Details for: KCNC4

Gene ID: 3749

Symbol: KCNC4

Ensembl ID: ENSG00000116396

Description: potassium voltage-gated channel subfamily C member 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.56
    Marker Score: 1675
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.1
    Marker Score: 580
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71805
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48030
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.99
    Marker Score: 60698
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 499
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 453
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.94
    Marker Score: 722
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.92
    Marker Score: 8721
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2733
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5170
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.9
    Marker Score: 1833
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 317
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.87
    Marker Score: 3546
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5278
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.84
    Marker Score: 262
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.82
    Marker Score: 12803
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.8
    Marker Score: 1325
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.77
    Marker Score: 1948
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1252
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.76
    Marker Score: 7181
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.76
    Marker Score: 695
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 388
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 672
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.73
    Marker Score: 1489.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.72
    Marker Score: 287
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.7
    Marker Score: 6051
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.7
    Marker Score: 536
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2926
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.68
    Marker Score: 409
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.68
    Marker Score: 2631
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.68
    Marker Score: 2847
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 172
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.67
    Marker Score: 1902
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.67
    Marker Score: 1029
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.64
    Marker Score: 426
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.64
    Marker Score: 905
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.64
    Marker Score: 205
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.62
    Marker Score: 6401
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.61
    Marker Score: 691
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.61
    Marker Score: 646
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.59
    Marker Score: 22377
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.58
    Marker Score: 3505
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.57
    Marker Score: 274
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.56
    Marker Score: 11134
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.55
    Marker Score: 526
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 436
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.52
    Marker Score: 7720
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.51
    Marker Score: 327
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.5
    Marker Score: 140
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.49
    Marker Score: 976
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.48
    Marker Score: 501
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.48
    Marker Score: 3694
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.47
    Marker Score: 190
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.46
    Marker Score: 1238.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.45
    Marker Score: 743.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.45
    Marker Score: 269
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.45
    Marker Score: 9561
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.43
    Marker Score: 181
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.43
    Marker Score: 129
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.43
    Marker Score: 1043
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.42
    Marker Score: 397
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.41
    Marker Score: 354
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.4
    Marker Score: 940
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.4
    Marker Score: 281
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.39
    Marker Score: 1458
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.39
    Marker Score: 891
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.39
    Marker Score: 397.5
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.39
    Marker Score: 450
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.39
    Marker Score: 101
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.38
    Marker Score: 2851
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.38
    Marker Score: 1477
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.37
    Marker Score: 82
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.37
    Marker Score: 360
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.37
    Marker Score: 480
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.37
    Marker Score: 164
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.37
    Marker Score: 902
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.37
    Marker Score: 329
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.35
    Marker Score: 738
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.35
    Marker Score: 110
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.34
    Marker Score: 93
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.33
    Marker Score: 758
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.33
    Marker Score: 572
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.33
    Marker Score: 122
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.32
    Marker Score: 146
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.31
    Marker Score: 11608.5
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.31
    Marker Score: 3150
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.3
    Marker Score: 80.5
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.3
    Marker Score: 420
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.3
    Marker Score: 110
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3
    Marker Score: 201
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.29
    Marker Score: 291
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.29
    Marker Score: 151
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.29
    Marker Score: 84
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.27
    Marker Score: 90
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.27
    Marker Score: 759.5
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.27
    Marker Score: 1235
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.27
    Marker Score: 387

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Other Information

**Key characteristics:** * KCNC4 is a transmembrane protein that belongs to the potassium channel superfamily. * It is expressed in high levels in the plasma membrane of endothelial cells, where it is involved in maintaining the resting potential of the cell. * It is also expressed in the plasma membrane of renal cells, where it is involved in regulating water and electrolyte balance. * In neurons, KCNC4 is expressed in the axonal terminus, where it is involved in the generation and propagation of action potentials. * It is also expressed in the dendritic membrane, neuronal cell body membrane, and presynaptic membrane. **Pathways and functions:** * KCNC4 is a key component of the axonal terminus, where it is involved in the opening of potassium channels in the plasma membrane of nerve cells. * It is also involved in chemical synaptic transmission, where it forms a complex with other channel proteins to regulate the release of neurotransmitters from presynaptic terminals. * In the neuronal cell body, KCNC4 is involved in the regulation of neuronal excitability and synaptic plasticity. * It is also involved in the regulation of neuronal differentiation and survival. **Clinical significance:** Mutations in KCNC4 have been linked to several human diseases, including hypertension, stroke, and heart failure. These diseases are characterized by abnormal potassium channel function, which can be caused by mutations in KCNC4 or other potassium channel genes. **Additional notes:** * KCNC4 is a highly conserved protein, with a similar sequence in mammals, birds, and fish. * It is a member of the potassium channel superfamily, which is the largest family of voltage-gated ion channels. * KCNC4 is a relatively new protein, with the first functional gene encoding it identified in 2004.

Genular Protein ID: 3638147697

Symbol: KCNC4_HUMAN

Name: Potassium voltage-gated channel subfamily C member 4

UniProtKB Accession Codes:

Q03721 Q3MIM4 Q5TBI6

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 4 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 3 PRINTS 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1381835

Title: Cloning of ShIII (Shaw-like) cDNAs encoding a novel high-voltage-activating, TEA-sensitive, type-A K+ channel.

PubMed ID: 1381835

DOI: 10.1098/rspb.1992.0036

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7993631

Title: Elimination of rapid potassium channel inactivation by phosphorylation of the inactivation gate.

PubMed ID: 7993631

DOI: 10.1016/0896-6273(94)90425-1

PubMed ID: 9649584

Title: Interactions between multiple phosphorylation sites in the inactivation particle of a K+ channel. Insights into the molecular mechanism of protein kinase C action.

PubMed ID: 9649584

DOI: 10.1085/jgp.112.1.71

PubMed ID: 9000078

Title: NMR structure of inactivation gates from mammalian voltage-dependent potassium channels.

PubMed ID: 9000078

DOI: 10.1038/385272a0

PubMed ID: 10048926

Title: Control of K+ channel gating by protein phosphorylation: structural switches of the inactivation gate.

PubMed ID: 10048926

DOI: 10.1038/5833

Sequence Information:

  • Length: 635
  • Mass: 69767
  • Checksum: 8A36F0A16AD17722
  • Sequence:
    • MISSVCVSSY RGRKSGNKPP SKTCLKEEMA KGEASEKIII NVGGTRHETY RSTLRTLPGT 
RLAWLADPDG GGRPETDGGG VGSSGSSGGG GCEFFFDRHP GVFAYVLNYY RTGKLHCPAD 
VCGPLFEEEL TFWGIDETDV EPCCWMTYRQ HRDAEEALDI FESPDGGGSG AGPSDEAGDD 
ERELALQRLG PHEGGAGHGA GSGGCRGWQP RMWALFEDPY SSRAARVVAF ASLFFILVSI 
TTFCLETHEA FNIDRNVTEI LRVGNITSVH FRREVETEPI LTYIEGVCVL WFTLEFLVRI 
VCCPDTLDFV KNLLNIIDFV AILPFYLEVG LSGLSSKAAR DVLGFLRVVR FVRILRIFKL 
TRHFVGLRVL GHTLRASTNE FLLLIIFLAL GVLIFATMIY YAERIGARPS DPRGNDHTDF 
KNIPIGFWWA VVTMTTLGYG DMYPKTWSGM LVGALCALAG VLTIAMPVPV IVNNFGMYYS 
LAMAKQKLPK KRKKHVPRPA QLESPMYCKS EETSPRDSTC SDTSPPAREE GMIERKRADS 
KQNGDANAVL SDEEGAGLTQ PLASSPTPEE RRALRRSTTR DRNKKAAACF LLSTGDYACA 
DGSVRKGTFV LRDLPLQHSP EAACPPTAGT LFLPH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.