Details for: KCND1

Gene ID: 3750

Symbol: KCND1

Ensembl ID: ENSG00000102057

Description: potassium voltage-gated channel subfamily D member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 19.8656
    Cell Significance Index: -3.0900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 12.1036
    Cell Significance Index: -3.0700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 6.1784
    Cell Significance Index: -2.5100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 2.6395
    Cell Significance Index: -2.5200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.5143
    Cell Significance Index: -3.1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1340
    Cell Significance Index: 36.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7128
    Cell Significance Index: 32.3100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5510
    Cell Significance Index: 104.8600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3794
    Cell Significance Index: 37.5400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3109
    Cell Significance Index: 280.7000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2021
    Cell Significance Index: 21.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2000
    Cell Significance Index: 32.5200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1596
    Cell Significance Index: 3.9800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.1583
    Cell Significance Index: 2.2500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1477
    Cell Significance Index: 8.8700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.1141
    Cell Significance Index: 1.8800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1047
    Cell Significance Index: 1.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0987
    Cell Significance Index: 6.8300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0625
    Cell Significance Index: 1.8000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0451
    Cell Significance Index: 2.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0317
    Cell Significance Index: 2.0000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0231
    Cell Significance Index: 0.5000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0212
    Cell Significance Index: 4.2500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.0202
    Cell Significance Index: 0.2900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0158
    Cell Significance Index: 2.0200
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.0130
    Cell Significance Index: 0.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0115
    Cell Significance Index: 4.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0065
    Cell Significance Index: 0.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0060
    Cell Significance Index: 0.8300
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.0043
    Cell Significance Index: 0.0600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0035
    Cell Significance Index: 1.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0025
    Cell Significance Index: 0.1300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0020
    Cell Significance Index: 0.2300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0012
    Cell Significance Index: 0.0300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0004
    Cell Significance Index: 0.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0002
    Cell Significance Index: 0.1300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0007
    Cell Significance Index: -0.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0011
    Cell Significance Index: -2.1100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0028
    Cell Significance Index: -5.1600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0031
    Cell Significance Index: -4.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0038
    Cell Significance Index: -2.8100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0039
    Cell Significance Index: -2.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0040
    Cell Significance Index: -3.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0046
    Cell Significance Index: -0.5700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0046
    Cell Significance Index: -0.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0047
    Cell Significance Index: -6.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0052
    Cell Significance Index: -3.8500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0062
    Cell Significance Index: -0.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0067
    Cell Significance Index: -0.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0072
    Cell Significance Index: -4.0800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0079
    Cell Significance Index: -3.5800
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.0084
    Cell Significance Index: -0.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0103
    Cell Significance Index: -0.2200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0111
    Cell Significance Index: -3.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0114
    Cell Significance Index: -1.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0117
    Cell Significance Index: -1.3400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0132
    Cell Significance Index: -0.5400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0135
    Cell Significance Index: -0.6300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0139
    Cell Significance Index: -0.3600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0146
    Cell Significance Index: -0.2500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0176
    Cell Significance Index: -0.2800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0202
    Cell Significance Index: -0.5500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0212
    Cell Significance Index: -1.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0214
    Cell Significance Index: -3.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0217
    Cell Significance Index: -4.5800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0235
    Cell Significance Index: -2.4000
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0241
    Cell Significance Index: -0.3200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0247
    Cell Significance Index: -3.1900
  • Cell Name: brush cell (CL0002204)
    Fold Change: -0.0251
    Cell Significance Index: -0.2300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0272
    Cell Significance Index: -0.5700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0277
    Cell Significance Index: -0.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0296
    Cell Significance Index: -3.0800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0322
    Cell Significance Index: -0.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0343
    Cell Significance Index: -4.0400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0353
    Cell Significance Index: -1.5400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0392
    Cell Significance Index: -2.5300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0394
    Cell Significance Index: -2.9400
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0404
    Cell Significance Index: -0.6000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0409
    Cell Significance Index: -0.7100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0419
    Cell Significance Index: -0.6100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0454
    Cell Significance Index: -0.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0490
    Cell Significance Index: -2.7500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0503
    Cell Significance Index: -2.3700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0553
    Cell Significance Index: -1.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0558
    Cell Significance Index: -2.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0565
    Cell Significance Index: -4.3400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0574
    Cell Significance Index: -2.0100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0576
    Cell Significance Index: -0.8500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0584
    Cell Significance Index: -0.8800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0589
    Cell Significance Index: -1.9300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0591
    Cell Significance Index: -0.4000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0606
    Cell Significance Index: -1.9300
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.0612
    Cell Significance Index: -0.8700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0623
    Cell Significance Index: -1.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0656
    Cell Significance Index: -2.9000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0669
    Cell Significance Index: -1.1200
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.0686
    Cell Significance Index: -0.9400
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: -0.0689
    Cell Significance Index: -0.7300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0694
    Cell Significance Index: -1.5000
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0712
    Cell Significance Index: -1.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene structure and function:** KCND1 is a single-copy gene that encodes a potassium channel subunit, which forms heteromeric channels with KCND2, KCND3, and KCND4. 2. **Channel properties:** KCND1 channels are characterized by a high permeability to potassium ions, with a fast activation and inactivation kinetics, allowing for rapid modulation of cellular excitability. 3. **Cellular localization:** KCND1 channels are primarily localized to the plasma membrane, where they contribute to the regulation of cell excitability and signaling. 4. **Regulatory mechanisms:** KCND1 channels are modulated by various factors, including calcium, magnesium, and small molecule ligands, which can influence their activity and expression. **Pathways and Functions:** 1. **A-type potassium channel activity:** KCND1 channels are a key component of the A-type potassium (Ito) channels, which play a crucial role in regulating the excitability of neurons and immune cells. 2. **Cardiac conduction:** KCND1 channels are also expressed in the heart, where they contribute to the regulation of cardiac excitability and conduction. 3. **Neuronal signaling:** KCND1 channels modulate neuronal signaling, particularly in the regulation of excitatory neurotransmitter release and synaptic plasticity. 4. **Immune system regulation:** KCND1 channels are expressed in immune cells, where they contribute to the regulation of immune cell excitability and function. **Clinical Significance:** 1. **Cardiac arrhythmias:** Mutations in the KCND1 gene have been associated with cardiac arrhythmias, including long QT syndrome and Brugada syndrome. 2. **Neurological disorders:** KCND1 channels have been implicated in various neurological disorders, including epilepsy, migraine, and Parkinson's disease. 3. **Immune system dysregulation:** KCND1 channels may contribute to immune system dysregulation, which is observed in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 4. **Cancer:** KCND1 channels have been expressed in various types of cancer, including colon, breast, and lung cancer, suggesting a potential role in tumor progression and metastasis. In conclusion, the KCND1 gene plays a critical role in regulating cellular excitability and function in various cell types, including immune cells, neurons, and epithelial cells. Understanding the molecular mechanisms underlying KCND1 channel function and regulation will provide valuable insights into the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 3738817683

Symbol: KCND1_HUMAN

Name: Voltage-gated potassium channel subunit Kv4.1

UniProtKB Accession Codes:

Q9NSA2 A6NEF1 B2RCG0 O75671

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 12 Ensembl 4 ExpressionAtlas 1 GO 10 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 Rhea 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10729221

Title: Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA).

PubMed ID: 10729221

DOI: 10.1006/geno.2000.6117

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15454437

Title: Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10).

PubMed ID: 15454437

DOI: 10.1529/biophysj.104.042358

Sequence Information:

  • Length: 647
  • Mass: 71330
  • Checksum: 8672C299CDB7C5AA
  • Sequence:
    • MAAGLATWLP FARAAAVGWL PLAQQPLPPA PGVKASRGDE VLVVNVSGRR FETWKNTLDR 
YPDTLLGSSE KEFFYDADSG EYFFDRDPDM FRHVLNFYRT GRLHCPRQEC IQAFDEELAF 
YGLVPELVGD CCLEEYRDRK KENAERLAED EEAEQAGDGP ALPAGSSLRQ RLWRAFENPH 
TSTAALVFYY VTGFFIAVSV IANVVETIPC RGSARRSSRE QPCGERFPQA FFCMDTACVL 
IFTGEYLLRL FAAPSRCRFL RSVMSLIDVV AILPYYIGLL VPKNDDVSGA FVTLRVFRVF 
RIFKFSRHSQ GLRILGYTLK SCASELGFLL FSLTMAIIIF ATVMFYAEKG TNKTNFTSIP 
AAFWYTIVTM TTLGYGDMVP STIAGKIFGS ICSLSGVLVI ALPVPVIVSN FSRIYHQNQR 
ADKRRAQQKV RLARIRLAKS GTTNAFLQYK QNGGLEDSGS GEEQALCVRN RSAFEQQHHH 
LLHCLEKTTC HEFTDELTFS EALGAVSPGG RTSRSTSVSS QPVGPGSLLS SCCPRRAKRR 
AIRLANSTAS VSRGSMQELD MLAGLRRSHA PQSRSSLNAK PHDSLDLNCD SRDFVAAIIS 
IPTPPANTPD ESQPSSPGGG GRAGSTLRNS SLGTPCLFPE TVKISSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.