Details for: INSR
Associated with
Cells (max top 100)
(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 6.6
Marker Score: 117174 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 4.06
Marker Score: 5462 - Cell Name: hepatoblast (CL0005026)
Fold Change: 4.04
Marker Score: 13244 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 3.48
Marker Score: 4210 - Cell Name: regular ventricular cardiac myocyte (CL0002131)
Fold Change: 3.47
Marker Score: 77434 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 3.25
Marker Score: 2254 - Cell Name: lung goblet cell (CL1000143)
Fold Change: 2.81
Marker Score: 809 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 2.74
Marker Score: 1801 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 2.72
Marker Score: 1593 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 2.69
Marker Score: 11253 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 2.69
Marker Score: 2384 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 2.67
Marker Score: 6680 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 2.6
Marker Score: 4998.5 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 2.49
Marker Score: 1486 - Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.48
Marker Score: 37135 - Cell Name: contractile cell (CL0000183)
Fold Change: 2.47
Marker Score: 1336 - Cell Name: fat cell (CL0000136)
Fold Change: 2.46
Marker Score: 1374 - Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 2.45
Marker Score: 2815 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 2.42
Marker Score: 708 - Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.42
Marker Score: 18530.5 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.39
Marker Score: 47499.5 - Cell Name: cardiac neuron (CL0010022)
Fold Change: 2.37
Marker Score: 2956 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 2.37
Marker Score: 8403 - Cell Name: subcutaneous fat cell (CL0002521)
Fold Change: 2.34
Marker Score: 857 - Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 2.34
Marker Score: 10803 - Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.32
Marker Score: 88267 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 2.28
Marker Score: 2437 - Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 2.27
Marker Score: 1322 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 2.24
Marker Score: 82545 - Cell Name: renal principal cell (CL0005009)
Fold Change: 2.23
Marker Score: 1721 - Cell Name: taste receptor cell (CL0000209)
Fold Change: 2.19
Marker Score: 1893 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: 2.19
Marker Score: 692 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 2.16
Marker Score: 4568 - Cell Name: renal alpha-intercalated cell (CL0005011)
Fold Change: 2.16
Marker Score: 1136 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 2.16
Marker Score: 4733 - Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 2.15
Marker Score: 8917.5 - Cell Name: skin fibroblast (CL0002620)
Fold Change: 2.14
Marker Score: 555 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 2.13
Marker Score: 72059.5 - Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.12
Marker Score: 8212 - Cell Name: renal interstitial pericyte (CL1001318)
Fold Change: 2.1
Marker Score: 2003 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 2.1
Marker Score: 44822.5 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 2.07
Marker Score: 598 - Cell Name: regular atrial cardiac myocyte (CL0002129)
Fold Change: 2.04
Marker Score: 7249 - Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 2.01
Marker Score: 18942 - Cell Name: endocrine cell (CL0000163)
Fold Change: 1.94
Marker Score: 1004 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.93
Marker Score: 118777 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.92
Marker Score: 600 - Cell Name: oligodendrocyte (CL0000128)
Fold Change: 1.91
Marker Score: 4571 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.91
Marker Score: 19311 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.89
Marker Score: 10185 - Cell Name: decidual cell (CL2000002)
Fold Change: 1.89
Marker Score: 8163 - Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 1.88
Marker Score: 789 - Cell Name: acinar cell (CL0000622)
Fold Change: 1.87
Marker Score: 1320 - Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 1.87
Marker Score: 3734 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 1.82
Marker Score: 501.5 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.81
Marker Score: 4134 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.79
Marker Score: 17046 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.76
Marker Score: 11331 - Cell Name: double negative thymocyte (CL0002489)
Fold Change: 1.76
Marker Score: 2422 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.74
Marker Score: 1835 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.74
Marker Score: 14942 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.73
Marker Score: 17882 - Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 1.72
Marker Score: 546.5 - Cell Name: secretory cell (CL0000151)
Fold Change: 1.72
Marker Score: 3143 - Cell Name: tracheobronchial goblet cell (CL0019003)
Fold Change: 1.72
Marker Score: 471 - Cell Name: epithelial cell of lower respiratory tract (CL0002632)
Fold Change: 1.71
Marker Score: 7149 - Cell Name: neuron (CL0000540)
Fold Change: 1.71
Marker Score: 6970 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.69
Marker Score: 7312 - Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 1.68
Marker Score: 936 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 1.67
Marker Score: 625 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.67
Marker Score: 3923 - Cell Name: chromaffin cell (CL0000166)
Fold Change: 1.66
Marker Score: 2333 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.64
Marker Score: 2422 - Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 1.63
Marker Score: 4379 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.63
Marker Score: 3320 - Cell Name: podocyte (CL0000653)
Fold Change: 1.63
Marker Score: 603 - Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 1.63
Marker Score: 414.5 - Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 1.63
Marker Score: 1755 - Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.61
Marker Score: 2346 - Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 1.61
Marker Score: 556 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 1.61
Marker Score: 794 - Cell Name: A2 amacrine cell (CL0004219)
Fold Change: 1.6
Marker Score: 508 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.59
Marker Score: 1756 - Cell Name: prostate gland microvascular endothelial cell (CL2000059)
Fold Change: 1.58
Marker Score: 614 - Cell Name: basal cell of epidermis (CL0002187)
Fold Change: 1.58
Marker Score: 689 - Cell Name: ON retinal ganglion cell (CL4023032)
Fold Change: 1.57
Marker Score: 430 - Cell Name: club cell (CL0000158)
Fold Change: 1.57
Marker Score: 1832 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 1.55
Marker Score: 1646 - Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 1.54
Marker Score: 1648 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.54
Marker Score: 2380 - Cell Name: mucus secreting cell (CL0000319)
Fold Change: 1.54
Marker Score: 392 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: 1.53
Marker Score: 715 - Cell Name: mature astrocyte (CL0002627)
Fold Change: 1.51
Marker Score: 995.5 - Cell Name: epicardial adipocyte (CL1000309)
Fold Change: 1.51
Marker Score: 734 - Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 1.5
Marker Score: 1410 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 1.49
Marker Score: 480 - Cell Name: luminal cell of prostate epithelium (CL0002340)
Fold Change: 1.45
Marker Score: 847 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 1.44
Marker Score: 1496 - Cell Name: endothelial cell (CL0000115)
Fold Change: 1.43
Marker Score: 1285 - Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 1.43
Marker Score: 3611
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Other Information
Genular Protein ID: 55734010
Symbol: INSR_HUMAN
Name: Insulin receptor
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2859121
Title: The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling.
PubMed ID: 2859121
PubMed ID: 2983222
Title: Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes.
PubMed ID: 2983222
DOI: 10.1038/313756a0
PubMed ID: 2210055
Title: Human insulin-receptor gene. Partial sequence and amplification of exons by polymerase chain reaction.
PubMed ID: 2210055
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 3680248
Title: Characterization of the promoter region of the human insulin receptor gene. Evidence for promoter activity.
PubMed ID: 3680248
PubMed ID: 2806055
Title: Characterization of the promoter region of the human insulin receptor gene.
PubMed ID: 2806055
PubMed ID: 2777789
Title: Characterization of the promoter region and 3' end of the human insulin receptor gene.
PubMed ID: 2777789
PubMed ID: 2280779
Title: Structural and functional analysis of the insulin receptor promoter.
PubMed ID: 2280779
DOI: 10.1210/mend-4-4-647
PubMed ID: 2211730
Title: Substructural analysis of the insulin receptor by microsequence analyses of limited tryptic fragments isolated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis in the absence or presence of dithiothreitol.
PubMed ID: 2211730
PubMed ID: 8257688
Title: Characterization of human placental insulin-like growth factor-I/insulin hybrid receptors by protein microsequencing and purification.
PubMed ID: 8257688
DOI: 10.1021/bi00212a019
PubMed ID: 2538124
Title: Alternative splicing of human insulin receptor messenger RNA.
PubMed ID: 2538124
PubMed ID: 2369896
Title: Functionally distinct insulin receptors generated by tissue-specific alternative splicing.
PubMed ID: 2369896
PubMed ID: 2566545
Title: Molecular and clinical characterization of an insertional polymorphism of the insulin-receptor gene.
PubMed ID: 2566545
PubMed ID: 3166375
Title: Studies on the autophosphorylation of the insulin receptor from human placenta. Analysis of the sites phosphorylated by two-dimensional peptide mapping.
PubMed ID: 3166375
DOI: 10.1042/bj2520607
PubMed ID: 2544997
Title: Human diabetes associated with a deletion of the tyrosine kinase domain of the insulin receptor.
PubMed ID: 2544997
PubMed ID: 3447155
Title: Partial amino acid sequence analyses of human placental insulin receptor.
PubMed ID: 3447155
PubMed ID: 3101064
Title: Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.
PubMed ID: 3101064
PubMed ID: 2842060
Title: Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity.
PubMed ID: 2842060
PubMed ID: 1321605
Title: Analysis of the order of autophosphorylation of human insulin receptor tyrosines 1158, 1162 and 1163.
PubMed ID: 1321605
PubMed ID: 1472036
Title: Identification of a disulfide bridge connecting the alpha-subunits of the extracellular domain of the insulin receptor.
PubMed ID: 1472036
PubMed ID: 8452530
Title: Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity.
PubMed ID: 8452530
DOI: 10.1042/bj2900419
PubMed ID: 8276809
Title: Direct activation of the phosphatidylinositol 3'-kinase by the insulin receptor.
PubMed ID: 8276809
PubMed ID: 7559478
Title: Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains.
PubMed ID: 7559478
PubMed ID: 7537849
Title: Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain.
PubMed ID: 7537849
PubMed ID: 9355755
Title: Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting.
PubMed ID: 9355755
DOI: 10.1042/bj3270209
PubMed ID: 9428692
Title: Identification of Stat 5B as a substrate of the insulin receptor.
PubMed ID: 9428692
PubMed ID: 8995282
Title: Functional association between the insulin receptor and the transmembrane protein-tyrosine phosphatase LAR in intact cells.
PubMed ID: 8995282
PubMed ID: 8999839
Title: Protein-tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine-phosphorylated in the presence of insulin.
PubMed ID: 8999839
PubMed ID: 9202395
Title: Distribution of insulin/insulin-like growth factor-I hybrid receptors in human tissues.
PubMed ID: 9202395
PubMed ID: 10207053
Title: Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells.
PubMed ID: 10207053
PubMed ID: 10615944
Title: Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit.
PubMed ID: 10615944
PubMed ID: 10734133
Title: Identification of tyrosine phosphatases that dephosphorylate the insulin receptor. A brute force approach based on 'substrate-trapping' mutants.
PubMed ID: 10734133
PubMed ID: 10803466
Title: Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2.
PubMed ID: 10803466
PubMed ID: 11374898
Title: Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B.
PubMed ID: 11374898
PubMed ID: 11598120
Title: Multiple activation loop conformations and their regulatory properties in the insulin receptor's kinase domain.
PubMed ID: 11598120
PubMed ID: 11726652
Title: Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14.
PubMed ID: 11726652
PubMed ID: 12138094
Title: Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved.
PubMed ID: 12138094
PubMed ID: 12493740
Title: Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor.
PubMed ID: 12493740
PubMed ID: 12612081
Title: Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP.
PubMed ID: 12612081
PubMed ID: 16127460
Title: Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans.
PubMed ID: 16127460
DOI: 10.1172/jci23853
PubMed ID: 16314505
Title: Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling.
PubMed ID: 16314505
PubMed ID: 15738637
Title: Receptor-type protein tyrosine phosphatase epsilon (PTPepsilonM) is a negative regulator of insulin signaling in primary hepatocytes and liver.
PubMed ID: 15738637
DOI: 10.2108/zsj.22.169
PubMed ID: 16831875
Title: Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant.
PubMed ID: 16831875
PubMed ID: 16493415
Title: Critical nodes in signalling pathways: insights into insulin action.
PubMed ID: 16493415
DOI: 10.1038/nrm1837
PubMed ID: 17347799
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19459609
Title: A thermodynamic study of ligand binding to the first three domains of the human insulin receptor: relationship between the receptor alpha-chain C-terminal peptide and the site 1 insulin mimetic peptides.
PubMed ID: 19459609
DOI: 10.1021/bi900261q
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19349973
Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.
PubMed ID: 19349973
DOI: 10.1038/nbt.1532
PubMed ID: 21707536
Title: Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling.
PubMed ID: 21707536
DOI: 10.1042/bj20110799
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25187647
Title: Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin.
PubMed ID: 25187647
PubMed ID: 27322061
Title: SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity.
PubMed ID: 27322061
DOI: 10.1172/jci84708
PubMed ID: 27617429
Title: A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin.
PubMed ID: 27617429
DOI: 10.1038/nsmb.3292
PubMed ID: 7997262
Title: Crystal structure of the tyrosine kinase domain of the human insulin receptor.
PubMed ID: 7997262
DOI: 10.1038/372746a0
PubMed ID: 9312016
Title: Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog.
PubMed ID: 9312016
PubMed ID: 11124964
Title: Crystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanism.
PubMed ID: 11124964
PubMed ID: 12707268
Title: Structural and biochemical evidence for an autoinhibitory role for tyrosine 984 in the juxtamembrane region of the insulin receptor.
PubMed ID: 12707268
PubMed ID: 14690593
Title: Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor.
PubMed ID: 14690593
PubMed ID: 16246733
Title: Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14.
PubMed ID: 16246733
PubMed ID: 16271887
Title: Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase.
PubMed ID: 16271887
PubMed ID: 16957736
Title: Structure of the insulin receptor ectodomain reveals a folded-over conformation.
PubMed ID: 16957736
DOI: 10.1038/nature05106
PubMed ID: 16894147
Title: The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity.
PubMed ID: 16894147
PubMed ID: 18278056
Title: Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2.
PubMed ID: 18278056
DOI: 10.1038/nsmb.1388
PubMed ID: 18767165
Title: Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors.
PubMed ID: 18767165
DOI: 10.1002/prot.22207
PubMed ID: 19071018
Title: Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity.
PubMed ID: 19071018
PubMed ID: 19056263
Title: Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines: potent inhibitors of the IGF-1R receptor tyrosine kinase.
PubMed ID: 19056263
PubMed ID: 19394223
Title: Discovery of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase.
PubMed ID: 19394223
PubMed ID: 20348418
Title: Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists.
PubMed ID: 20348418
PubMed ID: 23302862
Title: How insulin engages its primary binding site on the insulin receptor.
PubMed ID: 23302862
DOI: 10.1038/nature11781
PubMed ID: 3283938
Title: Insulin-resistant diabetes due to a point mutation that prevents insulin proreceptor processing.
PubMed ID: 3283938
PubMed ID: 2834824
Title: Two mutant alleles of the insulin receptor gene in a patient with extreme insulin resistance.
PubMed ID: 2834824
PubMed ID: 2479553
Title: A leucine-to-proline mutation in the insulin receptor in a family with insulin resistance.
PubMed ID: 2479553
PubMed ID: 2544998
Title: Human diabetes associated with a mutation in the tyrosine kinase domain of the insulin receptor.
PubMed ID: 2544998
PubMed ID: 2168397
Title: A naturally occurring mutation of insulin receptor alanine 1134 impairs tyrosine kinase function and is associated with dominantly inherited insulin resistance.
PubMed ID: 2168397
PubMed ID: 2121734
Title: Substitution of lysine for asparagine at position 15 in the alpha-subunit of the human insulin receptor. A mutation that impairs transport of receptors to the cell surface and decreases the affinity of insulin binding.
PubMed ID: 2121734
PubMed ID: 2365819
Title: Five mutant alleles of the insulin receptor gene in patients with genetic forms of insulin resistance.
PubMed ID: 2365819
DOI: 10.1172/jci114693
PubMed ID: 1963473
Title: Functional properties of a naturally occurring Trp1200-->Ser1200 mutation of the insulin receptor.
PubMed ID: 1963473
PubMed ID: 2040394
Title: Detection of mutations in insulin-receptor gene in NIDDM patients by analysis of single-stranded conformation polymorphisms.
PubMed ID: 2040394
PubMed ID: 2002058
Title: Insulin resistance and diabetes due to different mutations in the tyrosine kinase domain of both insulin receptor gene alleles.
PubMed ID: 2002058
PubMed ID: 1890161
Title: A mutation in the tyrosine kinase domain of the insulin receptor associated with insulin resistance in an obese woman.
PubMed ID: 1890161
PubMed ID: 1607067
Title: Detection of mutations in insulin receptor gene by denaturing gradient gel electrophoresis.
PubMed ID: 1607067
PubMed ID: 1607076
Title: NIDDM associated with mutation in tyrosine kinase domain of insulin receptor gene.
PubMed ID: 1607076
PubMed ID: 1563582
Title: Detection of mutations in the insulin receptor gene in patients with insulin resistance by analysis of single-stranded conformational polymorphisms.
PubMed ID: 1563582
DOI: 10.1007/bf00400927
PubMed ID: 1730625
Title: An Arg for Gly substitution at position 31 in the insulin receptor, linked to insulin resistance, inhibits receptor processing and transport.
PubMed ID: 1730625
PubMed ID: 1470163
Title: Insulin receptor Arg1131-->Gln: a novel mutation in the catalytic loop of insulin receptor observed in insulin resistant diabetes.
PubMed ID: 1470163
PubMed ID: 8432414
Title: Methionine for valine substitution in exon 17 of the insulin receptor gene in a pedigree with familial NIDDM.
PubMed ID: 8432414
PubMed ID: 8243830
Title: Ala1048-->Asp mutation in the kinase domain of insulin receptor causes defective kinase activity and insulin resistance.
PubMed ID: 8243830
PubMed ID: 8458533
Title: Patients with lipodystrophic diabetes mellitus of the Seip-Berardinelli type, express normal insulin receptors.
PubMed ID: 8458533
DOI: 10.1007/bf00400701
PubMed ID: 8390949
Title: A mutation (Trp1193-->Leu1193) in the tyrosine kinase domain of the insulin receptor associated with type A syndrome of insulin resistance.
PubMed ID: 8390949
DOI: 10.1007/bf00402277
PubMed ID: 8242067
Title: Substitution of Leu for Pro-193 in the insulin receptor in a patient with a genetic form of severe insulin resistance.
PubMed ID: 8242067
DOI: 10.1093/hmg/2.9.1437
PubMed ID: 8096518
Title: Substitution of glutamic acid for alanine 1135 in the putative 'catalytic loop' of the tyrosine kinase domain of the human insulin receptor. A mutation that impairs proteolytic processing into subunits and inhibits receptor tyrosine kinase activity.
PubMed ID: 8096518
PubMed ID: 8388389
Title: Antibodies to the extracellular receptor domain restore the hormone-insensitive kinase and conformation of the mutant insulin receptor valine 382.
PubMed ID: 8388389
PubMed ID: 8326490
Title: A syndrome of insulin resistance resembling leprechaunism in five sibs of consanguineous parents.
PubMed ID: 8326490
DOI: 10.1136/jmg.30.6.470
PubMed ID: 8419945
Title: Activation of glucose transport by a natural mutation in the human insulin receptor.
PubMed ID: 8419945
DOI: 10.1073/pnas.90.1.60
PubMed ID: 8288049
Title: Prevalence of mutations in the insulin receptor gene in subjects with features of the type A syndrome of insulin resistance.
PubMed ID: 8288049
PubMed ID: 8314008
Title: Molecular scanning of the insulin receptor gene in syndromes of insulin resistance.
PubMed ID: 8314008
PubMed ID: 8082780
Title: Functional properties of a heterozygous mutation (Arg1174-->Gln) in the tyrosine kinase domain of the insulin receptor from a type A insulin resistant patient.
PubMed ID: 8082780
Sequence Information:
- Length: 1382
- Mass: 156333
- Checksum: 709A955660739066
- Sequence:
MATGGRRGAA AAPLLVAVAA LLLGAAGHLY PGEVCPGMDI RNNLTRLHEL ENCSVIEGHL QILLMFKTRP EDFRDLSFPK LIMITDYLLL FRVYGLESLK DLFPNLTVIR GSRLFFNYAL VIFEMVHLKE LGLYNLMNIT RGSVRIEKNN ELCYLATIDW SRILDSVEDN YIVLNKDDNE ECGDICPGTA KGKTNCPATV INGQFVERCW THSHCQKVCP TICKSHGCTA EGLCCHSECL GNCSQPDDPT KCVACRNFYL DGRCVETCPP PYYHFQDWRC VNFSFCQDLH HKCKNSRRQG CHQYVIHNNK CIPECPSGYT MNSSNLLCTP CLGPCPKVCH LLEGEKTIDS VTSAQELRGC TVINGSLIIN IRGGNNLAAE LEANLGLIEE ISGYLKIRRS YALVSLSFFR KLRLIRGETL EIGNYSFYAL DNQNLRQLWD WSKHNLTITQ GKLFFHYNPK LCLSEIHKME EVSGTKGRQE RNDIALKTNG DQASCENELL KFSYIRTSFD KILLRWEPYW PPDFRDLLGF MLFYKEAPYQ NVTEFDGQDA CGSNSWTVVD IDPPLRSNDP KSQNHPGWLM RGLKPWTQYA IFVKTLVTFS DERRTYGAKS DIIYVQTDAT NPSVPLDPIS VSNSSSQIIL KWKPPSDPNG NITHYLVFWE RQAEDSELFE LDYCLKGLKL PSRTWSPPFE SEDSQKHNQS EYEDSAGECC SCPKTDSQIL KELEESSFRK TFEDYLHNVV FVPRKTSSGT GAEDPRPSRK RRSLGDVGNV TVAVPTVAAF PNTSSTSVPT SPEEHRPFEK VVNKESLVIS GLRHFTGYRI ELQACNQDTP EERCSVAAYV SARTMPEAKA DDIVGPVTHE IFENNVVHLM WQEPKEPNGL IVLYEVSYRR YGDEELHLCV SRKHFALERG CRLRGLSPGN YSVRIRATSL AGNGSWTEPT YFYVTDYLDV PSNIAKIIIG PLIFVFLFSV VIGSIYLFLR KRQPDGPLGP LYASSNPEYL SASDVFPCSV YVPDEWEVSR EKITLLRELG QGSFGMVYEG NARDIIKGEA ETRVAVKTVN ESASLRERIE FLNEASVMKG FTCHHVVRLL GVVSKGQPTL VVMELMAHGD LKSYLRSLRP EAENNPGRPP PTLQEMIQMA AEIADGMAYL NAKKFVHRDL AARNCMVAHD FTVKIGDFGM TRDIYETDYY RKGGKGLLPV RWMAPESLKD GVFTTSSDMW SFGVVLWEIT SLAEQPYQGL SNEQVLKFVM DGGYLDQPDN CPERVTDLMR MCWQFNPKMR PTFLEIVNLL KDDLHPSFPE VSFFHSEENK APESEELEME FEDMENVPLD RSSHCQREEA GGRDGGSSLG FKRSYEEHIP YTHMNGGKKN GRILTLPRSN PS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.