Details for: SP110

Gene ID: 3431

Symbol: SP110

Ensembl ID: ENSG00000135899

Description: SP110 nuclear body protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 159.5677
    Cell Significance Index: -24.8200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 62.7189
    Cell Significance Index: -25.4800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 59.0199
    Cell Significance Index: -14.9700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 54.2589
    Cell Significance Index: -27.9100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.3163
    Cell Significance Index: -26.0800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.6658
    Cell Significance Index: -25.4800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.3088
    Cell Significance Index: -25.5200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.5585
    Cell Significance Index: -25.8800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.8495
    Cell Significance Index: -15.6700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.0353
    Cell Significance Index: 56.1000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 3.0101
    Cell Significance Index: 572.8300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.8217
    Cell Significance Index: 94.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.6569
    Cell Significance Index: 106.9000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.4110
    Cell Significance Index: 41.4400
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.2165
    Cell Significance Index: 5.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9839
    Cell Significance Index: 888.4200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7142
    Cell Significance Index: 77.6800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.6481
    Cell Significance Index: 12.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6227
    Cell Significance Index: 73.4300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.5703
    Cell Significance Index: 28.8200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5628
    Cell Significance Index: 91.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.5469
    Cell Significance Index: 14.6300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5342
    Cell Significance Index: 68.4800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.4213
    Cell Significance Index: 6.0600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.4036
    Cell Significance Index: 47.0400
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.3825
    Cell Significance Index: 6.7600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3747
    Cell Significance Index: 74.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2632
    Cell Significance Index: 32.3700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2564
    Cell Significance Index: 46.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2162
    Cell Significance Index: 2.9500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1720
    Cell Significance Index: 17.0100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1629
    Cell Significance Index: 11.2700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1398
    Cell Significance Index: 61.8300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0845
    Cell Significance Index: 1.8300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0744
    Cell Significance Index: 1.8600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0552
    Cell Significance Index: 2.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0486
    Cell Significance Index: 1.4000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0401
    Cell Significance Index: 5.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0190
    Cell Significance Index: 35.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0117
    Cell Significance Index: 0.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0060
    Cell Significance Index: 11.1300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0021
    Cell Significance Index: 3.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0001
    Cell Significance Index: 0.0200
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0008
    Cell Significance Index: -0.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0076
    Cell Significance Index: -4.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0151
    Cell Significance Index: -20.5800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0220
    Cell Significance Index: -16.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0285
    Cell Significance Index: -21.5700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0338
    Cell Significance Index: -6.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0361
    Cell Significance Index: -16.3700
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -0.0364
    Cell Significance Index: -0.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0387
    Cell Significance Index: -13.8700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0388
    Cell Significance Index: -28.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0457
    Cell Significance Index: -28.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0482
    Cell Significance Index: -27.1800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0595
    Cell Significance Index: -1.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0673
    Cell Significance Index: -11.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0730
    Cell Significance Index: -9.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0822
    Cell Significance Index: -23.6600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0920
    Cell Significance Index: -13.3700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0960
    Cell Significance Index: -4.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0968
    Cell Significance Index: -7.2200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1289
    Cell Significance Index: -6.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1417
    Cell Significance Index: -29.8500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1456
    Cell Significance Index: -3.1000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1486
    Cell Significance Index: -8.3400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1545
    Cell Significance Index: -5.4300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1599
    Cell Significance Index: -18.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1603
    Cell Significance Index: -11.3400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1684
    Cell Significance Index: -12.9200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1888
    Cell Significance Index: -5.0400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.2036
    Cell Significance Index: -1.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2279
    Cell Significance Index: -23.7300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2326
    Cell Significance Index: -6.3300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2799
    Cell Significance Index: -7.1500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2838
    Cell Significance Index: -4.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2952
    Cell Significance Index: -8.2500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3226
    Cell Significance Index: -25.5500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3475
    Cell Significance Index: -21.3600
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.3594
    Cell Significance Index: -1.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3696
    Cell Significance Index: -22.6600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3766
    Cell Significance Index: -25.3200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.4017
    Cell Significance Index: -6.6200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4211
    Cell Significance Index: -26.5400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.4300
    Cell Significance Index: -6.1800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4493
    Cell Significance Index: -14.3900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5047
    Cell Significance Index: -13.2700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5276
    Cell Significance Index: -12.1900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5375
    Cell Significance Index: -28.2200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5531
    Cell Significance Index: -24.4700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.5557
    Cell Significance Index: -9.5800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.5709
    Cell Significance Index: -16.3700
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: -0.6358
    Cell Significance Index: -3.8400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6430
    Cell Significance Index: -24.3500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6486
    Cell Significance Index: -22.7200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.6761
    Cell Significance Index: -10.4600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.6798
    Cell Significance Index: -5.7100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6981
    Cell Significance Index: -25.6300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7512
    Cell Significance Index: -24.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SP110 is a nuclear protein, predominantly expressed in cells of the immune system, including B cells, monocytes, and neurons. Its expression is significantly elevated in cells undergoing class switching and memory formation, indicating a critical role in the regulation of immune responses. SP110 is characterized by its ability to bind to DNA and RNA polymerase II, facilitating the transcriptional control of target genes. **Pathways and Functions:** The functions of SP110 are intricately linked to various signaling pathways, including: 1. **DNA-binding transcription factor activity:** SP110 recognizes specific DNA sequences, thereby regulating the expression of genes involved in immune responses. 2. **RNA polymerase II-specific:** SP110 interacts with RNA polymerase II, a key enzyme in transcription, to modulate the transcriptional output of target genes. 3. **Metal ion binding:** SP110's ability to bind metal ions allows it to recognize and interact with specific DNA sequences, influencing gene expression. Through these pathways, SP110 plays a multifaceted role in regulating immune cell development, differentiation, and function. Specifically: * **Immune cell development:** SP110 is essential for the development and differentiation of B cells, particularly during class switching and memory formation. * **Transcriptional control:** SP110 modulates the expression of genes involved in immune responses, including those related to inflammation, cytokine production, and immune cell activation. * **Neuronal function:** SP110 is also expressed in retinal bipolar neurons, suggesting a role in neuronal function and development. **Clinical Significance:** Dysregulation of SP110 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases:** Altered SP110 expression has been linked to autoimmune diseases, such as rheumatoid arthritis and lupus, highlighting the protein's role in immune homeostasis. 2. **Cancer:** SP110 has been shown to be overexpressed in certain types of cancer, including leukemia and lymphoma, suggesting a potential role in tumorigenesis. 3. **Infectious diseases:** SP110's expression in immune cells may influence the host's response to infections, particularly viral and bacterial infections. In conclusion, SP110 is a critical component of the immune system, playing a pivotal role in regulating transcription and immune cell development. Further research is necessary to fully elucidate the mechanisms underlying SP110's functions and its clinical significance in immune-related disorders.

Genular Protein ID: 105905803

Symbol: SP110_HUMAN

Name: Sp110 nuclear body protein

UniProtKB Accession Codes:

Q9HB58 B4DVI4 F5H1M1 Q14976 Q14977 Q53TG2 Q8WUZ6 Q9HCT8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 5 ExpressionAtlas 1 GO 6 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 7 Pumba 1 RNAct 1 RefSeq 3 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7693701

Title: Molecular cloning of two new interferon-induced, highly related nuclear phosphoproteins.

PubMed ID: 7693701

DOI: 10.1016/s0021-9258(20)80544-4

PubMed ID: 10913195

Title: Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivator.

PubMed ID: 10913195

DOI: 10.1128/mcb.20.16.6138-6146.2000

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14559998

Title: Modulation of retinoid signaling by a cytoplasmic viral protein via sequestration of Sp110b, a potent transcriptional corepressor of retinoic acid receptor, from the nucleus.

PubMed ID: 14559998

DOI: 10.1128/mcb.23.21.7498-7509.2003

PubMed ID: 16648851

Title: Mutations in the gene encoding the PML nuclear body protein Sp110 are associated with immunodeficiency and hepatic veno-occlusive disease.

PubMed ID: 16648851

DOI: 10.1038/ng1780

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25593309

Title: Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

PubMed ID: 25593309

DOI: 10.1101/gad.252189.114

PubMed ID: 16816019

Title: No associations of human pulmonary tuberculosis with Sp110 variants.

PubMed ID: 16816019

DOI: 10.1136/jmg.2005.037960

PubMed ID: 16803959

Title: Variants in the SP110 gene are associated with genetic susceptibility to tuberculosis in West Africa.

PubMed ID: 16803959

DOI: 10.1073/pnas.0603340103

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 689
  • Mass: 78396
  • Checksum: 31552E1A4C498EF7
  • Sequence:
    • MFTMTRAMEE ALFQHFMHQK LGIAYAIHKP FPFFEGLLDN SIITKRMYME SLEACRNLIP 
VSRVVHNILT QLERTFNLSL LVTLFSQINL REYPNLVTIY RSFKRVGASY EWQSRDTPIL 
LEAPTGLAEG SSLHTPLALP PPQPPQPSCS PCAPRVSEPG TSSQQSDEIL SESPSPSDPV 
LPLPALIQEG RSTSVTNDKL TSKMNAEEDS EEMPSLLTST VQVASDNLIP QIRDKEDPQE 
MPHSPLGSMP EIRDNSPEPN DPEEPQEVSS TPSDKKGKKR KRCIWSTPKR RHKKKSLPGG 
TASSRHGIQK KLKRVDQVPQ KKDDSTCNST VETRAQKART ECARKSRSEE IIDGTSEMNE 
GKRSQKTPST PRRVTQGAAS PGHGIQEKLQ VVDKVTQRKD DSTWNSEVMM RVQKARTKCA 
RKSRLKEKKK EKDICSSSKR RFQKNIHRRG KPKSDTVDFH CSKLPVTCGE AKGILYKKKM 
KHGSSVKCIR NEDGTWLTPN EFEVEGKGRN AKNWKRNIRC EGMTLGELLK RKNSDECEVC 
CQGGQLLCCG TCPRVFHEDC HIPPVEAKRM LWSCTFCRMK RSSGSQQCHH VSKTLERQMQ 
PQDQLIRDYG EPFQEAMWLD LVKERLITEM YTVAWFVRDM RLMFRNHKTF YKASDFGQVG 
LDLEAEFEKD LKDVLGFHEA NDGGFWTLP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.