Details for: KCNC4

Gene ID: 3749

Symbol: KCNC4

Ensembl ID: ENSG00000116396

Description: potassium voltage-gated channel subfamily C member 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 61.4291
    Cell Significance Index: -9.5600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 36.5080
    Cell Significance Index: -9.2600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 7.7699
    Cell Significance Index: -9.5800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.4353
    Cell Significance Index: -7.4800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.4303
    Cell Significance Index: -9.5900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 1.1923
    Cell Significance Index: 17.0800
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 0.9768
    Cell Significance Index: 3.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8825
    Cell Significance Index: 24.0200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.8750
    Cell Significance Index: 10.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8255
    Cell Significance Index: 55.5100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8085
    Cell Significance Index: 50.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8048
    Cell Significance Index: 161.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8012
    Cell Significance Index: 22.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.6862
    Cell Significance Index: 67.8800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6768
    Cell Significance Index: 14.8200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.6438
    Cell Significance Index: 7.9900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6319
    Cell Significance Index: 14.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5834
    Cell Significance Index: 7.9600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5681
    Cell Significance Index: 25.7500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.5404
    Cell Significance Index: 13.8900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4716
    Cell Significance Index: 89.7400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3820
    Cell Significance Index: 11.0100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3493
    Cell Significance Index: 20.9700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3318
    Cell Significance Index: 36.1000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3262
    Cell Significance Index: 53.0500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3094
    Cell Significance Index: 279.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3025
    Cell Significance Index: 108.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.2538
    Cell Significance Index: 11.9300
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.2392
    Cell Significance Index: 3.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1519
    Cell Significance Index: 7.0800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1306
    Cell Significance Index: 16.8700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.1205
    Cell Significance Index: 3.4400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1138
    Cell Significance Index: 7.8700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0784
    Cell Significance Index: 42.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0675
    Cell Significance Index: 29.8300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0589
    Cell Significance Index: 1.0100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0580
    Cell Significance Index: 40.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0576
    Cell Significance Index: 108.5200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0567
    Cell Significance Index: 4.0100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0526
    Cell Significance Index: 0.7300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0415
    Cell Significance Index: 7.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0376
    Cell Significance Index: 1.3200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0352
    Cell Significance Index: 0.7500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0332
    Cell Significance Index: 0.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0108
    Cell Significance Index: 6.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0101
    Cell Significance Index: 15.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0056
    Cell Significance Index: 10.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0043
    Cell Significance Index: 3.1600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0029
    Cell Significance Index: 0.1800
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.0011
    Cell Significance Index: 0.0100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0008
    Cell Significance Index: -0.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0014
    Cell Significance Index: -0.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0060
    Cell Significance Index: -8.2100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0080
    Cell Significance Index: -1.0200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0093
    Cell Significance Index: -1.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0105
    Cell Significance Index: -7.8000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0126
    Cell Significance Index: -9.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0158
    Cell Significance Index: -8.9300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0160
    Cell Significance Index: -1.8300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0168
    Cell Significance Index: -10.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0188
    Cell Significance Index: -2.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0202
    Cell Significance Index: -3.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0202
    Cell Significance Index: -9.1700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0211
    Cell Significance Index: -0.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0244
    Cell Significance Index: -7.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0265
    Cell Significance Index: -1.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0364
    Cell Significance Index: -2.0400
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0441
    Cell Significance Index: -0.4200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0468
    Cell Significance Index: -0.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0514
    Cell Significance Index: -10.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0580
    Cell Significance Index: -4.3200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0589
    Cell Significance Index: -3.6100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0601
    Cell Significance Index: -6.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0608
    Cell Significance Index: -7.0800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0687
    Cell Significance Index: -8.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0740
    Cell Significance Index: -5.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0782
    Cell Significance Index: -8.1400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0826
    Cell Significance Index: -1.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0908
    Cell Significance Index: -5.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0996
    Cell Significance Index: -3.1900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1128
    Cell Significance Index: -8.9300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1293
    Cell Significance Index: -3.1000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1326
    Cell Significance Index: -1.7200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1342
    Cell Significance Index: -1.9300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1407
    Cell Significance Index: -3.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1434
    Cell Significance Index: -7.4500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1542
    Cell Significance Index: -3.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1672
    Cell Significance Index: -8.7100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1694
    Cell Significance Index: -3.4000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1760
    Cell Significance Index: -5.6100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1869
    Cell Significance Index: -6.1200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2013
    Cell Significance Index: -3.9800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2037
    Cell Significance Index: -4.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2051
    Cell Significance Index: -9.0700
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2095
    Cell Significance Index: -2.9400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2164
    Cell Significance Index: -7.5800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2185
    Cell Significance Index: -5.4500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2193
    Cell Significance Index: -8.0500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2208
    Cell Significance Index: -9.6000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2224
    Cell Significance Index: -4.7200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Structure:** The KCNC4 gene consists of 11 exons and spans approximately 25 kilobases on chromosome 5q33. 2. **Protein Function:** KCNC4 is a voltage-gated potassium channel that regulates the flow of potassium ions into the cell, thereby modulating the resting membrane potential and neuronal excitability. 3. **Subcellular Localization:** KCNC4 is primarily expressed on the plasma membrane of neurons, where it forms heteromultimeric channels with other potassium channel subunits. 4. **Expression Pattern:** KCNC4 is widely expressed in the nervous system, including the cerebral cortex, hippocampus, and spinal cord, as well as in other tissues such as the kidney and intestine. **Pathways and Functions:** The KCNC4 gene is involved in several key pathways, including: 1. **Neuronal Excitability:** KCNC4 regulates the resting membrane potential and controls the influx of potassium ions into the cell, thereby modulating neuronal excitability. 2. **Synaptic Transmission:** KCNC4 is involved in the regulation of synaptic transmission, particularly at GABAergic synapses, where it modulates the amplitude and frequency of inhibitory postsynaptic currents. 3. **Neuroprotection:** KCNC4 may play a role in neuroprotection by regulating the excitability of neurons and preventing excessive neuronal activity. 4. **Cardiac Function:** KCNC4 is also expressed in the heart, where it regulates the flow of potassium ions into cardiac myocytes, thereby modulating cardiac excitability and contractility. **Clinical Significance:** Dysregulation of the KCNC4 gene has been implicated in several neurological disorders, including: 1. **Epilepsy:** KCNC4 mutations have been associated with epilepsy, particularly in cases where there is a family history of seizure disorders. 2. **Neuromuscular Disorders:** KCNC4 mutations have been linked to neuromuscular disorders, such as myotonia congenita and periodic paralysis. 3. **Psychiatric Disorders:** KCNC4 has also been implicated in psychiatric disorders, such as schizophrenia and bipolar disorder. 4. **Cancer:** KCNC4 has been found to be overexpressed in certain types of cancer, including colon cancer and breast cancer. In conclusion, the KCNC4 gene plays a critical role in regulating neuronal excitability and synaptic transmission, and its dysregulation has been implicated in several neurological disorders. Further research is needed to fully understand the mechanisms by which KCNC4 regulates neuronal function and to develop therapeutic strategies for the treatment of KCNC4-related disorders.

Genular Protein ID: 3638147697

Symbol: KCNC4_HUMAN

Name: Potassium voltage-gated channel subfamily C member 4

UniProtKB Accession Codes:

Q03721 Q3MIM4 Q5TBI6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 4 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRINTS 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 2 Rhea 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1381835

Title: Cloning of ShIII (Shaw-like) cDNAs encoding a novel high-voltage-activating, TEA-sensitive, type-A K+ channel.

PubMed ID: 1381835

DOI: 10.1098/rspb.1992.0036

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7993631

Title: Elimination of rapid potassium channel inactivation by phosphorylation of the inactivation gate.

PubMed ID: 7993631

DOI: 10.1016/0896-6273(94)90425-1

PubMed ID: 9649584

Title: Interactions between multiple phosphorylation sites in the inactivation particle of a K+ channel. Insights into the molecular mechanism of protein kinase C action.

PubMed ID: 9649584

DOI: 10.1085/jgp.112.1.71

PubMed ID: 9000078

Title: NMR structure of inactivation gates from mammalian voltage-dependent potassium channels.

PubMed ID: 9000078

DOI: 10.1038/385272a0

PubMed ID: 10048926

Title: Control of K+ channel gating by protein phosphorylation: structural switches of the inactivation gate.

PubMed ID: 10048926

DOI: 10.1038/5833

Sequence Information:

  • Length: 635
  • Mass: 69767
  • Checksum: 8A36F0A16AD17722
  • Sequence:
    • MISSVCVSSY RGRKSGNKPP SKTCLKEEMA KGEASEKIII NVGGTRHETY RSTLRTLPGT 
RLAWLADPDG GGRPETDGGG VGSSGSSGGG GCEFFFDRHP GVFAYVLNYY RTGKLHCPAD 
VCGPLFEEEL TFWGIDETDV EPCCWMTYRQ HRDAEEALDI FESPDGGGSG AGPSDEAGDD 
ERELALQRLG PHEGGAGHGA GSGGCRGWQP RMWALFEDPY SSRAARVVAF ASLFFILVSI 
TTFCLETHEA FNIDRNVTEI LRVGNITSVH FRREVETEPI LTYIEGVCVL WFTLEFLVRI 
VCCPDTLDFV KNLLNIIDFV AILPFYLEVG LSGLSSKAAR DVLGFLRVVR FVRILRIFKL 
TRHFVGLRVL GHTLRASTNE FLLLIIFLAL GVLIFATMIY YAERIGARPS DPRGNDHTDF 
KNIPIGFWWA VVTMTTLGYG DMYPKTWSGM LVGALCALAG VLTIAMPVPV IVNNFGMYYS 
LAMAKQKLPK KRKKHVPRPA QLESPMYCKS EETSPRDSTC SDTSPPAREE GMIERKRADS 
KQNGDANAVL SDEEGAGLTQ PLASSPTPEE RRALRRSTTR DRNKKAAACF LLSTGDYACA 
DGSVRKGTFV LRDLPLQHSP EAACPPTAGT LFLPH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.