 424

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**Key characteristics:** - ID4 is a protein of the immunoglobulin superfamily. - It is a transcriptional repressor that binds to the DNA binding domain of DBP4. - ID4 inhibits the binding of DBP4 to DNA, which leads to the repression of DBP4-mediated transcription. - ID4 is a key regulator of neuroblast proliferation, development, and differentiation. **Pathways and functions:** - ID4 inhibits the expression of DBP4, which leads to the repression of DBP4-mediated transcription. - ID4 is involved in the regulation of cell proliferation, survival, and differentiation in a variety of cell types. - In neuroblast development, ID4 inhibits the expression of genes that are required for the survival and proliferation of neuroblasts. - In thyroid development, ID4 is expressed in a subset of cells in the developing thyroid gland. - ID4 plays a role in the regulation of the nephric duct during development. **Clinical significance:** ID4 is a potential therapeutic target for a variety of diseases. For example, ID4 is expressed in high levels in cancer cells, and its inhibition has been shown to inhibit cancer cell growth and metastasis. ID4 inhibitors are currently being tested in clinical trials for the treatment of cancer and other diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

DNA-binding protein inhibitor ID-4

Genular Protein ID: 1933721824

Symbol: ID4_HUMAN

Name: DNA-binding protein inhibitor ID-4

UniProtKB Accession Codes:

P47928 Q13005

Database IDs:

Citations:

PubMed ID: 9872455

Title: cDNA cloning, tissue distribution and chromosomal localization of the human ID4 gene.

PubMed ID: 9872455

DOI: 10.1093/dnares/5.5.309

PubMed ID: 7665172

Title: Molecular cloning of ID4, a novel dominant negative helix-loop-helix human gene on chromosome 6p21.3-p22.

PubMed ID: 7665172

DOI: 10.1006/geno.1995.1026

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

Length: 161
Mass: 16622
Checksum: 5B14847AE7337339
Sequence:

MKAVSPVRPS GRKAPSGCGG GELALRCLAE HGHSLGGSAA AAAAAAAARC KAAEAAADEP 
ALCLQCDMND CYSRLRRLVP TIPPNKKVSK VEILQHVIDY ILDLQLALET HPALLRQPPP 
PAPPHHPAGT CPAAPPRTPL TALNTDPAGA VNKQGDSILC R

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: ID4

Associated with

Cells (max top 100)

Other Information

cDNA cloning, tissue distribution and chromosomal localization of the human ID4 gene. PubMed ID: 9872455

Molecular cloning of ID4, a novel dominant negative helix-loop-helix human gene on chromosome 6p21.3-p22. PubMed ID: 7665172

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Database document:

PubMed ID: 9872455

PubMed ID: 7665172

PubMed ID: 14574404

PubMed ID: 15489334