Details for: PRAMEF10

Gene ID: 343071

Symbol: PRAMEF10

Ensembl ID: ENSG00000187545

Description: PRAME family member 10

Associated with

  • Cul2-ring ubiquitin ligase complex
    (GO:0031462)
  • Cytoplasm
    (GO:0005737)
  • Negative regulation of apoptotic process
    (GO:0043066)
  • Negative regulation of cell differentiation
    (GO:0045596)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Proteasome-mediated ubiquitin-dependent protein catabolic process
    (GO:0043161)
  • Protein binding
    (GO:0005515)
  • Ubiquitin-like ligase-substrate adaptor activity
    (GO:1990756)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.2803
    Cell Significance Index: 7.1400
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1916
    Cell Significance Index: 3.1000
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.0837
    Cell Significance Index: 1.4300
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.0462
    Cell Significance Index: 0.4900
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0346
    Cell Significance Index: 0.4500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.0298
    Cell Significance Index: 0.4100
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.0180
    Cell Significance Index: 0.2100
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.0170
    Cell Significance Index: 0.2200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0147
    Cell Significance Index: 0.3900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0134
    Cell Significance Index: 0.2900
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.0117
    Cell Significance Index: 0.1400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.0021
    Cell Significance Index: 0.0300
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0008
    Cell Significance Index: -0.1500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0008
    Cell Significance Index: -0.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0009
    Cell Significance Index: -0.0400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0010
    Cell Significance Index: -0.2100
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0014
    Cell Significance Index: -0.0200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0022
    Cell Significance Index: -0.0300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0032
    Cell Significance Index: -0.0600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0043
    Cell Significance Index: -0.0600
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0043
    Cell Significance Index: -0.0900
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0044
    Cell Significance Index: -0.0500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0060
    Cell Significance Index: -0.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0064
    Cell Significance Index: -0.1700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0071
    Cell Significance Index: -0.0800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0072
    Cell Significance Index: -0.1400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0126
    Cell Significance Index: -0.1200
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0131
    Cell Significance Index: -0.1500
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.0135
    Cell Significance Index: -0.1800
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0138
    Cell Significance Index: -0.1700
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.0143
    Cell Significance Index: -0.1300
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0147
    Cell Significance Index: -0.1900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.0149
    Cell Significance Index: -0.1400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0156
    Cell Significance Index: -0.2100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0157
    Cell Significance Index: -0.3400
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.0160
    Cell Significance Index: -0.1500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0168
    Cell Significance Index: -0.1800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0170
    Cell Significance Index: -0.2100
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0171
    Cell Significance Index: -0.1600
  • Cell Name: alveolar adventitial fibroblast (CL4028006)
    Fold Change: -0.0171
    Cell Significance Index: -0.1900
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: -0.0175
    Cell Significance Index: -0.1900
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0177
    Cell Significance Index: -0.1500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0179
    Cell Significance Index: -0.3800
  • Cell Name: macrophage (CL0000235)
    Fold Change: -0.0179
    Cell Significance Index: -0.1800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0180
    Cell Significance Index: -0.1100
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0181
    Cell Significance Index: -0.2000
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.0185
    Cell Significance Index: -0.1700
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0192
    Cell Significance Index: -0.2000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0199
    Cell Significance Index: -0.1900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0209
    Cell Significance Index: -0.1700
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.0223
    Cell Significance Index: -0.2100
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0235
    Cell Significance Index: -0.1800
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.0236
    Cell Significance Index: -0.1900
  • Cell Name: malignant cell (CL0001064)
    Fold Change: -0.0242
    Cell Significance Index: -0.1300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0281
    Cell Significance Index: -0.1700
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0292
    Cell Significance Index: -0.4000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0311
    Cell Significance Index: -0.3700
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0320
    Cell Significance Index: -0.4000
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0324
    Cell Significance Index: -0.3700
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.0332
    Cell Significance Index: -0.4200
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0340
    Cell Significance Index: -0.4200
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.0364
    Cell Significance Index: -0.3200
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0373
    Cell Significance Index: -0.4500
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0497
    Cell Significance Index: -0.4100
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0527
    Cell Significance Index: -0.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** PRAMEF10 is widely expressed in various cell types, including hematopoietic stem cells, progenitor cells, and cells of the nervous system. 2. **Cellular Functions:** The gene is involved in negative regulation of apoptotic processes, cell differentiation, and DNA-templated transcription, indicating a potential role in maintaining cellular homeostasis. 3. **Protein Function:** The protein product of PRAMEF10, PRA10_HUMAN, lacks a known functional domain, suggesting that its biological functions may be attributed to its expression patterns rather than a specific protein-protein interaction. 4. **Pathway Involvement:** PRAMEF10 is implicated in cytoplasmic processes, including regulation of cell population proliferation and negative regulation of DNA-templated transcription. **Pathways and Functions:** PRAMEF10 is involved in several key biological pathways, including: 1. **Negative Regulation of Apoptotic Process:** PRAMEF10 is involved in the regulation of apoptosis, a process of programmed cell death, which is crucial for maintaining tissue homeostasis. 2. **Negative Regulation of Cell Differentiation:** PRAMEF10 may play a role in regulating cell differentiation, a process by which cells acquire specialized functions. 3. **Negative Regulation of DNA-templated Transcription:** PRAMEF10 is involved in the regulation of transcription, a process by which cells generate proteins, which is crucial for maintaining cellular homeostasis. 4. **Positive Regulation of Cell Population Proliferation:** PRAMEF10 may be involved in promoting cell proliferation, a process by which cells divide to produce more cells. **Clinical Significance:** While the functional significance of PRAMEF10 remains unclear, its expression in various cell types and its involvement in negative regulation of apoptotic processes, cell differentiation, and DNA-templated transcription suggest potential implications for: 1. **Cancer Research:** PRAMEF10 may be involved in cancer development and progression, particularly in cancers with hematopoietic or nervous system origins. 2. **Neurological Disorders:** PRAMEF10 expression in oligodendrocyte precursor cells and microglial cells may suggest a role in neurological disorders, such as multiple sclerosis or Alzheimer's disease. 3. **Hematological Disorders:** PRAMEF10 expression in hematopoietic stem cells and megakaryocytes may suggest a role in hematological disorders, such as leukemia or anemia. In conclusion, PRAMEF10 is a gene of ongoing research interest due to its diverse expression patterns and potential roles in various cellular processes. Further studies are needed to fully understand the functional significance of PRAMEF10 and its potential implications for human health and disease.

Genular Protein ID: 1216157679

Symbol: PRA10_HUMAN

Name: N/A

UniProtKB Accession Codes:

O60809 Q2M1V2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 GO 5 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 Proteomes 1 Pumba 1 RNAct 1 RefSeq 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 474
  • Mass: 55211
  • Checksum: 55DEAAD7962DC5E0
  • Sequence:
    • MSLQAPSRLL ELAGQSLLRN QFLTIFTLDE LPREVFPLMF MEAFSMRRFE ALKLMVQAWP 
FLRLPLGSLM KTPHLETLQA VLRGLDTLVA QKVRPRRWKL QVLDLRDVDE NFWTIWSGAR 
VLSCSPEAMS KRQTVEDCPR MGERQPLKVF IDLCLKESTL DECLSYLFGW IHYRRGLVHL 
CCSKVQNYSM PTSSFRNLLE RIYPDSIQEL EVWKKCSLNK TGKFAPYLSQ MSNLRELFLA 
FGYERELYVS VQWPCIPDLD SPFLCLYYPQ MLYIKKISNI KEHLEHLLRY LKNPLGAFIF 
SDAYLTDRDM ECLSQYPSLS QLKELRLIHI LMWTTNLEPL GVLLEKVAAT LKTLVLKDCR 
IQDPQLRVLL PALSHCSQLT TFNFHGNETS MNALKDLLRH TRGLSKLGLE LYPAPLESLD 
YKGHVNWEIL TPIRAELMRT LREVRQPKRI FFGPVPCPNC GSWPSEKVDF HLCS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.