Details for: ITGB4

Gene ID: 3691

Symbol: ITGB4

Ensembl ID: ENSG00000132470

Description: integrin subunit beta 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.28
    Marker Score: 16991
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.25
    Marker Score: 2805
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 2.2
    Marker Score: 1804
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.18
    Marker Score: 46536
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.98
    Marker Score: 1305
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.71
    Marker Score: 2518
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.68
    Marker Score: 10750
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.64
    Marker Score: 7876
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.61
    Marker Score: 702
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.51
    Marker Score: 5945
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.51
    Marker Score: 1944
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.48
    Marker Score: 433
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.47
    Marker Score: 1548
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.46
    Marker Score: 680
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.45
    Marker Score: 1285
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.32
    Marker Score: 280
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.31
    Marker Score: 314
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.3
    Marker Score: 1475
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.25
    Marker Score: 396
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.23
    Marker Score: 2803
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.22
    Marker Score: 3828
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.17
    Marker Score: 4877
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.12
    Marker Score: 5507
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.11
    Marker Score: 2529
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.11
    Marker Score: 681
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.07
    Marker Score: 1181
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.06
    Marker Score: 304.5
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.06
    Marker Score: 305
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.05
    Marker Score: 211
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251778
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 1.01
    Marker Score: 8535
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.01
    Marker Score: 965
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1
    Marker Score: 249
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1
    Marker Score: 669
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71796
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48021
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.98
    Marker Score: 1961
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.98
    Marker Score: 571
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.96
    Marker Score: 8310
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.95
    Marker Score: 2241
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.95
    Marker Score: 824
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.93
    Marker Score: 928.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5302
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.92
    Marker Score: 221
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2732
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.91
    Marker Score: 1841.5
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.91
    Marker Score: 314
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.9
    Marker Score: 614
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.89
    Marker Score: 1291
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5277
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.84
    Marker Score: 1490
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.84
    Marker Score: 29126
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.83
    Marker Score: 739.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.82
    Marker Score: 12876
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.82
    Marker Score: 1264
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.79
    Marker Score: 1880
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.79
    Marker Score: 682
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.79
    Marker Score: 1277
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.79
    Marker Score: 279
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.78
    Marker Score: 673
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.78
    Marker Score: 540
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.77
    Marker Score: 607
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 588
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.76
    Marker Score: 374
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.75
    Marker Score: 283
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 301
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.75
    Marker Score: 1368
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.74
    Marker Score: 765
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.73
    Marker Score: 2506
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.71
    Marker Score: 641
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 646
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.68
    Marker Score: 1144
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.67
    Marker Score: 162
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.66
    Marker Score: 1255
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2754
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.65
    Marker Score: 205
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.63
    Marker Score: 1531.5
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.61
    Marker Score: 357
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.61
    Marker Score: 545
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.6
    Marker Score: 978
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.59
    Marker Score: 200
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.59
    Marker Score: 190
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.58
    Marker Score: 549
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.58
    Marker Score: 784
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.58
    Marker Score: 921
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.57
    Marker Score: 665
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.56
    Marker Score: 371
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.56
    Marker Score: 248
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.56
    Marker Score: 974
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.56
    Marker Score: 334
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.55
    Marker Score: 346
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.54
    Marker Score: 219

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Other Information

**Key characteristics:** * ITGB4 is a transmembrane protein with a molecular weight of approximately 140 kDa. * It is a member of the integrin family of cell adhesion molecules. * ITGB4 is expressed in high levels in epithelial cells, where it is involved in cell-cell adhesion, tissue morphogenesis, and wound healing. * It is also expressed in neurons, where it plays a role in synaptic plasticity and neuronal migration. * ITGB4 is a key regulator of cell migration, as it is required for the formation of cell junctions and the maintenance of cell adhesion to extracellular matrix proteins. **Pathways and functions:** * ITGB4 is a key component of the integrin-mediated signaling pathway, which is involved in cell adhesion, migration, and signaling. * It interacts with other integrins, such as ITGB1 and ITGB3, to form the cell adhesion complex. * It also interacts with other extracellular matrix proteins, such as collagen, fibronectin, and laminin. * ITGB4 is involved in various cellular processes, including cell migration, tissue morphogenesis, angiogenesis, and wound healing. **Clinical significance:** * Mutations in ITGB4 have been linked to several human diseases, including cancer, cardiovascular disease, and diabetes. * ITGB4 inhibitors are being investigated as potential therapeutic agents for these diseases. **Additional information:** * ITGB4 is a highly conserved protein, with similar sequences found in mammals, birds, and reptiles. * It is a transmembrane protein that is expressed on the cell surface. * It is a tetraspanin, which means that it is composed of four transmembrane domains. * It is a key regulator of cell adhesion, migration, and tissue morphogenesis.

Genular Protein ID: 3675248007

Symbol: ITB4_HUMAN

Name: Integrin beta-4

UniProtKB Accession Codes:

P16144 A0AVL6 O14690 O14691 O15339 O15340 O15341 Q0VF97 Q9UIQ4

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CPTAC 2 CTD 1 ChEBI 12 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 ELM 1 EMBL 47 EPD 1 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 7 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 16 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 5 OrthoDB 1 PANTHER 2 PDB 22 PDBsum 13 PIR 2 PIRSF 1 PRINTS 2 PRO 1 PROSITE 4 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 7 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 4 RefSeq 4 SAM 1 SASBDB 1 SIGNOR 1 SMART 5 SMR 1 STRING 1 SUPFAM 6 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2311577

Title: Amino acid sequence of a novel integrin beta 4 subunit and primary expression of the mRNA in epithelial cells.

PubMed ID: 2311577

DOI: 10.1002/j.1460-2075.1990.tb08170.x

PubMed ID: 2311578

Title: Cloning and sequence analysis of beta-4 cDNA: an integrin subunit that contains a unique 118 kd cytoplasmic domain.

PubMed ID: 2311578

DOI: 10.1002/j.1460-2075.1990.tb08171.x

PubMed ID: 1976638

Title: Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4.

PubMed ID: 1976638

DOI: 10.1083/jcb.111.4.1593

PubMed ID: 9194858

Title: Genomic organization of the integrin beta 4 gene (ITGB4): a homozygous splice-site mutation in a patient with junctional epidermolysis bullosa associated with pyloric atresia.

PubMed ID: 9194858

PubMed ID: 9166594

Title: Genomic organization of the human integrin beta 4 gene.

PubMed ID: 9166594

DOI: 10.1007/s003359900467

PubMed ID: 9207246

Title: The unique cytoplasmic domain of the human integrin variant beta4E is produced by partial retention of intronic sequences.

PubMed ID: 9207246

DOI: 10.1006/bbrc.1997.6892

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2542022

Title: A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors.

PubMed ID: 2542022

DOI: 10.1002/j.1460-2075.1989.tb03425.x

PubMed ID: 7982032

Title: A novel structural variant of the human beta 4 integrin cDNA.

PubMed ID: 7982032

DOI: 10.3109/15419069409014197

PubMed ID: 10637308

Title: The N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosome.

PubMed ID: 10637308

DOI: 10.1091/mbc.11.1.277

PubMed ID: 11375975

Title: The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression.

PubMed ID: 11375975

DOI: 10.1074/jbc.m011005200

PubMed ID: 12485428

Title: Deletion of a cytoplasmic domain of integrin beta4 causes epidermolysis bullosa simplex.

PubMed ID: 12485428

DOI: 10.1046/j.1523-1747.2002.19609.x

PubMed ID: 12482924

Title: Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly.

PubMed ID: 12482924

DOI: 10.1242/jcs.00241

PubMed ID: 15611341

Title: Palmitoylation supports assembly and function of integrin-tetraspanin complexes.

PubMed ID: 15611341

DOI: 10.1083/jcb.200404100

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19403692

Title: BPAG1e maintains keratinocyte polarity through beta4 integrin-mediated modulation of Rac1 and cofilin activities.

PubMed ID: 19403692

DOI: 10.1091/mbc.e09-01-0051

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20682778

Title: Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling.

PubMed ID: 20682778

DOI: 10.1074/jbc.m110.113878

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22314500

Title: Palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin alpha6beta4.

PubMed ID: 22314500

DOI: 10.1007/s00018-012-0924-6

PubMed ID: 22351760

Title: Cross-talk between integrin alpha6beta4 and insulin-like growth factor-1 receptor (IGF1R) through direct alpha6beta4 binding to IGF1 and subsequent alpha6beta4-IGF1-IGF1R ternary complex formation in anchorage-independent conditions.

PubMed ID: 22351760

DOI: 10.1074/jbc.m111.304170

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28873464

Title: Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling.

PubMed ID: 28873464

DOI: 10.1371/journal.pone.0184285

PubMed ID: 10428948

Title: Crystal structure of a tandem pair of fibronectin type III domains from the cytoplasmic tail of integrin alpha6beta4.

PubMed ID: 10428948

DOI: 10.1093/emboj/18.15.4087

PubMed ID: 9792864

Title: Novel ITGB4 mutations in lethal and nonlethal variants of epidermolysis bullosa with pyloric atresia: missense versus nonsense.

PubMed ID: 9792864

DOI: 10.1086/302116

PubMed ID: 9422533

Title: Epidermolysis bullosa with pyloric atresia: novel mutations in the beta-4 integrin gene (ITGB4).

PubMed ID: 9422533

PubMed ID: 9546354

Title: Compound heterozygosity for missense (L156P) and nonsense (R554X) mutations in the beta-4 integrin gene (ITGB4) underlies mild, nonlethal phenotype of epidermolysis bullosa with pyloric atresia.

PubMed ID: 9546354

PubMed ID: 9892956

Title: Pyloric atresia-junctional epidermolysis bullosa syndrome: mutations in the integrin beta4 gene (ITGB4) in two unrelated patients with mild disease.

PubMed ID: 9892956

DOI: 10.1046/j.1365-2133.1998.02515.x

PubMed ID: 10873890

Title: Congenital focal segmental glomerulosclerosis associated with beta4 integrin mutation and epidermolysis bullosa.

PubMed ID: 10873890

DOI: 10.1053/ajkd.2000.8293

PubMed ID: 10792571

Title: A homozygous missense mutation in the cytoplasmic tail of beta4 integrin, G931D, that disrupts hemidesmosome assembly and underlies non-Herlitz junctional epidermolysis bullosa without pyloric atresia?

PubMed ID: 10792571

DOI: 10.1046/j.1523-1747.2000.00960-3.x

PubMed ID: 11251584

Title: Alpha 6 beta 4 integrin abnormalities in junctional epidermolysis bullosa with pyloric atresia.

PubMed ID: 11251584

DOI: 10.1046/j.1365-2133.2001.04038.x

PubMed ID: 11289717

Title: Nine novel single-nucleotide polymorphisms in the integrin beta4 (ITGB4) gene in the Japanese population.

PubMed ID: 11289717

DOI: 10.1007/s100380170122

PubMed ID: 11328943

Title: Epidermolysis bullosa with congenital pyloric atresia: novel mutations in the beta 4 integrin gene (ITGB4) and genotype/phenotype correlations.

PubMed ID: 11328943

DOI: 10.1203/00006450-200105000-00003

Sequence Information:

  • Length: 1822
  • Mass: 202167
  • Checksum: 09710FFBBD719469
  • Sequence:
    • MAGPRPSPWA RLLLAALISV SLSGTLANRC KKAPVKSCTE CVRVDKDCAY CTDEMFRDRR 
CNTQAELLAA GCQRESIVVM ESSFQITEET QIDTTLRRSQ MSPQGLRVRL RPGEERHFEL 
EVFEPLESPV DLYILMDFSN SMSDDLDNLK KMGQNLARVL SQLTSDYTIG FGKFVDKVSV 
PQTDMRPEKL KEPWPNSDPP FSFKNVISLT EDVDEFRNKL QGERISGNLD APEGGFDAIL 
QTAVCTRDIG WRPDSTHLLV FSTESAFHYE ADGANVLAGI MSRNDERCHL DTTGTYTQYR 
TQDYPSVPTL VRLLAKHNII PIFAVTNYSY SYYEKLHTYF PVSSLGVLQE DSSNIVELLE 
EAFNRIRSNL DIRALDSPRG LRTEVTSKMF QKTRTGSFHI RRGEVGIYQV QLRALEHVDG 
THVCQLPEDQ KGNIHLKPSF SDGLKMDAGI ICDVCTCELQ KEVRSARCSF NGDFVCGQCV 
CSEGWSGQTC NCSTGSLSDI QPCLREGEDK PCSGRGECQC GHCVCYGEGR YEGQFCEYDN 
FQCPRTSGFL CNDRGRCSMG QCVCEPGWTG PSCDCPLSNA TCIDSNGGIC NGRGHCECGR 
CHCHQQSLYT DTICEINYSA IHPGLCEDLR SCVQCQAWGT GEKKGRTCEE CNFKVKMVDE 
LKRAEEVVVR CSFRDEDDDC TYSYTMEGDG APGPNSTVLV HKKKDCPPGS FWWLIPLLLL 
LLPLLALLLL LCWKYCACCK ACLALLPCCN RGHMVGFKED HYMLRENLMA SDHLDTPMLR 
SGNLKGRDVV RWKVTNNMQR PGFATHAASI NPTELVPYGL SLRLARLCTE NLLKPDTREC 
AQLRQEVEEN LNEVYRQISG VHKLQQTKFR QQPNAGKKQD HTIVDTVLMA PRSAKPALLK 
LTEKQVEQRA FHDLKVAPGY YTLTADQDAR GMVEFQEGVE LVDVRVPLFI RPEDDDEKQL 
LVEAIDVPAG TATLGRRLVN ITIIKEQARD VVSFEQPEFS VSRGDQVARI PVIRRVLDGG 
KSQVSYRTQD GTAQGNRDYI PVEGELLFQP GEAWKELQVK LLELQEVDSL LRGRQVRRFH 
VQLSNPKFGA HLGQPHSTTI IIRDPDELDR SFTSQMLSSQ PPPHGDLGAP QNPNAKAAGS 
RKIHFNWLPP SGKPMGYRVK YWIQGDSESE AHLLDSKVPS VELTNLYPYC DYEMKVCAYG 
AQGEGPYSSL VSCRTHQEVP SEPGRLAFNV VSSTVTQLSW AEPAETNGEI TAYEVCYGLV 
NDDNRPIGPM KKVLVDNPKN RMLLIENLRE SQPYRYTVKA RNGAGWGPER EAIINLATQP 
KRPMSIPIIP DIPIVDAQSG EDYDSFLMYS DDVLRSPSGS QRPSVSDDTG CGWKFEPLLG 
EELDLRRVTW RLPPELIPRL SASSGRSSDA EAPHGPPDDG GAGGKGGSLP RSATPGPPGE 
HLVNGRMDFA FPGSTNSLHR MTTTSAAAYG THLSPHVPHR VLSTSSTLTR DYNSLTRSEH 
SHSTTLPRDY STLTSVSSHD SRLTAGVPDT PTRLVFSALG PTSLRVSWQE PRCERPLQGY 
SVEYQLLNGG ELHRLNIPNP AQTSVVVEDL LPNHSYVFRV RAQSQEGWGR EREGVITIES 
QVHPQSPLCP LPGSAFTLST PSAPGPLVFT ALSPDSLQLS WERPRRPNGD IVGYLVTCEM 
AQGGGPATAF RVDGDSPESR LTVPGLSENV PYKFKVQART TEGFGPEREG IITIESQDGG 
PFPQLGSRAG LFQHPLQSEY SSITTTHTSA TEPFLVDGLT LGAQHLEAGG SLTRHVTQEF 
VSRTLTTSGT LSTHMDQQFF QT

Genular Protein ID: 4291971899

Symbol: B7ZLD8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7ZLD8

Database IDs:

ARBA 11 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 7 Gene3D 7 GenomeRNAi 1 InterPro 16 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 2 PROSITE 4 PeptideAtlas 1 Pfam 7 RefSeq 1 RuleBase 1 SAM 2 SMART 5 SUPFAM 6

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 1752
  • Mass: 195041
  • Checksum: C39EC4D58A1A6DC6
  • Sequence:
    • MAGPRPSPWA RLLLAALISV SLSGTLANRC KKAPVKSCTE CVRVDKDCAY CTDEMFRDRR 
CNTQAELLAA GCQRESIVVM ESSFQITEET QIDTTLRRSQ MSPQGLRVRL RPGEERHFEL 
EVFEPLESPV DLYILMDFSN SMSDDLDNLK KMGQNLARVL SQLTSDYTIG FGKFVDKVSV 
PQTDMRPEKL KEPWPNSDPP FSFKNVISLT EDVDEFRNKL QGERISGNLD APEGGFDAIL 
QTAVCTRDIG WRPDSTHLLV FSTESAFHYE ADGANVLAGI MSRNDERCHL DTTGTYTQYR 
TQDYPSVPTL VRLLAKHNII PIFAVTNYSY SYYEKLHTYF PVSSLGVLQE DSSNIVELLE 
EAFNRIRSNL DIRALDSPRG LRTEVTSKMF QKTRTGSFHI RRGEVGIYQV QLRALEHVDG 
THVCQLPEDQ KGNIHLKPSF SDGLKMDAGI ICDVCTCELQ KEVRSARCSF NGDFVCGQCV 
CSEGWSGQTC NCSTGSLSDI QPCLREGEDK PCSGRGECQC GHCVCYGEGR YEGQFCEYDN 
FQCPRTSGFL CNDRGRCSMG QCVCEPGWTG PSCDCPLSNA TCIDSNGGIC NGRGHCECGR 
CHCHQQSLYT DTICEINYSA IHPGLCEDLR SCVQCQAWGT GEKKGRTCEE CNFKVKMVDE 
LKRAEEVVVR CSFRDEDDDC TYSYTMEGDG APGPNSTVLV HKKKDCPPGS FWWLIPLLLL 
LLPLLALLLL LCWKYCACCK ACLALLPCCN RGHMVGFKED HYMLRENLMA SDHLDTPMLR 
SGNLKGRDVV RWKVTNNMQR PGFATHAASI NPTELVPYGL SLRLARLCTE NLLKPDTREC 
AQLRQEVEEN LNEVYRQISG VHKLQQTKFR QQPNAGKKQD HTIVDTVLMA PRSAKPALLK 
LTEKQVEQRA FHDLKVAPGY YTLTADQDAR GMVEFREGVE LVDVRVPLFI RPEDDDEKQL 
LVEAIDVPAG TATLGRRLVN ITIIKEQARD VVSFEQPEFS VSRGDQVARI PVIRRVLDGG 
KSQVSYRTQD GTAQGNRDYI PVEGELLFQP GEAWKELQVK LLELQEVDSL LRGRQVRRFH 
VQLSNPKFGA HLGQPHSTTI IIRDPDELDR SFTSQMLSSQ PPPHGDLGAP QNPNAKAAGS 
RKIHFNWLPP SGKPMGYRVK YWIQGDSESE AHLLDSKVPS VELTNLYPYC DYEMKVCAYG 
AQGEGPYSSL VSCRTHQEVP SEPGRLAFNV VSSTVTQLSW AEPAETNGEI TAYEVCYGLV 
NDDNRPIGPM KKVLVDNPKN RMLLIENLRE SQPYRYTVKA RNGAGWGPER EAIINLATQP 
KRPMSIPIIP DIPIVDAQSG EDYDSFLMYS DDVLRSPSGS QRPSVSDDTE HLVNGRMDFA 
FPGSTNSLHR MTTTSAAAYG THLSPHVPHR VLSTSSTLTR DYNSLTRSEH SHSTTLPRDY 
STLTSVSSHD SRLTAGVPDT PTRLVFSALG PTSLRVSWQE PRCERPLQGY SVEYQLLNGG 
ELHRLNIPNP AQTSVVVEDL LPNHSYVFRV RAQSQEGWGR EREGVITIES QVHPQSPLCP 
LPGSAFTLST PSAPGPLVFT ALSPDSLQLS WERPRRPNGD IVGYLVTCEM AQGGGPATAF 
RVDGDSPESR LTVPGLSENV PYKFKVQART TEGFGPEREG IITIESQDGG PFPQLGSRAG 
LFQHPLQSEY SSITTTHTSA TEPFLVDGLT LGAQHLEAGG SLTRHVTQEF VSRTLTTSGT 
LSTHMDQQFF QT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.