Details for: IFIT1

Gene ID: 3434

Symbol: IFIT1

Ensembl ID: ENSG00000185745

Description: interferon induced protein with tetratricopeptide repeats 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 2.87
    Marker Score: 2301
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.68
    Marker Score: 23544
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168663
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.17
    Marker Score: 848
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4776
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.12
    Marker Score: 2283
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.02
    Marker Score: 1019
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71779
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48003
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 494
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 450
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2409
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.95
    Marker Score: 641
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.93
    Marker Score: 384
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.93
    Marker Score: 210
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.92
    Marker Score: 384
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.92
    Marker Score: 1509
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2726
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.91
    Marker Score: 363
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.89
    Marker Score: 5064
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 315
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5270
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.86
    Marker Score: 397
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.85
    Marker Score: 1232
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.81
    Marker Score: 50007
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.8
    Marker Score: 2144
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 592
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.77
    Marker Score: 1807
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1242
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.76
    Marker Score: 2596
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.75
    Marker Score: 172
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 682
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.75
    Marker Score: 685
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 493
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 385
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.73
    Marker Score: 362
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.71
    Marker Score: 1200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 173
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.66
    Marker Score: 2346
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.64
    Marker Score: 5536
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.64
    Marker Score: 981
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.63
    Marker Score: 1601
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.6
    Marker Score: 1491
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6
    Marker Score: 33472
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.59
    Marker Score: 529
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 372
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.58
    Marker Score: 5505
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.57
    Marker Score: 7469
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.56
    Marker Score: 401
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.55
    Marker Score: 670
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.55
    Marker Score: 521
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.55
    Marker Score: 14142
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.55
    Marker Score: 759
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.54
    Marker Score: 561
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.54
    Marker Score: 463
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.54
    Marker Score: 359
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.53
    Marker Score: 292
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.53
    Marker Score: 10541
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.53
    Marker Score: 5232
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.53
    Marker Score: 846
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.52
    Marker Score: 356
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.52
    Marker Score: 718
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.52
    Marker Score: 274
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.51
    Marker Score: 2096
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.51
    Marker Score: 506
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.5
    Marker Score: 1318
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.5
    Marker Score: 5193
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.5
    Marker Score: 18919
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.5
    Marker Score: 18367
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5
    Marker Score: 7780
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.5
    Marker Score: 208
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.49
    Marker Score: 683
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.49
    Marker Score: 5692
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.49
    Marker Score: 120
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.48
    Marker Score: 599
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.48
    Marker Score: 513
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.47
    Marker Score: 1828
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.47
    Marker Score: 478
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.47
    Marker Score: 1221
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.47
    Marker Score: 213
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.47
    Marker Score: 949
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.47
    Marker Score: 620
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.46
    Marker Score: 110
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.45
    Marker Score: 3938
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.44
    Marker Score: 122
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.44
    Marker Score: 226.5
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.43
    Marker Score: 265
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.43
    Marker Score: 725
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.42
    Marker Score: 112
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.42
    Marker Score: 408
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.42
    Marker Score: 111
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.41
    Marker Score: 6180
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.41
    Marker Score: 479
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.41
    Marker Score: 107
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.39
    Marker Score: 750
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.39
    Marker Score: 3706
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.39
    Marker Score: 233
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.39
    Marker Score: 244

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Other Information

**Key characteristics:** * IFIT1 is a protein of the interferon alpha/beta family. * It is a tetrameric protein with a molecular weight of approximately 120 kDa. * It has a tetratricopeptide repeat sequence in its N-terminal region. * It is a key regulator of the innate immune response to viruses. **Pathways and functions:** * IFIT1 binds to the viral RNA and blocks its translation. * This prevents the virus from producing new viral proteins, which can help to inhibit viral replication. * IFIT1 also regulates the expression of antiviral genes in target cells. * It is involved in the regulation of viral entry into cells, the production of infectious virus particles, and the release of viral proteins. **Clinical significance:** * Mutations in the IFIT1 gene have been linked to the development of several viral infections, including influenza, HIV, and hepatitis C virus. * IFIT1 is a potential therapeutic target for the treatment of viral infections. * Studies have shown that IFIT1 can be used to inhibit viral replication in vitro and in vivo. **Additional information:** * IFIT1 is a highly conserved protein that is found in humans, mice, and rats. * It is expressed in high levels in response to viral infection. * It is a key factor in the innate immune response to viruses.

Genular Protein ID: 3662513422

Symbol: IFIT1_HUMAN

Name: Interferon-induced protein with tetratricopeptide repeats 1

UniProtKB Accession Codes:

P09914 B3KS50 D3DR31 Q5T7J1 Q96QM5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CPTC 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EPD 1 Ensembl 2 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 8 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3753936

Title: Molecular cloning, full-length sequence and preliminary characterization of a 56-kDa protein induced by human interferons.

PubMed ID: 3753936

DOI: 10.1111/j.1432-1033.1986.tb09452.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6186990

Title: Interferon-induced 56,000 Mr protein and its mRNA in human cells: molecular cloning and partial sequence of the cDNA.

PubMed ID: 6186990

DOI: 10.1093/nar/11.5.1213

PubMed ID: 3121313

Title: New inducers revealed by the promoter sequence analysis of two interferon-activated human genes.

PubMed ID: 3121313

DOI: 10.1111/j.1432-1033.1987.tb13614.x

PubMed ID: 3360121

Title: The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family.

PubMed ID: 3360121

DOI: 10.1016/0014-5793(88)80724-5

PubMed ID: 16009940

Title: Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.

PubMed ID: 16009940

DOI: 10.1073/pnas.0504754102

PubMed ID: 16023166

Title: Induction and mode of action of the viral stress-inducible murine proteins, P56 and P54.

PubMed ID: 16023166

DOI: 10.1016/j.virol.2005.06.011

PubMed ID: 19008854

Title: Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1.

PubMed ID: 19008854

DOI: 10.1038/emboj.2008.241

PubMed ID: 19416887

Title: ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response.

PubMed ID: 19416887

DOI: 10.1073/pnas.0900818106

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21612406

Title: A novel interaction between interferon-inducible protein p56 and ribosomal protein L15 in gastric cancer cells.

PubMed ID: 21612406

DOI: 10.1089/dna.2010.1149

PubMed ID: 21190939

Title: The interferon stimulated gene 54 promotes apoptosis.

PubMed ID: 21190939

DOI: 10.1074/jbc.m110.207068

PubMed ID: 20950130

Title: The ISG56/IFIT1 gene family.

PubMed ID: 20950130

DOI: 10.1089/jir.2010.0101

PubMed ID: 21976647

Title: ISG56 and IFITM1 proteins inhibit hepatitis C virus replication.

PubMed ID: 21976647

DOI: 10.1128/jvi.05633-11

PubMed ID: 21685951

Title: Where, in antiviral defense, does IFIT1 fit?

PubMed ID: 21685951

DOI: 10.1038/ni.2061

PubMed ID: 21642987

Title: IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA.

PubMed ID: 21642987

DOI: 10.1038/ni.2048

PubMed ID: 23334420

Title: Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins.

PubMed ID: 23334420

DOI: 10.1038/nature11783

Sequence Information:

  • Length: 478
  • Mass: 55360
  • Checksum: EF46E652A366E721
  • Sequence:
    • MSTNGDDHQV KDSLEQLRCH FTWELSIDDD EMPDLENRVL DQIEFLDTKY SVGIHNLLAY 
VKHLKGQNEE ALKSLKEAEN LMQEEHDNQA NVRSLVTWGN FAWMYYHMGR LAEAQTYLDK 
VENICKKLSN PFRYRMECPE IDCEEGWALL KCGGKNYERA KACFEKVLEV DPENPESSAG 
YAISAYRLDG FKLATKNHKP FSLLPLRQAV RLNPDNGYIK VLLALKLQDE GQEAEGEKYI 
EEALANMSSQ TYVFRYAAKF YRRKGSVDKA LELLKKALQE TPTSVLLHHQ IGLCYKAQMI 
QIKEATKGQP RGQNREKLDK MIRSAIFHFE SAVEKKPTFE VAHLDLARMY IEAGNHRKAE 
ENFQKLLCMK PVVEETMQDI HFHYGRFQEF QKKSDVNAII HYLKAIKIEQ ASLTRDKSIN 
SLKKLVLRKL RRKALDLESL SLLGFVYKLE GNMNEALEYY ERALRLAADF ENSVRQGP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.