Details for: IL13RA2

Gene ID: 3598

Symbol: IL13RA2

Ensembl ID: ENSG00000123496

Description: interleukin 13 receptor subunit alpha 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: T cell (CL0000084)
    Fold Change: 2.26
    Marker Score: 3899
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 1.72
    Marker Score: 954
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 1.56
    Marker Score: 608
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.13
    Marker Score: 2150
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.11
    Marker Score: 7360
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251819
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71837
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48062
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.98
    Marker Score: 2478
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 495
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.82
    Marker Score: 803
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.8
    Marker Score: 762
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 401
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.64
    Marker Score: 162
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.61
    Marker Score: 1233
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 478
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.58
    Marker Score: 348
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.56
    Marker Score: 233
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.49
    Marker Score: 121
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.48
    Marker Score: 121
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.48
    Marker Score: 7450
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.46
    Marker Score: 739
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.44
    Marker Score: 100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.44
    Marker Score: 438
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.44
    Marker Score: 606
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.44
    Marker Score: 183
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.44
    Marker Score: 762
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.43
    Marker Score: 623
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.43
    Marker Score: 188
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.42
    Marker Score: 118
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.34
    Marker Score: 224
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.34
    Marker Score: 378
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.31
    Marker Score: 70
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.28
    Marker Score: 61
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.25
    Marker Score: 157
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.24
    Marker Score: 115
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.23
    Marker Score: 80
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.19
    Marker Score: 71
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.18
    Marker Score: 189
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.18
    Marker Score: 79
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.17
    Marker Score: 94
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.16
    Marker Score: 158
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.16
    Marker Score: 257
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.15
    Marker Score: 129
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.15
    Marker Score: 38
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.15
    Marker Score: 1958
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.12
    Marker Score: 297
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.12
    Marker Score: 169
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.12
    Marker Score: 58
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1
    Marker Score: 3529
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.1
    Marker Score: 540
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.1
    Marker Score: 47
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.1
    Marker Score: 94
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.1
    Marker Score: 835
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.09
    Marker Score: 362
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.09
    Marker Score: 92
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.09
    Marker Score: 194
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.09
    Marker Score: 58
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.09
    Marker Score: 329
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.08
    Marker Score: 29
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.08
    Marker Score: 33
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.08
    Marker Score: 36
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.07
    Marker Score: 66
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.07
    Marker Score: 42
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.07
    Marker Score: 183
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.07
    Marker Score: 127
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.07
    Marker Score: 62
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.07
    Marker Score: 68
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.07
    Marker Score: 28
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.07
    Marker Score: 36
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.07
    Marker Score: 14
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.06
    Marker Score: 22
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.06
    Marker Score: 35
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.06
    Marker Score: 32
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.06
    Marker Score: 2295
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.06
    Marker Score: 90
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.05
    Marker Score: 522
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.05
    Marker Score: 419
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.05
    Marker Score: 62
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.05
    Marker Score: 32
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.05
    Marker Score: 438
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.05
    Marker Score: 16
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.05
    Marker Score: 28
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.05
    Marker Score: 14

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Other Information

**Key characteristics:** * IL13RA2 is a type I cytokine receptor. * It is expressed in a variety of cell types, including T cells, erythrocytes, neuroendocrine cells, cardiac endothelial cells, goblet cells, and intestinal crypt stem cells. * It is a negative regulator of immunoglobulin production. * It is a negative regulator of mast cell degranulation. **Pathways and functions:** * IL13RA2 is a receptor for IL-13, a cytokine that is produced by immune cells. * IL-13 binds to IL13RA2 on the surface of immune cells, triggering a signaling cascade. * The signaling cascade leads to the activation of downstream targets, including the transcription factor STAT3, which regulates the expression of immune genes. * IL-13 also plays a role in the regulation of inflammation. **Clinical significance:** * Mutations in the IL13RA2 gene have been linked to a number of autoimmune diseases, including rheumatoid arthritis, asthma, and psoriasis. * IL13RA2 is a potential therapeutic target for these diseases. **Additional notes:** * IL13RA2 is a highly conserved protein, with a similar sequence in mice and humans. * It is a member of the interleukin-13 receptor family, which is a large family of cytokines that are involved in a variety of immune responses. * IL13RA2 is a key regulator of the immune system, and its dysfunction can lead to a variety of inflammatory diseases.

Genular Protein ID: 2376842357

Symbol: I13R2_HUMAN

Name: Interleukin-13 receptor subunit alpha-2

UniProtKB Accession Codes:

Q14627 A8K7E2 O00667

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 8 Ensembl 2 EvolutionaryTrace 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8663118

Title: Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain.

PubMed ID: 8663118

DOI: 10.1074/jbc.271.28.16921

PubMed ID: 9177784

Title: Chromosome mapping and expression of the human interleukin-13 receptor.

PubMed ID: 9177784

DOI: 10.1006/geno.1997.4628

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20223216

Title: Molecular basis for shared cytokine recognition revealed in the structure of an unusually high affinity complex between IL-13 and IL-13Ralpha2.

PubMed ID: 20223216

DOI: 10.1016/j.str.2010.01.003

Sequence Information:

  • Length: 380
  • Mass: 44176
  • Checksum: 3C6ACB1B5562C887
  • Sequence:
    • MAFVCLAIGC LYTFLISTTF GCTSSSDTEI KVNPPQDFEI VDPGYLGYLY LQWQPPLSLD 
HFKECTVEYE LKYRNIGSET WKTIITKNLH YKDGFDLNKG IEAKIHTLLP WQCTNGSEVQ 
SSWAETTYWI SPQGIPETKV QDMDCVYYNW QYLLCSWKPG IGVLLDTNYN LFYWYEGLDH 
ALQCVDYIKA DGQNIGCRFP YLEASDYKDF YICVNGSSEN KPIRSSYFTF QLQNIVKPLP 
PVYLTFTRES SCEIKLKWSI PLGPIPARCF DYEIEIREDD TTLVTATVEN ETYTLKTTNE 
TRQLCFVVRS KVNIYCSDDG IWSEWSDKQC WEGEDLSKKT LLRFWLPFGF ILILVIFVTG 
LLLRKPNTYP KMIPEFFCDT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.