Details for: IFNAR1
Gene ID: 3454
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: IFNAR1
Ensembl ID: ENSG00000142166
Description: interferon alpha and beta receptor subunit 1
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 16.97rCSI 16.67%PRS 40.49
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CSI 14.89rCSI 11.54%PRS 26.24
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CSI 12.66rCSI 23.9%PRS 34.12
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CSI 8.86rCSI 31.9%PRS 15.62
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CSI 8.39rCSI 6.95%PRS 27.32
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CSI 7.23rCSI 5.84%PRS 27.05
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CSI 6.47rCSI 15.43%PRS 29.83
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CSI 6.35rCSI 4.43%PRS 28.43
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CSI 6.29rCSI 4.84%PRS 25.31
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CSI 5.96rCSI 13.37%PRS 17.1
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CSI 5.85rCSI 16.77%PRS 39.83
-
CSI 5.54rCSI 4.66%PRS 41.31
-
CSI 5.47rCSI 8.33%PRS 24.81
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CSI 5.37rCSI 6.84%PRS 30.89
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CSI 5.08rCSI 12.35%PRS 16.11
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CSI 5.06rCSI 4.2%PRS 25.63
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CSI 4.77rCSI 11.47%PRS 41.46
-
CSI 4.73rCSI 4.95%PRS 25.11
-
CSI 4.71rCSI 12.23%PRS 33.01
-
CSI 4.45rCSI 6.09%PRS 29.6
-
CSI 4.45rCSI 17.31%PRS 43.23
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CSI 4.33rCSI 5.43%PRS 34.52
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CSI 4.3rCSI 14.39%PRS 19.66
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CSI 4.04rCSI 10.22%PRS 33
-
CSI 3.8rCSI 11.88%PRS 17.31
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CSI 3.8rCSI 27.92%PRS 17.49
-
CSI 3.78rCSI 4.61%PRS 33.17
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CSI 3.72rCSI 2.83%PRS 35.44
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CSI 3.7rCSI 9.41%PRS 26.22
-
CSI 3.67rCSI 13.86%PRS 17.15
-
CSI 3.64rCSI 3.23%PRS 27.01
-
CSI 3.64rCSI 4.35%PRS 16.3
-
CSI 3.52rCSI 16.85%PRS 23.55
-
CSI 3.49rCSI 9.21%PRS 32.06
-
CSI 3.38rCSI 2.7%PRS 45.79
-
CSI 3.29rCSI 4.76%PRS 40.03
-
CSI 3.21rCSI 3.87%PRS 32.26
-
CSI 3.15rCSI 3.28%PRS 27.59
-
CSI 3.14rCSI 6.45%PRS 25.53
-
CSI 3.04rCSI 12.25%PRS 25.23
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CSI 3.01rCSI 5.21%PRS 20.68
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CSI 2.95rCSI 2.32%PRS 32.24
-
CSI 2.83rCSI 4.52%PRS 23.02
-
CSI 2.81rCSI 2.65%PRS 28.11
-
CSI 2.8rCSI 14.04%PRS 35.27
-
CSI 2.72rCSI 3.19%PRS 37.73
-
CSI 2.7rCSI 3.6%PRS 33.94
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CSI 2.65rCSI 4.08%PRS 32.07
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CSI 2.63rCSI 4.21%PRS 60.1
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CSI 2.58rCSI 3.1%PRS 26.04
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CSI 2.36rCSI 4.89%PRS 26.57
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CSI 2.34rCSI 3.8%PRS 26.78
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CSI 2.34rCSI 1.74%PRS 38.35
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CSI 2.31rCSI 2.23%PRS 50.13
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CSI 2.28rCSI 1.69%PRS 23.09
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CSI 2.25rCSI 2.47%PRS 30.01
-
CSI 2.24rCSI 1.56%PRS 32.47
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CSI 2.21rCSI 3.06%PRS 34.99
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CSI 2.2rCSI 8.24%PRS 22.69
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CSI 2.2rCSI 1.58%PRS 36.64
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CSI 2.19rCSI 5.41%PRS 25.12
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CSI 2.13rCSI 2.63%PRS 23.73
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CSI 2.12rCSI 5.04%PRS 32.43
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CSI 2.1rCSI 1.94%PRS 27.99
-
CSI 2.08rCSI 5.42%PRS 25.57
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CSI 2.06rCSI 1.67%PRS 27.99
-
CSI 2.04rCSI 2.79%PRS 30.33
-
CSI 2.04rCSI 1.87%PRS 31.99
-
CSI 2.01rCSI 3.24%PRS 38.35
-
CSI 1.99rCSI 3.15%PRS 34.45
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CSI 1.94rCSI 2.24%PRS 20.03
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CSI 1.93rCSI 5.71%PRS 31.24
-
CSI 1.93rCSI 3.88%PRS 20.05
-
CSI 1.93rCSI 2.57%PRS 29.61
-
CSI 1.93rCSI 4.4%PRS 23.09
-
CSI 1.92rCSI 9.45%PRS 35.91
-
CSI 1.9rCSI 1.83%PRS 27.76
-
CSI 1.9rCSI 1.87%PRS 28.83
-
CSI 1.88rCSI 2.56%PRS 23.43
-
CSI 1.85rCSI 43.02%PRS 48
-
CSI 1.84rCSI 2.42%PRS 72.3
-
CSI 1.84rCSI 2.07%PRS 41.51
-
CSI 1.83rCSI 1.87%PRS 45.89
-
CSI 1.83rCSI 10.76%PRS 17.31
-
CSI 1.82rCSI 4.27%PRS 37.05
-
CSI 1.81rCSI 2.58%PRS 29.76
-
CSI 1.81rCSI 10.41%PRS 32.11
-
CSI 1.8rCSI 2.26%PRS 39.46
-
CSI 1.79rCSI 5.58%PRS 18.8
-
CSI 1.78rCSI 4.26%PRS 38.55
-
CSI 1.77rCSI 2.71%PRS 30.66
-
CSI 1.75rCSI 2.49%PRS 25.01
-
CSI 1.75rCSI 1.52%PRS 30.05
-
CSI 1.7rCSI 1.58%PRS 26.91
-
CSI 1.69rCSI 2.48%PRS 35.03
-
CSI 1.68rCSI 2.95%PRS 21.08
-
CSI 1.67rCSI 4.32%PRS 24.79
-
CSI 1.67rCSI 1.46%PRS 30.74
-
CSI 1.64rCSI 1.24%PRS 36.4
-
CSI 1.63rCSI 2.96%PRS 40.39
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CSI 0.2rCSI 1.8%PRS 44.9%
-
CSI 0.2rCSI 1.1%PRS 48.0%
-
CSI 0.2rCSI 1.1%PRS 38.5%
-
CSI 0.2rCSI 0.6%PRS 21.2%
-
CSI 0.2rCSI 4.1%PRS 59.4%
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CSI 0.3rCSI 1.4%PRS 37.9%
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CSI 0.3rCSI 3.6%PRS 47.8%
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CSI 0.4rCSI 1.8%PRS 49.3%
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CSI 0.4rCSI 1.0%PRS 30.0%
-
CSI 0.4rCSI 2.9%PRS 47.1%
-
CSI 0.4rCSI 1.3%PRS 41.3%
-
CSI 0.4rCSI 2.3%PRS 53.5%
-
CSI 0.4rCSI 2.3%PRS 40.3%
-
CSI 0.5rCSI 2.7%PRS 38.2%
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CSI 0.5rCSI 1.4%PRS 44.4%
-
CSI 0.5rCSI 2.3%PRS 50.3%
-
CSI 0.5rCSI 0.4%PRS 39.2%
-
CSI 0.5rCSI 1.3%PRS 20.7%
-
CSI 0.5rCSI 1.1%PRS 24.8%
-
CSI 0.5rCSI 2.3%PRS 75.2%
-
CSI 0.6rCSI 2.4%PRS 26.1%
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CSI 0.6rCSI 3.1%PRS 43.5%
-
CSI 0.6rCSI 1.9%PRS 35.9%
-
CSI 0.6rCSI 1.7%PRS 32.4%
-
CSI 0.6rCSI 1.2%PRS 27.8%
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CSI 0.6rCSI 2.3%PRS 67.7%
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CSI 0.6rCSI 1.0%PRS 20.7%
-
CSI 0.7rCSI 1.9%PRS 42.1%
-
CSI 0.7rCSI 2.9%PRS 46.3%
-
CSI 0.7rCSI 1.8%PRS 34.6%
-
CSI 0.7rCSI 2.6%PRS 35.9%
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CSI 0.7rCSI 1.4%PRS 43.2%
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CSI 0.7rCSI 5.0%PRS 59.7%
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CSI 0.7rCSI 1.9%PRS 42.4%
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CSI 0.7rCSI 4.0%PRS 16.8%
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CSI 0.8rCSI 2.2%PRS 45.5%
-
CSI 0.8rCSI 0.9%PRS 30.6%
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CSI 0.8rCSI 1.7%PRS 35.4%
-
CSI 0.8rCSI 1.8%PRS 19.4%
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CSI 0.8rCSI 2.9%PRS 43.6%
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CSI 0.8rCSI 2.3%PRS 22.5%
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CSI 0.8rCSI 2.0%PRS 38.6%
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CSI 0.9rCSI 1.3%PRS 25.3%
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CSI 0.9rCSI 1.1%PRS 37.6%
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CSI 0.9rCSI 1.3%PRS 21.2%
-
CSI 0.9rCSI 1.5%PRS 31.4%
-
CSI 0.9rCSI 0.9%PRS 46.0%
-
CSI 1.0rCSI 1.2%PRS 30.9%
-
CSI 1.0rCSI 0.7%PRS 43.4%
-
CSI 1.0rCSI 1.2%PRS 25.7%
-
CSI 1.0rCSI 1.5%PRS 27.6%
-
CSI 1.0rCSI 1.6%PRS 17.9%
-
CSI 1.0rCSI 1.4%PRS 29.7%
-
CSI 1.0rCSI 0.9%PRS 24.5%
-
CSI 1.0rCSI 0.9%PRS 33.6%
-
CSI 1.0rCSI 1.8%PRS 22.4%
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CSI 1.0rCSI 1.7%PRS 35.5%
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CSI 1.0rCSI 2.4%PRS 37.9%
-
CSI 1.0rCSI 1.2%PRS 49.8%
-
CSI 1.0rCSI 1.9%PRS 19.8%
-
CSI 1.0rCSI 1.4%PRS 38.9%
-
CSI 1.0rCSI 2.4%PRS 27.2%
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CSI 1.0rCSI 2.5%PRS 44.4%
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CSI 1.1rCSI 3.1%PRS 49.8%
-
CSI 1.1rCSI 9.1%PRS 16.2%
-
CSI 1.1rCSI 1.6%PRS 28.6%
-
CSI 1.1rCSI 1.6%PRS 41.0%
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CSI 1.1rCSI 1.9%PRS 42.2%
-
CSI 1.1rCSI 1.6%PRS 24.9%
-
CSI 1.1rCSI 1.7%PRS 44.4%
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CSI 1.1rCSI 1.9%PRS 16.5%
-
CSI 1.1rCSI 2.0%PRS 26.2%
-
CSI 1.1rCSI 2.0%PRS 23.1%
-
CSI 1.1rCSI 1.4%PRS 17.1%
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CSI 1.1rCSI 1.6%PRS 35.0%
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CSI 1.1rCSI 1.7%PRS 34.4%
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CSI 1.1rCSI 1.8%PRS 27.2%
-
CSI 1.2rCSI 1.2%PRS 37.7%
-
CSI 1.2rCSI 1.9%PRS 29.5%
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CSI 1.2rCSI 2.1%PRS 56.2%
-
CSI 1.2rCSI 2.7%PRS 55.5%
-
CSI 1.2rCSI 1.3%PRS 43.0%
-
CSI 1.2rCSI 2.7%PRS 31.4%
-
CSI 1.2rCSI 4.8%PRS 27.3%
-
CSI 1.2rCSI 1.0%PRS 31.5%
-
CSI 1.2rCSI 1.7%PRS 40.6%
-
CSI 1.2rCSI 2.7%PRS 30.5%
-
CSI 1.2rCSI 1.3%PRS 27.6%
-
CSI 1.3rCSI 1.3%PRS 31.7%
-
CSI 1.3rCSI 1.9%PRS 30.6%
-
CSI 1.3rCSI 1.4%PRS 24.9%
-
CSI 1.3rCSI 3.0%PRS 21.9%
-
CSI 1.3rCSI 1.5%PRS 37.7%
-
CSI 1.3rCSI 3.5%PRS 49.0%
-
CSI 1.3rCSI 2.9%PRS 47.9%
-
CSI 1.3rCSI 0.9%PRS 33.4%
-
CSI 1.3rCSI 32.2%PRS 16.3%
-
CSI 1.3rCSI 1.3%PRS 23.0%
-
CSI 1.3rCSI 1.7%PRS 28.8%
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CSI 1.3rCSI 1.6%PRS 44.5%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 552340339
Symbol: INAR1_HUMAN
Name: Interferon alpha/beta receptor 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2153461
Title: Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA.
PubMed ID: 2153461
PubMed ID: 1370833
Title: The structure of the human interferon alpha/beta receptor gene.
PubMed ID: 1370833
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 10830953
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 7813427
Title: Differential tyrosine phosphorylation of the IFNAR chain of the type I interferon receptor and of an associated surface protein in response to IFN-alpha and IFN-beta.
PubMed ID: 7813427
PubMed ID: 8307198
Title: Identification of mRNAs encoding two different soluble forms of the human interferon alpha-receptor.
PubMed ID: 8307198
PubMed ID: 7526154
Title: Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase.
PubMed ID: 7526154
PubMed ID: 7665574
Title: Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling.
PubMed ID: 7665574
PubMed ID: 9121453
Title: Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling.
PubMed ID: 9121453
PubMed ID: 10049744
Title: Formation of a uniquely stable type I interferon receptor complex by interferon beta is dependent upon particular interactions between interferon beta and its receptor and independent of tyrosine phosphorylation.
PubMed ID: 10049744
PubMed ID: 14532120
Title: SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor.
PubMed ID: 14532120
DOI: 10.1093/emboj/cdg524
PubMed ID: 15337770
Title: Phosphorylation and specific ubiquitin acceptor sites are required for ubiquitination and degradation of the IFNAR1 subunit of type I interferon receptor.
PubMed ID: 15337770
PubMed ID: 18056411
Title: Site-specific ubiquitination exposes a linear motif to promote interferon-alpha receptor endocytosis.
PubMed ID: 18056411
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19561067
Title: Palmitoylation of interferon-alpha (IFN-alpha) receptor subunit IFNAR1 is required for the activation of Stat1 and Stat2 by IFN-alpha.
PubMed ID: 19561067
PubMed ID: 19349973
Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.
PubMed ID: 19349973
DOI: 10.1038/nbt.1532
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 24075985
Title: A BRISC-SHMT complex deubiquitinates IFNAR1 and regulates interferon responses.
PubMed ID: 24075985
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 31270247
Title: Inherited IFNAR1 deficiency in otherwise healthy patients with adverse reaction to measles and yellow fever live vaccines.
PubMed ID: 31270247
DOI: 10.1084/jem.20182295
PubMed ID: 33811647
Title: TRIM10 binds to IFN-alpha/beta receptor 1 to negatively regulate type I IFN signal transduction.
PubMed ID: 33811647
PubMed ID: 21854986
Title: Structural linkage between ligand discrimination and receptor activation by type I interferons.
PubMed ID: 21854986
PubMed ID: 24704786
Title: Structural basis of recognition of interferon-alpha receptor by tyrosine kinase 2.
PubMed ID: 24704786
DOI: 10.1038/nsmb.2807
PubMed ID: 32972995
Title: Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.
PubMed ID: 32972995
PubMed ID: 33252644
Title: A Novel Case of Homozygous Interferon Alpha/Beta Receptor Alpha Chain (IFNAR1) Deficiency With Hemophagocytic Lymphohistiocytosis.
PubMed ID: 33252644
DOI: 10.1093/cid/ciaa1790
PubMed ID: 35442418
Title: A loss-of-function IFNAR1 allele in Polynesia underlies severe viral diseases in homozygotes.
PubMed ID: 35442418
DOI: 10.1084/jem.20220028
Sequence Information:
- Length: 557
- Mass: 63525
- Checksum: 24A01779DB7F356F
- Sequence:
MMVVLLGATT LVLVAVAPWV LSAAAGGKNL KSPQKVEVDI IDDNFILRWN RSDESVGNVT FSFDYQKTGM DNWIKLSGCQ NITSTKCNFS SLKLNVYEEI KLRIRAEKEN TSSWYEVDSF TPFRKAQIGP PEVHLEAEDK AIVIHISPGT KDSVMWALDG LSFTYSLVIW KNSSGVEERI ENIYSRHKIY KLSPETTYCL KVKAALLTSW KIGVYSPVHC IKTTVENELP PPENIEVSVQ NQNYVLKWDY TYANMTFQVQ WLHAFLKRNP GNHLYKWKQI PDCENVKTTQ CVFPQNVFQK GIYLLRVQAS DGNNTSFWSE EIKFDTEIQA FLLPPVFNIR SLSDSFHIYI GAPKQSGNTP VIQDYPLIYE IIFWENTSNA ERKIIEKKTD VTVPNLKPLT VYCVKARAHT MDEKLNKSSV FSDAVCEKTK PGNTSKIWLI VGICIALFAL PFVIYAAKVF LRCINYVFFP SLKPSSSIDE YFSEQPLKNL LLSTSEEQIE KCFIIENIST IATVEETNQT DEDHKKYSSQ TSQDSGNYSN EDESESKTSE ELQQDFV