Details for: INSR
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 534.3141
Cell Significance Index: -83.1100 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 338.8222
Cell Significance Index: -85.9400 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 181.3935
Cell Significance Index: -85.6400 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 181.3876
Cell Significance Index: -73.6900 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 164.7987
Cell Significance Index: -84.7700 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 127.8050
Cell Significance Index: -85.7600 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 77.1936
Cell Significance Index: -73.7000 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 70.7244
Cell Significance Index: -87.2000 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 31.7187
Cell Significance Index: -84.9700 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 22.4985
Cell Significance Index: -49.2400 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 22.2526
Cell Significance Index: -87.8100 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 5.5805
Cell Significance Index: 149.5300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 4.0102
Cell Significance Index: 307.7400 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 2.9255
Cell Significance Index: 49.2800 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.4421
Cell Significance Index: 484.6400 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.0844
Cell Significance Index: 747.6500 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.0045
Cell Significance Index: 402.1100 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 1.9733
Cell Significance Index: 13.3700 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.9636
Cell Significance Index: 1358.0900 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 1.9016
Cell Significance Index: 48.8800 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 1.6616
Cell Significance Index: 77.4700 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.4685
Cell Significance Index: 94.7400 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.3834
Cell Significance Index: 77.6300 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 1.2509
Cell Significance Index: 30.5200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.1977
Cell Significance Index: 194.8000 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.1837
Cell Significance Index: 1609.5500 - Cell Name: lactocyte (CL0002325)
Fold Change: 1.0774
Cell Significance Index: 139.2000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.9918
Cell Significance Index: 1829.1400 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.9243
Cell Significance Index: 126.9300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.8946
Cell Significance Index: 152.7600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.8836
Cell Significance Index: 41.5300 - Cell Name: preadipocyte (CL0002334)
Fold Change: 0.8587
Cell Significance Index: 16.7600 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.7345
Cell Significance Index: 15.7000 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.7292
Cell Significance Index: 44.8200 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.6913
Cell Significance Index: 75.2000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.6794
Cell Significance Index: 30.8000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.6789
Cell Significance Index: 1045.0800 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 0.6218
Cell Significance Index: 9.1800 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5930
Cell Significance Index: 17.0900 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.5604
Cell Significance Index: 101.0200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.4656
Cell Significance Index: 876.6100 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.4273
Cell Significance Index: 52.5400 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.3826
Cell Significance Index: 243.0000 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.3825
Cell Significance Index: 2.3600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3758
Cell Significance Index: 166.1300 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.3578
Cell Significance Index: 45.8700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2297
Cell Significance Index: 125.4200 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.2067
Cell Significance Index: 5.6300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1780
Cell Significance Index: 33.8700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1707
Cell Significance Index: 4.7700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1649
Cell Significance Index: 8.5700 - Cell Name: peg cell (CL4033014)
Fold Change: 0.1459
Cell Significance Index: 3.3700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1220
Cell Significance Index: 12.0700 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.1173
Cell Significance Index: 2.0100 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.0897
Cell Significance Index: 1.2900 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0702
Cell Significance Index: 31.8600 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0302
Cell Significance Index: 27.3100 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0273
Cell Significance Index: -0.7300 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0460
Cell Significance Index: -33.7200 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0571
Cell Significance Index: -42.2900 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0837
Cell Significance Index: -12.1600 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0850
Cell Significance Index: -53.1000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0878
Cell Significance Index: -66.4900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.1221
Cell Significance Index: -4.2900 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1233
Cell Significance Index: -69.5100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1654
Cell Significance Index: -11.1200 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.1738
Cell Significance Index: -12.9500 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.2358
Cell Significance Index: -3.4800 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.2446
Cell Significance Index: -24.9900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.2701
Cell Significance Index: -77.7200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.2981
Cell Significance Index: -62.7800 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4441
Cell Significance Index: -46.2400 - Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.4547
Cell Significance Index: -6.5300 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4890
Cell Significance Index: -55.8200 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.4904
Cell Significance Index: -57.1500 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.4972
Cell Significance Index: -56.9600 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: -0.5351
Cell Significance Index: -4.7500 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.6252
Cell Significance Index: -44.2200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.6339
Cell Significance Index: -13.5000 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.6399
Cell Significance Index: -8.7300 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.6722
Cell Significance Index: -17.6800 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.7162
Cell Significance Index: -37.6100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.7169
Cell Significance Index: -84.5500 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.7197
Cell Significance Index: -17.2600 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.7815
Cell Significance Index: -25.0300 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.8571
Cell Significance Index: -17.7800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.8613
Cell Significance Index: -18.6600 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.9297
Cell Significance Index: -26.6500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.9662
Cell Significance Index: -76.5200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.0094
Cell Significance Index: -44.6500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.0461
Cell Significance Index: -65.9300 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -1.1165
Cell Significance Index: -16.7300 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -1.1210
Cell Significance Index: -42.4500 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: -1.1477
Cell Significance Index: -79.3700 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -1.2466
Cell Significance Index: -76.4300 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -1.3794
Cell Significance Index: -71.8500 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -1.5583
Cell Significance Index: -54.1500 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -1.5718
Cell Significance Index: -33.3600 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -1.6311
Cell Significance Index: -35.7200 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: -1.6756
Cell Significance Index: -21.1000
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 55734010
Symbol: INSR_HUMAN
Name: Insulin receptor
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2859121
Title: The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling.
PubMed ID: 2859121
PubMed ID: 2983222
Title: Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes.
PubMed ID: 2983222
DOI: 10.1038/313756a0
PubMed ID: 2210055
Title: Human insulin-receptor gene. Partial sequence and amplification of exons by polymerase chain reaction.
PubMed ID: 2210055
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 3680248
Title: Characterization of the promoter region of the human insulin receptor gene. Evidence for promoter activity.
PubMed ID: 3680248
PubMed ID: 2806055
Title: Characterization of the promoter region of the human insulin receptor gene.
PubMed ID: 2806055
PubMed ID: 2777789
Title: Characterization of the promoter region and 3' end of the human insulin receptor gene.
PubMed ID: 2777789
PubMed ID: 2280779
Title: Structural and functional analysis of the insulin receptor promoter.
PubMed ID: 2280779
DOI: 10.1210/mend-4-4-647
PubMed ID: 2211730
Title: Substructural analysis of the insulin receptor by microsequence analyses of limited tryptic fragments isolated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis in the absence or presence of dithiothreitol.
PubMed ID: 2211730
PubMed ID: 8257688
Title: Characterization of human placental insulin-like growth factor-I/insulin hybrid receptors by protein microsequencing and purification.
PubMed ID: 8257688
DOI: 10.1021/bi00212a019
PubMed ID: 2538124
Title: Alternative splicing of human insulin receptor messenger RNA.
PubMed ID: 2538124
PubMed ID: 2369896
Title: Functionally distinct insulin receptors generated by tissue-specific alternative splicing.
PubMed ID: 2369896
PubMed ID: 2566545
Title: Molecular and clinical characterization of an insertional polymorphism of the insulin-receptor gene.
PubMed ID: 2566545
PubMed ID: 3166375
Title: Studies on the autophosphorylation of the insulin receptor from human placenta. Analysis of the sites phosphorylated by two-dimensional peptide mapping.
PubMed ID: 3166375
DOI: 10.1042/bj2520607
PubMed ID: 2544997
Title: Human diabetes associated with a deletion of the tyrosine kinase domain of the insulin receptor.
PubMed ID: 2544997
PubMed ID: 3447155
Title: Partial amino acid sequence analyses of human placental insulin receptor.
PubMed ID: 3447155
PubMed ID: 3101064
Title: Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity.
PubMed ID: 3101064
PubMed ID: 2842060
Title: Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect its tyrosine kinase activity.
PubMed ID: 2842060
PubMed ID: 1321605
Title: Analysis of the order of autophosphorylation of human insulin receptor tyrosines 1158, 1162 and 1163.
PubMed ID: 1321605
PubMed ID: 1472036
Title: Identification of a disulfide bridge connecting the alpha-subunits of the extracellular domain of the insulin receptor.
PubMed ID: 1472036
PubMed ID: 8452530
Title: Purified hybrid insulin/insulin-like growth factor-I receptors bind insulin-like growth factor-I, but not insulin, with high affinity.
PubMed ID: 8452530
DOI: 10.1042/bj2900419
PubMed ID: 8276809
Title: Direct activation of the phosphatidylinositol 3'-kinase by the insulin receptor.
PubMed ID: 8276809
PubMed ID: 7559478
Title: Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains.
PubMed ID: 7559478
PubMed ID: 7537849
Title: Phosphotyrosine-dependent interaction of SHC and insulin receptor substrate 1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain.
PubMed ID: 7537849
PubMed ID: 9355755
Title: Insulin receptor/IGF-I receptor hybrids are widely distributed in mammalian tissues: quantification of individual receptor species by selective immunoprecipitation and immunoblotting.
PubMed ID: 9355755
DOI: 10.1042/bj3270209
PubMed ID: 9428692
Title: Identification of Stat 5B as a substrate of the insulin receptor.
PubMed ID: 9428692
PubMed ID: 8995282
Title: Functional association between the insulin receptor and the transmembrane protein-tyrosine phosphatase LAR in intact cells.
PubMed ID: 8995282
PubMed ID: 8999839
Title: Protein-tyrosine phosphatase 1B complexes with the insulin receptor in vivo and is tyrosine-phosphorylated in the presence of insulin.
PubMed ID: 8999839
PubMed ID: 9202395
Title: Distribution of insulin/insulin-like growth factor-I hybrid receptors in human tissues.
PubMed ID: 9202395
PubMed ID: 10207053
Title: Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells.
PubMed ID: 10207053
PubMed ID: 10615944
Title: Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit.
PubMed ID: 10615944
PubMed ID: 10734133
Title: Identification of tyrosine phosphatases that dephosphorylate the insulin receptor. A brute force approach based on 'substrate-trapping' mutants.
PubMed ID: 10734133
PubMed ID: 10803466
Title: Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2.
PubMed ID: 10803466
PubMed ID: 11374898
Title: Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B.
PubMed ID: 11374898
PubMed ID: 11598120
Title: Multiple activation loop conformations and their regulatory properties in the insulin receptor's kinase domain.
PubMed ID: 11598120
PubMed ID: 11726652
Title: Inhibition of insulin receptor catalytic activity by the molecular adapter Grb14.
PubMed ID: 11726652
PubMed ID: 12138094
Title: Insulin/insulin-like growth factor I hybrid receptors have different biological characteristics depending on the insulin receptor isoform involved.
PubMed ID: 12138094
PubMed ID: 12493740
Title: Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor.
PubMed ID: 12493740
PubMed ID: 12612081
Title: Regulation of insulin receptor signaling by the protein tyrosine phosphatase TCPTP.
PubMed ID: 12612081
PubMed ID: 16127460
Title: Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans.
PubMed ID: 16127460
DOI: 10.1172/jci23853
PubMed ID: 16314505
Title: Tyrosine phosphorylation of phosphoinositide-dependent kinase 1 by the insulin receptor is necessary for insulin metabolic signaling.
PubMed ID: 16314505
PubMed ID: 15738637
Title: Receptor-type protein tyrosine phosphatase epsilon (PTPepsilonM) is a negative regulator of insulin signaling in primary hepatocytes and liver.
PubMed ID: 15738637
DOI: 10.2108/zsj.22.169
PubMed ID: 16831875
Title: Hybrid receptors formed by insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) have low insulin and high IGF-1 affinity irrespective of the IR splice variant.
PubMed ID: 16831875
PubMed ID: 16493415
Title: Critical nodes in signalling pathways: insights into insulin action.
PubMed ID: 16493415
DOI: 10.1038/nrm1837
PubMed ID: 17347799
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19459609
Title: A thermodynamic study of ligand binding to the first three domains of the human insulin receptor: relationship between the receptor alpha-chain C-terminal peptide and the site 1 insulin mimetic peptides.
PubMed ID: 19459609
DOI: 10.1021/bi900261q
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19349973
Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.
PubMed ID: 19349973
DOI: 10.1038/nbt.1532
PubMed ID: 21707536
Title: Dock/Nck facilitates PTP61F/PTP1B regulation of insulin signalling.
PubMed ID: 21707536
DOI: 10.1042/bj20110799
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25187647
Title: Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin.
PubMed ID: 25187647
PubMed ID: 27322061
Title: SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity.
PubMed ID: 27322061
DOI: 10.1172/jci84708
PubMed ID: 27617429
Title: A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin.
PubMed ID: 27617429
DOI: 10.1038/nsmb.3292
PubMed ID: 38056462
Title: An enzyme that selectively S-nitrosylates proteins to regulate insulin signaling.
PubMed ID: 38056462
PubMed ID: 7997262
Title: Crystal structure of the tyrosine kinase domain of the human insulin receptor.
PubMed ID: 7997262
DOI: 10.1038/372746a0
PubMed ID: 9312016
Title: Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog.
PubMed ID: 9312016
PubMed ID: 11124964
Title: Crystallographic and solution studies of an activation loop mutant of the insulin receptor tyrosine kinase: insights into kinase mechanism.
PubMed ID: 11124964
PubMed ID: 12707268
Title: Structural and biochemical evidence for an autoinhibitory role for tyrosine 984 in the juxtamembrane region of the insulin receptor.
PubMed ID: 12707268
PubMed ID: 14690593
Title: Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor.
PubMed ID: 14690593
PubMed ID: 16246733
Title: Structural basis for inhibition of the insulin receptor by the adaptor protein Grb14.
PubMed ID: 16246733
PubMed ID: 16271887
Title: Crystal structure of a complex between protein tyrosine phosphatase 1B and the insulin receptor tyrosine kinase.
PubMed ID: 16271887
PubMed ID: 16957736
Title: Structure of the insulin receptor ectodomain reveals a folded-over conformation.
PubMed ID: 16957736
DOI: 10.1038/nature05106
PubMed ID: 16894147
Title: The first three domains of the insulin receptor differ structurally from the insulin-like growth factor 1 receptor in the regions governing ligand specificity.
PubMed ID: 16894147
PubMed ID: 18278056
Title: Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2.
PubMed ID: 18278056
DOI: 10.1038/nsmb.1388
PubMed ID: 18767165
Title: Identification of a key element for hydrogen-bonding patterns between protein kinases and their inhibitors.
PubMed ID: 18767165
DOI: 10.1002/prot.22207
PubMed ID: 19071018
Title: Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity.
PubMed ID: 19071018
PubMed ID: 19056263
Title: Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines: potent inhibitors of the IGF-1R receptor tyrosine kinase.
PubMed ID: 19056263
PubMed ID: 19394223
Title: Discovery of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase.
PubMed ID: 19394223
PubMed ID: 20348418
Title: Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists.
PubMed ID: 20348418
PubMed ID: 23302862
Title: How insulin engages its primary binding site on the insulin receptor.
PubMed ID: 23302862
DOI: 10.1038/nature11781
PubMed ID: 3283938
Title: Insulin-resistant diabetes due to a point mutation that prevents insulin proreceptor processing.
PubMed ID: 3283938
PubMed ID: 2834824
Title: Two mutant alleles of the insulin receptor gene in a patient with extreme insulin resistance.
PubMed ID: 2834824
PubMed ID: 2479553
Title: A leucine-to-proline mutation in the insulin receptor in a family with insulin resistance.
PubMed ID: 2479553
PubMed ID: 2544998
Title: Human diabetes associated with a mutation in the tyrosine kinase domain of the insulin receptor.
PubMed ID: 2544998
PubMed ID: 2168397
Title: A naturally occurring mutation of insulin receptor alanine 1134 impairs tyrosine kinase function and is associated with dominantly inherited insulin resistance.
PubMed ID: 2168397
PubMed ID: 2121734
Title: Substitution of lysine for asparagine at position 15 in the alpha-subunit of the human insulin receptor. A mutation that impairs transport of receptors to the cell surface and decreases the affinity of insulin binding.
PubMed ID: 2121734
PubMed ID: 2365819
Title: Five mutant alleles of the insulin receptor gene in patients with genetic forms of insulin resistance.
PubMed ID: 2365819
DOI: 10.1172/jci114693
PubMed ID: 1963473
Title: Functional properties of a naturally occurring Trp1200-->Ser1200 mutation of the insulin receptor.
PubMed ID: 1963473
PubMed ID: 2040394
Title: Detection of mutations in insulin-receptor gene in NIDDM patients by analysis of single-stranded conformation polymorphisms.
PubMed ID: 2040394
PubMed ID: 2002058
Title: Insulin resistance and diabetes due to different mutations in the tyrosine kinase domain of both insulin receptor gene alleles.
PubMed ID: 2002058
PubMed ID: 1890161
Title: A mutation in the tyrosine kinase domain of the insulin receptor associated with insulin resistance in an obese woman.
PubMed ID: 1890161
PubMed ID: 1607067
Title: Detection of mutations in insulin receptor gene by denaturing gradient gel electrophoresis.
PubMed ID: 1607067
PubMed ID: 1607076
Title: NIDDM associated with mutation in tyrosine kinase domain of insulin receptor gene.
PubMed ID: 1607076
PubMed ID: 1563582
Title: Detection of mutations in the insulin receptor gene in patients with insulin resistance by analysis of single-stranded conformational polymorphisms.
PubMed ID: 1563582
DOI: 10.1007/bf00400927
PubMed ID: 1730625
Title: An Arg for Gly substitution at position 31 in the insulin receptor, linked to insulin resistance, inhibits receptor processing and transport.
PubMed ID: 1730625
PubMed ID: 1470163
Title: Insulin receptor Arg1131-->Gln: a novel mutation in the catalytic loop of insulin receptor observed in insulin resistant diabetes.
PubMed ID: 1470163
PubMed ID: 8432414
Title: Methionine for valine substitution in exon 17 of the insulin receptor gene in a pedigree with familial NIDDM.
PubMed ID: 8432414
PubMed ID: 8243830
Title: Ala1048-->Asp mutation in the kinase domain of insulin receptor causes defective kinase activity and insulin resistance.
PubMed ID: 8243830
PubMed ID: 8458533
Title: Patients with lipodystrophic diabetes mellitus of the Seip-Berardinelli type, express normal insulin receptors.
PubMed ID: 8458533
DOI: 10.1007/bf00400701
PubMed ID: 8390949
Title: A mutation (Trp1193-->Leu1193) in the tyrosine kinase domain of the insulin receptor associated with type A syndrome of insulin resistance.
PubMed ID: 8390949
DOI: 10.1007/bf00402277
PubMed ID: 8242067
Title: Substitution of Leu for Pro-193 in the insulin receptor in a patient with a genetic form of severe insulin resistance.
PubMed ID: 8242067
DOI: 10.1093/hmg/2.9.1437
PubMed ID: 8096518
Title: Substitution of glutamic acid for alanine 1135 in the putative 'catalytic loop' of the tyrosine kinase domain of the human insulin receptor. A mutation that impairs proteolytic processing into subunits and inhibits receptor tyrosine kinase activity.
PubMed ID: 8096518
PubMed ID: 8388389
Title: Antibodies to the extracellular receptor domain restore the hormone-insensitive kinase and conformation of the mutant insulin receptor valine 382.
PubMed ID: 8388389
PubMed ID: 8326490
Title: A syndrome of insulin resistance resembling leprechaunism in five sibs of consanguineous parents.
PubMed ID: 8326490
DOI: 10.1136/jmg.30.6.470
PubMed ID: 8419945
Title: Activation of glucose transport by a natural mutation in the human insulin receptor.
PubMed ID: 8419945
DOI: 10.1073/pnas.90.1.60
PubMed ID: 8288049
Title: Prevalence of mutations in the insulin receptor gene in subjects with features of the type A syndrome of insulin resistance.
PubMed ID: 8288049
PubMed ID: 8314008
Title: Molecular scanning of the insulin receptor gene in syndromes of insulin resistance.
PubMed ID: 8314008
Sequence Information:
- Length: 1382
- Mass: 156333
- Checksum: 709A955660739066
- Sequence:
MATGGRRGAA AAPLLVAVAA LLLGAAGHLY PGEVCPGMDI RNNLTRLHEL ENCSVIEGHL QILLMFKTRP EDFRDLSFPK LIMITDYLLL FRVYGLESLK DLFPNLTVIR GSRLFFNYAL VIFEMVHLKE LGLYNLMNIT RGSVRIEKNN ELCYLATIDW SRILDSVEDN YIVLNKDDNE ECGDICPGTA KGKTNCPATV INGQFVERCW THSHCQKVCP TICKSHGCTA EGLCCHSECL GNCSQPDDPT KCVACRNFYL DGRCVETCPP PYYHFQDWRC VNFSFCQDLH HKCKNSRRQG CHQYVIHNNK CIPECPSGYT MNSSNLLCTP CLGPCPKVCH LLEGEKTIDS VTSAQELRGC TVINGSLIIN IRGGNNLAAE LEANLGLIEE ISGYLKIRRS YALVSLSFFR KLRLIRGETL EIGNYSFYAL DNQNLRQLWD WSKHNLTITQ GKLFFHYNPK LCLSEIHKME EVSGTKGRQE RNDIALKTNG DQASCENELL KFSYIRTSFD KILLRWEPYW PPDFRDLLGF MLFYKEAPYQ NVTEFDGQDA CGSNSWTVVD IDPPLRSNDP KSQNHPGWLM RGLKPWTQYA IFVKTLVTFS DERRTYGAKS DIIYVQTDAT NPSVPLDPIS VSNSSSQIIL KWKPPSDPNG NITHYLVFWE RQAEDSELFE LDYCLKGLKL PSRTWSPPFE SEDSQKHNQS EYEDSAGECC SCPKTDSQIL KELEESSFRK TFEDYLHNVV FVPRKTSSGT GAEDPRPSRK RRSLGDVGNV TVAVPTVAAF PNTSSTSVPT SPEEHRPFEK VVNKESLVIS GLRHFTGYRI ELQACNQDTP EERCSVAAYV SARTMPEAKA DDIVGPVTHE IFENNVVHLM WQEPKEPNGL IVLYEVSYRR YGDEELHLCV SRKHFALERG CRLRGLSPGN YSVRIRATSL AGNGSWTEPT YFYVTDYLDV PSNIAKIIIG PLIFVFLFSV VIGSIYLFLR KRQPDGPLGP LYASSNPEYL SASDVFPCSV YVPDEWEVSR EKITLLRELG QGSFGMVYEG NARDIIKGEA ETRVAVKTVN ESASLRERIE FLNEASVMKG FTCHHVVRLL GVVSKGQPTL VVMELMAHGD LKSYLRSLRP EAENNPGRPP PTLQEMIQMA AEIADGMAYL NAKKFVHRDL AARNCMVAHD FTVKIGDFGM TRDIYETDYY RKGGKGLLPV RWMAPESLKD GVFTTSSDMW SFGVVLWEIT SLAEQPYQGL SNEQVLKFVM DGGYLDQPDN CPERVTDLMR MCWQFNPKMR PTFLEIVNLL KDDLHPSFPE VSFFHSEENK APESEELEME FEDMENVPLD RSSHCQREEA GGRDGGSSLG FKRSYEEHIP YTHMNGGKKN GRILTLPRSN PS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.