Details for: INPP4A

Gene ID: 3631

Symbol: INPP4A

Ensembl ID: ENSG00000040933

Description: inositol polyphosphate-4-phosphatase type I A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 263.8139
    Cell Significance Index: -41.0400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 161.5260
    Cell Significance Index: -40.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 91.3428
    Cell Significance Index: -43.1300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 85.7954
    Cell Significance Index: -34.8600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 78.2099
    Cell Significance Index: -40.2300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 36.5701
    Cell Significance Index: -34.9200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 33.5900
    Cell Significance Index: -41.4200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 12.7366
    Cell Significance Index: -39.1200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.7181
    Cell Significance Index: -34.0700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.5853
    Cell Significance Index: -41.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.0549
    Cell Significance Index: 1386.5100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.8995
    Cell Significance Index: 128.2500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.8275
    Cell Significance Index: 107.0700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.8222
    Cell Significance Index: 35.0100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.7749
    Cell Significance Index: 60.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.6815
    Cell Significance Index: 537.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.3841
    Cell Significance Index: 160.3100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.9943
    Cell Significance Index: 715.3100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 1.8579
    Cell Significance Index: 53.0200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.7016
    Cell Significance Index: 29.1600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.6392
    Cell Significance Index: 15.1000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.3029
    Cell Significance Index: 31.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2179
    Cell Significance Index: 241.7000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.1837
    Cell Significance Index: 72.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1669
    Cell Significance Index: 115.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.0364
    Cell Significance Index: 58.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0241
    Cell Significance Index: 924.7100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.0007
    Cell Significance Index: 692.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7115
    Cell Significance Index: 54.6000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5820
    Cell Significance Index: 104.9200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5605
    Cell Significance Index: 91.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.5515
    Cell Significance Index: 57.4200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.4905
    Cell Significance Index: 12.2600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4023
    Cell Significance Index: 43.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3988
    Cell Significance Index: 49.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2907
    Cell Significance Index: 547.3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2592
    Cell Significance Index: 13.6100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2543
    Cell Significance Index: 13.2100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1958
    Cell Significance Index: 122.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1632
    Cell Significance Index: 221.8400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1440
    Cell Significance Index: 221.7100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1151
    Cell Significance Index: 73.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1042
    Cell Significance Index: 7.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0939
    Cell Significance Index: 51.2700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0867
    Cell Significance Index: 159.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0687
    Cell Significance Index: 13.0700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0535
    Cell Significance Index: 6.2400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0362
    Cell Significance Index: 0.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0305
    Cell Significance Index: 0.8800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0243
    Cell Significance Index: 1.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0174
    Cell Significance Index: 0.6100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0076
    Cell Significance Index: 0.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0037
    Cell Significance Index: -0.1000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0176
    Cell Significance Index: -7.7700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0242
    Cell Significance Index: -17.9200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0424
    Cell Significance Index: -1.9200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0455
    Cell Significance Index: -25.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0464
    Cell Significance Index: -34.0200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0512
    Cell Significance Index: -7.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0551
    Cell Significance Index: -41.6800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0994
    Cell Significance Index: -1.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0995
    Cell Significance Index: -16.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1156
    Cell Significance Index: -24.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1248
    Cell Significance Index: -35.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1251
    Cell Significance Index: -18.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1413
    Cell Significance Index: -3.9500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1688
    Cell Significance Index: -17.2400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1708
    Cell Significance Index: -4.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1807
    Cell Significance Index: -23.1700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1859
    Cell Significance Index: -12.0000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2079
    Cell Significance Index: -4.1100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2266
    Cell Significance Index: -4.8100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.2336
    Cell Significance Index: -3.0300
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.2358
    Cell Significance Index: -2.9400
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.2568
    Cell Significance Index: -2.6800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2611
    Cell Significance Index: -33.7300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2832
    Cell Significance Index: -32.4500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2900
    Cell Significance Index: -3.1600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2931
    Cell Significance Index: -34.5600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3191
    Cell Significance Index: -4.5700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3307
    Cell Significance Index: -37.7500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3584
    Cell Significance Index: -11.4200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3676
    Cell Significance Index: -7.3800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3756
    Cell Significance Index: -4.7400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3815
    Cell Significance Index: -12.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4032
    Cell Significance Index: -25.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4037
    Cell Significance Index: -30.0900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4062
    Cell Significance Index: -19.0900
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.4220
    Cell Significance Index: -5.6300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4549
    Cell Significance Index: -32.1700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4836
    Cell Significance Index: -38.3000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4857
    Cell Significance Index: -13.0200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4965
    Cell Significance Index: -10.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5327
    Cell Significance Index: -27.7500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5492
    Cell Significance Index: -17.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5836
    Cell Significance Index: -27.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5864
    Cell Significance Index: -35.9500
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.6075
    Cell Significance Index: -5.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6362
    Cell Significance Index: -13.5500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6405
    Cell Significance Index: -13.8400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** INPP4A is a dual-specificity phosphatase, meaning it can remove phosphate groups from both inositol-1,3,4-trisphosphate (IP3) and inositol-3,4-bisphosphate (IP4). This unique ability allows INPP4A to regulate the levels of these inositol phosphates, which in turn modulate various cellular processes, including calcium signaling, cell proliferation, and differentiation. INPP4A is also involved in the regulation of the PI3K/Akt signaling pathway, which is critical for cell survival, growth, and metabolism. **Pathways and Functions** INPP4A is involved in several key signaling pathways, including: 1. **Calcium signaling**: INPP4A regulates the levels of IP3, which is a key calcium second messenger in cellular signaling. By degrading IP3, INPP4A helps to terminate calcium signaling and prevent excessive calcium influx into cells. 2. **PI3K/Akt signaling**: INPP4A interacts with the PI3K/Akt pathway, which is critical for cell survival, growth, and metabolism. INPP4A can regulate the activity of PI3K, leading to changes in the levels of phosphatidylinositol-3,4,5-trisphosphate (PIP3), a key lipid second messenger. 3. **Neurotransmitter signaling**: INPP4A is expressed in neurons and plays a role in the regulation of neurotransmitter release and synaptic plasticity. 4. **Muscle contraction**: INPP4A is expressed in smooth muscle cells and plays a role in regulating muscle contraction and relaxation. **Clinical Significance** Dysregulation of INPP4A has been implicated in various diseases, including: 1. **Neurodegenerative disorders**: Mutations in INPP4A have been associated with neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease. 2. **Muscle disorders**: INPP4A dysfunction has been implicated in muscle disorders, such as muscular dystrophy and myasthenia gravis. 3. **Cancer**: INPP4A has been shown to play a role in cancer development and progression, particularly in the PI3K/Akt pathway. 4. **Cardiovascular disease**: INPP4A has been implicated in the development of cardiovascular disease, including hypertension and atherosclerosis. In conclusion, INPP4A is a critical enzyme involved in the regulation of inositol phosphate metabolism, a key signaling pathway in various cellular processes. Its dysregulation has been implicated in various diseases, highlighting the importance of INPP4A in maintaining cellular homeostasis and preventing disease.

Genular Protein ID: 2680522981

Symbol: INP4A_HUMAN

Name: Type I inositol 3,4-bisphosphate 4-phosphatase

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7608176

Title: The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase.

PubMed ID: 7608176

DOI: 10.1074/jbc.270.27.16128

PubMed ID: 9295334

Title: The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family.

PubMed ID: 9295334

DOI: 10.1074/jbc.272.38.23859

PubMed ID: 11485317

Title: Identification of a novel spliceoform of inositol polyphosphate 4-phosphatase type Ialpha expressed in human platelets: structure of human inositol polyphosphate 4-phosphatase type I gene.

PubMed ID: 11485317

DOI: 10.1006/bbrc.2001.5331

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15716355

Title: The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane.

PubMed ID: 15716355

DOI: 10.1091/mbc.e04-09-0799

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20463662

Title: The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death.

PubMed ID: 20463662

DOI: 10.1038/nature09023

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25869668

Title: Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway.

PubMed ID: 25869668

DOI: 10.1083/jcb.201409064

PubMed ID: 30071275

Title: Novel nuclear translocation of inositol polyphosphate 4-phosphatase is associated with cell cycle, proliferation and survival.

PubMed ID: 30071275

DOI: 10.1016/j.bbamcr.2018.07.013

Sequence Information:

  • Length: 977
  • Mass: 109956
  • Checksum: 14087B24256B2D05
  • Sequence:
  • MTAREHSPRH GARARAMQRA STIDVAADML GLSLAGNIQD PDEPILEFSL ACSELHTPSL 
    DRKPNSFVAV SVTTPPQAFW TKHAQTEIIE GTNNPIFLSS IAFFQDSLIN QMTQVKLSVY 
    DVKDRSQGTM YLLGSGTFIV KDLLQDRHHR LHLTLRSAES DRVGNITVIG WQMEEKSDQR 
    PPVTRSVDTV NGRMVLPVDE SLTEALGIRS KYASLRKDTL LKSVFGGAIC RMYRFPTTDG 
    NHLRILEQMA ESVLSLHVPR QFVKLLLEED AARVCELEEL GELSPCWESL RRQIVTQYQT 
    IILTYQENLT DLHQYRGPSF KASSLKADKK LEFVPTNLHI QRMRVQDDGG SDQNYDIVTI 
    GAPAAHCQGF KSGGLRKKLH KFEETKKHFE ECCTSSGCQS IIYIPQDVVR AKEIIAQINT 
    LKTQVSYYAE RLSRAAKDRS ATGLERTLAI LADKTRQLVT VCDCKLLANS IHGLNAARPD 
    YIASKASPTS TEEEQVMLRN DQDTLMARWT GRNSRSSLQV DWHEEEWEKV WLNVDKSLEC 
    IIQRVDKLLQ KERLHGEGCE DVFPCAGSCT SKKGNPDSHA YWIRPEDPFC DVPSSPCPST 
    MPSTACHPHL TTHCSPPPEE SSPGEWSEAL YPLLTTLTDC VAMMSDKAKK AMVFLLMQDS 
    APTIATYLSL QYRRDVVFCQ TLTALICGFI IKLRNCLHDD GFLRQLYTIG LLAQFESLLS 
    TYGEELAMLE DMSLGIMDLR NVTFKVTQAT SSASADMLPV ITGNRDGFNV RVPLPGPLFD 
    ALPREIQSGM LLRVQPVLFN VGINEQQTLA ERFGDTSLQE VINVESLVRL NSYFEQFKEV 
    LPEDCLPRSR SQTCLPELLR FLGQNVHARK NKNVDILWQA AEICRRLNGV RFTSCKSAKD 
    RTAMSVTLEQ CLILQHEHGM APQVFTQALE CMRSEGCRRE NTMKNVGSRK YAFNSLQLKA 
    FPKHYRPPEG TYGKVET

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.