Details for: ITGB4
Gene ID: 3691
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: ITGB4
Ensembl ID: ENSG00000132470
Description: integrin subunit beta 4
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 14.59rCSI 22.55%PRS 66.48
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CSI 12.47rCSI 30.87%PRS 66.72
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CSI 10.37rCSI 10.86%PRS 64.61
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CSI 8.51rCSI 8.19%PRS 67.7
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CSI 6.36rCSI 5.33%PRS 71.49
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CSI 6.15rCSI 5.41%PRS 55.9
-
CSI 5.69rCSI 4.22%PRS 60.82
-
CSI 4.44rCSI 23.35%PRS 72.26
-
CSI 4.16rCSI 8.45%PRS 46.51
-
CSI 4.13rCSI 5.65%PRS 60.58
-
CSI 4.01rCSI 4.93%PRS 78.49
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CSI 3.67rCSI 15.59%PRS 60.59
-
CSI 3.6rCSI 25.41%PRS 79.26
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CSI 3.43rCSI 7.12%PRS 64.99
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CSI 3.4rCSI 7.24%PRS 77.47
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CSI 3.31rCSI 2.57%PRS 70.97
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CSI 2.96rCSI 3.09%PRS 67.81
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CSI 2.83rCSI 8.05%PRS 65.61
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CSI 2.75rCSI 4.46%PRS 63.92
-
CSI 2.67rCSI 6.09%PRS 59.51
-
CSI 2.56rCSI 10.31%PRS 67.18
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CSI 2.43rCSI 2.01%PRS 67.67
-
CSI 2.38rCSI 3.9%PRS 57.08
-
CSI 2.37rCSI 3.17%PRS 67.83
-
CSI 2.29rCSI 2.16%PRS 67.01
-
CSI 2.17rCSI 1.93%PRS 65.67
-
CSI 2.17rCSI 3.45%PRS 78.28
-
CSI 2.16rCSI 2.87%PRS 74.16
-
CSI 2.08rCSI 3.05%PRS 72.71
-
CSI 2.03rCSI 3.12%PRS 61.25
-
CSI 1.98rCSI 2.1%PRS 76.26
-
CSI 1.96rCSI 2.1%PRS 68.1
-
CSI 1.92rCSI 3.42%PRS 80.2
-
CSI 1.91rCSI 2.8%PRS 79.07
-
CSI 1.86rCSI 4.72%PRS 75.33
-
CSI 1.84rCSI 2.24%PRS 75.22
-
CSI 1.82rCSI 2.27%PRS 69.69
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CSI 1.74rCSI 3.29%PRS 83.89
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CSI 1.72rCSI 2.78%PRS 70.01
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CSI 1.7rCSI 4.04%PRS 70.6
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CSI 1.69rCSI 2.58%PRS 68.69
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CSI 1.68rCSI 1.62%PRS 59.36
-
CSI 1.67rCSI 2.67%PRS 72.24
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CSI 1.65rCSI 1.71%PRS 73.67
-
CSI 1.64rCSI 2.35%PRS 70.51
-
CSI 1.61rCSI 5.17%PRS 65.28
-
CSI 1.55rCSI 2.12%PRS 78.84
-
CSI 1.55rCSI 3.48%PRS 49.93
-
CSI 1.53rCSI 1.53%PRS 61.43
-
CSI 1.51rCSI 2.31%PRS 79.86
-
CSI 1.49rCSI 1.91%PRS 72.4
-
CSI 1.47rCSI 2.15%PRS 63.01
-
CSI 1.43rCSI 2.06%PRS 77.33
-
CSI 1.43rCSI 3.33%PRS 77.26
-
CSI 1.42rCSI 1.67%PRS 69.95
-
CSI 1.4rCSI 4.04%PRS 79.14
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CSI 1.38rCSI 3.63%PRS 84.03
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CSI 1.35rCSI 1.67%PRS 64.81
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CSI 1.35rCSI 2.67%PRS 81.67
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CSI 1.34rCSI 2.05%PRS 72.18
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CSI 1.33rCSI 2.59%PRS 71.02
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CSI 1.33rCSI 1.54%PRS 74.57
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CSI 1.2rCSI 4.58%PRS 58.45
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CSI 1.14rCSI 5%PRS 80.51
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CSI 1.1rCSI 2.61%PRS 75.75
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CSI 1.04rCSI 1.2%PRS 58.77
-
CSI 1.04rCSI 2.91%PRS 77.83
-
CSI 1.02rCSI 1.86%PRS 81.65
-
CSI 1.02rCSI 2.24%PRS 75.07
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CSI 1rCSI 2.18%PRS 79.15
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CSI 0.95rCSI 2.16%PRS 63.57
-
CSI 0.91rCSI 2.45%PRS 74.27
-
CSI 0.88rCSI 6.41%PRS 82.06
-
CSI 0.86rCSI 2.45%PRS 78.23
-
CSI 0.86rCSI 4.5%PRS 76.16
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CSI 0.78rCSI 3.38%PRS 78.93
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CSI 0.77rCSI 17.83%PRS 84.11
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CSI 0.69rCSI 2.76%PRS 81.31
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CSI 0.67rCSI 2.38%PRS 75.03
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CSI 0.62rCSI 5.52%PRS 81.94
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CSI 0.4rCSI 6.42%PRS 84.92
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CSI 0.2rCSI 3.42%PRS 85.41
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CSI 0.17rCSI 1.86%PRS 80.47
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3675248007
Symbol: ITB4_HUMAN
Name: Integrin beta-4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2311577
Title: Amino acid sequence of a novel integrin beta 4 subunit and primary expression of the mRNA in epithelial cells.
PubMed ID: 2311577
PubMed ID: 2311578
Title: Cloning and sequence analysis of beta-4 cDNA: an integrin subunit that contains a unique 118 kd cytoplasmic domain.
PubMed ID: 2311578
PubMed ID: 1976638
Title: Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4.
PubMed ID: 1976638
PubMed ID: 9194858
Title: Genomic organization of the integrin beta 4 gene (ITGB4): a homozygous splice-site mutation in a patient with junctional epidermolysis bullosa associated with pyloric atresia.
PubMed ID: 9194858
PubMed ID: 9166594
Title: Genomic organization of the human integrin beta 4 gene.
PubMed ID: 9166594
PubMed ID: 9207246
Title: The unique cytoplasmic domain of the human integrin variant beta4E is produced by partial retention of intronic sequences.
PubMed ID: 9207246
PubMed ID: 16625196
Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
PubMed ID: 16625196
DOI: 10.1038/nature04689
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2542022
Title: A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors.
PubMed ID: 2542022
PubMed ID: 7982032
Title: A novel structural variant of the human beta 4 integrin cDNA.
PubMed ID: 7982032
PubMed ID: 10637308
Title: The N terminus of the transmembrane protein BP180 interacts with the N-terminal domain of BP230, thereby mediating keratin cytoskeleton anchorage to the cell surface at the site of the hemidesmosome.
PubMed ID: 10637308
DOI: 10.1091/mbc.11.1.277
PubMed ID: 11375975
Title: The hemidesmosomal protein bullous pemphigoid antigen 1 and the integrin beta 4 subunit bind to ERBIN. Molecular cloning of multiple alternative splice variants of ERBIN and analysis of their tissue expression.
PubMed ID: 11375975
PubMed ID: 12485428
Title: Deletion of a cytoplasmic domain of integrin beta4 causes epidermolysis bullosa simplex.
PubMed ID: 12485428
PubMed ID: 12482924
Title: Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly.
PubMed ID: 12482924
DOI: 10.1242/jcs.00241
PubMed ID: 15611341
Title: Palmitoylation supports assembly and function of integrin-tetraspanin complexes.
PubMed ID: 15611341
PubMed ID: 16335952
Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
PubMed ID: 16335952
DOI: 10.1021/pr0502065
PubMed ID: 16964243
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
PubMed ID: 16964243
DOI: 10.1038/nbt1240
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 19403692
Title: BPAG1e maintains keratinocyte polarity through beta4 integrin-mediated modulation of Rac1 and cofilin activities.
PubMed ID: 19403692
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 20682778
Title: Direct binding of the EGF-like domain of neuregulin-1 to integrins ({alpha}v{beta}3 and {alpha}6{beta}4) is involved in neuregulin-1/ErbB signaling.
PubMed ID: 20682778
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22314500
Title: Palmitoylation by DHHC3 is critical for the function, expression, and stability of integrin alpha6beta4.
PubMed ID: 22314500
PubMed ID: 22351760
Title: Cross-talk between integrin alpha6beta4 and insulin-like growth factor-1 receptor (IGF1R) through direct alpha6beta4 binding to IGF1 and subsequent alpha6beta4-IGF1-IGF1R ternary complex formation in anchorage-independent conditions.
PubMed ID: 22351760
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 28873464
Title: Direct integrin binding to insulin-like growth factor-2 through the C-domain is required for insulin-like growth factor receptor type 1 (IGF1R) signaling.
PubMed ID: 28873464
PubMed ID: 30361615
Title: Deletion of TMEM268 inhibits growth of gastric cancer cells by downregulating the ITGB4 signaling pathway.
PubMed ID: 30361615
PubMed ID: 10428948
Title: Crystal structure of a tandem pair of fibronectin type III domains from the cytoplasmic tail of integrin alpha6beta4.
PubMed ID: 10428948
PubMed ID: 9792864
Title: Novel ITGB4 mutations in lethal and nonlethal variants of epidermolysis bullosa with pyloric atresia: missense versus nonsense.
PubMed ID: 9792864
DOI: 10.1086/302116
PubMed ID: 9422533
Title: Epidermolysis bullosa with pyloric atresia: novel mutations in the beta-4 integrin gene (ITGB4).
PubMed ID: 9422533
PubMed ID: 9546354
Title: Compound heterozygosity for missense (L156P) and nonsense (R554X) mutations in the beta-4 integrin gene (ITGB4) underlies mild, nonlethal phenotype of epidermolysis bullosa with pyloric atresia.
PubMed ID: 9546354
PubMed ID: 9892956
Title: Pyloric atresia-junctional epidermolysis bullosa syndrome: mutations in the integrin beta4 gene (ITGB4) in two unrelated patients with mild disease.
PubMed ID: 9892956
PubMed ID: 10873890
Title: Congenital focal segmental glomerulosclerosis associated with beta4 integrin mutation and epidermolysis bullosa.
PubMed ID: 10873890
PubMed ID: 10792571
Title: A homozygous missense mutation in the cytoplasmic tail of beta4 integrin, G931D, that disrupts hemidesmosome assembly and underlies non-Herlitz junctional epidermolysis bullosa without pyloric atresia?
PubMed ID: 10792571
PubMed ID: 11251584
Title: Alpha 6 beta 4 integrin abnormalities in junctional epidermolysis bullosa with pyloric atresia.
PubMed ID: 11251584
PubMed ID: 11289717
Title: Nine novel single-nucleotide polymorphisms in the integrin beta4 (ITGB4) gene in the Japanese population.
PubMed ID: 11289717
PubMed ID: 11328943
Title: Epidermolysis bullosa with congenital pyloric atresia: novel mutations in the beta 4 integrin gene (ITGB4) and genotype/phenotype correlations.
PubMed ID: 11328943
Sequence Information:
- Length: 1822
- Mass: 202167
- Checksum: 09710FFBBD719469
- Sequence:
MAGPRPSPWA RLLLAALISV SLSGTLANRC KKAPVKSCTE CVRVDKDCAY CTDEMFRDRR CNTQAELLAA GCQRESIVVM ESSFQITEET QIDTTLRRSQ MSPQGLRVRL RPGEERHFEL EVFEPLESPV DLYILMDFSN SMSDDLDNLK KMGQNLARVL SQLTSDYTIG FGKFVDKVSV PQTDMRPEKL KEPWPNSDPP FSFKNVISLT EDVDEFRNKL QGERISGNLD APEGGFDAIL QTAVCTRDIG WRPDSTHLLV FSTESAFHYE ADGANVLAGI MSRNDERCHL DTTGTYTQYR TQDYPSVPTL VRLLAKHNII PIFAVTNYSY SYYEKLHTYF PVSSLGVLQE DSSNIVELLE EAFNRIRSNL DIRALDSPRG LRTEVTSKMF QKTRTGSFHI RRGEVGIYQV QLRALEHVDG THVCQLPEDQ KGNIHLKPSF SDGLKMDAGI ICDVCTCELQ KEVRSARCSF NGDFVCGQCV CSEGWSGQTC NCSTGSLSDI QPCLREGEDK PCSGRGECQC GHCVCYGEGR YEGQFCEYDN FQCPRTSGFL CNDRGRCSMG QCVCEPGWTG PSCDCPLSNA TCIDSNGGIC NGRGHCECGR CHCHQQSLYT DTICEINYSA IHPGLCEDLR SCVQCQAWGT GEKKGRTCEE CNFKVKMVDE LKRAEEVVVR CSFRDEDDDC TYSYTMEGDG APGPNSTVLV HKKKDCPPGS FWWLIPLLLL LLPLLALLLL LCWKYCACCK ACLALLPCCN RGHMVGFKED HYMLRENLMA SDHLDTPMLR SGNLKGRDVV RWKVTNNMQR PGFATHAASI NPTELVPYGL SLRLARLCTE NLLKPDTREC AQLRQEVEEN LNEVYRQISG VHKLQQTKFR QQPNAGKKQD HTIVDTVLMA PRSAKPALLK LTEKQVEQRA FHDLKVAPGY YTLTADQDAR GMVEFQEGVE LVDVRVPLFI RPEDDDEKQL LVEAIDVPAG TATLGRRLVN ITIIKEQARD VVSFEQPEFS VSRGDQVARI PVIRRVLDGG KSQVSYRTQD GTAQGNRDYI PVEGELLFQP GEAWKELQVK LLELQEVDSL LRGRQVRRFH VQLSNPKFGA HLGQPHSTTI IIRDPDELDR SFTSQMLSSQ PPPHGDLGAP QNPNAKAAGS RKIHFNWLPP SGKPMGYRVK YWIQGDSESE AHLLDSKVPS VELTNLYPYC DYEMKVCAYG AQGEGPYSSL VSCRTHQEVP SEPGRLAFNV VSSTVTQLSW AEPAETNGEI TAYEVCYGLV NDDNRPIGPM KKVLVDNPKN RMLLIENLRE SQPYRYTVKA RNGAGWGPER EAIINLATQP KRPMSIPIIP DIPIVDAQSG EDYDSFLMYS DDVLRSPSGS QRPSVSDDTG CGWKFEPLLG EELDLRRVTW RLPPELIPRL SASSGRSSDA EAPHGPPDDG GAGGKGGSLP RSATPGPPGE HLVNGRMDFA FPGSTNSLHR MTTTSAAAYG THLSPHVPHR VLSTSSTLTR DYNSLTRSEH SHSTTLPRDY STLTSVSSHD SRLTAGVPDT PTRLVFSALG PTSLRVSWQE PRCERPLQGY SVEYQLLNGG ELHRLNIPNP AQTSVVVEDL LPNHSYVFRV RAQSQEGWGR EREGVITIES QVHPQSPLCP LPGSAFTLST PSAPGPLVFT ALSPDSLQLS WERPRRPNGD IVGYLVTCEM AQGGGPATAF RVDGDSPESR LTVPGLSENV PYKFKVQART TEGFGPEREG IITIESQDGG PFPQLGSRAG LFQHPLQSEY SSITTTHTSA TEPFLVDGLT LGAQHLEAGG SLTRHVTQEF VSRTLTTSGT LSTHMDQQFF QT
Genular Protein ID: 4291971899
Symbol: B7ZLD8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
Sequence Information:
- Length: 1752
- Mass: 195041
- Checksum: C39EC4D58A1A6DC6
- Sequence:
MAGPRPSPWA RLLLAALISV SLSGTLANRC KKAPVKSCTE CVRVDKDCAY CTDEMFRDRR CNTQAELLAA GCQRESIVVM ESSFQITEET QIDTTLRRSQ MSPQGLRVRL RPGEERHFEL EVFEPLESPV DLYILMDFSN SMSDDLDNLK KMGQNLARVL SQLTSDYTIG FGKFVDKVSV PQTDMRPEKL KEPWPNSDPP FSFKNVISLT EDVDEFRNKL QGERISGNLD APEGGFDAIL QTAVCTRDIG WRPDSTHLLV FSTESAFHYE ADGANVLAGI MSRNDERCHL DTTGTYTQYR TQDYPSVPTL VRLLAKHNII PIFAVTNYSY SYYEKLHTYF PVSSLGVLQE DSSNIVELLE EAFNRIRSNL DIRALDSPRG LRTEVTSKMF QKTRTGSFHI RRGEVGIYQV QLRALEHVDG THVCQLPEDQ KGNIHLKPSF SDGLKMDAGI ICDVCTCELQ KEVRSARCSF NGDFVCGQCV CSEGWSGQTC NCSTGSLSDI QPCLREGEDK PCSGRGECQC GHCVCYGEGR YEGQFCEYDN FQCPRTSGFL CNDRGRCSMG QCVCEPGWTG PSCDCPLSNA TCIDSNGGIC NGRGHCECGR CHCHQQSLYT DTICEINYSA IHPGLCEDLR SCVQCQAWGT GEKKGRTCEE CNFKVKMVDE LKRAEEVVVR CSFRDEDDDC TYSYTMEGDG APGPNSTVLV HKKKDCPPGS FWWLIPLLLL LLPLLALLLL LCWKYCACCK ACLALLPCCN RGHMVGFKED HYMLRENLMA SDHLDTPMLR SGNLKGRDVV RWKVTNNMQR PGFATHAASI NPTELVPYGL SLRLARLCTE NLLKPDTREC AQLRQEVEEN LNEVYRQISG VHKLQQTKFR QQPNAGKKQD HTIVDTVLMA PRSAKPALLK LTEKQVEQRA FHDLKVAPGY YTLTADQDAR GMVEFREGVE LVDVRVPLFI RPEDDDEKQL LVEAIDVPAG TATLGRRLVN ITIIKEQARD VVSFEQPEFS VSRGDQVARI PVIRRVLDGG KSQVSYRTQD GTAQGNRDYI PVEGELLFQP GEAWKELQVK LLELQEVDSL LRGRQVRRFH VQLSNPKFGA HLGQPHSTTI IIRDPDELDR SFTSQMLSSQ PPPHGDLGAP QNPNAKAAGS RKIHFNWLPP SGKPMGYRVK YWIQGDSESE AHLLDSKVPS VELTNLYPYC DYEMKVCAYG AQGEGPYSSL VSCRTHQEVP SEPGRLAFNV VSSTVTQLSW AEPAETNGEI TAYEVCYGLV NDDNRPIGPM KKVLVDNPKN RMLLIENLRE SQPYRYTVKA RNGAGWGPER EAIINLATQP KRPMSIPIIP DIPIVDAQSG EDYDSFLMYS DDVLRSPSGS QRPSVSDDTE HLVNGRMDFA FPGSTNSLHR MTTTSAAAYG THLSPHVPHR VLSTSSTLTR DYNSLTRSEH SHSTTLPRDY STLTSVSSHD SRLTAGVPDT PTRLVFSALG PTSLRVSWQE PRCERPLQGY SVEYQLLNGG ELHRLNIPNP AQTSVVVEDL LPNHSYVFRV RAQSQEGWGR EREGVITIES QVHPQSPLCP LPGSAFTLST PSAPGPLVFT ALSPDSLQLS WERPRRPNGD IVGYLVTCEM AQGGGPATAF RVDGDSPESR LTVPGLSENV PYKFKVQART TEGFGPEREG IITIESQDGG PFPQLGSRAG LFQHPLQSEY SSITTTHTSA TEPFLVDGLT LGAQHLEAGG SLTRHVTQEF VSRTLTTSGT LSTHMDQQFF QT