Details for: SP110

Gene ID: 3431

Symbol: SP110

Ensembl ID: ENSG00000135899

Description: SP110 nuclear body protein

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.26
    Marker Score: 27565
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 2.5
    Marker Score: 2458
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.41
    Marker Score: 2267
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.41
    Marker Score: 1450
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.39
    Marker Score: 27834.5
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.15
    Marker Score: 761
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.09
    Marker Score: 116756
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.03
    Marker Score: 3948
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.99
    Marker Score: 3472
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.9
    Marker Score: 3987
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.8
    Marker Score: 1361
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.79
    Marker Score: 94691
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.74
    Marker Score: 1556
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.74
    Marker Score: 868
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.72
    Marker Score: 3072
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.67
    Marker Score: 384
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.66
    Marker Score: 1601
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.65
    Marker Score: 3243
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.64
    Marker Score: 963
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.64
    Marker Score: 5185
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 1.6
    Marker Score: 1060
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.55
    Marker Score: 15686
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.54
    Marker Score: 663
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.52
    Marker Score: 15068
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.51
    Marker Score: 13253
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 166992
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.43
    Marker Score: 6127
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.42
    Marker Score: 1328
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.42
    Marker Score: 494
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.41
    Marker Score: 3433
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.4
    Marker Score: 695
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.39
    Marker Score: 1007
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.38
    Marker Score: 1392
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.38
    Marker Score: 1668
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.37
    Marker Score: 8763
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 1.35
    Marker Score: 3269
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.35
    Marker Score: 3787
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.34
    Marker Score: 303
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.33
    Marker Score: 909
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.33
    Marker Score: 3610
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.3
    Marker Score: 1018
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.28
    Marker Score: 1127
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.28
    Marker Score: 1281
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.26
    Marker Score: 1678
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.26
    Marker Score: 1852
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.26
    Marker Score: 916
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.25
    Marker Score: 435
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.24
    Marker Score: 1263
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.24
    Marker Score: 906
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.23
    Marker Score: 406
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.21
    Marker Score: 375
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.2
    Marker Score: 1421.5
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.2
    Marker Score: 3122
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.17
    Marker Score: 229
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 1.16
    Marker Score: 749
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.15
    Marker Score: 1593
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.15
    Marker Score: 566
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.13
    Marker Score: 1942
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.12
    Marker Score: 1027
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 1.12
    Marker Score: 1211
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.12
    Marker Score: 339
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 1.11
    Marker Score: 1231
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.1
    Marker Score: 1192
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.1
    Marker Score: 240
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.09
    Marker Score: 921
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 1.09
    Marker Score: 1049
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.09
    Marker Score: 638
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.08
    Marker Score: 243.5
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.06
    Marker Score: 1179
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.06
    Marker Score: 869
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.04
    Marker Score: 14041
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.04
    Marker Score: 924
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 1.04
    Marker Score: 273
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.03
    Marker Score: 506
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.02
    Marker Score: 1861
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 1.01
    Marker Score: 697
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.01
    Marker Score: 857
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1
    Marker Score: 346
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 1
    Marker Score: 248
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1
    Marker Score: 238
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71599
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1
    Marker Score: 246
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47824
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.99
    Marker Score: 414
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.99
    Marker Score: 316
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30376
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.97
    Marker Score: 226
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.97
    Marker Score: 597
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.96
    Marker Score: 240
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.96
    Marker Score: 649.5
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.96
    Marker Score: 219
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.95
    Marker Score: 1615.5
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.95
    Marker Score: 486
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.94
    Marker Score: 385
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.94
    Marker Score: 327
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.94
    Marker Score: 227
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.94
    Marker Score: 1330
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.94
    Marker Score: 238
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.94
    Marker Score: 458
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.94
    Marker Score: 688

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Other Information

**Key characteristics:** - SP110 is a nuclear body protein, which are large proteins that regulate gene expression by binding to DNA and facilitating the binding of RNA polymerase to specific DNA sequences. - It is a key regulator of B cell development and differentiation, and is essential for the generation of plasma cells and memory B cells. - It is also involved in the regulation of innate immune responses, and is expressed in macrophages, dendritic cells, and other immune cells. **Pathways and functions:** - SP110 is a key regulator of the immune response to viral infection. It is induced by viral infection and binds to DNA sequences in the promoters of viral genes. This binding activates the transcription of these genes, which leads to the production of viral proteins. - In addition to its role in viral infection, SP110 is also involved in the regulation of cell growth, differentiation, and survival. It is expressed in proliferating cells, and its expression is upregulated in tumors. - SP110 is also involved in the regulation of inflammation and immune responses. It is expressed in macrophages and dendritic cells, and its expression is upregulated in response to inflammatory stimuli. **Clinical significance:** - Mutations in the SP110 gene have been linked to several autoimmune diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. - SP110 is a potential target for the treatment of autoimmune diseases. By blocking the activity of SP110, it may be possible to suppress the immune response and reduce inflammation. **Conclusion:** The SP110 nuclear body protein is a critical regulator of immune responses and cell growth and differentiation. Its expression and activity are regulated by various stimuli, including viral infection, cytokines, and growth factors. Mutations in the SP110 gene have been linked to several autoimmune diseases, highlighting its importance in maintaining immune homeostasis.

Genular Protein ID: 105905803

Symbol: SP110_HUMAN

Name: Sp110 nuclear body protein

UniProtKB Accession Codes:

Q9HB58 B4DVI4 F5H1M1 Q14976 Q14977 Q53TG2 Q8WUZ6 Q9HCT8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 5 ExpressionAtlas 1 GO 6 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 4 PROSITE-ProRule 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 7 Pumba 1 RNAct 1 RefSeq 3 SAM 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7693701

Title: Molecular cloning of two new interferon-induced, highly related nuclear phosphoproteins.

PubMed ID: 7693701

DOI: 10.1016/s0021-9258(20)80544-4

PubMed ID: 10913195

Title: Sp110 localizes to the PML-Sp100 nuclear body and may function as a nuclear hormone receptor transcriptional coactivator.

PubMed ID: 10913195

DOI: 10.1128/mcb.20.16.6138-6146.2000

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14559998

Title: Modulation of retinoid signaling by a cytoplasmic viral protein via sequestration of Sp110b, a potent transcriptional corepressor of retinoic acid receptor, from the nucleus.

PubMed ID: 14559998

DOI: 10.1128/mcb.23.21.7498-7509.2003

PubMed ID: 16648851

Title: Mutations in the gene encoding the PML nuclear body protein Sp110 are associated with immunodeficiency and hepatic veno-occlusive disease.

PubMed ID: 16648851

DOI: 10.1038/ng1780

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25593309

Title: Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

PubMed ID: 25593309

DOI: 10.1101/gad.252189.114

PubMed ID: 16816019

Title: No associations of human pulmonary tuberculosis with Sp110 variants.

PubMed ID: 16816019

DOI: 10.1136/jmg.2005.037960

PubMed ID: 16803959

Title: Variants in the SP110 gene are associated with genetic susceptibility to tuberculosis in West Africa.

PubMed ID: 16803959

DOI: 10.1073/pnas.0603340103

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 689
  • Mass: 78396
  • Checksum: 31552E1A4C498EF7
  • Sequence:
    • MFTMTRAMEE ALFQHFMHQK LGIAYAIHKP FPFFEGLLDN SIITKRMYME SLEACRNLIP 
VSRVVHNILT QLERTFNLSL LVTLFSQINL REYPNLVTIY RSFKRVGASY EWQSRDTPIL 
LEAPTGLAEG SSLHTPLALP PPQPPQPSCS PCAPRVSEPG TSSQQSDEIL SESPSPSDPV 
LPLPALIQEG RSTSVTNDKL TSKMNAEEDS EEMPSLLTST VQVASDNLIP QIRDKEDPQE 
MPHSPLGSMP EIRDNSPEPN DPEEPQEVSS TPSDKKGKKR KRCIWSTPKR RHKKKSLPGG 
TASSRHGIQK KLKRVDQVPQ KKDDSTCNST VETRAQKART ECARKSRSEE IIDGTSEMNE 
GKRSQKTPST PRRVTQGAAS PGHGIQEKLQ VVDKVTQRKD DSTWNSEVMM RVQKARTKCA 
RKSRLKEKKK EKDICSSSKR RFQKNIHRRG KPKSDTVDFH CSKLPVTCGE AKGILYKKKM 
KHGSSVKCIR NEDGTWLTPN EFEVEGKGRN AKNWKRNIRC EGMTLGELLK RKNSDECEVC 
CQGGQLLCCG TCPRVFHEDC HIPPVEAKRM LWSCTFCRMK RSSGSQQCHH VSKTLERQMQ 
PQDQLIRDYG EPFQEAMWLD LVKERLITEM YTVAWFVRDM RLMFRNHKTF YKASDFGQVG 
LDLEAEFEKD LKDVLGFHEA NDGGFWTLP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.