Details for: ITGA5

Gene ID: 3678

Symbol: ITGA5

Ensembl ID: ENSG00000161638

Description: integrin subunit alpha 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 142.9809
    Cell Significance Index: -22.2400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 81.8078
    Cell Significance Index: -20.7500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 46.3439
    Cell Significance Index: -21.8800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 18.0785
    Cell Significance Index: -22.2900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.7911
    Cell Significance Index: -19.2400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 7.5493
    Cell Significance Index: 46.9100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.6867
    Cell Significance Index: -22.4400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.8687
    Cell Significance Index: 110.9000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.5906
    Cell Significance Index: 40.0800
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.9097
    Cell Significance Index: 11.2800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.8375
    Cell Significance Index: 12.4500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.6478
    Cell Significance Index: 18.7200
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 1.6305
    Cell Significance Index: 11.7100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.1743
    Cell Significance Index: 16.8900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.1189
    Cell Significance Index: 20.6800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.1032
    Cell Significance Index: 19.5000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.7925
    Cell Significance Index: 13.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5242
    Cell Significance Index: 104.0400
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.4843
    Cell Significance Index: 1.6900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.4823
    Cell Significance Index: 24.3700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.4336
    Cell Significance Index: 2.6200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.3545
    Cell Significance Index: 5.0900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2710
    Cell Significance Index: 5.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2560
    Cell Significance Index: 19.6500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2473
    Cell Significance Index: 33.9600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2463
    Cell Significance Index: 15.8900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1988
    Cell Significance Index: 23.1700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1686
    Cell Significance Index: 3.5300
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.1177
    Cell Significance Index: 0.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0755
    Cell Significance Index: 5.6300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0366
    Cell Significance Index: 49.7900
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.0192
    Cell Significance Index: 0.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0159
    Cell Significance Index: 7.0100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0007
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0034
    Cell Significance Index: -6.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0066
    Cell Significance Index: -10.2200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0100
    Cell Significance Index: -6.2500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0126
    Cell Significance Index: -9.3200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0133
    Cell Significance Index: -24.4700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0151
    Cell Significance Index: -1.7400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0181
    Cell Significance Index: -3.6300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0262
    Cell Significance Index: -16.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0269
    Cell Significance Index: -20.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0270
    Cell Significance Index: -15.2400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0279
    Cell Significance Index: -20.4500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0304
    Cell Significance Index: -5.1900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0339
    Cell Significance Index: -15.3800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0362
    Cell Significance Index: -12.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0380
    Cell Significance Index: -20.7400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0388
    Cell Significance Index: -4.4300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0495
    Cell Significance Index: -14.2500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0597
    Cell Significance Index: -10.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0636
    Cell Significance Index: -13.4000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0708
    Cell Significance Index: -9.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0790
    Cell Significance Index: -9.7100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0828
    Cell Significance Index: -1.3900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0848
    Cell Significance Index: -8.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0875
    Cell Significance Index: -11.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0903
    Cell Significance Index: -13.1300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1832
    Cell Significance Index: -21.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2027
    Cell Significance Index: -9.5300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2085
    Cell Significance Index: -21.7100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2441
    Cell Significance Index: -6.5300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2674
    Cell Significance Index: -6.8300
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: -0.2675
    Cell Significance Index: -3.0000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3085
    Cell Significance Index: -17.3100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3321
    Cell Significance Index: -22.3300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3388
    Cell Significance Index: -21.3600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3531
    Cell Significance Index: -21.7100
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.3595
    Cell Significance Index: -1.6600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3606
    Cell Significance Index: -22.1100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3670
    Cell Significance Index: -17.1100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3831
    Cell Significance Index: -11.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3969
    Cell Significance Index: -20.6200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.4112
    Cell Significance Index: -17.8800
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.4250
    Cell Significance Index: -5.8200
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.4276
    Cell Significance Index: -2.2500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4458
    Cell Significance Index: -19.7200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4672
    Cell Significance Index: -24.5300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4792
    Cell Significance Index: -21.7200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4870
    Cell Significance Index: -17.0600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4872
    Cell Significance Index: -8.2000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.4973
    Cell Significance Index: -7.8900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5018
    Cell Significance Index: -19.0000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5094
    Cell Significance Index: -7.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5488
    Cell Significance Index: -16.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.5618
    Cell Significance Index: -15.7000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.5652
    Cell Significance Index: -19.6400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.5788
    Cell Significance Index: -9.7500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.5901
    Cell Significance Index: -8.7100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5922
    Cell Significance Index: -21.7400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.5939
    Cell Significance Index: -14.4900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6035
    Cell Significance Index: -19.2200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6038
    Cell Significance Index: -16.1800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6115
    Cell Significance Index: -20.0200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.6170
    Cell Significance Index: -15.3900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6671
    Cell Significance Index: -14.2600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.7098
    Cell Significance Index: -10.3100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.7125
    Cell Significance Index: -13.9300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.7206
    Cell Significance Index: -25.3200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ITGA5 is a member of the integrin family, a group of transmembrane receptors that facilitate cell-cell and cell-extracellular matrix interactions. ITGA5 is composed of two subunits, alpha 5 and beta 1, which form a heterodimeric complex that binds to specific ligands, such as fibronectin and vitronectin. The alpha 5 subunit is highly expressed on various cell types, including immune cells, epithelial cells, and endothelial cells. **Pathways and Functions:** ITGA5 is involved in several signaling pathways, including: 1. **Cell-cell adhesion:** ITGA5 mediates adhesion between cells, facilitating interactions between immune cells, epithelial cells, and endothelial cells. 2. **Cell migration:** ITGA5 plays a crucial role in cell migration, particularly in the context of immune responses, wound healing, and angiogenesis. 3. **Signaling:** ITGA5 interacts with various ligands, triggering signaling cascades that regulate cellular processes, including proliferation, differentiation, and survival. 4. **Immune response:** ITGA5 is expressed on immune cells, such as T cells and B cells, and plays a role in the regulation of immune responses, including the activation of T cells and the production of cytokines. **Signaling Pathways:** 1. **Cd40 signaling pathway:** ITGA5 interacts with Cd40, a receptor on immune cells, to regulate the activation of immune responses. 2. **Vascular endothelial growth factor receptor signaling pathway:** ITGA5 regulates angiogenesis by interacting with vascular endothelial growth factor receptors. 3. **G alpha (s) signaling events:** ITGA5 interacts with G alpha (s) proteins, regulating signaling pathways involved in cell migration and adhesion. **Clinical Significance:** ITGA5 is significantly expressed on various cell types, including immune cells, epithelial cells, and endothelial cells. Abnormal expression or function of ITGA5 has been implicated in several diseases, including: 1. **Cancer:** ITGA5 is overexpressed in various types of cancer, including breast and lung cancer, and is associated with poor prognosis. 2. **Autoimmune diseases:** ITGA5 is involved in the regulation of immune responses, and its dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus. 3. **Cardiovascular diseases:** ITGA5 plays a role in vascular endothelial function and is associated with cardiovascular diseases, such as atherosclerosis and hypertension. In conclusion, ITGA5 is a multifunctional receptor that plays a crucial role in various cellular processes, including cell-cell adhesion, migration, and signaling. Its dysregulation has been implicated in several diseases, highlighting the importance of ITGA5 in immune response and disease. Further research is needed to fully understand the role of ITGA5 in human health and disease.

Genular Protein ID: 2171937948

Symbol: ITA5_HUMAN

Name: CD49 antigen-like family member E

UniProtKB Accession Codes:

P08648 Q96HA5

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChEBI 24 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 ELM 1 EMBL 3 EMDB 2 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 42 Gene3D 5 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 2 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 8 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 7 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2958481

Title: Amino acid sequence of the human fibronectin receptor.

PubMed ID: 2958481

DOI: 10.1083/jcb.105.3.1183

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1834647

Title: The alpha 5 beta 1 fibronectin receptor. Characterization of the alpha 5 gene promoter.

PubMed ID: 1834647

DOI: 10.1016/s0021-9258(18)54959-0

PubMed ID: 2450560

Title: Comparison of cDNA-derived protein sequences of the human fibronectin and vitronectin receptor alpha-subunits and platelet glycoprotein IIb.

PubMed ID: 2450560

DOI: 10.1021/bi00399a021

PubMed ID: 2944883

Title: cDNA sequences from the alpha subunit of the fibronectin receptor predict a transmembrane domain and a short cytoplasmic peptide.

PubMed ID: 2944883

DOI: 10.1016/s0021-9258(18)69249-x

PubMed ID: 3033641

Title: The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis.

PubMed ID: 3033641

DOI: 10.1073/pnas.84.10.3239

PubMed ID: 10397733

Title: The Tat protein of human immunodeficiency virus type-1 promotes vascular cell growth and locomotion by engaging the alpha5beta1 and alphavbeta3 integrins and by mobilizing sequestered basic fibroblast growth factor.

PubMed ID: 10397733

PubMed ID: 10094488

Title: Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domains.

PubMed ID: 10094488

DOI: 10.1016/s0014-5793(99)00151-9

PubMed ID: 11912194

Title: Insulin receptor substrate 4 associates with the protein IRAS.

PubMed ID: 11912194

DOI: 10.1074/jbc.m111838200

PubMed ID: 14596610

Title: Mass spectrometric based mapping of the disulfide bonding patterns of integrin alpha chains.

PubMed ID: 14596610

DOI: 10.1021/bi034726u

PubMed ID: 12907437

Title: Alpha5beta1 integrin as a cellular coreceptor for human parvovirus B19: requirement of functional activation of beta1 integrin for viral entry.

PubMed ID: 12907437

DOI: 10.1182/blood-2003-05-1522

PubMed ID: 12695522

Title: CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family.

PubMed ID: 12695522

DOI: 10.1074/jbc.m302028200

PubMed ID: 12807887

Title: Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins.

PubMed ID: 12807887

DOI: 10.1074/jbc.m303159200

PubMed ID: 16051604

Title: Cartilage oligomeric matrix protein/thrombospondin 5 supports chondrocyte attachment through interaction with integrins.

PubMed ID: 16051604

DOI: 10.1074/jbc.m504778200

PubMed ID: 16754960

Title: Small GTPase Rab21 regulates cell adhesion and controls endosomal traffic of beta1-integrins.

PubMed ID: 16754960

DOI: 10.1083/jcb.200509019

PubMed ID: 17158881

Title: alphaVbeta6 is a novel receptor for human fibrillin-1. Comparative studies of molecular determinants underlying integrin-rgd affinity and specificity.

PubMed ID: 17158881

DOI: 10.1074/jbc.m607008200

PubMed ID: 18635536

Title: Pro-inflammatory secretory phospholipase A2 type IIA binds to integrins alphavbeta3 and alpha4beta1 and induces proliferation of monocytic cells in an integrin-dependent manner.

PubMed ID: 18635536

DOI: 10.1074/jbc.m804835200

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22740495

Title: Cleavage of endometrial alpha-integrins into their functional forms is mediated by proprotein convertase 5/6.

PubMed ID: 22740495

DOI: 10.1093/humrep/des203

PubMed ID: 24011356

Title: Identification of novel integrin binding partners for calcium and integrin binding protein 1 (CIB1): structural and thermodynamic basis of CIB1 promiscuity.

PubMed ID: 24011356

DOI: 10.1021/bi400678y

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24478423

Title: Roles of the putative integrin-binding motif of the human metapneumovirus fusion (f) protein in cell-cell fusion, viral infectivity, and pathogenesis.

PubMed ID: 24478423

DOI: 10.1128/jvi.03491-13

PubMed ID: 25398877

Title: Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a newly identified binding site (site 2) in integrins alphavbeta3, alpha4beta1, and alpha5beta1.

PubMed ID: 25398877

DOI: 10.1074/jbc.m114.579946

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29030430

Title: Direct binding to integrins and loss of disulfide linkage in interleukin-1beta (IL-1beta) are involved in the agonistic action of IL-1beta.

PubMed ID: 29030430

DOI: 10.1074/jbc.m117.818302

PubMed ID: 31331973

Title: Integrin Binding to the Trimeric Interface of CD40L Plays a Critical Role in CD40/CD40L Signaling.

PubMed ID: 31331973

DOI: 10.4049/jimmunol.1801630

PubMed ID: 33102950

Title: The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection.

PubMed ID: 33102950

DOI: 10.1016/j.jacbts.2020.10.003

PubMed ID: 32908006

Title: Characterization of ANGPT2 mutations associated with primary lymphedema.

PubMed ID: 32908006

DOI: 10.1126/scitranslmed.aax8013

PubMed ID: 37184585

Title: The C-type lectin domain of CD62P (P-selectin) functions as an integrin ligand.

PubMed ID: 37184585

DOI: 10.26508/lsa.202201747

PubMed ID: 22451694

Title: Crystal structure of alpha5beta1 integrin ectodomain: atomic details of the fibronectin receptor.

PubMed ID: 22451694

DOI: 10.1083/jcb.201111077

PubMed ID: 33962943

Title: Structural insights into integrin alpha5beta1 opening by fibronectin ligand.

PubMed ID: 33962943

DOI: 10.1126/sciadv.abe9716

Sequence Information:

  • Length: 1049
  • Mass: 114536
  • Checksum: 6B4D558D4F739CBA
  • Sequence:
    • MGSRTPESPL HAVQLRWGPR RRPPLLPLLL LLLPPPPRVG GFNLDAEAPA VLSGPPGSFF 
GFSVEFYRPG TDGVSVLVGA PKANTSQPGV LQGGAVYLCP WGASPTQCTP IEFDSKGSRL 
LESSLSSSEG EEPVEYKSLQ WFGATVRAHG SSILACAPLY SWRTEKEPLS DPVGTCYLST 
DNFTRILEYA PCRSDFSWAA GQGYCQGGFS AEFTKTGRVV LGGPGSYFWQ GQILSATQEQ 
IAESYYPEYL INLVQGQLQT RQASSIYDDS YLGYSVAVGE FSGDDTEDFV AGVPKGNLTY 
GYVTILNGSD IRSLYNFSGE QMASYFGYAV AATDVNGDGL DDLLVGAPLL MDRTPDGRPQ 
EVGRVYVYLQ HPAGIEPTPT LTLTGHDEFG RFGSSLTPLG DLDQDGYNDV AIGAPFGGET 
QQGVVFVFPG GPGGLGSKPS QVLQPLWAAS HTPDFFGSAL RGGRDLDGNG YPDLIVGSFG 
VDKAVVYRGR PIVSASASLT IFPAMFNPEE RSCSLEGNPV ACINLSFCLN ASGKHVADSI 
GFTVELQLDW QKQKGGVRRA LFLASRQATL TQTLLIQNGA REDCREMKIY LRNESEFRDK 
LSPIHIALNF SLDPQAPVDS HGLRPALHYQ SKSRIEDKAQ ILLDCGEDNI CVPDLQLEVF 
GEQNHVYLGD KNALNLTFHA QNVGEGGAYE AELRVTAPPE AEYSGLVRHP GNFSSLSCDY 
FAVNQSRLLV CDLGNPMKAG ASLWGGLRFT VPHLRDTKKT IQFDFQILSK NLNNSQSDVV 
SFRLSVEAQA QVTLNGVSKP EAVLFPVSDW HPRDQPQKEE DLGPAVHHVY ELINQGPSSI 
SQGVLELSCP QALEGQQLLY VTRVTGLNCT TNHPINPKGL ELDPEGSLHH QQKREAPSRS 
SASSGPQILK CPEAECFRLR CELGPLHQQE SQSLQLHFRV WAKTFLQREH QPFSLQCEAV 
YKALKMPYRI LPRQLPQKER QVATAVQWTK AEGSYGVPLW IIILAILFGL LLLGLLIYIL 
YKLGFFKRSL PYGTAMEKAQ LKPPATSDA

Genular Protein ID: 238077805

Symbol: B2R627_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2R627

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 9 Gene3D 5 InterPro 9 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PROSITE-ProRule 1 Pfam 7 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 1049
  • Mass: 114480
  • Checksum: 721EB10B257E1833
  • Sequence:
    • MGSRTPESPL HAVQLRWGPR RRPPLLPLLL LLLPPPPRVG GFNLDAEAPA VLSGPPGSFF 
GFSVEFYRPG TDGVSVLVGA PKANTSQPGV LQGGAVYLCP WGASPTQCTP IEFDSKGSRL 
LESSLSSSEG EEPVEYKSLQ WFGATVRAHG SSILACAPLY SWRTEKEPLS DPVGTCYLST 
DNFTRILEYA PCRSDFSWAA GQGYCQGGFS AEFTKTGRVV LGGPGSYFWQ GQILSATQEQ 
IAESYYPEYL INLVQGQLQT RQASSIYDDS YLGYSVAVGE FSGDDTEDFV AGVPKGNLTY 
GYVTILNGSD IRSLYNFSGE QMASYFGYAV AATDVNGDGL DDLLVGAPLL MDRTPDGRPQ 
GVGRVYVYLQ HPAGIEPTPT LTLTGHDEFG RFGSSLTPLG DLDQDGYNDV AIGAPFGGET 
QQGVVFVFPG GPGGLGSKLS QVLQPLWAAS HTPDFFGSAL RGGRDLDGNG YPDLIVGSFG 
VDKAVVYRGR PIVSASASLT IFPAMFNPEE RSCSLEGNPV ACINLSFCLN ASGKHVADSI 
GFTVELQLDW QKQKGGVRRA LFLASRQATL TQTLLIQNGA REDCREMKIY LRNESEFRDK 
LSPIHIALNF SLDPQAPVDS HGLRPALHYQ SKSRIEDKAQ ILLDCGEDNI CVPDLQLEVF 
GEQNHVYLGD KNALNLTFHA QNVGEGGAYE AELRVTAPPE AEYSGLVRHP GNFSSLSCDY 
FAVNQSRLLV CDLGNPMKAG ASLWGGLRFT VPHLRDTKKT IQFDFQILSK NLNNSQSDVV 
SFRLSVEAQA QVTLNGVSKP EAVLFPVSDW HPRDQPQKEE DLGPAVHHVY ELINQGPSSI 
SQGVLELSCP QALEGQQLLY VTRVTGLNCT TNHPINPKGL ELDPEGSLHH QQKREAPSRS 
SASSGPQILK CPEAECFRLR CELGPLHQQE SQSLQLHFRV WAKTFLQREH QPFSLQCEAV 
YKALKMPYRI LPRQLPQKER QVATAVQWTK AEGSYGVPLW IIILAILFGL LLLGLLIYIL 
YKLGFFKRSL PYGTAMEKAQ LKPPATSDA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.