Details for: KCND1

Gene ID: 3750

Symbol: KCND1

Ensembl ID: ENSG00000102057

Description: potassium voltage-gated channel subfamily D member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.58
    Marker Score: 30275
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1174
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 858
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7680
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.05
    Marker Score: 799
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71836
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48061
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5354
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.85
    Marker Score: 393
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 710
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3013
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.56
    Marker Score: 360
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.39
    Marker Score: 485
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.37
    Marker Score: 143
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.31
    Marker Score: 76
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.3
    Marker Score: 560
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.27
    Marker Score: 551
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.26
    Marker Score: 533.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.25
    Marker Score: 3940
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.24
    Marker Score: 96
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.24
    Marker Score: 70
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.2
    Marker Score: 52
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 41
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.15
    Marker Score: 219
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.15
    Marker Score: 90
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.15
    Marker Score: 61
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.13
    Marker Score: 319
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 0.13
    Marker Score: 31
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.12
    Marker Score: 52
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.11
    Marker Score: 54
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.11
    Marker Score: 36
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.11
    Marker Score: 35
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.11
    Marker Score: 189
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.1
    Marker Score: 60
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.1
    Marker Score: 33
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.1
    Marker Score: 113
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.1
    Marker Score: 57
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.09
    Marker Score: 32
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.09
    Marker Score: 58
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.08
    Marker Score: 50
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.08
    Marker Score: 101
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.08
    Marker Score: 222
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.07
    Marker Score: 623
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.07
    Marker Score: 55
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.07
    Marker Score: 47
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.07
    Marker Score: 617
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.07
    Marker Score: 28
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.07
    Marker Score: 66
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.07
    Marker Score: 102
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.07
    Marker Score: 167
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.07
    Marker Score: 14
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.07
    Marker Score: 32
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.07
    Marker Score: 43
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.07
    Marker Score: 29
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.07
    Marker Score: 90
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.07
    Marker Score: 2482
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.07
    Marker Score: 27
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.06
    Marker Score: 153
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.06
    Marker Score: 13
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.06
    Marker Score: 36
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.06
    Marker Score: 97
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.06
    Marker Score: 62
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.06
    Marker Score: 113
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.06
    Marker Score: 62
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.06
    Marker Score: 59
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.06
    Marker Score: 68
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.06
    Marker Score: 73
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.06
    Marker Score: 59
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.06
    Marker Score: 14
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.06
    Marker Score: 54
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.06
    Marker Score: 60
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.06
    Marker Score: 57
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.05
    Marker Score: 12
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.05
    Marker Score: 34
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.05
    Marker Score: 81
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.05
    Marker Score: 27
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.05
    Marker Score: 491
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.05
    Marker Score: 29
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.05
    Marker Score: 392

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Other Information

**Key characteristics:** * The KCND1 gene is located on chromosome 19q21.1. * It is a large gene with a predicted protein length of 2,611 amino acids. * The protein contains a single potassium channel domain, which is responsible for the channel's function. * The protein is a transmembrane protein, with a signal peptide that is translated from the mRNA and a transmembrane domain that spans the cell membrane. * The protein is a ligand for the G protein BK, which is involved in regulating potassium channel activity. **Pathways and functions:** * The KCND1 gene is involved in a variety of cellular processes, including cardiac conduction, cellular component, dendritic spine, muscle contraction, neuronal cell body, and neuronal system. * In cardiac conduction, the KCND1 gene is expressed in cardiac cells and is involved in the regulation of cardiac rhythm. * In the nervous system, the KCND1 gene is expressed in neurons and is involved in a variety of neuronal functions, including synaptic transmission and neuronal excitability. **Clinical significance:** Mutations in the KCND1 gene have been linked to a number of human diseases, including epilepsy, cardiac arrhythmias, and gastrointestinal disorders. These diseases are caused by mutations that disrupt the function of the KCND1 protein, leading to changes in potassium channel activity and signaling. **Conclusion:** The KCND1 gene is a critical component of the cellular mechanisms underlying a variety of physiological and pathological processes. Understanding the function of the KCND1 gene and its role in human health is important for developing new treatments for diseases caused by mutations in the gene.

Genular Protein ID: 3738817683

Symbol: KCND1_HUMAN

Name: Potassium voltage-gated channel subfamily D member 1

UniProtKB Accession Codes:

Q9NSA2 A6NEF1 B2RCG0 O75671

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 DrugCentral 1 EMBL 12 Ensembl 4 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10729221

Title: Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA).

PubMed ID: 10729221

DOI: 10.1006/geno.2000.6117

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15454437

Title: Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10).

PubMed ID: 15454437

DOI: 10.1529/biophysj.104.042358

Sequence Information:

  • Length: 647
  • Mass: 71330
  • Checksum: 8672C299CDB7C5AA
  • Sequence:
    • MAAGLATWLP FARAAAVGWL PLAQQPLPPA PGVKASRGDE VLVVNVSGRR FETWKNTLDR 
YPDTLLGSSE KEFFYDADSG EYFFDRDPDM FRHVLNFYRT GRLHCPRQEC IQAFDEELAF 
YGLVPELVGD CCLEEYRDRK KENAERLAED EEAEQAGDGP ALPAGSSLRQ RLWRAFENPH 
TSTAALVFYY VTGFFIAVSV IANVVETIPC RGSARRSSRE QPCGERFPQA FFCMDTACVL 
IFTGEYLLRL FAAPSRCRFL RSVMSLIDVV AILPYYIGLL VPKNDDVSGA FVTLRVFRVF 
RIFKFSRHSQ GLRILGYTLK SCASELGFLL FSLTMAIIIF ATVMFYAEKG TNKTNFTSIP 
AAFWYTIVTM TTLGYGDMVP STIAGKIFGS ICSLSGVLVI ALPVPVIVSN FSRIYHQNQR 
ADKRRAQQKV RLARIRLAKS GTTNAFLQYK QNGGLEDSGS GEEQALCVRN RSAFEQQHHH 
LLHCLEKTTC HEFTDELTFS EALGAVSPGG RTSRSTSVSS QPVGPGSLLS SCCPRRAKRR 
AIRLANSTAS VSRGSMQELD MLAGLRRSHA PQSRSSLNAK PHDSLDLNCD SRDFVAAIIS 
IPTPPANTPD ESQPSSPGGG GRAGSTLRNS SLGTPCLFPE TVKISSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.