Details for: IFNA1

Gene ID: 3439

Symbol: IFNA1

Ensembl ID: ENSG00000197919

Description: interferon alpha 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.15
    Marker Score: 52530
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.39
    Marker Score: 7904
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.55
    Marker Score: 6470
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.97
    Marker Score: 2989
  • Cell Name: T cell (CL0000084)
    Fold Change: 2.19
    Marker Score: 3780
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 2
    Marker Score: 525
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 1.95
    Marker Score: 507
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.85
    Marker Score: 2066
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.62
    Marker Score: 508
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.58
    Marker Score: 510
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.48
    Marker Score: 470
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.37
    Marker Score: 508
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.37
    Marker Score: 496
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.23
    Marker Score: 707
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.23
    Marker Score: 1170
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.17
    Marker Score: 533
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7677
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 1.11
    Marker Score: 492
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.1
    Marker Score: 495
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.01
    Marker Score: 1076
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 1.01
    Marker Score: 482
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 0.99
    Marker Score: 71347
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47572
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30353
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5205
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2727
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5267
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 498
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.8
    Marker Score: 500
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.79
    Marker Score: 522.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1273
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.76
    Marker Score: 524
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.74
    Marker Score: 487
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.74
    Marker Score: 389
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.73
    Marker Score: 1173.5
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.71
    Marker Score: 681.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.67
    Marker Score: 533
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.6
    Marker Score: 707
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.6
    Marker Score: 349
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.59
    Marker Score: 527
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.58
    Marker Score: 349
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.56
    Marker Score: 1149
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.48
    Marker Score: 553
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 285.5
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.47
    Marker Score: 528
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.45
    Marker Score: 344.5
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.45
    Marker Score: 495
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 388
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.43
    Marker Score: 553
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.37
    Marker Score: 757
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.36
    Marker Score: 680
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.32
    Marker Score: 327
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.32
    Marker Score: 411
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.31
    Marker Score: 445
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.28
    Marker Score: 2841
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.26
    Marker Score: 704
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.22
    Marker Score: 526
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.21
    Marker Score: 660
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.21
    Marker Score: 3259.5
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.2
    Marker Score: 365
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.18
    Marker Score: 1103
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.17
    Marker Score: 684
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.13
    Marker Score: 554
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.13
    Marker Score: 299.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.13
    Marker Score: 444
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.09
    Marker Score: 529
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.06
    Marker Score: 514
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.06
    Marker Score: 529
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.02
    Marker Score: 465
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.02
    Marker Score: 527
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.01
    Marker Score: 529
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.01
    Marker Score: 512
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.01
    Marker Score: 512

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Other Information

**Key characteristics:** - IFNA1 is a member of the interferon family of proteins. - It is a type I interferon, which are produced by cells that are infected with viruses or bacteria. - IFNA1 is a key regulator of the innate immune response. - It is involved in the regulation of inflammation, cell growth, and differentiation. **Pathways and functions:** - IFNA1 is produced in response to viral infection. - It binds to its receptor, IFNAR1, which is expressed on various cell types. - Binding of IFNA1 to IFNAR1 triggers a signaling cascade that involves the phosphorylation of IRF7, a key transcription factor. - Phosphorylated IRF7 then binds to DNA in the promoters of target genes, promoting their expression. - These target genes include those involved in inflammation, cell growth, and differentiation. **Clinical significance:** - Mutations in IFNA1 have been linked to the development of several autoimmune diseases, including rheumatoid arthritis, Crohn's disease, and hepatitis C. - IFNA1 is also involved in the regulation of inflammation in the lungs during respiratory syncytial virus (RSV) infection. - Blockade of IFNA1 signaling has been shown to be effective in reducing inflammation and disease severity in animal models of these diseases.

Genular Protein ID: 3664006444

Symbol: IFNA1_HUMAN

Name: Interferon alpha-1/13

UniProtKB Accession Codes:

P01562 D4Q9M8 Q14605 Q2M1L8 Q52LB8 Q5VYQ2 Q7M4Q1 Q8WZ68 Q9UMJ3

Database IDs:

ABCD 1 AGR 2 AlphaFoldDB 1 Antibodypedia 2 Bgee 1 BioGRID 2 BioGRID-ORCS 2 BioMuta 1 CCDS 1 CDD 1 CTD 2 ChEMBL 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 2 EMBL 18 Ensembl 2 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 2 GeneTree 1 GeneWiki 2 Genevisible 1 HGNC 2 HOGENOM 1 HPA 2 InParanoid 1 IntAct 1 InterPro 2 KEGG 2 MANE-Select 1 MIM 2 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 3 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 5 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 2 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 6157600

Title: The nucleotide sequence of a cloned human leukocyte interferon cDNA.

PubMed ID: 6157600

DOI: 10.1016/0378-1119(80)90137-7

PubMed ID: 6157095

Title: Human leukocyte and fibroblast interferons are structurally related.

PubMed ID: 6157095

DOI: 10.1038/285547a0

PubMed ID: 6163083

Title: The structure of eight distinct cloned human leukocyte interferon cDNAs.

PubMed ID: 6163083

DOI: 10.1038/290020a0

PubMed ID: 6479148

Title: Two non-allelic human interferon alpha genes with identical coding regions.

PubMed ID: 6479148

DOI: 10.1002/j.1460-2075.1984.tb02050.x

PubMed ID: 4057246

Title: Structural relationship of human interferon alpha genes and pseudogenes.

PubMed ID: 4057246

DOI: 10.1016/0022-2836(85)90401-2

PubMed ID: 2985969

Title: Two distinct families of human and bovine interferon-alpha genes are coordinately expressed and encode functional polypeptides.

PubMed ID: 2985969

DOI: 10.1128/mcb.5.4.768-779.1985

PubMed ID: 20857263

Title: Novel cis-active structures in the coding region mediate CRM1-dependent nuclear export of IFN-alpha 1 mRNA.

PubMed ID: 20857263

DOI: 10.1007/s00795-010-0492-5

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6310510

Title: Formation of genes coding for hybrid proteins by recombination between related, cloned genes in E. coli.

PubMed ID: 6310510

DOI: 10.1093/nar/11.16.5661

PubMed ID: 1634550

Title: Purification and characterization of multiple components of human lymphoblastoid interferon-alpha.

PubMed ID: 1634550

DOI: 10.1016/s0021-9258(18)42167-9

PubMed ID: 9425112

Title: Identification of nine interferon-alpha subtypes produced by Sendai virus-induced human peripheral blood leucocytes.

PubMed ID: 9425112

DOI: 10.1042/bj3290295

PubMed ID: 11032395

Title: IFN-alpha-1a gene is the major variant in the North American population.

PubMed ID: 11032395

DOI: 10.1089/10799900050151021

PubMed ID: 22307521

Title: Structural insights into a human anti-IFN antibody exerting therapeutic potential for systemic lupus erythematosus.

PubMed ID: 22307521

DOI: 10.1007/s00109-012-0866-3

Sequence Information:

  • Length: 189
  • Mass: 21725
  • Checksum: F32F9CB969606B69
  • Sequence:
    • MASPFALLMV LVVLSCKSSC SLGCDLPETH SLDNRRTLML LAQMSRISPS SCLMDRHDFG 
FPQEEFDGNQ FQKAPAISVL HELIQQIFNL FTTKDSSAAW DEDLLDKFCT ELYQQLNDLE 
ACVMQEERVG ETPLMNADSI LAVKKYFRRI TLYLTEKKYS PCAWEVVRAE IMRSLSLSTN 
LQERLRRKE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.