Details for: IFNAR1

Gene ID: 3454

Symbol: IFNAR1

Ensembl ID: ENSG00000142166

Description: interferon alpha and beta receptor subunit 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.69
    Marker Score: 3842
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.64
    Marker Score: 2418
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.62
    Marker Score: 966
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.6
    Marker Score: 18642
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.6
    Marker Score: 14064
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.51
    Marker Score: 1815.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.49
    Marker Score: 50642
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.47
    Marker Score: 1954
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.46
    Marker Score: 2592
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.44
    Marker Score: 3630
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.44
    Marker Score: 1537
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 1.43
    Marker Score: 1222
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.39
    Marker Score: 793
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.39
    Marker Score: 945
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.38
    Marker Score: 1455
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.37
    Marker Score: 3364
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.36
    Marker Score: 11707
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.35
    Marker Score: 471
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.35
    Marker Score: 1401
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.35
    Marker Score: 900
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.33
    Marker Score: 1189
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.32
    Marker Score: 1321.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.32
    Marker Score: 81067
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.32
    Marker Score: 615.5
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.31
    Marker Score: 765
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.3
    Marker Score: 72534
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.28
    Marker Score: 3198
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.28
    Marker Score: 12175
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.27
    Marker Score: 366
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.26
    Marker Score: 1189
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.25
    Marker Score: 5084
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 1.25
    Marker Score: 344
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.25
    Marker Score: 353
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.22
    Marker Score: 11500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.22
    Marker Score: 281
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.22
    Marker Score: 672
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.22
    Marker Score: 830
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.21
    Marker Score: 289
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.2
    Marker Score: 3220
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 1.19
    Marker Score: 314
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.19
    Marker Score: 1375
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.19
    Marker Score: 304
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.19
    Marker Score: 4610
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.18
    Marker Score: 2060
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.18
    Marker Score: 44716
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.17
    Marker Score: 285
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 1.17
    Marker Score: 409
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.17
    Marker Score: 23322
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.17
    Marker Score: 2130
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.16
    Marker Score: 2322
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.16
    Marker Score: 579
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.15
    Marker Score: 11850
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.15
    Marker Score: 565
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.15
    Marker Score: 249
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.14
    Marker Score: 4935
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.14
    Marker Score: 17106
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.14
    Marker Score: 1160
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.13
    Marker Score: 418
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.12
    Marker Score: 277
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.12
    Marker Score: 1203
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.12
    Marker Score: 1722
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.11
    Marker Score: 452
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.11
    Marker Score: 1191
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.11
    Marker Score: 8483
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.1
    Marker Score: 1829
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.1
    Marker Score: 428
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 1.1
    Marker Score: 274
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.1
    Marker Score: 2990
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.1
    Marker Score: 1287.5
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.1
    Marker Score: 728.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.09
    Marker Score: 40156
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.08
    Marker Score: 635
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.08
    Marker Score: 1892.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.08
    Marker Score: 9367.5
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.07
    Marker Score: 1079
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.07
    Marker Score: 957
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.07
    Marker Score: 27437
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.07
    Marker Score: 448
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.06
    Marker Score: 253
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.06
    Marker Score: 255
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.05
    Marker Score: 1527
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 1.05
    Marker Score: 262
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.05
    Marker Score: 11858
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 1.05
    Marker Score: 2198
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 1.04
    Marker Score: 454
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.04
    Marker Score: 2190
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.03
    Marker Score: 16195
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.03
    Marker Score: 971
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.03
    Marker Score: 35667
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.03
    Marker Score: 237
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.03
    Marker Score: 1200
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.03
    Marker Score: 2001
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 1.02
    Marker Score: 550
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.02
    Marker Score: 1321
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.02
    Marker Score: 414
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.02
    Marker Score: 937
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.02
    Marker Score: 906
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.01
    Marker Score: 232
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 1.01
    Marker Score: 265
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.01
    Marker Score: 7519

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Other Information

**Key characteristics:** * The IFNAR1 gene is located on chromosome 15q21.1 in humans. * It is a large gene, encoding a protein of 1413 amino acids. * The protein is a type I transmembrane receptor that is expressed on the surface of immune cells. * It is a member of the interferon alpha/beta receptor family. * It is a key regulator of innate and adaptive immune responses. * It plays a role in the regulation of viral infection. **Pathways and functions:** * The IFNAR1 gene is involved in a variety of immune responses, including viral infection, inflammation, and tissue repair. * It is a key regulator of the type I interferon (IFN) signaling pathway. * The IFN signaling pathway is a critical innate immune response that is activated by a variety of pathogens. * IFNAR1 is a key component of the IFN signaling pathway. * It is responsible for the production of type I interferons, which are cytokines that are critical for the innate immune response. * Type I interferons activate a variety of immune cells, including macrophages, dendritic cells, and B cells. * They also promote the activation of T cells. **Clinical significance:** * Mutations in the IFNAR1 gene have been linked to a number of human diseases, including systemic sclerosis, lupus, and tuberculosis. * These mutations can lead to the loss of function of the IFNAR1 protein, which can result in a weakened immune system and an increased susceptibility to infection. * Targeting the IFNAR1 gene has been explored as a therapeutic strategy for these diseases. **Additional notes:** * The IFNAR1 gene is also involved in the regulation of inflammation and tissue repair. * It is a key regulator of the immune response to viral infection. * It is a target for therapeutic intervention in a variety of human diseases.

Genular Protein ID: 552340339

Symbol: INAR1_HUMAN

Name: Interferon alpha/beta receptor 1

UniProtKB Accession Codes:

P17181 B2R6L9 B4DNT3 D3DSF0 Q53GW9 Q53H11 Q6PKD7 Q7M4L2 Q8WTZ2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 16 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 15 DrugCentral 1 ELM 1 EMBL 15 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 4 PIR 2 PIRSF 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 4 RefSeq 2 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2153461

Title: Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA.

PubMed ID: 2153461

DOI: 10.1016/0092-8674(90)90738-z

PubMed ID: 1370833

Title: The structure of the human interferon alpha/beta receptor gene.

PubMed ID: 1370833

DOI: 10.1016/s0021-9258(18)45950-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7813427

Title: Differential tyrosine phosphorylation of the IFNAR chain of the type I interferon receptor and of an associated surface protein in response to IFN-alpha and IFN-beta.

PubMed ID: 7813427

DOI: 10.1002/j.1460-2075.1994.tb06932.x

PubMed ID: 8307198

Title: Identification of mRNAs encoding two different soluble forms of the human interferon alpha-receptor.

PubMed ID: 8307198

DOI: 10.1016/0014-5793(94)80287-4

PubMed ID: 7526154

Title: Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase.

PubMed ID: 7526154

DOI: 10.1128/mcb.14.12.8133-8142.1994

PubMed ID: 7665574

Title: Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling.

PubMed ID: 7665574

DOI: 10.1074/jbc.270.37.21606

PubMed ID: 9121453

Title: Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling.

PubMed ID: 9121453

DOI: 10.1128/mcb.17.4.2048

PubMed ID: 10049744

Title: Formation of a uniquely stable type I interferon receptor complex by interferon beta is dependent upon particular interactions between interferon beta and its receptor and independent of tyrosine phosphorylation.

PubMed ID: 10049744

DOI: 10.1006/bbrc.1998.0105

PubMed ID: 14532120

Title: SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor.

PubMed ID: 14532120

DOI: 10.1093/emboj/cdg524

PubMed ID: 15337770

Title: Phosphorylation and specific ubiquitin acceptor sites are required for ubiquitination and degradation of the IFNAR1 subunit of type I interferon receptor.

PubMed ID: 15337770

DOI: 10.1074/jbc.m407082200

PubMed ID: 18056411

Title: Site-specific ubiquitination exposes a linear motif to promote interferon-alpha receptor endocytosis.

PubMed ID: 18056411

DOI: 10.1083/jcb.200706034

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19561067

Title: Palmitoylation of interferon-alpha (IFN-alpha) receptor subunit IFNAR1 is required for the activation of Stat1 and Stat2 by IFN-alpha.

PubMed ID: 19561067

DOI: 10.1074/jbc.m109.021915

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 24075985

Title: A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses.

PubMed ID: 24075985

DOI: 10.1016/j.celrep.2013.08.025

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 31270247

Title: Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines.

PubMed ID: 31270247

DOI: 10.1084/jem.20182295

PubMed ID: 33811647

Title: TRIM10 binds to IFN-alpha/beta receptor 1 to negatively regulate type I IFN signal transduction.

PubMed ID: 33811647

DOI: 10.1002/eji.202049073

PubMed ID: 21854986

Title: Structural linkage between ligand discrimination and receptor activation by type I interferons.

PubMed ID: 21854986

DOI: 10.1016/j.cell.2011.06.048

PubMed ID: 24704786

Title: Structural basis of recognition of interferon-alpha receptor by tyrosine kinase 2.

PubMed ID: 24704786

DOI: 10.1038/nsmb.2807

PubMed ID: 32972995

Title: Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.

PubMed ID: 32972995

DOI: 10.1126/science.abd4570

PubMed ID: 33252644

Title: A Novel Case of Homozygous Interferon Alpha/Beta Receptor Alpha Chain (IFNAR1) Deficiency With Hemophagocytic Lymphohistiocytosis.

PubMed ID: 33252644

DOI: 10.1093/cid/ciaa1790

PubMed ID: 35442418

Title: A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes.

PubMed ID: 35442418

DOI: 10.1084/jem.20220028

Sequence Information:

  • Length: 557
  • Mass: 63525
  • Checksum: 24A01779DB7F356F
  • Sequence:
    • MMVVLLGATT LVLVAVAPWV LSAAAGGKNL KSPQKVEVDI IDDNFILRWN RSDESVGNVT 
FSFDYQKTGM DNWIKLSGCQ NITSTKCNFS SLKLNVYEEI KLRIRAEKEN TSSWYEVDSF 
TPFRKAQIGP PEVHLEAEDK AIVIHISPGT KDSVMWALDG LSFTYSLVIW KNSSGVEERI 
ENIYSRHKIY KLSPETTYCL KVKAALLTSW KIGVYSPVHC IKTTVENELP PPENIEVSVQ 
NQNYVLKWDY TYANMTFQVQ WLHAFLKRNP GNHLYKWKQI PDCENVKTTQ CVFPQNVFQK 
GIYLLRVQAS DGNNTSFWSE EIKFDTEIQA FLLPPVFNIR SLSDSFHIYI GAPKQSGNTP 
VIQDYPLIYE IIFWENTSNA ERKIIEKKTD VTVPNLKPLT VYCVKARAHT MDEKLNKSSV 
FSDAVCEKTK PGNTSKIWLI VGICIALFAL PFVIYAAKVF LRCINYVFFP SLKPSSSIDE 
YFSEQPLKNL LLSTSEEQIE KCFIIENIST IATVEETNQT DEDHKKYSSQ TSQDSGNYSN 
EDESESKTSE ELQQDFV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.