Details for: INPPL1
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.05
Marker Score: 22363 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.04
Marker Score: 2443 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.01
Marker Score: 15818 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71742 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47966 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30398 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.96
Marker Score: 8408 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.95
Marker Score: 53344 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.94
Marker Score: 2399 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.93
Marker Score: 479 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.92
Marker Score: 436 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2711 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5291 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.86
Marker Score: 4912.5 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.85
Marker Score: 307 - Cell Name: pulmonary ionocyte (CL0017000)
Fold Change: 0.83
Marker Score: 510 - Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.8
Marker Score: 537 - Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.79
Marker Score: 722 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1263 - Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.75
Marker Score: 372 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.74
Marker Score: 565 - Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.73
Marker Score: 2844 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.73
Marker Score: 236 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.73
Marker Score: 293 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.72
Marker Score: 375 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.72
Marker Score: 2841 - Cell Name: preosteoblast (CL0007010)
Fold Change: 0.72
Marker Score: 204 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.72
Marker Score: 472 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.71
Marker Score: 614 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.7
Marker Score: 1423 - Cell Name: CD14-positive monocyte (CL0001054)
Fold Change: 0.7
Marker Score: 1732 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.68
Marker Score: 2858 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.67
Marker Score: 390 - Cell Name: osteoclast (CL0000092)
Fold Change: 0.67
Marker Score: 333 - Cell Name: respiratory epithelial cell (CL0002368)
Fold Change: 0.67
Marker Score: 367 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.67
Marker Score: 453 - Cell Name: brush cell (CL0002204)
Fold Change: 0.66
Marker Score: 604 - Cell Name: glandular epithelial cell (CL0000150)
Fold Change: 0.66
Marker Score: 1620 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.66
Marker Score: 168 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: 0.65
Marker Score: 785 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.65
Marker Score: 675 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.64
Marker Score: 2285 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.64
Marker Score: 201 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.64
Marker Score: 162 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 0.63
Marker Score: 698 - Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.62
Marker Score: 2307 - Cell Name: osteoblast (CL0000062)
Fold Change: 0.62
Marker Score: 331 - Cell Name: lung macrophage (CL1001603)
Fold Change: 0.61
Marker Score: 698 - Cell Name: central nervous system macrophage (CL0000878)
Fold Change: 0.61
Marker Score: 303 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 0.61
Marker Score: 1624 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.6
Marker Score: 9695 - Cell Name: elicited macrophage (CL0000861)
Fold Change: 0.6
Marker Score: 3666 - Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 0.6
Marker Score: 991 - Cell Name: ependymal cell (CL0000065)
Fold Change: 0.6
Marker Score: 208 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.59
Marker Score: 626 - Cell Name: hematopoietic cell (CL0000988)
Fold Change: 0.58
Marker Score: 387 - Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.58
Marker Score: 277 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.58
Marker Score: 656 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.58
Marker Score: 3470 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.58
Marker Score: 1215 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 0.57
Marker Score: 547 - Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.57
Marker Score: 2812 - Cell Name: germ cell (CL0000586)
Fold Change: 0.57
Marker Score: 990 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.57
Marker Score: 19625.5 - Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 0.56
Marker Score: 1322.5 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.56
Marker Score: 337 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.56
Marker Score: 754 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.56
Marker Score: 586 - Cell Name: Unknown (CL0002371)
Fold Change: 0.56
Marker Score: 590 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: 0.55
Marker Score: 237.5 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.54
Marker Score: 360 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.54
Marker Score: 1239 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.54
Marker Score: 1046 - Cell Name: common dendritic progenitor (CL0001029)
Fold Change: 0.54
Marker Score: 187 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.54
Marker Score: 5470 - Cell Name: type I pneumocyte (CL0002062)
Fold Change: 0.54
Marker Score: 646 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.54
Marker Score: 1176 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.53
Marker Score: 249 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.53
Marker Score: 425 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.53
Marker Score: 1324 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.52
Marker Score: 565 - Cell Name: epithelial cell of lung (CL0000082)
Fold Change: 0.52
Marker Score: 2743 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.52
Marker Score: 2177 - Cell Name: podocyte (CL0000653)
Fold Change: 0.51
Marker Score: 190 - Cell Name: ciliated cell (CL0000064)
Fold Change: 0.51
Marker Score: 1761 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: 0.51
Marker Score: 282 - Cell Name: neural cell (CL0002319)
Fold Change: 0.51
Marker Score: 245 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.51
Marker Score: 497 - Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.5
Marker Score: 172 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.5
Marker Score: 145 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.5
Marker Score: 494 - Cell Name: type II pneumocyte (CL0002063)
Fold Change: 0.49
Marker Score: 3196 - Cell Name: cell of skeletal muscle (CL0000188)
Fold Change: 0.48
Marker Score: 368 - Cell Name: epithelial cell of glomerular capsule (CL1000450)
Fold Change: 0.48
Marker Score: 122 - Cell Name: kidney cell (CL1000497)
Fold Change: 0.47
Marker Score: 315 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 0.47
Marker Score: 384 - Cell Name: myofibroblast cell (CL0000186)
Fold Change: 0.47
Marker Score: 577 - Cell Name: ionocyte (CL0005006)
Fold Change: 0.46
Marker Score: 141 - Cell Name: mesodermal cell (CL0000222)
Fold Change: 0.46
Marker Score: 6115 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.46
Marker Score: 681
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Other Information
Genular Protein ID: 2593391669
Symbol: SHIP2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8530088
Title: Cloning and characterization of a human cDNA (INPPL1) sharing homology with inositol polyphosphate phosphatases.
PubMed ID: 8530088
PubMed ID: 9367831
Title: Identification of a second SH2-domain-containing protein closely related to the phosphatidylinositol polyphosphate 5-phosphatase SHIP.
PubMed ID: 9367831
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9660833
Title: Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein.
PubMed ID: 9660833
PubMed ID: 10194451
Title: A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells.
PubMed ID: 10194451
PubMed ID: 11016922
Title: Molecular basis of the recruitment of the SH2 domain-containing inositol 5-phosphatases SHIP1 and SHIP2 by fcgamma RIIB.
PubMed ID: 11016922
PubMed ID: 11349134
Title: The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells.
PubMed ID: 11349134
PubMed ID: 11739414
Title: The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin.
PubMed ID: 11739414
PubMed ID: 11158326
Title: SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading.
PubMed ID: 11158326
PubMed ID: 11687594
Title: Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway.
PubMed ID: 11687594
PubMed ID: 12235291
Title: Src family tyrosine kinases regulate adhesion-dependent tyrosine phosphorylation of 5'-inositol phosphatase SHIP2 during cell attachment and spreading on collagen I.
PubMed ID: 12235291
DOI: 10.1242/jcs.00070
PubMed ID: 12504111
Title: The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2.
PubMed ID: 12504111
PubMed ID: 12676785
Title: SHIP-2 forms a tetrameric complex with filamin, actin, and GPIb-IX-V: localization of SHIP-2 to the activated platelet actin cytoskeleton.
PubMed ID: 12676785
PubMed ID: 12690104
Title: SHIP-2 inositol phosphatase is inducibly expressed in human monocytes and serves to regulate Fcgamma receptor-mediated signaling.
PubMed ID: 12690104
PubMed ID: 15592455
Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
PubMed ID: 15592455
DOI: 10.1038/nbt1046
PubMed ID: 17081983
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
PubMed ID: 17081983
PubMed ID: 16824732
Title: The influence of anionic lipids on SHIP2 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase activity.
PubMed ID: 16824732
PubMed ID: 16302969
Title: SHIP2 interaction with the cytoskeletal protein Vinexin.
PubMed ID: 16302969
PubMed ID: 15668240
Title: SH2-containing 5'-inositol phosphatase, SHIP2, regulates cytoskeleton organization and ligand-dependent down-regulation of the epidermal growth factor receptor.
PubMed ID: 15668240
PubMed ID: 15735664
Title: The SH2-domain-containing inositol 5-phosphatase (SHIP)-2 binds to c-Met directly via tyrosine residue 1356 and involves hepatocyte growth factor (HGF)-induced lamellipodium formation, cell scattering and cell spreading.
PubMed ID: 15735664
PubMed ID: 17314030
Title: The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner.
PubMed ID: 17314030
PubMed ID: 17135240
Title: Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-Kinase-dependent Rac1 activation.
PubMed ID: 17135240
PubMed ID: 17219406
Title: Regulation of PDGF-stimulated SHIP2 tyrosine phosphorylation and association with Shc in 3T3-L1 preadipocytes.
PubMed ID: 17219406
DOI: 10.1002/jcp.20965
PubMed ID: 15220217
Title: Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome.
PubMed ID: 15220217
PubMed ID: 15687335
Title: Impact of SRC homology 2-containing inositol 5'-phosphatase 2 gene polymorphisms detected in a Japanese population on insulin signaling.
PubMed ID: 15687335
DOI: 10.1210/jc.2004-1724
PubMed ID: 17557929
Title: Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension.
PubMed ID: 17557929
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 20933011
Title: FCRL6 receptor: expression and associated proteins.
PubMed ID: 20933011
PubMed ID: 21624956
Title: SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain.
PubMed ID: 21624956
PubMed ID: 23273569
Title: Exome sequencing identifies INPPL1 mutations as a cause of opsismodysplasia.
PubMed ID: 23273569
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
Sequence Information:
- Length: 1258
- Mass: 138599
- Checksum: D76B5AA8ACDE8CBA
- Sequence:
MASACGAPGP GGALGSQAPS WYHRDLSRAA AEELLARAGR DGSFLVRDSE SVAGAFALCV LYQKHVHTYR ILPDGEDFLA VQTSQGVPVR RFQTLGELIG LYAQPNQGLV CALLLPVEGE REPDPPDDRD ASDGEDEKPP LPPRSGSTSI SAPTGPSSPL PAPETPTAPA AESAPNGLST VSHDYLKGSY GLDLEAVRGG ASHLPHLTRT LATSCRRLHS EVDKVLSGLE ILSKVFDQQS SPMVTRLLQQ QNLPQTGEQE LESLVLKLSV LKDFLSGIQK KALKALQDMS STAPPAPQPS TRKAKTIPVQ AFEVKLDVTL GDLTKIGKSQ KFTLSVDVEG GRLVLLRRQR DSQEDWTTFT HDRIRQLIKS QRVQNKLGVV FEKEKDRTQR KDFIFVSARK REAFCQLLQL MKNKHSKQDE PDMISVFIGT WNMGSVPPPK NVTSWFTSKG LGKTLDEVTV TIPHDIYVFG TQENSVGDRE WLDLLRGGLK ELTDLDYRPI AMQSLWNIKV AVLVKPEHEN RISHVSTSSV KTGIANTLGN KGAVGVSFMF NGTSFGFVNC HLTSGNEKTA RRNQNYLDIL RLLSLGDRQL NAFDISLRFT HLFWFGDLNY RLDMDIQEIL NYISRKEFEP LLRVDQLNLE REKHKVFLRF SEEEISFPPT YRYERGSRDT YAWHKQKPTG VRTNVPSWCD RILWKSYPET HIICNSYGCT DDIVTSDHSP VFGTFEVGVT SQFISKKGLS KTSDQAYIEF ESIEAIVKTA SRTKFFIEFY STCLEEYKKS FENDAQSSDN INFLKVQWSS RQLPTLKPIL ADIEYLQDQH LLLTVKSMDG YESYGECVVA LKSMIGSTAQ QFLTFLSHRG EETGNIRGSM KVRVPTERLG TRERLYEWIS IDKDEAGAKS KAPSVSRGSQ EPRSGSRKPA FTEASCPLSR LFEEPEKPPP TGRPPAPPRA APREEPLTPR LKPEGAPEPE GVAAPPPKNS FNNPAYYVLE GVPHQLLPPE PPSPARAPVP SATKNKVAIT VPAPQLGHHR HPRVGEGSSS DEESGGTLPP PDFPPPPLPD SAIFLPPSLD PLPGPVVRGR GGAEARGPPP PKAHPRPPLP PGPSPASTFL GEVASGDDRS CSVLQMAKTL SEVDYAPAGP ARSALLPGPL ELQPPRGLPS DYGRPLSFPP PRIRESIQED LAEEAPCLQG GRASGLGEAG MSAWLRAIGL ERYEEGLVHN GWDDLEFLSD ITEEDLEEAG VQDPAHKRLL LDTLQLSK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.