Details for: INPP4A
Gene ID: 3631
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: INPP4A
Ensembl ID: ENSG00000040933
Description: inositol polyphosphate-4-phosphatase type I A
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 36.05rCSI 44.85%PRS 20.13
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CSI 35.48rCSI 59.56%PRS 21.36
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CSI 34.84rCSI 44.91%PRS 22.08
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CSI 25.87rCSI 62.87%PRS 20.77
-
CSI 23.29rCSI 27.81%PRS 21.25
-
CSI 21.62rCSI 34.77%PRS 23.18
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CSI 21.08rCSI 37.23%PRS 20.64
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CSI 20.51rCSI 64.15%PRS 24.19
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CSI 19.9rCSI 62.18%PRS 22.34
-
CSI 17.54rCSI 63.13%PRS 20.36
-
CSI 16.95rCSI 36.77%PRS 26.41
-
CSI 16.55rCSI 62.53%PRS 22.21
-
CSI 14.9rCSI 23.69%PRS 28.48
-
CSI 13.96rCSI 31.93%PRS 33.18
-
CSI 13.81rCSI 33.04%PRS 25.39
-
CSI 13.3rCSI 18.81%PRS 43.47
-
CSI 12.81rCSI 16.78%PRS 45.73
-
CSI 12.56rCSI 27.74%PRS 24.6
-
CSI 12.07rCSI 32.14%PRS 28.68
-
CSI 10.5rCSI 61.81%PRS 22.49
-
CSI 10.42rCSI 16.62%PRS 28.84
-
CSI 10.34rCSI 18.23%PRS 32.86
-
CSI 9.99rCSI 20.07%PRS 25.55
-
CSI 9.14rCSI 14.43%PRS 34.3
-
CSI 9.03rCSI 6.3%PRS 35.32
-
CSI 9rCSI 66.15%PRS 23.79
-
CSI 8.52rCSI 11.7%PRS 54.33
-
CSI 8.44rCSI 4.98%PRS 46.29
-
CSI 8.36rCSI 6.76%PRS 45.3
-
CSI 7.9rCSI 45.54%PRS 37.64
-
CSI 7.88rCSI 18.78%PRS 36.79
-
CSI 7.57rCSI 25.91%PRS 28.43
-
CSI 7.29rCSI 23.96%PRS 25
-
CSI 7.2rCSI 9.23%PRS 38.09
-
CSI 7.17rCSI 9.2%PRS 32.18
-
CSI 6.93rCSI 8.63%PRS 44.52
-
CSI 6.46rCSI 10.64%PRS 38.55
-
CSI 6.29rCSI 11.3%PRS 28.41
-
CSI 6.21rCSI 23.42%PRS 32.75
-
CSI 6.17rCSI 6.06%PRS 47.85
-
CSI 5.97rCSI 4.19%PRS 59.41
-
CSI 5.73rCSI 21.47%PRS 28.65
-
CSI 5.73rCSI 4.36%PRS 43.25
-
CSI 5.61rCSI 4.49%PRS 54.12
-
CSI 5.5rCSI 18.23%PRS 36.18
-
CSI 5.45rCSI 46.93%PRS 22.85
-
CSI 5.17rCSI 11.37%PRS 37.4
-
CSI 5.16rCSI 6.05%PRS 46.78
-
CSI 5.05rCSI 7.88%PRS 60.79
-
CSI 5rCSI 10.38%PRS 32.77
-
CSI 4.99rCSI 3.84%PRS 32.04
-
CSI 4.95rCSI 11.43%PRS 27.82
-
CSI 4.92rCSI 5.94%PRS 40.03
-
CSI 4.8rCSI 4.37%PRS 47.99
-
CSI 4.73rCSI 3.29%PRS 40.43
-
CSI 4.7rCSI 18.97%PRS 32.6
-
CSI 4.69rCSI 6.39%PRS 28.98
-
CSI 4.69rCSI 8.21%PRS 27.25
-
CSI 4.62rCSI 3.32%PRS 44.79
-
CSI 4.61rCSI 3.21%PRS 45.17
-
CSI 4.55rCSI 12.17%PRS 28.65
-
CSI 4.48rCSI 6.77%PRS 34.79
-
CSI 4.41rCSI 3.27%PRS 28.98
-
CSI 4.37rCSI 8.19%PRS 25.56
-
CSI 4.33rCSI 6.6%PRS 31.21
-
CSI 4.31rCSI 10.94%PRS 26.32
-
CSI 4.26rCSI 6.33%PRS 36.99
-
CSI 4.23rCSI 6.93%PRS 26.45
-
CSI 4.17rCSI 6.38%PRS 41.93
-
CSI 4.12rCSI 58.44%PRS 28.25
-
CSI 4.01rCSI 25.03%PRS 27.77
-
CSI 3.99rCSI 6.83%PRS 54.73
-
CSI 3.91rCSI 7.94%PRS 20.07
-
CSI 3.86rCSI 10.07%PRS 32.86
-
CSI 3.82rCSI 11.34%PRS 44.32
-
CSI 3.81rCSI 2.96%PRS 48.27
-
CSI 3.8rCSI 3.5%PRS 34.79
-
CSI 3.7rCSI 30.1%PRS 30.52
-
CSI 3.52rCSI 9.69%PRS 31.62
-
CSI 3.45rCSI 7.71%PRS 39.08
-
CSI 3.22rCSI 65.65%PRS 28.63
-
CSI 3.05rCSI 2.69%PRS 25.01
-
CSI 2.98rCSI 12.14%PRS 33.25
-
CSI 2.98rCSI 2.24%PRS 36.18
-
CSI 2.97rCSI 60.46%PRS 29.75
-
CSI 2.93rCSI 3.39%PRS 25.58
-
CSI 2.91rCSI 7.47%PRS 38.37
-
CSI 2.82rCSI 4.88%PRS 26.22
-
CSI 2.78rCSI 3.32%PRS 52.55
-
CSI 2.77rCSI 2.19%PRS 23.77
-
CSI 2.75rCSI 2.94%PRS 31.53
-
CSI 2.72rCSI 6.64%PRS 31.53
-
CSI 2.72rCSI 65.11%PRS 20.8
-
CSI 2.71rCSI 2.76%PRS 45.41
-
CSI 2.7rCSI 3.87%PRS 26.9
-
CSI 2.69rCSI 64.89%PRS 21.61
-
CSI 2.65rCSI 6.91%PRS 33.97
-
CSI 2.64rCSI 5.93%PRS 21.94
-
CSI 2.6rCSI 5.76%PRS 31.17
-
CSI 2.57rCSI 3.95%PRS 39.51
-
CSI 0.2rCSI 1.1%PRS 45.8%
-
CSI 0.3rCSI 0.7%PRS 42.2%
-
CSI 0.5rCSI 2.6%PRS 43.1%
-
CSI 0.6rCSI 3.2%PRS 34.9%
-
CSI 0.7rCSI 8.3%PRS 75.4%
-
CSI 0.8rCSI 3.9%PRS 57.0%
-
CSI 0.9rCSI 3.6%PRS 39.0%
-
CSI 1.0rCSI 8.6%PRS 24.8%
-
CSI 1.2rCSI 3.2%PRS 76.4%
-
CSI 1.2rCSI 1.5%PRS 30.1%
-
CSI 1.2rCSI 2.8%PRS 54.1%
-
CSI 1.3rCSI 7.4%PRS 33.2%
-
CSI 1.3rCSI 2.6%PRS 51.2%
-
CSI 1.3rCSI 1.6%PRS 52.1%
-
CSI 1.4rCSI 6.0%PRS 23.8%
-
CSI 1.5rCSI 1.6%PRS 35.6%
-
CSI 1.5rCSI 2.2%PRS 48.5%
-
CSI 1.7rCSI 3.1%PRS 41.8%
-
CSI 1.8rCSI 5.9%PRS 25.2%
-
CSI 1.8rCSI 6.8%PRS 29.9%
-
CSI 1.8rCSI 3.6%PRS 33.9%
-
CSI 1.8rCSI 1.4%PRS 54.4%
-
CSI 1.8rCSI 12.9%PRS 43.5%
-
CSI 1.8rCSI 10.2%PRS 22.6%
-
CSI 1.9rCSI 5.0%PRS 30.9%
-
CSI 1.9rCSI 3.7%PRS 63.6%
-
CSI 2.0rCSI 3.9%PRS 62.5%
-
CSI 2.0rCSI 1.5%PRS 33.3%
-
CSI 2.0rCSI 5.3%PRS 39.7%
-
CSI 2.0rCSI 3.7%PRS 62.4%
-
CSI 2.0rCSI 5.1%PRS 31.9%
-
CSI 2.1rCSI 3.1%PRS 37.9%
-
CSI 2.1rCSI 1.4%PRS 41.9%
-
CSI 2.1rCSI 9.4%PRS 29.2%
-
CSI 2.1rCSI 2.9%PRS 32.1%
-
CSI 2.2rCSI 3.3%PRS 51.2%
-
CSI 2.2rCSI 4.5%PRS 31.0%
-
CSI 2.3rCSI 6.4%PRS 48.9%
-
CSI 2.3rCSI 10.9%PRS 31.6%
-
CSI 2.3rCSI 7.3%PRS 30.8%
-
CSI 2.3rCSI 3.4%PRS 31.3%
-
CSI 2.4rCSI 2.4%PRS 52.4%
-
CSI 2.4rCSI 3.8%PRS 26.3%
-
CSI 2.4rCSI 3.7%PRS 37.9%
-
CSI 2.4rCSI 6.2%PRS 66.3%
-
CSI 2.4rCSI 6.9%PRS 35.0%
-
CSI 2.4rCSI 2.7%PRS 48.9%
-
CSI 2.4rCSI 2.0%PRS 32.1%
-
CSI 2.5rCSI 7.2%PRS 27.1%
-
CSI 2.5rCSI 3.4%PRS 45.0%
-
CSI 2.5rCSI 5.1%PRS 42.6%
-
CSI 2.6rCSI 7.9%PRS 45.8%
-
CSI 2.6rCSI 4.0%PRS 39.5%
-
CSI 2.6rCSI 5.8%PRS 31.2%
-
CSI 2.6rCSI 5.9%PRS 21.9%
-
CSI 2.7rCSI 6.9%PRS 34.0%
-
CSI 2.7rCSI 64.9%PRS 21.6%
-
CSI 2.7rCSI 3.9%PRS 26.9%
-
CSI 2.7rCSI 2.8%PRS 45.4%
-
CSI 2.7rCSI 65.1%PRS 20.8%
-
CSI 2.7rCSI 6.6%PRS 31.5%
-
CSI 2.8rCSI 2.9%PRS 31.5%
-
CSI 2.8rCSI 2.2%PRS 23.8%
-
CSI 2.8rCSI 3.3%PRS 52.6%
-
CSI 2.8rCSI 4.9%PRS 26.2%
-
CSI 2.9rCSI 7.5%PRS 38.4%
-
CSI 2.9rCSI 3.4%PRS 25.6%
-
CSI 3.0rCSI 60.5%PRS 29.8%
-
CSI 3.0rCSI 2.2%PRS 36.2%
-
CSI 3.0rCSI 12.1%PRS 33.3%
-
CSI 3.1rCSI 2.7%PRS 25.0%
-
CSI 3.2rCSI 65.7%PRS 28.6%
-
CSI 3.5rCSI 7.7%PRS 39.1%
-
CSI 3.5rCSI 9.7%PRS 31.6%
-
CSI 3.7rCSI 30.1%PRS 30.5%
-
CSI 3.8rCSI 3.5%PRS 34.8%
-
CSI 3.8rCSI 3.0%PRS 48.3%
-
CSI 3.8rCSI 11.3%PRS 44.3%
-
CSI 3.9rCSI 10.1%PRS 32.9%
-
CSI 3.9rCSI 7.9%PRS 20.1%
-
CSI 4.0rCSI 6.8%PRS 54.7%
-
CSI 4.0rCSI 25.0%PRS 27.8%
-
CSI 4.1rCSI 58.4%PRS 28.3%
-
CSI 4.2rCSI 6.4%PRS 41.9%
-
CSI 4.2rCSI 6.9%PRS 26.5%
-
CSI 4.3rCSI 6.3%PRS 37.0%
-
CSI 4.3rCSI 10.9%PRS 26.3%
-
CSI 4.3rCSI 6.6%PRS 31.2%
-
CSI 4.4rCSI 8.2%PRS 25.6%
-
CSI 4.4rCSI 3.3%PRS 29.0%
-
CSI 4.5rCSI 6.8%PRS 34.8%
-
CSI 4.6rCSI 12.2%PRS 28.7%
-
CSI 4.6rCSI 3.2%PRS 45.2%
-
CSI 4.6rCSI 3.3%PRS 44.8%
-
CSI 4.7rCSI 8.2%PRS 27.3%
-
CSI 4.7rCSI 6.4%PRS 29.0%
-
CSI 4.7rCSI 19.0%PRS 32.6%
-
CSI 4.7rCSI 3.3%PRS 40.4%
-
CSI 4.8rCSI 4.4%PRS 48.0%
-
CSI 4.9rCSI 5.9%PRS 40.0%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 2680522981
Symbol: INP4A_HUMAN
Name: Type I inositol 3,4-bisphosphate 4-phosphatase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7608176
Title: The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase.
PubMed ID: 7608176
PubMed ID: 9295334
Title: The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family.
PubMed ID: 9295334
PubMed ID: 11485317
Title: Identification of a novel spliceoform of inositol polyphosphate 4-phosphatase type Ialpha expressed in human platelets: structure of human inositol polyphosphate 4-phosphatase type I gene.
PubMed ID: 11485317
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15716355
Title: The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane.
PubMed ID: 15716355
PubMed ID: 15592455
Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
PubMed ID: 15592455
DOI: 10.1038/nbt1046
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20463662
Title: The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death.
PubMed ID: 20463662
DOI: 10.1038/nature09023
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25869668
Title: Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway.
PubMed ID: 25869668
PubMed ID: 30071275
Title: Novel nuclear translocation of inositol polyphosphate 4-phosphatase is associated with cell cycle, proliferation and survival.
PubMed ID: 30071275
Sequence Information:
- Length: 977
- Mass: 109956
- Checksum: 14087B24256B2D05
- Sequence:
MTAREHSPRH GARARAMQRA STIDVAADML GLSLAGNIQD PDEPILEFSL ACSELHTPSL DRKPNSFVAV SVTTPPQAFW TKHAQTEIIE GTNNPIFLSS IAFFQDSLIN QMTQVKLSVY DVKDRSQGTM YLLGSGTFIV KDLLQDRHHR LHLTLRSAES DRVGNITVIG WQMEEKSDQR PPVTRSVDTV NGRMVLPVDE SLTEALGIRS KYASLRKDTL LKSVFGGAIC RMYRFPTTDG NHLRILEQMA ESVLSLHVPR QFVKLLLEED AARVCELEEL GELSPCWESL RRQIVTQYQT IILTYQENLT DLHQYRGPSF KASSLKADKK LEFVPTNLHI QRMRVQDDGG SDQNYDIVTI GAPAAHCQGF KSGGLRKKLH KFEETKKHFE ECCTSSGCQS IIYIPQDVVR AKEIIAQINT LKTQVSYYAE RLSRAAKDRS ATGLERTLAI LADKTRQLVT VCDCKLLANS IHGLNAARPD YIASKASPTS TEEEQVMLRN DQDTLMARWT GRNSRSSLQV DWHEEEWEKV WLNVDKSLEC IIQRVDKLLQ KERLHGEGCE DVFPCAGSCT SKKGNPDSHA YWIRPEDPFC DVPSSPCPST MPSTACHPHL TTHCSPPPEE SSPGEWSEAL YPLLTTLTDC VAMMSDKAKK AMVFLLMQDS APTIATYLSL QYRRDVVFCQ TLTALICGFI IKLRNCLHDD GFLRQLYTIG LLAQFESLLS TYGEELAMLE DMSLGIMDLR NVTFKVTQAT SSASADMLPV ITGNRDGFNV RVPLPGPLFD ALPREIQSGM LLRVQPVLFN VGINEQQTLA ERFGDTSLQE VINVESLVRL NSYFEQFKEV LPEDCLPRSR SQTCLPELLR FLGQNVHARK NKNVDILWQA AEICRRLNGV RFTSCKSAKD RTAMSVTLEQ CLILQHEHGM APQVFTQALE CMRSEGCRRE NTMKNVGSRK YAFNSLQLKA FPKHYRPPEG TYGKVET