Details for: INPP4A
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 263.8139
Cell Significance Index: -41.0400 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 161.5260
Cell Significance Index: -40.9700 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 91.3428
Cell Significance Index: -43.1300 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 85.7954
Cell Significance Index: -34.8600 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 78.2099
Cell Significance Index: -40.2300 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 36.5701
Cell Significance Index: -34.9200 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 33.5900
Cell Significance Index: -41.4200 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 12.7366
Cell Significance Index: -39.1200 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 12.7181
Cell Significance Index: -34.0700 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 10.5853
Cell Significance Index: -41.7700 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 3.0549
Cell Significance Index: 1386.5100 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 2.8995
Cell Significance Index: 128.2500 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 2.8275
Cell Significance Index: 107.0700 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.8222
Cell Significance Index: 35.0100 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 2.7749
Cell Significance Index: 60.7600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.6815
Cell Significance Index: 537.9100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 2.3841
Cell Significance Index: 160.3100 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.9943
Cell Significance Index: 715.3100 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 1.8579
Cell Significance Index: 53.0200 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 1.7016
Cell Significance Index: 29.1600 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 1.6392
Cell Significance Index: 15.1000 - Cell Name: cortical interneuron (CL0008031)
Fold Change: 1.3029
Cell Significance Index: 31.2500 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.2179
Cell Significance Index: 241.7000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 1.1837
Cell Significance Index: 72.7600 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.1669
Cell Significance Index: 115.4300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.0364
Cell Significance Index: 58.1600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.0241
Cell Significance Index: 924.7100 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.0007
Cell Significance Index: 692.1300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.7115
Cell Significance Index: 54.6000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.5820
Cell Significance Index: 104.9200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5605
Cell Significance Index: 91.1700 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 0.5515
Cell Significance Index: 57.4200 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.4905
Cell Significance Index: 12.2600 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.4023
Cell Significance Index: 43.7600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.3988
Cell Significance Index: 49.0400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2907
Cell Significance Index: 547.3300 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.2592
Cell Significance Index: 13.6100 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2543
Cell Significance Index: 13.2100 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.1958
Cell Significance Index: 122.2800 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1632
Cell Significance Index: 221.8400 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.1440
Cell Significance Index: 221.7100 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1151
Cell Significance Index: 73.1000 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1042
Cell Significance Index: 7.2100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0939
Cell Significance Index: 51.2700 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0867
Cell Significance Index: 159.9800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0687
Cell Significance Index: 13.0700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.0535
Cell Significance Index: 6.2400 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.0362
Cell Significance Index: 0.5200 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.0305
Cell Significance Index: 0.8800 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.0243
Cell Significance Index: 1.4600 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0174
Cell Significance Index: 0.6100 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.0076
Cell Significance Index: 0.1100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0037
Cell Significance Index: -0.1000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0176
Cell Significance Index: -7.7700 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0242
Cell Significance Index: -17.9200 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.0424
Cell Significance Index: -1.9200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0455
Cell Significance Index: -25.6400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0464
Cell Significance Index: -34.0200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0512
Cell Significance Index: -7.0300 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0551
Cell Significance Index: -41.6800 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0994
Cell Significance Index: -1.9400 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0995
Cell Significance Index: -16.9900 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1156
Cell Significance Index: -24.3500 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1248
Cell Significance Index: -35.9200 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1251
Cell Significance Index: -18.1900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1413
Cell Significance Index: -3.9500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1688
Cell Significance Index: -17.2400 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1708
Cell Significance Index: -4.3900 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.1807
Cell Significance Index: -23.1700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1859
Cell Significance Index: -12.0000 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.2079
Cell Significance Index: -4.1100 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2266
Cell Significance Index: -4.8100 - Cell Name: hippocampal interneuron (CL1001569)
Fold Change: -0.2336
Cell Significance Index: -3.0300 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.2358
Cell Significance Index: -2.9400 - Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: -0.2568
Cell Significance Index: -2.6800 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.2611
Cell Significance Index: -33.7300 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2832
Cell Significance Index: -32.4500 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.2900
Cell Significance Index: -3.1600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2931
Cell Significance Index: -34.5600 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.3191
Cell Significance Index: -4.5700 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.3307
Cell Significance Index: -37.7500 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.3584
Cell Significance Index: -11.4200 - Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: -0.3676
Cell Significance Index: -7.3800 - Cell Name: ON midget ganglion cell (CL4033046)
Fold Change: -0.3756
Cell Significance Index: -4.7400 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.3815
Cell Significance Index: -12.4900 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.4032
Cell Significance Index: -25.4100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.4037
Cell Significance Index: -30.0900 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.4062
Cell Significance Index: -19.0900 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.4220
Cell Significance Index: -5.6300 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.4549
Cell Significance Index: -32.1700 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.4836
Cell Significance Index: -38.3000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.4857
Cell Significance Index: -13.0200 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.4965
Cell Significance Index: -10.3000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.5327
Cell Significance Index: -27.7500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.5492
Cell Significance Index: -17.5900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.5836
Cell Significance Index: -27.2100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.5864
Cell Significance Index: -35.9500 - Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: -0.6075
Cell Significance Index: -5.7800 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.6362
Cell Significance Index: -13.5500 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.6405
Cell Significance Index: -13.8400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2680522981
Symbol: INP4A_HUMAN
Name: Type I inositol 3,4-bisphosphate 4-phosphatase
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 7608176
Title: The isolation and characterization of cDNA encoding human and rat brain inositol polyphosphate 4-phosphatase.
PubMed ID: 7608176
PubMed ID: 9295334
Title: The cDNA cloning and characterization of inositol polyphosphate 4-phosphatase type II. Evidence for conserved alternative splicing in the 4-phosphatase family.
PubMed ID: 9295334
PubMed ID: 11485317
Title: Identification of a novel spliceoform of inositol polyphosphate 4-phosphatase type Ialpha expressed in human platelets: structure of human inositol polyphosphate 4-phosphatase type I gene.
PubMed ID: 11485317
PubMed ID: 15815621
Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
PubMed ID: 15815621
DOI: 10.1038/nature03466
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15716355
Title: The type Ialpha inositol polyphosphate 4-phosphatase generates and terminates phosphoinositide 3-kinase signals on endosomes and the plasma membrane.
PubMed ID: 15716355
PubMed ID: 15592455
Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
PubMed ID: 15592455
DOI: 10.1038/nbt1046
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20463662
Title: The PtdIns(3,4)P(2) phosphatase INPP4A is a suppressor of excitotoxic neuronal death.
PubMed ID: 20463662
DOI: 10.1038/nature09023
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25869668
Title: Sac2/INPP5F is an inositol 4-phosphatase that functions in the endocytic pathway.
PubMed ID: 25869668
PubMed ID: 30071275
Title: Novel nuclear translocation of inositol polyphosphate 4-phosphatase is associated with cell cycle, proliferation and survival.
PubMed ID: 30071275
Sequence Information:
- Length: 977
- Mass: 109956
- Checksum: 14087B24256B2D05
- Sequence:
MTAREHSPRH GARARAMQRA STIDVAADML GLSLAGNIQD PDEPILEFSL ACSELHTPSL DRKPNSFVAV SVTTPPQAFW TKHAQTEIIE GTNNPIFLSS IAFFQDSLIN QMTQVKLSVY DVKDRSQGTM YLLGSGTFIV KDLLQDRHHR LHLTLRSAES DRVGNITVIG WQMEEKSDQR PPVTRSVDTV NGRMVLPVDE SLTEALGIRS KYASLRKDTL LKSVFGGAIC RMYRFPTTDG NHLRILEQMA ESVLSLHVPR QFVKLLLEED AARVCELEEL GELSPCWESL RRQIVTQYQT IILTYQENLT DLHQYRGPSF KASSLKADKK LEFVPTNLHI QRMRVQDDGG SDQNYDIVTI GAPAAHCQGF KSGGLRKKLH KFEETKKHFE ECCTSSGCQS IIYIPQDVVR AKEIIAQINT LKTQVSYYAE RLSRAAKDRS ATGLERTLAI LADKTRQLVT VCDCKLLANS IHGLNAARPD YIASKASPTS TEEEQVMLRN DQDTLMARWT GRNSRSSLQV DWHEEEWEKV WLNVDKSLEC IIQRVDKLLQ KERLHGEGCE DVFPCAGSCT SKKGNPDSHA YWIRPEDPFC DVPSSPCPST MPSTACHPHL TTHCSPPPEE SSPGEWSEAL YPLLTTLTDC VAMMSDKAKK AMVFLLMQDS APTIATYLSL QYRRDVVFCQ TLTALICGFI IKLRNCLHDD GFLRQLYTIG LLAQFESLLS TYGEELAMLE DMSLGIMDLR NVTFKVTQAT SSASADMLPV ITGNRDGFNV RVPLPGPLFD ALPREIQSGM LLRVQPVLFN VGINEQQTLA ERFGDTSLQE VINVESLVRL NSYFEQFKEV LPEDCLPRSR SQTCLPELLR FLGQNVHARK NKNVDILWQA AEICRRLNGV RFTSCKSAKD RTAMSVTLEQ CLILQHEHGM APQVFTQALE CMRSEGCRRE NTMKNVGSRK YAFNSLQLKA FPKHYRPPEG TYGKVET
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.