Details for: INPPL1

Gene ID: 3636

Symbol: INPPL1

Ensembl ID: ENSG00000165458

Description: inositol polyphosphate phosphatase like 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 116.8149
    Cell Significance Index: -18.1700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 70.5715
    Cell Significance Index: -17.9000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 39.3436
    Cell Significance Index: -18.5800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 38.6701
    Cell Significance Index: -15.7100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 34.8183
    Cell Significance Index: -17.9100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 16.4861
    Cell Significance Index: -15.7400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 14.9722
    Cell Significance Index: -18.4600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 6.6372
    Cell Significance Index: -17.7800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 4.9976
    Cell Significance Index: -15.3500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.7389
    Cell Significance Index: -18.7000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.4275
    Cell Significance Index: -9.6900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.5125
    Cell Significance Index: 40.3900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.2878
    Cell Significance Index: 17.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.2666
    Cell Significance Index: 206.0000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.0384
    Cell Significance Index: 54.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8911
    Cell Significance Index: 804.5600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.8356
    Cell Significance Index: 22.3900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8327
    Cell Significance Index: 90.5800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6588
    Cell Significance Index: 18.4100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6522
    Cell Significance Index: 29.5600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5425
    Cell Significance Index: 32.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4888
    Cell Significance Index: 10.5900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4509
    Cell Significance Index: 31.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4444
    Cell Significance Index: 88.2000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.3749
    Cell Significance Index: 6.9300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3578
    Cell Significance Index: 16.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3311
    Cell Significance Index: 9.5400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3205
    Cell Significance Index: 20.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3149
    Cell Significance Index: 56.7600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3020
    Cell Significance Index: 164.9100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2640
    Cell Significance Index: 36.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2414
    Cell Significance Index: 18.5300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2047
    Cell Significance Index: 10.6400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1928
    Cell Significance Index: 4.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1917
    Cell Significance Index: 23.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1640
    Cell Significance Index: 21.0300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1613
    Cell Significance Index: 19.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1604
    Cell Significance Index: 5.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1381
    Cell Significance Index: 6.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1338
    Cell Significance Index: 25.4700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0948
    Cell Significance Index: 41.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0715
    Cell Significance Index: 14.3500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0596
    Cell Significance Index: 3.0100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0508
    Cell Significance Index: 5.0300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0299
    Cell Significance Index: 5.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0264
    Cell Significance Index: 49.7100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0228
    Cell Significance Index: 42.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0221
    Cell Significance Index: 0.4700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0193
    Cell Significance Index: 12.2700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0162
    Cell Significance Index: 1.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0113
    Cell Significance Index: 17.4300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0024
    Cell Significance Index: 1.0800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0032
    Cell Significance Index: -2.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0092
    Cell Significance Index: -6.9400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0100
    Cell Significance Index: -7.3500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0125
    Cell Significance Index: -17.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0155
    Cell Significance Index: -1.5800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0223
    Cell Significance Index: -16.5500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0258
    Cell Significance Index: -1.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0280
    Cell Significance Index: -15.8000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0320
    Cell Significance Index: -20.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0421
    Cell Significance Index: -15.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0548
    Cell Significance Index: -7.9600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0580
    Cell Significance Index: -16.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0591
    Cell Significance Index: -7.6300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0592
    Cell Significance Index: -0.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0627
    Cell Significance Index: -7.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0698
    Cell Significance Index: -1.9000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0727
    Cell Significance Index: -1.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0776
    Cell Significance Index: -5.7800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0821
    Cell Significance Index: -1.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0827
    Cell Significance Index: -2.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0905
    Cell Significance Index: -10.3700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0958
    Cell Significance Index: -20.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0961
    Cell Significance Index: -2.5700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1330
    Cell Significance Index: -4.6200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1397
    Cell Significance Index: -9.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1451
    Cell Significance Index: -15.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1585
    Cell Significance Index: -5.0800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1795
    Cell Significance Index: -14.2200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1844
    Cell Significance Index: -4.8500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1873
    Cell Significance Index: -3.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2199
    Cell Significance Index: -13.4800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2336
    Cell Significance Index: -14.3600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2510
    Cell Significance Index: -4.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2818
    Cell Significance Index: -18.9500
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.2961
    Cell Significance Index: -4.1400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2961
    Cell Significance Index: -7.6100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3003
    Cell Significance Index: -6.4200
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.3078
    Cell Significance Index: -4.2700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3199
    Cell Significance Index: -4.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3270
    Cell Significance Index: -17.1700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3346
    Cell Significance Index: -6.5300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.3348
    Cell Significance Index: -8.1700
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3895
    Cell Significance Index: -5.7500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3925
    Cell Significance Index: -11.5600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4038
    Cell Significance Index: -17.8600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4126
    Cell Significance Index: -8.5600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4226
    Cell Significance Index: -12.4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4293
    Cell Significance Index: -15.0400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** INPPL1 is a phosphatase enzyme that belongs to the inositol polyphosphate phosphatase family. It is characterized by its ability to dephosphorylate phosphatidylinositol 3,4,5-trisphosphate (PIP3) and phosphatidylinositol 4,5-bisphosphate (PIP2), which are key signaling molecules involved in various cellular processes. INPPL1 is highly expressed in immune cells, such as monocytes and macrophages, where it plays a critical role in regulating immune responses. **Pathways and Functions:** INPPL1 is involved in several key pathways, including: 1. **Cytokine Signaling:** INPPL1 regulates the signaling of interleukin-2 (IL-2) and its receptor, which is essential for the proliferation and differentiation of T cells. 2. **Immune Response:** INPPL1 modulates the activity of immune cells, such as macrophages and monocytes, by regulating the production of inflammatory cytokines and chemokines. 3. **Cell Metabolism:** INPPL1 is involved in the regulation of glucose metabolism and lipid biosynthesis, which are essential for the proper functioning of immune cells. 4. **Cell Adhesion:** INPPL1 regulates the expression of adhesion molecules, such as integrins and selectins, which are critical for the migration and homing of immune cells. **Clinical Significance:** Dysregulation of INPPL1 has been implicated in various diseases, including: 1. **Autoimmune Disorders:** Alterations in INPPL1 expression have been linked to autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer:** INPPL1 has been shown to be overexpressed in certain types of cancer, including leukemia and lymphoma, where it promotes tumor growth and metastasis. 3. **Inflammatory Diseases:** INPPL1 plays a critical role in regulating the inflammatory response, and its dysregulation has been implicated in diseases such as atherosclerosis and inflammatory bowel disease. In conclusion, INPPL1 is a critical gene that regulates immune response and cellular metabolism. Its dysregulation has been implicated in various diseases, highlighting the importance of this gene in maintaining immune homeostasis and promoting tissue health. **Implications for Future Research:** 1. **Therapeutic Targeting:** INPPL1 could be a potential therapeutic target for autoimmune disorders and cancer. 2. **Immunomodulation:** Understanding the role of INPPL1 in regulating immune responses could lead to the development of novel immunomodulatory therapies. 3. **Cellular Metabolism:** Further research on INPPL1's role in cellular metabolism could lead to the development of new therapies for metabolic disorders. As an expert immunologist, I believe that INPPL1 is a gene that warrants further investigation, and its dysregulation could have significant implications for human health.

Genular Protein ID: 2593391669

Symbol: SHIP2_HUMAN

Name: N/A

UniProtKB Accession Codes:

O15357 B2RTX5 Q13577 Q13578

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DEPOD 1 DIP 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 1 EMBL 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 35 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 4 RefSeq 2 Rhea 6 SABIO-RK 1 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 2 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8530088

Title: Cloning and characterization of a human cDNA (INPPL1) sharing homology with inositol polyphosphate phosphatases.

PubMed ID: 8530088

DOI: 10.1006/geno.1995.1247

PubMed ID: 9367831

Title: Identification of a second SH2-domain-containing protein closely related to the phosphatidylinositol polyphosphate 5-phosphatase SHIP.

PubMed ID: 9367831

DOI: 10.1006/bbrc.1997.7538

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9660833

Title: Growth factors and insulin stimulate tyrosine phosphorylation of the 51C/SHIP2 protein.

PubMed ID: 9660833

DOI: 10.1074/jbc.273.29.18605

PubMed ID: 10194451

Title: A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells.

PubMed ID: 10194451

PubMed ID: 11016922

Title: Molecular basis of the recruitment of the SH2 domain-containing inositol 5-phosphatases SHIP1 and SHIP2 by fcgamma RIIB.

PubMed ID: 11016922

DOI: 10.1074/jbc.m003518200

PubMed ID: 11349134

Title: The Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cells.

PubMed ID: 11349134

DOI: 10.1074/jbc.m103537200

PubMed ID: 11739414

Title: The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin.

PubMed ID: 11739414

DOI: 10.1083/jcb.200104005

PubMed ID: 11158326

Title: SH2-containing inositol 5'-phosphatase SHIP2 associates with the p130(Cas) adapter protein and regulates cellular adhesion and spreading.

PubMed ID: 11158326

DOI: 10.1128/mcb.21.4.1416-1428.2001

PubMed ID: 11687594

Title: Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway.

PubMed ID: 11687594

DOI: 10.1074/jbc.m109992200

PubMed ID: 12235291

Title: Src family tyrosine kinases regulate adhesion-dependent tyrosine phosphorylation of 5'-inositol phosphatase SHIP2 during cell attachment and spreading on collagen I.

PubMed ID: 12235291

DOI: 10.1242/jcs.00070

PubMed ID: 12504111

Title: The c-Cbl-associated protein and c-Cbl are two new partners of the SH2-containing inositol polyphosphate 5-phosphatase SHIP2.

PubMed ID: 12504111

DOI: 10.1016/s0006-291x(02)02894-2

PubMed ID: 12676785

Title: SHIP-2 forms a tetrameric complex with filamin, actin, and GPIb-IX-V: localization of SHIP-2 to the activated platelet actin cytoskeleton.

PubMed ID: 12676785

DOI: 10.1182/blood-2002-09-2897

PubMed ID: 12690104

Title: SHIP-2 inositol phosphatase is inducibly expressed in human monocytes and serves to regulate Fcgamma receptor-mediated signaling.

PubMed ID: 12690104

DOI: 10.1074/jbc.m302907200

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16824732

Title: The influence of anionic lipids on SHIP2 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase activity.

PubMed ID: 16824732

DOI: 10.1016/j.cellsig.2006.05.010

PubMed ID: 16302969

Title: SHIP2 interaction with the cytoskeletal protein Vinexin.

PubMed ID: 16302969

DOI: 10.1111/j.1742-4658.2005.04996.x

PubMed ID: 15668240

Title: SH2-containing 5'-inositol phosphatase, SHIP2, regulates cytoskeleton organization and ligand-dependent down-regulation of the epidermal growth factor receptor.

PubMed ID: 15668240

DOI: 10.1074/jbc.m410289200

PubMed ID: 15735664

Title: The SH2-domain-containing inositol 5-phosphatase (SHIP)-2 binds to c-Met directly via tyrosine residue 1356 and involves hepatocyte growth factor (HGF)-induced lamellipodium formation, cell scattering and cell spreading.

PubMed ID: 15735664

DOI: 10.1038/sj.onc.1208558

PubMed ID: 17314030

Title: The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner.

PubMed ID: 17314030

DOI: 10.1016/j.cellsig.2006.12.015

PubMed ID: 17135240

Title: Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-Kinase-dependent Rac1 activation.

PubMed ID: 17135240

DOI: 10.1074/jbc.m608509200

PubMed ID: 17219406

Title: Regulation of PDGF-stimulated SHIP2 tyrosine phosphorylation and association with Shc in 3T3-L1 preadipocytes.

PubMed ID: 17219406

DOI: 10.1002/jcp.20965

PubMed ID: 15220217

Title: Polymorphisms in type II SH2 domain-containing inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome.

PubMed ID: 15220217

DOI: 10.2337/diabetes.53.7.1900

PubMed ID: 15687335

Title: Impact of SRC homology 2-containing inositol 5'-phosphatase 2 gene polymorphisms detected in a Japanese population on insulin signaling.

PubMed ID: 15687335

DOI: 10.1210/jc.2004-1724

PubMed ID: 17557929

Title: Genetic association analysis of inositol polyphosphate phosphatase-like 1 (INPPL1, SHIP2) variants with essential hypertension.

PubMed ID: 17557929

DOI: 10.1136/jmg.2007.049718

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 20933011

Title: FCRL6 receptor: expression and associated proteins.

PubMed ID: 20933011

DOI: 10.1016/j.imlet.2010.09.023

PubMed ID: 21624956

Title: SH3YL1 regulates dorsal ruffle formation by a novel phosphoinositide-binding domain.

PubMed ID: 21624956

DOI: 10.1083/jcb.201012161

PubMed ID: 23273569

Title: Exome sequencing identifies INPPL1 mutations as a cause of opsismodysplasia.

PubMed ID: 23273569

DOI: 10.1016/j.ajhg.2012.11.015

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

  • Length: 1258
  • Mass: 138599
  • Checksum: D76B5AA8ACDE8CBA
  • Sequence:
    • MASACGAPGP GGALGSQAPS WYHRDLSRAA AEELLARAGR DGSFLVRDSE SVAGAFALCV 
LYQKHVHTYR ILPDGEDFLA VQTSQGVPVR RFQTLGELIG LYAQPNQGLV CALLLPVEGE 
REPDPPDDRD ASDGEDEKPP LPPRSGSTSI SAPTGPSSPL PAPETPTAPA AESAPNGLST 
VSHDYLKGSY GLDLEAVRGG ASHLPHLTRT LATSCRRLHS EVDKVLSGLE ILSKVFDQQS 
SPMVTRLLQQ QNLPQTGEQE LESLVLKLSV LKDFLSGIQK KALKALQDMS STAPPAPQPS 
TRKAKTIPVQ AFEVKLDVTL GDLTKIGKSQ KFTLSVDVEG GRLVLLRRQR DSQEDWTTFT 
HDRIRQLIKS QRVQNKLGVV FEKEKDRTQR KDFIFVSARK REAFCQLLQL MKNKHSKQDE 
PDMISVFIGT WNMGSVPPPK NVTSWFTSKG LGKTLDEVTV TIPHDIYVFG TQENSVGDRE 
WLDLLRGGLK ELTDLDYRPI AMQSLWNIKV AVLVKPEHEN RISHVSTSSV KTGIANTLGN 
KGAVGVSFMF NGTSFGFVNC HLTSGNEKTA RRNQNYLDIL RLLSLGDRQL NAFDISLRFT 
HLFWFGDLNY RLDMDIQEIL NYISRKEFEP LLRVDQLNLE REKHKVFLRF SEEEISFPPT 
YRYERGSRDT YAWHKQKPTG VRTNVPSWCD RILWKSYPET HIICNSYGCT DDIVTSDHSP 
VFGTFEVGVT SQFISKKGLS KTSDQAYIEF ESIEAIVKTA SRTKFFIEFY STCLEEYKKS 
FENDAQSSDN INFLKVQWSS RQLPTLKPIL ADIEYLQDQH LLLTVKSMDG YESYGECVVA 
LKSMIGSTAQ QFLTFLSHRG EETGNIRGSM KVRVPTERLG TRERLYEWIS IDKDEAGAKS 
KAPSVSRGSQ EPRSGSRKPA FTEASCPLSR LFEEPEKPPP TGRPPAPPRA APREEPLTPR 
LKPEGAPEPE GVAAPPPKNS FNNPAYYVLE GVPHQLLPPE PPSPARAPVP SATKNKVAIT 
VPAPQLGHHR HPRVGEGSSS DEESGGTLPP PDFPPPPLPD SAIFLPPSLD PLPGPVVRGR 
GGAEARGPPP PKAHPRPPLP PGPSPASTFL GEVASGDDRS CSVLQMAKTL SEVDYAPAGP 
ARSALLPGPL ELQPPRGLPS DYGRPLSFPP PRIRESIQED LAEEAPCLQG GRASGLGEAG 
MSAWLRAIGL ERYEEGLVHN GWDDLEFLSD ITEEDLEEAG VQDPAHKRLL LDTLQLSK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.