Details for: IL12A

Gene ID: 3592

Symbol: IL12A

Ensembl ID: ENSG00000168811

Description: interleukin 12A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 13.6938
    Cell Significance Index: -2.1300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 5.4801
    Cell Significance Index: -1.3900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.8049
    Cell Significance Index: 12.1300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6090
    Cell Significance Index: 115.8900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 0.5525
    Cell Significance Index: -2.1800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5046
    Cell Significance Index: 49.9200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4599
    Cell Significance Index: 9.8000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3544
    Cell Significance Index: 319.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2668
    Cell Significance Index: 43.4000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2628
    Cell Significance Index: 28.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1892
    Cell Significance Index: 11.3600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1318
    Cell Significance Index: 9.1200
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.0964
    Cell Significance Index: 0.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0715
    Cell Significance Index: 3.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0594
    Cell Significance Index: 3.7500
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.0443
    Cell Significance Index: 0.5600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0413
    Cell Significance Index: 1.1900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0262
    Cell Significance Index: 0.7500
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.0252
    Cell Significance Index: 0.2900
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: 0.0193
    Cell Significance Index: 0.2700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0175
    Cell Significance Index: 0.3800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0077
    Cell Significance Index: 0.1600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0068
    Cell Significance Index: 0.1700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0048
    Cell Significance Index: 0.1700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0032
    Cell Significance Index: 0.6400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0010
    Cell Significance Index: 0.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0003
    Cell Significance Index: 0.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0008
    Cell Significance Index: -0.3400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0011
    Cell Significance Index: -2.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0016
    Cell Significance Index: -2.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0019
    Cell Significance Index: -2.9200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0020
    Cell Significance Index: -2.7700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0022
    Cell Significance Index: -0.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0025
    Cell Significance Index: -0.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0025
    Cell Significance Index: -1.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0026
    Cell Significance Index: -0.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0029
    Cell Significance Index: -0.5900
  • Cell Name: ionocyte (CL0005006)
    Fold Change: -0.0029
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0032
    Cell Significance Index: -2.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0039
    Cell Significance Index: -2.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0049
    Cell Significance Index: -2.2100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0049
    Cell Significance Index: -0.2300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0051
    Cell Significance Index: -1.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0052
    Cell Significance Index: -0.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0064
    Cell Significance Index: -1.1600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0077
    Cell Significance Index: -0.4000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0078
    Cell Significance Index: -0.4800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0078
    Cell Significance Index: -0.5800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0079
    Cell Significance Index: -0.3700
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.0089
    Cell Significance Index: -0.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0092
    Cell Significance Index: -1.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0101
    Cell Significance Index: -1.7300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0102
    Cell Significance Index: -1.2500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0109
    Cell Significance Index: -2.3000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0129
    Cell Significance Index: -1.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0136
    Cell Significance Index: -0.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0137
    Cell Significance Index: -1.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0142
    Cell Significance Index: -1.4500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0178
    Cell Significance Index: -0.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0184
    Cell Significance Index: -1.1900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0195
    Cell Significance Index: -0.1400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0197
    Cell Significance Index: -0.6300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0200
    Cell Significance Index: -0.8200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0204
    Cell Significance Index: -0.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0207
    Cell Significance Index: -1.2700
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0222
    Cell Significance Index: -0.4800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0246
    Cell Significance Index: -0.6600
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0247
    Cell Significance Index: -0.2500
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.0264
    Cell Significance Index: -0.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0274
    Cell Significance Index: -2.1000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0286
    Cell Significance Index: -0.4100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0295
    Cell Significance Index: -0.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0305
    Cell Significance Index: -0.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0305
    Cell Significance Index: -2.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0323
    Cell Significance Index: -0.8800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0334
    Cell Significance Index: -1.7400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0383
    Cell Significance Index: -2.0100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0387
    Cell Significance Index: -0.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0406
    Cell Significance Index: -2.2800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0411
    Cell Significance Index: -1.1000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0411
    Cell Significance Index: -1.0500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0420
    Cell Significance Index: -1.5400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0430
    Cell Significance Index: -1.5100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0440
    Cell Significance Index: -0.7400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0447
    Cell Significance Index: -0.6100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0455
    Cell Significance Index: -1.3400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0465
    Cell Significance Index: -1.6200
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.0492
    Cell Significance Index: -0.6900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0519
    Cell Significance Index: -0.7200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0524
    Cell Significance Index: -1.5400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0534
    Cell Significance Index: -1.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0543
    Cell Significance Index: -2.4000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0580
    Cell Significance Index: -1.9000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0592
    Cell Significance Index: -1.5800
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0596
    Cell Significance Index: -0.7700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0607
    Cell Significance Index: -1.2100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0607
    Cell Significance Index: -0.8700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0619
    Cell Significance Index: -1.5000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0637
    Cell Significance Index: -2.0300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0640
    Cell Significance Index: -2.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IL12A is a subunit of the IL-12 heterodimer, which is composed of IL12A and IL12B. It is primarily expressed in antigen-presenting cells (APCs), such as dendritic cells and macrophages, as well as in certain epithelial cells, including goblet cells and intestinal crypt stem cells. IL12A is encoded by the IL12A gene, which is located on chromosome 2q33.1. **Pathways and Functions:** IL12A is involved in various cellular processes, including: 1. **Cytokine signaling:** IL12A interacts with the IL-12 receptor, which triggers a signaling cascade that leads to the activation of T cells, NK cells, and other immune cells. 2. **Immune response:** IL12A promotes the activation of T cells, particularly T-helper 17 (Th17) cells, which are essential for the defense against fungal infections and cancer. 3. **NK cell activation:** IL12A stimulates the activation of NK cells, which are critical for the control of viral infections and tumor metastasis. 4. **Apoptosis:** IL12A can induce apoptosis in certain cell types, including cancer cells. 5. **Angiogenesis:** IL12A can inhibit angiogenesis by suppressing the expression of vascular endothelial growth factor (VEGF). **Clinical Significance:** IL12A has been implicated in various diseases, including: 1. **Cancer:** IL12A has been shown to inhibit tumor growth and metastasis by promoting the activation of NK cells and the induction of apoptosis in cancer cells. 2. **Autoimmune diseases:** IL12A has been implicated in the pathogenesis of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis, by promoting the activation of T cells and the production of pro-inflammatory cytokines. 3. **Infectious diseases:** IL12A plays a critical role in the defense against viral infections, such as HIV and influenza, by promoting the activation of T cells and NK cells. 4. **Immunodeficiency disorders:** IL12A has been shown to be deficient in individuals with immunodeficiency disorders, such as chronic granulomatous disease (CGD), which can lead to increased susceptibility to infections. In conclusion, IL12A is a critical cytokine that plays a pivotal role in the regulation of the immune response, particularly in the activation of T cells and NK cells. Its dysregulation has been implicated in various diseases, including cancer, autoimmune diseases, and infectious diseases. Further research is needed to fully understand the mechanisms of IL12A and its potential therapeutic applications.

Genular Protein ID: 2153106993

Symbol: IL12A_HUMAN

Name: Interleukin-12 subunit alpha

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1673147

Title: Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells.

PubMed ID: 1673147

PubMed ID: 1674604

Title: Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.

PubMed ID: 1674604

DOI: 10.1073/pnas.88.10.4143

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 2204066

Title: Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells.

PubMed ID: 2204066

DOI: 10.1073/pnas.87.17.6808

PubMed ID: 1374259

Title: Sequence similarity between NKSF and the IL-6/G-CSF family.

PubMed ID: 1374259

DOI: 10.1016/0167-5699(92)90140-3

PubMed ID: 7528775

Title: Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12.

PubMed ID: 7528775

DOI: 10.1084/jem.181.1.399

PubMed ID: 7638186

Title: Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.

PubMed ID: 7638186

DOI: 10.1073/pnas.92.16.7307

PubMed ID: 8605935

Title: Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells.

PubMed ID: 8605935

DOI: 10.1002/eji.1830260323

PubMed ID: 8943050

Title: A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits.

PubMed ID: 8943050

DOI: 10.1073/pnas.93.24.14002

PubMed ID: 9342359

Title: Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin.

PubMed ID: 9342359

DOI: 10.1073/pnas.94.22.12041

PubMed ID: 16548883

Title: Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.

PubMed ID: 16548883

DOI: 10.1111/j.1462-5822.2005.00644.x

PubMed ID: 22306691

Title: The composition and signaling of the IL-35 receptor are unconventional.

PubMed ID: 22306691

DOI: 10.1038/ni.2227

PubMed ID: 10899108

Title: Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12.

PubMed ID: 10899108

DOI: 10.1093/emboj/19.14.3530

PubMed ID: 20691190

Title: Structural basis for the dual recognition of IL-12 and IL-23 by ustekinumab.

PubMed ID: 20691190

DOI: 10.1016/j.jmb.2010.07.046

Sequence Information:

  • Length: 219
  • Mass: 24874
  • Checksum: 7C658AB7716112B2
  • Sequence:
  • MCPARSLLLV ATLVLLDHLS LARNLPVATP DPGMFPCLHH SQNLLRAVSN MLQKARQTLE 
    FYPCTSEEID HEDITKDKTS TVEACLPLEL TKNESCLNSR ETSFITNGSC LASRKTSFMM 
    ALCLSSIYED LKMYQVEFKT MNAKLLMDPK RQIFLDQNML AVIDELMQAL NFNSETVPQK 
    SSLEEPDFYK TKIKLCILLH AFRIRAVTID RVMSYLNAS

Genular Protein ID: 2142037082

Symbol: O60595_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

  • Length: 253
  • Mass: 28293
  • Checksum: FAC56ACD2A620BD5
  • Sequence:
  • MWPPGSASQP PPSPAAATGL HPAARPVSLQ CRLSMCPARS LLLVATLVLL DHLSLARNLP 
    VATPDPGMFP CLHHSQNLLR AVSNMLQKAR QTLEFYPCTS EEIDHEDITK DKTSTVEACL 
    PLELTKNESC LNSRETSFIT NGSCLASRKT SFMMALCLSS IYEDLKMYQV EFKTMNAKLL 
    MDPKRQIFLD QNMLAVIDEL MQALNFNSET VPQKSSLEEP DFYKTKIKLC ILLHAFRIRA 
    VTIDRVMSYL NAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.