Details for: IL12A
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 13.6938
Cell Significance Index: -2.1300 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 5.4801
Cell Significance Index: -1.3900 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.8049
Cell Significance Index: 12.1300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.6090
Cell Significance Index: 115.8900 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 0.5525
Cell Significance Index: -2.1800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.5046
Cell Significance Index: 49.9200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.4599
Cell Significance Index: 9.8000 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.3544
Cell Significance Index: 319.9600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.2668
Cell Significance Index: 43.4000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.2628
Cell Significance Index: 28.5900 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.1892
Cell Significance Index: 11.3600 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1318
Cell Significance Index: 9.1200 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.0964
Cell Significance Index: 0.6400 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0715
Cell Significance Index: 3.2400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0594
Cell Significance Index: 3.7500 - Cell Name: mesangial cell (CL0000650)
Fold Change: 0.0443
Cell Significance Index: 0.5600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0413
Cell Significance Index: 1.1900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.0262
Cell Significance Index: 0.7500 - Cell Name: myometrial cell (CL0002366)
Fold Change: 0.0252
Cell Significance Index: 0.2900 - Cell Name: melanocyte of skin (CL1000458)
Fold Change: 0.0193
Cell Significance Index: 0.2700 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0175
Cell Significance Index: 0.3800 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.0077
Cell Significance Index: 0.1600 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0068
Cell Significance Index: 0.1700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0048
Cell Significance Index: 0.1700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0032
Cell Significance Index: 0.6400 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0010
Cell Significance Index: 0.1300 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0003
Cell Significance Index: 0.1400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0008
Cell Significance Index: -0.3400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0011
Cell Significance Index: -2.0600 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0016
Cell Significance Index: -2.9200 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0019
Cell Significance Index: -2.9200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0020
Cell Significance Index: -2.7700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0022
Cell Significance Index: -0.2600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0025
Cell Significance Index: -0.7100 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0025
Cell Significance Index: -1.9200 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0026
Cell Significance Index: -0.3400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0029
Cell Significance Index: -0.5900 - Cell Name: ionocyte (CL0005006)
Fold Change: -0.0029
Cell Significance Index: -0.0300 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0032
Cell Significance Index: -2.3500 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0039
Cell Significance Index: -2.1900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0049
Cell Significance Index: -2.2100 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0049
Cell Significance Index: -0.2300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.0051
Cell Significance Index: -1.8200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0052
Cell Significance Index: -0.6000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.0064
Cell Significance Index: -1.1600 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.0077
Cell Significance Index: -0.4000 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0078
Cell Significance Index: -0.4800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0078
Cell Significance Index: -0.5800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0079
Cell Significance Index: -0.3700 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: -0.0089
Cell Significance Index: -0.0900 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0092
Cell Significance Index: -1.0900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0101
Cell Significance Index: -1.7300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.0102
Cell Significance Index: -1.2500 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0109
Cell Significance Index: -2.3000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0129
Cell Significance Index: -1.7700 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0136
Cell Significance Index: -0.3500 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0137
Cell Significance Index: -1.9900 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0142
Cell Significance Index: -1.4500 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0178
Cell Significance Index: -0.9000 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0184
Cell Significance Index: -1.1900 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: -0.0195
Cell Significance Index: -0.1400 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0197
Cell Significance Index: -0.6300 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0200
Cell Significance Index: -0.8200 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.0204
Cell Significance Index: -0.5700 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0207
Cell Significance Index: -1.2700 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.0222
Cell Significance Index: -0.4800 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.0246
Cell Significance Index: -0.6600 - Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: -0.0247
Cell Significance Index: -0.2500 - Cell Name: thyroid follicular cell (CL0002258)
Fold Change: -0.0264
Cell Significance Index: -0.2800 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0274
Cell Significance Index: -2.1000 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0286
Cell Significance Index: -0.4100 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.0295
Cell Significance Index: -0.3100 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0305
Cell Significance Index: -0.5100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0305
Cell Significance Index: -2.0500 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0323
Cell Significance Index: -0.8800 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0334
Cell Significance Index: -1.7400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0383
Cell Significance Index: -2.0100 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0387
Cell Significance Index: -0.8100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0406
Cell Significance Index: -2.2800 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0411
Cell Significance Index: -1.1000 - Cell Name: pro-T cell (CL0000827)
Fold Change: -0.0411
Cell Significance Index: -1.0500 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0420
Cell Significance Index: -1.5400 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0430
Cell Significance Index: -1.5100 - Cell Name: hepatoblast (CL0005026)
Fold Change: -0.0440
Cell Significance Index: -0.7400 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.0447
Cell Significance Index: -0.6100 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0455
Cell Significance Index: -1.3400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.0465
Cell Significance Index: -1.6200 - Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
Fold Change: -0.0492
Cell Significance Index: -0.6900 - Cell Name: epithelial cell of uterus (CL0002149)
Fold Change: -0.0519
Cell Significance Index: -0.7200 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.0524
Cell Significance Index: -1.5400 - Cell Name: lens fiber cell (CL0011004)
Fold Change: -0.0534
Cell Significance Index: -1.6900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0543
Cell Significance Index: -2.4000 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.0580
Cell Significance Index: -1.9000 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0592
Cell Significance Index: -1.5800 - Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: -0.0596
Cell Significance Index: -0.7700 - Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -0.0607
Cell Significance Index: -1.2100 - Cell Name: proerythroblast (CL0000547)
Fold Change: -0.0607
Cell Significance Index: -0.8700 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0619
Cell Significance Index: -1.5000 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.0637
Cell Significance Index: -2.0300 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.0640
Cell Significance Index: -2.4300
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2153106993
Symbol: IL12A_HUMAN
Name: Interleukin-12 subunit alpha
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 1673147
Title: Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells.
PubMed ID: 1673147
PubMed ID: 1674604
Title: Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.
PubMed ID: 1674604
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 2204066
Title: Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells.
PubMed ID: 2204066
PubMed ID: 1374259
Title: Sequence similarity between NKSF and the IL-6/G-CSF family.
PubMed ID: 1374259
PubMed ID: 7528775
Title: Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12.
PubMed ID: 7528775
PubMed ID: 7638186
Title: Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.
PubMed ID: 7638186
PubMed ID: 8605935
Title: Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells.
PubMed ID: 8605935
PubMed ID: 8943050
Title: A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits.
PubMed ID: 8943050
PubMed ID: 9342359
Title: Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin.
PubMed ID: 9342359
PubMed ID: 16548883
Title: Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.
PubMed ID: 16548883
PubMed ID: 22306691
Title: The composition and signaling of the IL-35 receptor are unconventional.
PubMed ID: 22306691
DOI: 10.1038/ni.2227
PubMed ID: 10899108
Title: Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12.
PubMed ID: 10899108
PubMed ID: 20691190
Title: Structural basis for the dual recognition of IL-12 and IL-23 by ustekinumab.
PubMed ID: 20691190
Sequence Information:
- Length: 219
- Mass: 24874
- Checksum: 7C658AB7716112B2
- Sequence:
MCPARSLLLV ATLVLLDHLS LARNLPVATP DPGMFPCLHH SQNLLRAVSN MLQKARQTLE FYPCTSEEID HEDITKDKTS TVEACLPLEL TKNESCLNSR ETSFITNGSC LASRKTSFMM ALCLSSIYED LKMYQVEFKT MNAKLLMDPK RQIFLDQNML AVIDELMQAL NFNSETVPQK SSLEEPDFYK TKIKLCILLH AFRIRAVTID RVMSYLNAS
Genular Protein ID: 2142037082
Symbol: O60595_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 11181995
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
Sequence Information:
- Length: 253
- Mass: 28293
- Checksum: FAC56ACD2A620BD5
- Sequence:
MWPPGSASQP PPSPAAATGL HPAARPVSLQ CRLSMCPARS LLLVATLVLL DHLSLARNLP VATPDPGMFP CLHHSQNLLR AVSNMLQKAR QTLEFYPCTS EEIDHEDITK DKTSTVEACL PLELTKNESC LNSRETSFIT NGSCLASRKT SFMMALCLSS IYEDLKMYQV EFKTMNAKLL MDPKRQIFLD QNMLAVIDEL MQALNFNSET VPQKSSLEEP DFYKTKIKLC ILLHAFRIRA VTIDRVMSYL NAS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.