Gene IL12A - ENSG00000168811 | NCBI Gene ID: 3592

Details for: IL12A

Gene ID: 3592

Symbol: IL12A

Ensembl ID: ENSG00000168811

Description: interleukin 12A

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Immune system
(R-HSA-168256)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Interleukin-10 signaling
(R-HSA-6783783)
Interleukin-12 family signaling
(R-HSA-447115)
Interleukin-12 signaling
(R-HSA-9020591)
Interleukin-35 signalling
(R-HSA-8984722)
Signaling by interleukins
(R-HSA-449147)
Cell migration
(GO:0016477)
Cellular response to virus
(GO:0098586)
Cytokine activity
(GO:0005125)
Defense response to gram-positive bacterium
(GO:0050830)
Endoplasmic reticulum lumen
(GO:0005788)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Extrinsic apoptotic signaling pathway
(GO:0097191)
Growth factor activity
(GO:0008083)
Immune response
(GO:0006955)
Interleukin-12 beta subunit binding
(GO:0042163)
Interleukin-12 complex
(GO:0043514)
Interleukin-12 receptor binding
(GO:0005143)
Interleukin-12-mediated signaling pathway
(GO:0035722)
Interleukin-27 binding
(GO:0045513)
Late endosome lumen
(GO:0031906)
Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
(GO:1903588)
Negative regulation of interleukin-17 production
(GO:0032700)
Negative regulation of protein secretion
(GO:0050709)
Negative regulation of smooth muscle cell proliferation
(GO:0048662)
Negative regulation of vascular endothelial growth factor signaling pathway
(GO:1900747)
Positive regulation of cell adhesion
(GO:0045785)
Positive regulation of dendritic cell chemotaxis
(GO:2000510)
Positive regulation of lymphocyte proliferation
(GO:0050671)
Positive regulation of mononuclear cell proliferation
(GO:0032946)
Positive regulation of natural killer cell activation
(GO:0032816)
Positive regulation of natural killer cell mediated cytotoxicity
(GO:0045954)
Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
(GO:0002860)
Positive regulation of nk t cell activation
(GO:0051135)
Positive regulation of smooth muscle cell apoptotic process
(GO:0034393)
Positive regulation of t cell mediated cytotoxicity
(GO:0001916)
Positive regulation of type ii interferon production
(GO:0032729)
Positive regulation of tyrosine phosphorylation of stat protein
(GO:0042531)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Response to lipopolysaccharide
(GO:0032496)
Response to uv-b
(GO:0010224)
Response to virus
(GO:0009615)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.61
Marker Score: 1170
Cell Name: T-helper 17 cell (CL0000899)
Fold Change: 1.05
Marker Score: 686
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71831
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48056
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.98
Marker Score: 506
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30409
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.97
Marker Score: 459
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5337
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.93
Marker Score: 371
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2740
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.91
Marker Score: 614.5
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9
Marker Score: 323
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.88
Marker Score: 363.5
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5288
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.78
Marker Score: 1616
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1261
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 701
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 394
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.76
Marker Score: 3182
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.74
Marker Score: 569
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 175
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.56
Marker Score: 8809
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.51
Marker Score: 326.5
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.51
Marker Score: 538
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.39
Marker Score: 738
Cell Name: plasmablast (CL0000980)
Fold Change: 0.39
Marker Score: 513
Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
Fold Change: 0.36
Marker Score: 275
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.35
Marker Score: 721.5
Cell Name: interstitial cell of Cajal (CL0002088)
Fold Change: 0.26
Marker Score: 90
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.24
Marker Score: 3621
Cell Name: renal beta-intercalated cell (CL0002201)
Fold Change: 0.23
Marker Score: 74
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.23
Marker Score: 72
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.22
Marker Score: 135
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.22
Marker Score: 63
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.22
Marker Score: 69
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.22
Marker Score: 418
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.21
Marker Score: 72
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.21
Marker Score: 119
Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 0.21
Marker Score: 109
Cell Name: CD8-positive, alpha-beta cytotoxic T cell (CL0000794)
Fold Change: 0.21
Marker Score: 181
Cell Name: gut endothelial cell (CL0000131)
Fold Change: 0.2
Marker Score: 73
Cell Name: plasmacytoid dendritic cell (CL0000784)
Fold Change: 0.2
Marker Score: 109
Cell Name: tracheal goblet cell (CL1000329)
Fold Change: 0.19
Marker Score: 527
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.19
Marker Score: 78
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.19
Marker Score: 85
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.19
Marker Score: 123
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.17
Marker Score: 83
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.17
Marker Score: 1463
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.17
Marker Score: 44
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 41
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 0.16
Marker Score: 410
Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.16
Marker Score: 60
Cell Name: IgG plasma cell (CL0000985)
Fold Change: 0.16
Marker Score: 68
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.15
Marker Score: 348
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 0.14
Marker Score: 105
Cell Name: thymocyte (CL0000893)
Fold Change: 0.14
Marker Score: 147
Cell Name: ciliated cell (CL0000064)
Fold Change: 0.14
Marker Score: 474
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.14
Marker Score: 50
Cell Name: renal principal cell (CL0005009)
Fold Change: 0.14
Marker Score: 106
Cell Name: IgM plasma cell (CL0000986)
Fold Change: 0.13
Marker Score: 46
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 0.13
Marker Score: 210
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.12
Marker Score: 39
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.12
Marker Score: 108
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 0.12
Marker Score: 1043
Cell Name: plasma cell (CL0000786)
Fold Change: 0.12
Marker Score: 134
Cell Name: goblet cell (CL0000160)
Fold Change: 0.12
Marker Score: 795
Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
Fold Change: 0.12
Marker Score: 35
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.11
Marker Score: 50
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 0.11
Marker Score: 38
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 0.11
Marker Score: 64
Cell Name: erythrocyte (CL0000232)
Fold Change: 0.1
Marker Score: 58
Cell Name: erythroid progenitor cell, mammalian (CL0001066)
Fold Change: 0.1
Marker Score: 32
Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
Fold Change: 0.1
Marker Score: 59
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.09
Marker Score: 92
Cell Name: astrocyte (CL0000127)
Fold Change: 0.09
Marker Score: 81
Cell Name: follicular B cell (CL0000843)
Fold Change: 0.09
Marker Score: 101
Cell Name: podocyte (CL0000653)
Fold Change: 0.09
Marker Score: 34
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 0.09
Marker Score: 79
Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
Fold Change: 0.09
Marker Score: 44
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.09
Marker Score: 41
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.09
Marker Score: 46
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.09
Marker Score: 52
Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
Fold Change: 0.09
Marker Score: 19
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.09
Marker Score: 2909
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.08
Marker Score: 417
Cell Name: capillary endothelial cell (CL0002144)
Fold Change: 0.08
Marker Score: 91
Cell Name: mast cell (CL0000097)
Fold Change: 0.08
Marker Score: 49
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 0.08
Marker Score: 49
Cell Name: IgA plasma cell (CL0000987)
Fold Change: 0.08
Marker Score: 71
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 0.08
Marker Score: 53
Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.08
Marker Score: 196
Cell Name: mucus secreting cell (CL0000319)
Fold Change: 0.08
Marker Score: 20
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.08
Marker Score: 37
Cell Name: endothelial tip cell (CL0000704)
Fold Change: 0.08
Marker Score: 18
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 0.08
Marker Score: 49
Cell Name: B cell (CL0000236)
Fold Change: 0.08
Marker Score: 73
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.08
Marker Score: 116
Cell Name: B-1a B cell (CL0000820)
Fold Change: 0.08
Marker Score: 18

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**Key characteristics:** * IL-12A is a cytokine that belongs to the interleukin-12 family of cytokines. * It is a pro-inflammatory cytokine that promotes the differentiation and activation of immune cells, including T cells and B cells. * It is produced by various cell types, including epithelial cells, macrophages, dendritic cells, and lymphocytes. **Pathways and functions:** * IL-12A primarily acts through the IL-12 receptor, which is expressed on various immune cells. * It promotes the activation of T cells, promoting the differentiation of naive CD4+ T cells into effector T cells, such as Th1, Th2, Th17, and Th22 cells. * It also promotes the differentiation of naive B cells into plasma cells, which can produce antibodies. * IL-12A also has anti-inflammatory effects, promoting the suppression of inflammatory responses and maintaining immune tolerance. **Clinical significance:** * IL-12A plays a crucial role in maintaining immune homeostasis in the gut. * Dysregulation of IL-12A signaling has been implicated in various inflammatory diseases, including inflammatory bowel disease (IBD), colorectal cancer, and obesity. * Inhibition of IL-12A signaling has shown therapeutic potential in preclinical models of inflammatory diseases. **Additional notes:** * IL-12A is a pleiotropic cytokine with both pro-inflammatory and anti-inflammatory effects. * It is produced in response to various stimuli, including infection, injury, and inflammation. * It is a key cytokine in shaping the immune response against extracellular bacteria and parasites.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Interleukin-12 subunit alpha
O60595_HUMAN

Genular Protein ID: 2153106993

Symbol: IL12A_HUMAN

Name: Interleukin-12 subunit alpha

UniProtKB Accession Codes:

P29459 Q96QZ1

Database IDs:

Citations:

PubMed ID: 1673147

Title: Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells.

PubMed ID: 1673147

PubMed ID: 1674604

Title: Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor.

PubMed ID: 1674604

DOI: 10.1073/pnas.88.10.4143

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 2204066

Title: Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells.

PubMed ID: 2204066

DOI: 10.1073/pnas.87.17.6808

PubMed ID: 1374259

Title: Sequence similarity between NKSF and the IL-6/G-CSF family.

PubMed ID: 1374259

DOI: 10.1016/0167-5699(92)90140-3

PubMed ID: 7528775

Title: Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12.

PubMed ID: 7528775

DOI: 10.1084/jem.181.1.399

PubMed ID: 7638186

Title: Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes.

PubMed ID: 7638186

DOI: 10.1073/pnas.92.16.7307

PubMed ID: 8605935

Title: Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells.

PubMed ID: 8605935

DOI: 10.1002/eji.1830260323

PubMed ID: 8943050

Title: A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits.

PubMed ID: 8943050

DOI: 10.1073/pnas.93.24.14002

PubMed ID: 9342359

Title: Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin.

PubMed ID: 9342359

DOI: 10.1073/pnas.94.22.12041

PubMed ID: 16548883

Title: Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection.

PubMed ID: 16548883

DOI: 10.1111/j.1462-5822.2005.00644.x

PubMed ID: 22306691

Title: The composition and signaling of the IL-35 receptor are unconventional.

PubMed ID: 22306691

DOI: 10.1038/ni.2227

PubMed ID: 10899108

Title: Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12.

PubMed ID: 10899108

DOI: 10.1093/emboj/19.14.3530

PubMed ID: 20691190

Title: Structural basis for the dual recognition of IL-12 and IL-23 by ustekinumab.

PubMed ID: 20691190

DOI: 10.1016/j.jmb.2010.07.046

Sequence Information:

Length: 219
Mass: 24874
Checksum: 7C658AB7716112B2
Sequence:

MCPARSLLLV ATLVLLDHLS LARNLPVATP DPGMFPCLHH SQNLLRAVSN MLQKARQTLE 
FYPCTSEEID HEDITKDKTS TVEACLPLEL TKNESCLNSR ETSFITNGSC LASRKTSFMM 
ALCLSSIYED LKMYQVEFKT MNAKLLMDPK RQIFLDQNML AVIDELMQAL NFNSETVPQK 
SSLEEPDFYK TKIKLCILLH AFRIRAVTID RVMSYLNAS

Genular Protein ID: 2142037082

Symbol: O60595_HUMAN

Name: N/A

UniProtKB Accession Codes:

O60595

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

Sequence Information:

Length: 253
Mass: 28293
Checksum: FAC56ACD2A620BD5
Sequence:

MWPPGSASQP PPSPAAATGL HPAARPVSLQ CRLSMCPARS LLLVATLVLL DHLSLARNLP 
VATPDPGMFP CLHHSQNLLR AVSNMLQKAR QTLEFYPCTS EEIDHEDITK DKTSTVEACL 
PLELTKNESC LNSRETSFIT NGSCLASRKT SFMMALCLSS IYEDLKMYQV EFKTMNAKLL 
MDPKRQIFLD QNMLAVIDEL MQALNFNSET VPQKSSLEEP DFYKTKIKLC ILLHAFRIRA 
VTIDRVMSYL NAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: IL12A

Associated with

Cells (max top 100)

Other Information

Cloning of cDNA for natural killer cell stimulatory factor, a heterodimeric cytokine with multiple biologic effects on T and natural killer cells. PubMed ID: 1673147

Coexpression of two distinct genes is required to generate secreted bioactive cytotoxic lymphocyte maturation factor. PubMed ID: 1674604

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. PubMed ID: 2204066

Sequence similarity between NKSF and the IL-6/G-CSF family. PubMed ID: 1374259

Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12. PubMed ID: 7528775

Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes. PubMed ID: 7638186

Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells. PubMed ID: 8605935

A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. PubMed ID: 8943050

Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin. PubMed ID: 9342359

Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. PubMed ID: 16548883

The composition and signaling of the IL-35 receptor are unconventional. PubMed ID: 22306691

Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12. PubMed ID: 10899108

Structural basis for the dual recognition of IL-12 and IL-23 by ustekinumab. PubMed ID: 20691190

The sequence of the human genome. PubMed ID: 11181995

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

Database document:

PubMed ID: 1673147

PubMed ID: 1674604

PubMed ID: 16641997

PubMed ID: 2204066

PubMed ID: 1374259

PubMed ID: 7528775

PubMed ID: 7638186

PubMed ID: 8605935

PubMed ID: 8943050

PubMed ID: 9342359

PubMed ID: 16548883

PubMed ID: 22306691

PubMed ID: 10899108

PubMed ID: 20691190

PubMed ID: 11181995

PubMed ID: 15489334

PubMed ID: 16641997