Details for: IL13RA2

Gene ID: 3598

Symbol: IL13RA2

Ensembl ID: ENSG00000123496

Description: interleukin 13 receptor subunit alpha 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 19.8326
    Cell Significance Index: -8.1700
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 7.9985
    Cell Significance Index: 29.8100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 7.2271
    Cell Significance Index: -6.9000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.6703
    Cell Significance Index: 10.3700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3111
    Cell Significance Index: 215.1500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1062
    Cell Significance Index: 66.3200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0975
    Cell Significance Index: 2.6600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0165
    Cell Significance Index: 5.9200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0010
    Cell Significance Index: 0.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0017
    Cell Significance Index: -0.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0032
    Cell Significance Index: -1.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0035
    Cell Significance Index: -6.5200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0061
    Cell Significance Index: -0.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0083
    Cell Significance Index: -1.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0094
    Cell Significance Index: -4.2800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0102
    Cell Significance Index: -6.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0108
    Cell Significance Index: -8.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0126
    Cell Significance Index: -6.9000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0129
    Cell Significance Index: -2.7100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0179
    Cell Significance Index: -3.0500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0203
    Cell Significance Index: -0.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0218
    Cell Significance Index: -0.6100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0238
    Cell Significance Index: -0.6000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0244
    Cell Significance Index: -7.0100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0262
    Cell Significance Index: -1.2200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0311
    Cell Significance Index: -6.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0323
    Cell Significance Index: -5.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0348
    Cell Significance Index: -3.9900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0361
    Cell Significance Index: -4.4400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0364
    Cell Significance Index: -4.1600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0369
    Cell Significance Index: -0.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0393
    Cell Significance Index: -5.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0410
    Cell Significance Index: -5.6400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0431
    Cell Significance Index: -0.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0497
    Cell Significance Index: -1.0400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0501
    Cell Significance Index: -1.2500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0617
    Cell Significance Index: -7.9700
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.0645
    Cell Significance Index: -0.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0648
    Cell Significance Index: -3.9800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0653
    Cell Significance Index: -6.8000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0660
    Cell Significance Index: -6.7500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0666
    Cell Significance Index: -7.7600
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0667
    Cell Significance Index: -0.5800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0678
    Cell Significance Index: -3.5300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0751
    Cell Significance Index: -3.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0770
    Cell Significance Index: -6.1000
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0917
    Cell Significance Index: -0.4800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0971
    Cell Significance Index: -6.5300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1004
    Cell Significance Index: -7.7100
  • Cell Name: tendon cell (CL0000388)
    Fold Change: -0.1052
    Cell Significance Index: -1.4300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1079
    Cell Significance Index: -8.0400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1086
    Cell Significance Index: -4.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1111
    Cell Significance Index: -5.7700
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1119
    Cell Significance Index: -1.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1126
    Cell Significance Index: -4.9800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1143
    Cell Significance Index: -1.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1165
    Cell Significance Index: -3.3400
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1195
    Cell Significance Index: -1.7000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1315
    Cell Significance Index: -4.9800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1430
    Cell Significance Index: -7.5100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1481
    Cell Significance Index: -1.6100
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1519
    Cell Significance Index: -1.7200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1536
    Cell Significance Index: -6.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1669
    Cell Significance Index: -10.5200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1688
    Cell Significance Index: -7.9400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1708
    Cell Significance Index: -4.5600
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.1714
    Cell Significance Index: -1.0500
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.1740
    Cell Significance Index: -1.7100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1821
    Cell Significance Index: -6.3800
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: -0.1884
    Cell Significance Index: -1.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1912
    Cell Significance Index: -6.2600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2019
    Cell Significance Index: -6.4300
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.2062
    Cell Significance Index: -1.9600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2081
    Cell Significance Index: -7.6400
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.2153
    Cell Significance Index: -1.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2213
    Cell Significance Index: -5.8200
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: -0.2235
    Cell Significance Index: -2.8300
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2252
    Cell Significance Index: -3.1600
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.2257
    Cell Significance Index: -2.6600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2298
    Cell Significance Index: -6.7700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2386
    Cell Significance Index: -6.8100
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.2454
    Cell Significance Index: -3.1700
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.2572
    Cell Significance Index: -1.5100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2607
    Cell Significance Index: -2.1900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2614
    Cell Significance Index: -6.5200
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: -0.2620
    Cell Significance Index: -1.4200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2640
    Cell Significance Index: -5.3000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2662
    Cell Significance Index: -6.8000
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.2730
    Cell Significance Index: -3.2100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2805
    Cell Significance Index: -3.5400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2856
    Cell Significance Index: -6.1100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2987
    Cell Significance Index: -6.3400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2994
    Cell Significance Index: -7.1800
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3043
    Cell Significance Index: -5.9900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3156
    Cell Significance Index: -6.2400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3277
    Cell Significance Index: -7.0800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3299
    Cell Significance Index: -7.9900
  • Cell Name: activated type II NK T cell (CL0000931)
    Fold Change: -0.3398
    Cell Significance Index: -0.8700
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.3430
    Cell Significance Index: -4.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3448
    Cell Significance Index: -7.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IL13RA2 is a transmembrane receptor subunit that belongs to the interleukin receptor family. It is composed of two immunoglobulin-like domains and a transmembrane domain, which allows it to interact with IL-13 and modulate its signaling. The receptor subunit is expressed on the surface of various cell types, including T cells, erythrocytes, and goblet cells, and is involved in the regulation of immune responses, inflammation, and tissue homeostasis. **Pathways and Functions:** IL13RA2 is a key component of the IL-13 signaling pathway, which is involved in the regulation of immune responses, inflammation, and tissue homeostasis. The receptor subunit interacts with IL-13, a cytokine produced by Th2 cells and mast cells, to modulate its signaling. IL13RA2 is involved in the following pathways: 1. **Cytokine-mediated signaling pathway:** IL13RA2 interacts with IL-13 to activate the JAK/STAT signaling pathway, which regulates gene expression and cell proliferation. 2. **Negative regulation of immunoglobulin production:** IL13RA2 is involved in the negative regulation of immunoglobulin production by inhibiting the activation of B cells. 3. **Negative regulation of mast cell degranulation:** IL13RA2 is involved in the negative regulation of mast cell degranulation by inhibiting the release of histamine and other mediators. 4. **Signaling by interleukins:** IL13RA2 is involved in the signaling of other interleukins, including IL-4 and IL-13, which regulate immune responses and inflammation. **Clinical Significance:** Dysregulation of IL13RA2 has been implicated in several diseases, including: 1. **Allergic disorders:** IL13RA2 is involved in the regulation of IgE production and the activation of mast cells, which are key players in allergic responses. 2. **Asthma:** IL13RA2 is involved in the regulation of airway inflammation and remodeling, which are key features of asthma. 3. **Autoimmune conditions:** IL13RA2 is involved in the regulation of immune responses and the activation of autoreactive T cells, which are key players in autoimmune diseases. 4. **Cancer:** IL13RA2 is involved in the regulation of tumor growth and metastasis, and its dysregulation has been implicated in several types of cancer. In conclusion, IL13RA2 is a critical receptor subunit that plays a significant role in the regulation of immune responses, inflammation, and tissue homeostasis. Its dysregulation has been implicated in several diseases, and further research is needed to fully understand its role in human disease.

Genular Protein ID: 2376842357

Symbol: I13R2_HUMAN

Name: Interleukin-13 receptor subunit alpha-2

UniProtKB Accession Codes:

Q14627 A8K7E2 O00667

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 8 Ensembl 2 EvolutionaryTrace 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8663118

Title: Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain.

PubMed ID: 8663118

DOI: 10.1074/jbc.271.28.16921

PubMed ID: 9177784

Title: Chromosome mapping and expression of the human interleukin-13 receptor.

PubMed ID: 9177784

DOI: 10.1006/geno.1997.4628

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11861389

Title: IL-13R(alpha)2, a decoy receptor for IL-13 acts as an inhibitor of IL-4-dependent signal transduction in glioblastoma cells.

PubMed ID: 11861389

PubMed ID: 17030238

Title: IL-13 receptor alpha 2: a regulator of IL-13 and IL-4 signal transduction in primary human fibroblasts.

PubMed ID: 17030238

DOI: 10.1016/j.jaci.2006.06.041

PubMed ID: 16327802

Title: IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosis.

PubMed ID: 16327802

DOI: 10.1038/nm1332

PubMed ID: 18694590

Title: Matrix metalloproteinase 8 contributes to solubilization of IL-13 receptor alpha2 in vivo.

PubMed ID: 18694590

DOI: 10.1016/j.jaci.2008.06.022

PubMed ID: 20223216

Title: Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2.

PubMed ID: 20223216

DOI: 10.1016/j.str.2010.01.003

Sequence Information:

  • Length: 380
  • Mass: 44176
  • Checksum: 3C6ACB1B5562C887
  • Sequence:
    • MAFVCLAIGC LYTFLISTTF GCTSSSDTEI KVNPPQDFEI VDPGYLGYLY LQWQPPLSLD 
HFKECTVEYE LKYRNIGSET WKTIITKNLH YKDGFDLNKG IEAKIHTLLP WQCTNGSEVQ 
SSWAETTYWI SPQGIPETKV QDMDCVYYNW QYLLCSWKPG IGVLLDTNYN LFYWYEGLDH 
ALQCVDYIKA DGQNIGCRFP YLEASDYKDF YICVNGSSEN KPIRSSYFTF QLQNIVKPLP 
PVYLTFTRES SCEIKLKWSI PLGPIPARCF DYEIEIREDD TTLVTATVEN ETYTLKTTNE 
TRQLCFVVRS KVNIYCSDDG IWSEWSDKQC WEGEDLSKKT LLRFWLPFGF ILILVIFVTG 
LLLRKPNTYP KMIPEFFCDT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.