Details for: INPP4A

Gene ID: 3631

Symbol: INPP4A

Ensembl ID: ENSG00000040933

Description: inositol polyphosphate-4-phosphatase type I A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.38
    Marker Score: 7427
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.98
    Marker Score: 100744
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.5
    Marker Score: 1319
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.48
    Marker Score: 782
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.46
    Marker Score: 48943
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.41
    Marker Score: 9997
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.31
    Marker Score: 34580
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.31
    Marker Score: 10680
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.31
    Marker Score: 87596
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.23
    Marker Score: 82343
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.15
    Marker Score: 16467
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.12
    Marker Score: 1239
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.11
    Marker Score: 19830
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.1
    Marker Score: 5990
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.02
    Marker Score: 7811
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.02
    Marker Score: 123935
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2
    Marker Score: 636
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.97
    Marker Score: 3312
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.94
    Marker Score: 812
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.89
    Marker Score: 40419
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.88
    Marker Score: 2162
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.87
    Marker Score: 17770
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.87
    Marker Score: 19298
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.83
    Marker Score: 15702
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.71
    Marker Score: 7177.5
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.69
    Marker Score: 2049
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 1.59
    Marker Score: 6626
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.59
    Marker Score: 434
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.58
    Marker Score: 6447
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.58
    Marker Score: 2441
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.58
    Marker Score: 11891
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.57
    Marker Score: 910
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.56
    Marker Score: 599
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.55
    Marker Score: 8126
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.5
    Marker Score: 8068
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.46
    Marker Score: 819
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.46
    Marker Score: 724
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.4
    Marker Score: 1208
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.37
    Marker Score: 442
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.37
    Marker Score: 4588
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.36
    Marker Score: 655
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.35
    Marker Score: 3097.5
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.34
    Marker Score: 1797
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.33
    Marker Score: 776
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.26
    Marker Score: 400
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.26
    Marker Score: 2427
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.23
    Marker Score: 741
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.2
    Marker Score: 1040
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.18
    Marker Score: 18468
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.14
    Marker Score: 4396
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.13
    Marker Score: 1243
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.1
    Marker Score: 321
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.09
    Marker Score: 470
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.02
    Marker Score: 1272
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.02
    Marker Score: 367
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.01
    Marker Score: 1423
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71690
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47914
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30390
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.96
    Marker Score: 2300
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.96
    Marker Score: 915
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.96
    Marker Score: 2252
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.95
    Marker Score: 3527
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2400
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.94
    Marker Score: 206
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.93
    Marker Score: 558
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.92
    Marker Score: 1861.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.91
    Marker Score: 746
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2707
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.9
    Marker Score: 1113
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.9
    Marker Score: 15900
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.89
    Marker Score: 179
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.88
    Marker Score: 878.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.88
    Marker Score: 5262
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.87
    Marker Score: 452
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 0.87
    Marker Score: 196
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.86
    Marker Score: 227
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.86
    Marker Score: 450
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4915
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.86
    Marker Score: 927
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 305
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.83
    Marker Score: 402
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.82
    Marker Score: 303
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.82
    Marker Score: 256
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.82
    Marker Score: 908
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.8
    Marker Score: 964
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.8
    Marker Score: 323
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.79
    Marker Score: 3323
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.79
    Marker Score: 315
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 599.5
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.77
    Marker Score: 433
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.77
    Marker Score: 829.5
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.77
    Marker Score: 222
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.77
    Marker Score: 2417.5
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.76
    Marker Score: 1835
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.74
    Marker Score: 1206
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.74
    Marker Score: 1093

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Other Information

**Key characteristics:** * INPP4A is a protein of the phosphatidylinositol 3,4-bisphosphate 4-phosphatase family. * It is a highly conserved protein with a predicted molecular weight of approximately 130 kDa. * It is found in the cytoplasm, nucleus, and plasma membrane. * It is a key regulator of IP4Pase activity, which is an enzyme that breaks down inositol 1,3,4-trisphosphate (IP3) to its components, inositol 1,3,4-bisphosphate (IP2) and inositol 3-phosphate (IP3). * INPP4A activity is regulated by a variety of factors, including calcium, magnesium, and phosphatidylinositol 3,4-bisphosphate (PIP2). **Pathways and functions:** * INPP4A is involved in a variety of cellular processes, including cell cycle regulation, cell signaling, and apoptosis. * It is essential for the maintenance of cellular homeostasis and the regulation of intracellular signaling pathways. * It is involved in the regulation of ciliary muscle contraction, which is essential for the maintenance of eye focus. * It is also involved in the regulation of Purkinje cell function, which is essential for the regulation of metabolism in the kidney. * It is involved in the regulation of renal cell function, which is essential for the maintenance of water and electrolyte balance in the body. **Clinical significance:** INPP4A gene mutations have been linked to a number of human diseases, including retinal dystrophia, nephropathies, and cancer. These diseases are caused by mutations in genes that are involved in the regulation of IP4Pase activity and the metabolism of inositol and related molecules.

Genular Protein ID: 2680522981

Symbol: INP4A_HUMAN

Name: Type I inositol 3,4-bisphosphate 4-phosphatase

UniProtKB Accession Codes:

Q96PE3 O15326 Q13187 Q53TD8 Q8TC02

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 1 CTD 1 ChEBI 12 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 5 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 3 RefSeq 5 Rhea 6 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7608176

Title: The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase.

PubMed ID: 7608176

DOI: 10.1074/jbc.270.27.16128

PubMed ID: 9295334

Title: The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family.

PubMed ID: 9295334

DOI: 10.1074/jbc.272.38.23859

PubMed ID: 11485317

Title: Identification of a novel spliceoform of inositol polyphosphate 4-phosphatase type Ialpha expressed in human platelets: structure of human inositol polyphosphate 4-phosphatase type I gene.

PubMed ID: 11485317

DOI: 10.1006/bbrc.2001.5331

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15716355

Title: The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane.

PubMed ID: 15716355

DOI: 10.1091/mbc.e04-09-0799

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20463662

Title: The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death.

PubMed ID: 20463662

DOI: 10.1038/nature09023

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25869668

Title: Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway.

PubMed ID: 25869668

DOI: 10.1083/jcb.201409064

PubMed ID: 30071275

Title: Novel nuclear translocation of inositol polyphosphate 4-phosphatase is associated with cell cycle, proliferation and survival.

PubMed ID: 30071275

DOI: 10.1016/j.bbamcr.2018.07.013

Sequence Information:

  • Length: 977
  • Mass: 109956
  • Checksum: 14087B24256B2D05
  • Sequence:
    • MTAREHSPRH GARARAMQRA STIDVAADML GLSLAGNIQD PDEPILEFSL ACSELHTPSL 
DRKPNSFVAV SVTTPPQAFW TKHAQTEIIE GTNNPIFLSS IAFFQDSLIN QMTQVKLSVY 
DVKDRSQGTM YLLGSGTFIV KDLLQDRHHR LHLTLRSAES DRVGNITVIG WQMEEKSDQR 
PPVTRSVDTV NGRMVLPVDE SLTEALGIRS KYASLRKDTL LKSVFGGAIC RMYRFPTTDG 
NHLRILEQMA ESVLSLHVPR QFVKLLLEED AARVCELEEL GELSPCWESL RRQIVTQYQT 
IILTYQENLT DLHQYRGPSF KASSLKADKK LEFVPTNLHI QRMRVQDDGG SDQNYDIVTI 
GAPAAHCQGF KSGGLRKKLH KFEETKKHFE ECCTSSGCQS IIYIPQDVVR AKEIIAQINT 
LKTQVSYYAE RLSRAAKDRS ATGLERTLAI LADKTRQLVT VCDCKLLANS IHGLNAARPD 
YIASKASPTS TEEEQVMLRN DQDTLMARWT GRNSRSSLQV DWHEEEWEKV WLNVDKSLEC 
IIQRVDKLLQ KERLHGEGCE DVFPCAGSCT SKKGNPDSHA YWIRPEDPFC DVPSSPCPST 
MPSTACHPHL TTHCSPPPEE SSPGEWSEAL YPLLTTLTDC VAMMSDKAKK AMVFLLMQDS 
APTIATYLSL QYRRDVVFCQ TLTALICGFI IKLRNCLHDD GFLRQLYTIG LLAQFESLLS 
TYGEELAMLE DMSLGIMDLR NVTFKVTQAT SSASADMLPV ITGNRDGFNV RVPLPGPLFD 
ALPREIQSGM LLRVQPVLFN VGINEQQTLA ERFGDTSLQE VINVESLVRL NSYFEQFKEV 
LPEDCLPRSR SQTCLPELLR FLGQNVHARK NKNVDILWQA AEICRRLNGV RFTSCKSAKD 
RTAMSVTLEQ CLILQHEHGM APQVFTQALE CMRSEGCRRE NTMKNVGSRK YAFNSLQLKA 
FPKHYRPPEG TYGKVET

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.