Details for: IFIT1

Gene ID: 3434

Symbol: IFIT1

Ensembl ID: ENSG00000185745

Description: interferon induced protein with tetratricopeptide repeats 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 111.0288
    Cell Significance Index: -17.2700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 65.7616
    Cell Significance Index: -16.6800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 42.2627
    Cell Significance Index: -17.4100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 36.5532
    Cell Significance Index: -14.8500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 35.3510
    Cell Significance Index: -16.6900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 15.6063
    Cell Significance Index: -14.9000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.7475
    Cell Significance Index: -16.9500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.0772
    Cell Significance Index: -16.2800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 5.3213
    Cell Significance Index: 277.1800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.4044
    Cell Significance Index: -17.3800
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.9951
    Cell Significance Index: 18.5300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 2.6196
    Cell Significance Index: 22.5100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.0438
    Cell Significance Index: 133.8100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.8797
    Cell Significance Index: 15.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6645
    Cell Significance Index: 126.4700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.5290
    Cell Significance Index: 14.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5240
    Cell Significance Index: 105.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.4796
    Cell Significance Index: 25.1800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.4267
    Cell Significance Index: 13.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3490
    Cell Significance Index: 315.0800
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.3404
    Cell Significance Index: 2.0000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2866
    Cell Significance Index: 28.3600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2824
    Cell Significance Index: 4.4800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.2121
    Cell Significance Index: 1.6400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1834
    Cell Significance Index: 65.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1673
    Cell Significance Index: 27.2100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1600
    Cell Significance Index: 1.3100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1424
    Cell Significance Index: 19.5500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1044
    Cell Significance Index: 1.9300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1036
    Cell Significance Index: 11.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0773
    Cell Significance Index: 15.3400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0669
    Cell Significance Index: 29.5900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0491
    Cell Significance Index: 36.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0412
    Cell Significance Index: 2.0800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0323
    Cell Significance Index: 3.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0208
    Cell Significance Index: 1.4400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0100
    Cell Significance Index: 5.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0087
    Cell Significance Index: 5.5400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0060
    Cell Significance Index: 11.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0051
    Cell Significance Index: 0.1800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0026
    Cell Significance Index: 0.0400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0026
    Cell Significance Index: 0.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0057
    Cell Significance Index: -0.3800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0064
    Cell Significance Index: -8.6600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0078
    Cell Significance Index: -14.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0082
    Cell Significance Index: -12.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0139
    Cell Significance Index: -0.4000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0165
    Cell Significance Index: -12.5000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0200
    Cell Significance Index: -1.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0208
    Cell Significance Index: -0.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0217
    Cell Significance Index: -2.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0249
    Cell Significance Index: -18.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0283
    Cell Significance Index: -17.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0287
    Cell Significance Index: -16.2000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0327
    Cell Significance Index: -14.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0379
    Cell Significance Index: -1.7200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0451
    Cell Significance Index: -12.9800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0457
    Cell Significance Index: -0.9900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0524
    Cell Significance Index: -4.1500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0693
    Cell Significance Index: -12.5000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0777
    Cell Significance Index: -8.9000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0817
    Cell Significance Index: -5.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0843
    Cell Significance Index: -12.2600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0854
    Cell Significance Index: -14.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0935
    Cell Significance Index: -19.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1136
    Cell Significance Index: -6.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1169
    Cell Significance Index: -14.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1235
    Cell Significance Index: -15.9600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1326
    Cell Significance Index: -2.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1357
    Cell Significance Index: -8.5500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1367
    Cell Significance Index: -9.6700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1442
    Cell Significance Index: -17.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1621
    Cell Significance Index: -12.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1635
    Cell Significance Index: -17.0200
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1692
    Cell Significance Index: -5.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1765
    Cell Significance Index: -4.6400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1846
    Cell Significance Index: -11.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1945
    Cell Significance Index: -9.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1960
    Cell Significance Index: -9.1400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1995
    Cell Significance Index: -2.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2037
    Cell Significance Index: -15.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2395
    Cell Significance Index: -5.1000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.2442
    Cell Significance Index: -3.6800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2449
    Cell Significance Index: -4.7800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2664
    Cell Significance Index: -13.8400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2726
    Cell Significance Index: -7.4200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2726
    Cell Significance Index: -11.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2800
    Cell Significance Index: -15.7100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2801
    Cell Significance Index: -12.3900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2869
    Cell Significance Index: -7.6600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3043
    Cell Significance Index: -5.2200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3138
    Cell Significance Index: -8.7700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3725
    Cell Significance Index: -13.0500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3762
    Cell Significance Index: -11.9800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3789
    Cell Significance Index: -10.8600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.3793
    Cell Significance Index: -8.0500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3813
    Cell Significance Index: -14.4400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3846
    Cell Significance Index: -8.3100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.3894
    Cell Significance Index: -8.1500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3949
    Cell Significance Index: -12.9300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IFIT1 is a small, acidic protein that belongs to the family of interferon-induced proteins. It is characterized by the presence of four tetratricopeptide repeats (TPRs), which are essential for its interaction with other proteins. IFIT1 is produced in response to type I interferon (IFN) signaling, particularly IFN-alpha and IFN-beta, and is upregulated in various cell types, including pulmonary interstitial fibroblasts, lung endothelial cells, and enterocytes. **Pathways and Functions:** IFIT1 participates in multiple signaling pathways that regulate antiviral immunity and cellular responses to viral infections. These pathways include: 1. **Antiviral Innate Immunity:** IFIT1 contributes to the antiviral innate immune response by inhibiting viral replication and promoting the production of interferons. 2. **Interferon Signaling:** IFIT1 is a key component of the IFN signaling pathway, interacting with interferons and other ISGs to modulate the host's defense mechanisms. 3. **Cytokine Signaling:** IFIT1 influences cytokine signaling, particularly in the context of immune responses to viral infections. 4. **Intracellular Transport of Viral Proteins:** IFIT1 regulates the intracellular transport of viral proteins, thereby inhibiting viral replication. **Clinical Significance:** IFIT1 plays a crucial role in protecting against viral infections, including influenza, HIV, and hepatitis. Its dysregulation has been implicated in various diseases, such as: 1. **Viral Infections:** IFIT1 deficiency or dysfunction can lead to increased susceptibility to viral infections. 2. **Cancer:** IFIT1 has been shown to have antitumor properties, making it a potential therapeutic target for cancer treatment. 3. **Neurological Disorders:** IFIT1 has been implicated in the pathogenesis of neurological disorders, such as multiple sclerosis and Alzheimer's disease. In conclusion, IFIT1 is a vital component of the innate immune response against viral infections, and its dysregulation can have significant consequences for human health. Further research is needed to fully elucidate the mechanisms of IFIT1-mediated antiviral immunity and its potential applications in disease therapy.

Genular Protein ID: 3662513422

Symbol: IFIT1_HUMAN

Name: Interferon-induced protein with tetratricopeptide repeats 1

UniProtKB Accession Codes:

P09914 B3KS50 D3DR31 Q5T7J1 Q96QM5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CPTC 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 EvolutionaryTrace 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3753936

Title: Molecular cloning, full-length sequence and preliminary characterization of a 56-kDa protein induced by human interferons.

PubMed ID: 3753936

DOI: 10.1111/j.1432-1033.1986.tb09452.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6186990

Title: Interferon-induced 56,000 Mr protein and its mRNA in human cells: molecular cloning and partial sequence of the cDNA.

PubMed ID: 6186990

DOI: 10.1093/nar/11.5.1213

PubMed ID: 3121313

Title: New inducers revealed by the promoter sequence analysis of two interferon-activated human genes.

PubMed ID: 3121313

DOI: 10.1111/j.1432-1033.1987.tb13614.x

PubMed ID: 3360121

Title: The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family.

PubMed ID: 3360121

DOI: 10.1016/0014-5793(88)80724-5

PubMed ID: 16009940

Title: Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.

PubMed ID: 16009940

DOI: 10.1073/pnas.0504754102

PubMed ID: 16023166

Title: Induction and mode of action of the viral stress-inducible murine proteins, P56 and P54.

PubMed ID: 16023166

DOI: 10.1016/j.virol.2005.06.011

PubMed ID: 19008854

Title: Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1.

PubMed ID: 19008854

DOI: 10.1038/emboj.2008.241

PubMed ID: 19416887

Title: ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response.

PubMed ID: 19416887

DOI: 10.1073/pnas.0900818106

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21612406

Title: A novel interaction between interferon-inducible protein p56 and ribosomal protein L15 in gastric cancer cells.

PubMed ID: 21612406

DOI: 10.1089/dna.2010.1149

PubMed ID: 21190939

Title: The interferon stimulated gene 54 promotes apoptosis.

PubMed ID: 21190939

DOI: 10.1074/jbc.m110.207068

PubMed ID: 20950130

Title: The ISG56/IFIT1 gene family.

PubMed ID: 20950130

DOI: 10.1089/jir.2010.0101

PubMed ID: 21976647

Title: ISG56 and IFITM1 proteins inhibit hepatitis C virus replication.

PubMed ID: 21976647

DOI: 10.1128/jvi.05633-11

PubMed ID: 21685951

Title: Where, in antiviral defense, does IFIT1 fit?

PubMed ID: 21685951

DOI: 10.1038/ni.2061

PubMed ID: 21642987

Title: IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA.

PubMed ID: 21642987

DOI: 10.1038/ni.2048

PubMed ID: 23334420

Title: Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins.

PubMed ID: 23334420

DOI: 10.1038/nature11783

Sequence Information:

  • Length: 478
  • Mass: 55360
  • Checksum: EF46E652A366E721
  • Sequence:
    • MSTNGDDHQV KDSLEQLRCH FTWELSIDDD EMPDLENRVL DQIEFLDTKY SVGIHNLLAY 
VKHLKGQNEE ALKSLKEAEN LMQEEHDNQA NVRSLVTWGN FAWMYYHMGR LAEAQTYLDK 
VENICKKLSN PFRYRMECPE IDCEEGWALL KCGGKNYERA KACFEKVLEV DPENPESSAG 
YAISAYRLDG FKLATKNHKP FSLLPLRQAV RLNPDNGYIK VLLALKLQDE GQEAEGEKYI 
EEALANMSSQ TYVFRYAAKF YRRKGSVDKA LELLKKALQE TPTSVLLHHQ IGLCYKAQMI 
QIKEATKGQP RGQNREKLDK MIRSAIFHFE SAVEKKPTFE VAHLDLARMY IEAGNHRKAE 
ENFQKLLCMK PVVEETMQDI HFHYGRFQEF QKKSDVNAII HYLKAIKIEQ ASLTRDKSIN 
SLKKLVLRKL RRKALDLESL SLLGFVYKLE GNMNEALEYY ERALRLAADF ENSVRQGP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.