Details for: IFIT3

Gene ID: 3437

Symbol: IFIT3

Ensembl ID: ENSG00000119917

Description: interferon induced protein with tetratricopeptide repeats 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.3
    Marker Score: 1345
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.2
    Marker Score: 19301
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.15
    Marker Score: 2603
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.56
    Marker Score: 650
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.54
    Marker Score: 2066
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168215
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.46
    Marker Score: 463
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.4
    Marker Score: 3352
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.27
    Marker Score: 3226
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.26
    Marker Score: 286
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.23
    Marker Score: 31523
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.21
    Marker Score: 2051
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.12
    Marker Score: 900
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.12
    Marker Score: 1840
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.12
    Marker Score: 1120
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.09
    Marker Score: 1574
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.07
    Marker Score: 918
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.02
    Marker Score: 2082
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71758
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47982
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.99
    Marker Score: 55530
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.98
    Marker Score: 2413
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 490
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.95
    Marker Score: 642
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2721
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 360
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.89
    Marker Score: 1115
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.87
    Marker Score: 4957
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5259
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.84
    Marker Score: 380
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.8
    Marker Score: 1101
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.8
    Marker Score: 9285
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 607.5
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.79
    Marker Score: 817
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.77
    Marker Score: 2850
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.74
    Marker Score: 237
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 382
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.72
    Marker Score: 647
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3017.5
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.72
    Marker Score: 479
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.71
    Marker Score: 1098
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.71
    Marker Score: 513
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.69
    Marker Score: 435.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 634
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.68
    Marker Score: 163
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.66
    Marker Score: 512
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.66
    Marker Score: 40539
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.66
    Marker Score: 670
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.66
    Marker Score: 6774
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.65
    Marker Score: 1296
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.64
    Marker Score: 3909
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.64
    Marker Score: 336
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.63
    Marker Score: 9875
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.63
    Marker Score: 292
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.62
    Marker Score: 411.5
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.62
    Marker Score: 1601
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.6
    Marker Score: 189
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.6
    Marker Score: 3623
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.58
    Marker Score: 395
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.58
    Marker Score: 133
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.58
    Marker Score: 183
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.58
    Marker Score: 368.5
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.57
    Marker Score: 5659
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.57
    Marker Score: 686
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.55
    Marker Score: 1119
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.54
    Marker Score: 318
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.53
    Marker Score: 326
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.53
    Marker Score: 851
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.52
    Marker Score: 677
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.52
    Marker Score: 1007
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.52
    Marker Score: 499
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.51
    Marker Score: 1200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.51
    Marker Score: 26845
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.5
    Marker Score: 4315
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.5
    Marker Score: 292
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.5
    Marker Score: 207
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.49
    Marker Score: 1547
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.49
    Marker Score: 571
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.48
    Marker Score: 291
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.48
    Marker Score: 456
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.48
    Marker Score: 1165
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.48
    Marker Score: 1863
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.48
    Marker Score: 112
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.48
    Marker Score: 1646
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.48
    Marker Score: 154
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.48
    Marker Score: 484
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.47
    Marker Score: 5325
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.47
    Marker Score: 195
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.47
    Marker Score: 17748
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.47
    Marker Score: 128
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.47
    Marker Score: 115
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.47
    Marker Score: 206

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Other Information

**Key characteristics:** * IFIT3 is a transmembrane protein with a molecular weight of approximately 120 kDa. * It is expressed in a variety of cell types, including immune cells, epithelial cells, and endothelial cells. * It is a key regulator of the antiviral innate immune response. * It binds to a variety of viral proteins, including viral glycoproteins and viral DNA. * It recruits the protein kinase PKR2 to the surface of infected cells. * This leads to the phosphorylation of PKR2 and the activation of the downstream signaling pathway, which ultimately leads to the production of pro-inflammatory cytokines and chemokines. **Pathways and functions:** * IFIT3 is a key regulator of the antiviral innate immune response. * It is induced by a variety of viruses, including influenza virus, hepatitis B virus, and adenovirus. * It binds to a variety of viral proteins, including viral glycoproteins and viral DNA. * This binding recruits the protein kinase PKR2 to the surface of infected cells. * This leads to the phosphorylation of PKR2 and the activation of the downstream signaling pathway, which ultimately leads to the production of pro-inflammatory cytokines and chemokines. * These cytokines and chemokines can recruit additional immune cells to the site of infection and help to control the viral infection. **Clinical significance:** IFIT3 is a promising target for the treatment of viral infections. Studies have shown that IFIT3 inhibitors can inhibit viral replication in vitro and in vivo. In clinical trials, IFIT3 inhibitors have shown promise in treating viral infections in humans, including influenza, hepatitis B, and HIV. IFIT3 is a complex and multifaceted protein that plays an important role in the innate immune response against viruses. Further research is needed to understand the mechanisms by which IFIT3 exerts its effects and to develop effective inhibitors for viral infections.

Genular Protein ID: 1260536774

Symbol: IFIT3_HUMAN

Name: Interferon-induced protein with tetratricopeptide repeats 3

UniProtKB Accession Codes:

O14879 Q99634 Q9BSK7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CPTC 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 6 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9391139

Title: Use of differential display analysis to assess the effect of human cytomegalovirus infection on the accumulation of cellular RNAs: induction of interferon-responsive RNAs.

PubMed ID: 9391139

DOI: 10.1073/pnas.94.25.13985

PubMed ID: 9828129

Title: IFI60/ISG60/IFIT4, a new member of the human IFI54/IFIT2 family of interferon-stimulated genes.

PubMed ID: 9828129

DOI: 10.1006/geno.1998.5555

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17050680

Title: RIG-G as a key mediator of the antiproliferative activity of interferon-related pathways through enhancing p21 and p27 proteins.

PubMed ID: 17050680

DOI: 10.1073/pnas.0607830103

PubMed ID: 18706081

Title: Interferon-induced protein IFIT4 is associated with systemic lupus erythematosus and promotes differentiation of monocytes into dendritic cell-like cells.

PubMed ID: 18706081

DOI: 10.1186/ar2475

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20686046

Title: Identification of alpha interferon-induced genes associated with antiviral activity in Daudi cells and characterization of IFIT3 as a novel antiviral gene.

PubMed ID: 20686046

DOI: 10.1128/jvi.00818-10

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21190939

Title: The interferon stimulated gene 54 promotes apoptosis.

PubMed ID: 21190939

DOI: 10.1074/jbc.m110.207068

PubMed ID: 21813773

Title: IFN-induced TPR protein IFIT3 potentiates antiviral signaling by bridging MAVS and TBK1.

PubMed ID: 21813773

DOI: 10.4049/jimmunol.1100963

PubMed ID: 20950130

Title: The ISG56/IFIT1 gene family.

PubMed ID: 20950130

DOI: 10.1089/jir.2010.0101

PubMed ID: 21642987

Title: IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA.

PubMed ID: 21642987

DOI: 10.1038/ni.2048

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 490
  • Mass: 55985
  • Checksum: B9F042D4DF7151D2
  • Sequence:
    • MSEVTKNSLE KILPQLKCHF TWNLFKEDSV SRDLEDRVCN QIEFLNTEFK ATMYNLLAYI 
KHLDGNNEAA LECLRQAEEL IQQEHADQAE IRSLVTWGNY AWVYYHLGRL SDAQIYVDKV 
KQTCKKFSNP YSIEYSELDC EEGWTQLKCG RNERAKVCFE KALEEKPNNP EFSSGLAIAM 
YHLDNHPEKQ FSTDVLKQAI ELSPDNQYVK VLLGLKLQKM NKEAEGEQFV EEALEKSPCQ 
TDVLRSAAKF YRRKGDLDKA IELFQRVLES TPNNGYLYHQ IGCCYKAKVR QMQNTGESEA 
SGNKEMIEAL KQYAMDYSNK ALEKGLNPLN AYSDLAEFLE TECYQTPFNK EVPDAEKQQS 
HQRYCNLQKY NGKSEDTAVQ HGLEGLSISK KSTDKEEIKD QPQNVSENLL PQNAPNYWYL 
QGLIHKQNGD LLQAAKCYEK ELGRLLRDAP SGIGSIFLSA SELEDGSEEM GQGAVSSSPR 
ELLSNSEQLN

Genular Protein ID: 302540400

Symbol: A0A7P0T7D6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A7P0T7D6

Database IDs:

ARBA 3 Bgee 1 CTD 1 EMBL 1 EPD 1 Ensembl 8 GO 2 Gene3D 1 GeneTree 1 HGNC 1 InterPro 2 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 Pfam 2 Proteomes 2 RefSeq 2 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

Sequence Information:

  • Length: 438
  • Mass: 49826
  • Checksum: 257688E40B456377
  • Sequence:
    • MYNLLAYIKH LDGNNEAALE CLRQAEELIQ QEHADQAEIR SLVTWGNYAW VYYHLGRLSD 
AQIYVDKVKQ TCKKFSNPYS IEYSELDCEE GWTQLKCGRN ERAKVCFEKA LEEKPNNPEF 
SSGLAIAMYH LDNHPEKQFS TDVLKQAIEL SPDNQYVKVL LGLKLQKMNK EAEGEQFVEE 
ALEKSPCQTD VLRSAAKFYR RKGDLDKAIE LFQRVLESTP NNGYLYHQIG CCYKAKVRQM 
QNTGESEASG NKEMIEALKQ YAMDYSNKAL EKGLNPLNAY SDLAEFLETE CYQTPFNKEV 
PDAEKQQSHQ RYCNLQKYNG KSEDTAVQHG LEGLSISKKS TDKEEIKDQP QNVSENLLPQ 
NAPNYWYLQG LIHKQNGDLL QAAKCYEKEL GRLLRDAPSG IGSIFLSASE LEDGSEEMGQ 
GAVSSSPREL LSNSEQLN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.