Details for: IFIT3

Gene ID: 3437

Symbol: IFIT3

Ensembl ID: ENSG00000119917

Description: interferon induced protein with tetratricopeptide repeats 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 137.9663
    Cell Significance Index: -21.4600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 83.4242
    Cell Significance Index: -21.1600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 49.0330
    Cell Significance Index: -19.9200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 47.5194
    Cell Significance Index: -22.4400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 43.9262
    Cell Significance Index: -22.6000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 20.9899
    Cell Significance Index: -20.0400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.9650
    Cell Significance Index: -22.1500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 8.1266
    Cell Significance Index: -21.7700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.7577
    Cell Significance Index: -22.7200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.6117
    Cell Significance Index: 188.1300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.7443
    Cell Significance Index: 48.5000
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 2.4084
    Cell Significance Index: 20.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.0714
    Cell Significance Index: 394.2000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.6306
    Cell Significance Index: 26.1600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.0504
    Cell Significance Index: 22.3700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.7478
    Cell Significance Index: 11.5700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7410
    Cell Significance Index: 17.1200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7016
    Cell Significance Index: 42.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6073
    Cell Significance Index: 98.7700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5239
    Cell Significance Index: 67.1600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.4945
    Cell Significance Index: 9.1400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4690
    Cell Significance Index: 46.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4007
    Cell Significance Index: 80.3800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3798
    Cell Significance Index: 26.2700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3634
    Cell Significance Index: 49.9000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3572
    Cell Significance Index: 322.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3327
    Cell Significance Index: 17.4700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2256
    Cell Significance Index: 306.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2223
    Cell Significance Index: 342.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2154
    Cell Significance Index: 77.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2134
    Cell Significance Index: 13.1200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1951
    Cell Significance Index: 2.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1767
    Cell Significance Index: 20.5900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1708
    Cell Significance Index: 8.8700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1652
    Cell Significance Index: 3.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1166
    Cell Significance Index: 215.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0642
    Cell Significance Index: 4.1400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0456
    Cell Significance Index: 1.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0424
    Cell Significance Index: 18.7600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0393
    Cell Significance Index: 7.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0366
    Cell Significance Index: 19.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0339
    Cell Significance Index: 5.7900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0328
    Cell Significance Index: 6.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0295
    Cell Significance Index: 3.3800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0205
    Cell Significance Index: 0.5500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0196
    Cell Significance Index: 36.8900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0170
    Cell Significance Index: 10.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0153
    Cell Significance Index: 1.8800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0099
    Cell Significance Index: 6.8600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0099
    Cell Significance Index: 0.2700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0012
    Cell Significance Index: 0.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0063
    Cell Significance Index: -0.2200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0070
    Cell Significance Index: -5.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0076
    Cell Significance Index: -5.6300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0077
    Cell Significance Index: -4.8300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0150
    Cell Significance Index: -1.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0181
    Cell Significance Index: -10.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0200
    Cell Significance Index: -15.1400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0287
    Cell Significance Index: -8.2700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0332
    Cell Significance Index: -2.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0388
    Cell Significance Index: -17.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0459
    Cell Significance Index: -9.6700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0461
    Cell Significance Index: -2.0900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0463
    Cell Significance Index: -0.2800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0642
    Cell Significance Index: -1.8500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0874
    Cell Significance Index: -12.7100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0897
    Cell Significance Index: -10.2400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0938
    Cell Significance Index: -1.5700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0947
    Cell Significance Index: -1.1800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1338
    Cell Significance Index: -17.2900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1674
    Cell Significance Index: -11.8400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1834
    Cell Significance Index: -21.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2022
    Cell Significance Index: -5.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2114
    Cell Significance Index: -22.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2362
    Cell Significance Index: -18.1300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2438
    Cell Significance Index: -19.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2516
    Cell Significance Index: -18.7500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2565
    Cell Significance Index: -2.6600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2594
    Cell Significance Index: -6.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2784
    Cell Significance Index: -13.0900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2892
    Cell Significance Index: -3.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3247
    Cell Significance Index: -15.1400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3412
    Cell Significance Index: -8.7700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3677
    Cell Significance Index: -22.5400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3743
    Cell Significance Index: -10.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3891
    Cell Significance Index: -10.3900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3903
    Cell Significance Index: -24.6000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.3928
    Cell Significance Index: -5.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3956
    Cell Significance Index: -12.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3979
    Cell Significance Index: -22.3300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4130
    Cell Significance Index: -10.5500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4585
    Cell Significance Index: -6.8700
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4614
    Cell Significance Index: -7.3200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4666
    Cell Significance Index: -12.2700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4847
    Cell Significance Index: -16.9800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4848
    Cell Significance Index: -14.2800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.4980
    Cell Significance Index: -15.7500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5068
    Cell Significance Index: -25.6100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5116
    Cell Significance Index: -22.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5263
    Cell Significance Index: -18.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IFIT3 is a member of the interferon-induced protein family, which is known for its ability to modulate the immune response. The protein consists of four tetratricopeptide repeats (TPRs) and exhibits a high degree of homology with other IFIT proteins. IFIT3 is predominantly expressed in various cell types, including secondary lens fibers, lung endothelial cells, and activated CD8-positive T cells. **Pathways and Functions:** IFIT3 is involved in multiple signaling pathways, including: 1. **Antiviral Innate Immune Response:** IFIT3 acts as a negative regulator of viral replication by binding to viral proteins and inhibiting their translation. 2. **Interferon Alpha/Beta Signaling:** IFIT3 interacts with interferon-alpha/beta receptors, modulating the downstream signaling pathways and enhancing the antiviral response. 3. **Cytokine Signaling:** IFIT3 participates in cytokine signaling, influencing the production of pro-inflammatory cytokines and chemokines. 4. **Negative Regulation of Apoptosis and Cell Proliferation:** IFIT3 exhibits anti-apoptotic properties, preventing excessive cell death and promoting cell survival. **Mechanisms of Action:** IFIT3 exerts its antiviral effects by: 1. **Interfering with Viral Translation:** IFIT3 binds to viral RNA, preventing its translation and thereby inhibiting viral replication. 2. **Modulating Interferon Signaling:** IFIT3 interacts with interferon-alpha/beta receptors, enhancing the antiviral response and promoting the production of interferon-stimulated genes. **Clinical Significance:** IFIT3 plays a crucial role in the defense against viral infections, including: 1. **Viral Respiratory Infections:** IFIT3 is upregulated in response to respiratory viruses, such as influenza and respiratory syncytial virus (RSV). 2. **Cancer:** IFIT3 has been implicated in the regulation of apoptosis and cell proliferation in various cancer types, including breast and lung cancer. 3. **Neurological Disorders:** IFIT3 has been linked to the pathogenesis of neurodegenerative diseases, such as multiple sclerosis and Alzheimer's disease. In conclusion, IFIT3 is a vital component of the innate immune response, playing a crucial role in the defense against viral infections and regulating apoptosis and cell proliferation. Further research is needed to fully elucidate the mechanisms of IFIT3 and its clinical significance in various diseases. **References:** * [List relevant references cited in this article]

Genular Protein ID: 1260536774

Symbol: IFIT3_HUMAN

Name: Interferon-induced protein with tetratricopeptide repeats 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9391139

Title: Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs.

PubMed ID: 9391139

DOI: 10.1073/pnas.94.25.13985

PubMed ID: 9828129

Title: IFI60/ISG60/IFIT4, a new member of the human IFI54/IFIT2 family of interferon-stimulated genes.

PubMed ID: 9828129

DOI: 10.1006/geno.1998.5555

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17050680

Title: RIG-G as a key mediator of the antiproliferative activity of interferon-related pathways through enhancing p21 and p27 proteins.

PubMed ID: 17050680

DOI: 10.1073/pnas.0607830103

PubMed ID: 18706081

Title: Interferon-induced protein IFIT4 is associated with systemic lupus erythematosus and promotes differentiation of monocytes into dendritic cell-like cells.

PubMed ID: 18706081

DOI: 10.1186/ar2475

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20686046

Title: Identification of alpha interferon-induced genes associated with antiviral activity in Daudi cells and characterization of IFIT3 as a novel antiviral gene.

PubMed ID: 20686046

DOI: 10.1128/jvi.00818-10

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21190939

Title: The interferon stimulated gene 54 promotes apoptosis.

PubMed ID: 21190939

DOI: 10.1074/jbc.m110.207068

PubMed ID: 21813773

Title: IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1.

PubMed ID: 21813773

DOI: 10.4049/jimmunol.1100963

PubMed ID: 20950130

Title: The ISG56/IFIT1 gene family.

PubMed ID: 20950130

DOI: 10.1089/jir.2010.0101

PubMed ID: 21642987

Title: IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA.

PubMed ID: 21642987

DOI: 10.1038/ni.2048

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 490
  • Mass: 55985
  • Checksum: B9F042D4DF7151D2
  • Sequence:
  • MSEVTKNSLE KILPQLKCHF TWNLFKEDSV SRDLEDRVCN QIEFLNTEFK ATMYNLLAYI 
    KHLDGNNEAA LECLRQAEEL IQQEHADQAE IRSLVTWGNY AWVYYHLGRL SDAQIYVDKV 
    KQTCKKFSNP YSIEYSELDC EEGWTQLKCG RNERAKVCFE KALEEKPNNP EFSSGLAIAM 
    YHLDNHPEKQ FSTDVLKQAI ELSPDNQYVK VLLGLKLQKM NKEAEGEQFV EEALEKSPCQ 
    TDVLRSAAKF YRRKGDLDKA IELFQRVLES TPNNGYLYHQ IGCCYKAKVR QMQNTGESEA 
    SGNKEMIEAL KQYAMDYSNK ALEKGLNPLN AYSDLAEFLE TECYQTPFNK EVPDAEKQQS 
    HQRYCNLQKY NGKSEDTAVQ HGLEGLSISK KSTDKEEIKD QPQNVSENLL PQNAPNYWYL 
    QGLIHKQNGD LLQAAKCYEK ELGRLLRDAP SGIGSIFLSA SELEDGSEEM GQGAVSSSPR 
    ELLSNSEQLN

Genular Protein ID: 302540400

Symbol: A0A7P0T7D6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 438
  • Mass: 49826
  • Checksum: 257688E40B456377
  • Sequence:
  • MYNLLAYIKH LDGNNEAALE CLRQAEELIQ QEHADQAEIR SLVTWGNYAW VYYHLGRLSD 
    AQIYVDKVKQ TCKKFSNPYS IEYSELDCEE GWTQLKCGRN ERAKVCFEKA LEEKPNNPEF 
    SSGLAIAMYH LDNHPEKQFS TDVLKQAIEL SPDNQYVKVL LGLKLQKMNK EAEGEQFVEE 
    ALEKSPCQTD VLRSAAKFYR RKGDLDKAIE LFQRVLESTP NNGYLYHQIG CCYKAKVRQM 
    QNTGESEASG NKEMIEALKQ YAMDYSNKAL EKGLNPLNAY SDLAEFLETE CYQTPFNKEV 
    PDAEKQQSHQ RYCNLQKYNG KSEDTAVQHG LEGLSISKKS TDKEEIKDQP QNVSENLLPQ 
    NAPNYWYLQG LIHKQNGDLL QAAKCYEKEL GRLLRDAPSG IGSIFLSASE LEDGSEEMGQ 
    GAVSSSPREL LSNSEQLN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.