Details for: KCND3

Gene ID: 3752

Symbol: KCND3

Ensembl ID: ENSG00000171385

Description: potassium voltage-gated channel subfamily D member 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 4.2
    Marker Score: 22565
  • Cell Name: granule cell (CL0000120)
    Fold Change: 3.63
    Marker Score: 27405
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 3.46
    Marker Score: 18131
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.74
    Marker Score: 21030
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.68
    Marker Score: 40005
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 2.59
    Marker Score: 5960
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.53
    Marker Score: 56623
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.46
    Marker Score: 48843.5
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.42
    Marker Score: 10028
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 2.37
    Marker Score: 8426
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.31
    Marker Score: 8931
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.24
    Marker Score: 84933
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.22
    Marker Score: 10249
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 2.18
    Marker Score: 20461
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 2.09
    Marker Score: 5959
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.06
    Marker Score: 126409
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.02
    Marker Score: 6774
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 2.02
    Marker Score: 20849
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2
    Marker Score: 42709.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2
    Marker Score: 73725
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 1.94
    Marker Score: 3254
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.89
    Marker Score: 17985
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.88
    Marker Score: 7657.5
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.85
    Marker Score: 775
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.81
    Marker Score: 15569
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.78
    Marker Score: 561
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.64
    Marker Score: 2530
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.64
    Marker Score: 1604
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.63
    Marker Score: 914
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.56
    Marker Score: 427
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168967
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.46
    Marker Score: 852
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.45
    Marker Score: 3415
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.45
    Marker Score: 1804
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.39
    Marker Score: 724
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.33
    Marker Score: 20856
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 1.27
    Marker Score: 610
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 849
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.24
    Marker Score: 5205
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.24
    Marker Score: 1101
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.24
    Marker Score: 902
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.22
    Marker Score: 7829
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.2
    Marker Score: 5164
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.16
    Marker Score: 393
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4804
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.11
    Marker Score: 5993
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.07
    Marker Score: 676
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.06
    Marker Score: 620
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 791
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.03
    Marker Score: 2090
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71806.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48030.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.96
    Marker Score: 1186
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.96
    Marker Score: 664
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.95
    Marker Score: 625
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5213
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.89
    Marker Score: 30149
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.77
    Marker Score: 298
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 696
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.76
    Marker Score: 4550
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 0.75
    Marker Score: 418
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.75
    Marker Score: 276
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 457
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.71
    Marker Score: 225.5
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.71
    Marker Score: 265
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.71
    Marker Score: 424
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7
    Marker Score: 1026
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.67
    Marker Score: 1467
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.66
    Marker Score: 1277.5
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.65
    Marker Score: 813
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.65
    Marker Score: 565
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.63
    Marker Score: 183
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.62
    Marker Score: 196
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.58
    Marker Score: 275
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.57
    Marker Score: 2387
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.57
    Marker Score: 182
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.56
    Marker Score: 326
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.54
    Marker Score: 384
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.54
    Marker Score: 1273
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.53
    Marker Score: 453
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.53
    Marker Score: 1272
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.53
    Marker Score: 219
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.51
    Marker Score: 226
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.51
    Marker Score: 160
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.5
    Marker Score: 158
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5
    Marker Score: 603
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.5
    Marker Score: 470.5

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Other Information

# Summary KCND3 is a potassium voltage-gated channel subfamily D member 3, which is expressed in various cell types, including stellate neurons, granule cells, neurons associated cells, and cardiac myocytes. It plays a crucial role in regulating cardiac conduction, membrane repolarization, and muscle contraction. # Key characteristics - It is a transmembrane protein that belongs to the potassium channel superfamily. - It is expressed in high levels in cardiac muscle cells, where it is involved in maintaining the resting membrane potential and regulating cardiac conduction. - It is also expressed in other cell types, where it may have different functions. # Pathways and functions - The main pathway activated by KCND3 is the A-type (transient outward) potassium channel activity. - It is involved in repolarizing the cardiac membrane potential during cardiac muscle cell action potential. - It is also involved in maintaining the resting membrane potential in other cell types. # Clinical significance - Mutations in KCND3 have been linked to various cardiovascular diseases, including atrial fibrillation, ventricular tachycardia, and cardiomyopathy. - Targeting KCND3 with drugs is a promising strategy for treating these diseases. # Additional information - The KCND3 gene is located on chromosome 17q21.1. - It is a highly conserved protein, with a similar sequence in mammals, birds, and fish. - It is a member of the potassium channel superfamily, which is a large family of ion channels that are involved in a variety of cellular processes, including cardiac conduction, muscle contraction, and neuronal signaling.

Genular Protein ID: 3069972644

Symbol: KCND3_HUMAN

Name: Potassium voltage-gated channel subfamily D member 3

UniProtKB Accession Codes:

Q9UK17 O60576 O60577 Q14D71 Q5T0M0 Q9UH85 Q9UH86 Q9UK16

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 10 DrugCentral 1 EMBL 19 EMDB 4 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 6 PRINTS 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 6 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9843794

Title: Isolation and characterization of the human gene encoding Ito: further diversity by alternative mRNA splicing.

PubMed ID: 9843794

DOI: 10.1152/ajpheart.1998.275.6.h1963

PubMed ID: 10200233

Title: Cloning and expression of the human Kv4.3 potassium channel.

PubMed ID: 10200233

DOI: 10.1152/jn.1999.81.4.1974

PubMed ID: 10729221

Title: Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA).

PubMed ID: 10729221

DOI: 10.1006/geno.2000.6117

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12297301

Title: Modulation of Kv4.3 current by accessory subunits.

PubMed ID: 12297301

DOI: 10.1016/s0014-5793(02)03296-9

PubMed ID: 19213956

Title: Kv4 potassium channels form a tripartite complex with the anchoring protein SAP97 and CaMKII in cardiac myocytes.

PubMed ID: 19213956

DOI: 10.1161/circresaha.108.191007

PubMed ID: 21349352

Title: Transient outward current (I(to)) gain-of-function mutations in the KCND3-encoded Kv4.3 potassium channel and Brugada syndrome.

PubMed ID: 21349352

DOI: 10.1016/j.hrthm.2011.02.021

PubMed ID: 22457051

Title: Novel mutations in the KCND3-encoded Kv4.3 K+ channel associated with autopsy-negative sudden unexplained death.

PubMed ID: 22457051

DOI: 10.1002/humu.22058

PubMed ID: 14980207

Title: Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1.

PubMed ID: 14980207

DOI: 10.1016/s0896-6273(04)00049-2

PubMed ID: 17187064

Title: Structural basis for modulation of Kv4 K+ channels by auxiliary KChIP subunits.

PubMed ID: 17187064

DOI: 10.1038/nn1822

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 23280837

Title: Mutations in KCND3 cause spinocerebellar ataxia type 22.

PubMed ID: 23280837

DOI: 10.1002/ana.23701

PubMed ID: 23280838

Title: Mutations in potassium channel kcnd3 cause spinocerebellar ataxia type 19.

PubMed ID: 23280838

DOI: 10.1002/ana.23700

PubMed ID: 28895081

Title: Novel de novo KCND3 mutation in a Japanese patient with intellectual disability, cerebellar ataxia, myoclonus, and dystonia.

PubMed ID: 28895081

DOI: 10.1007/s12311-017-0883-4

Sequence Information:

  • Length: 655
  • Mass: 73451
  • Checksum: ADD1402A97204764
  • Sequence:
    • MAAGVAAWLP FARAAAIGWM PVANCPMPLA PADKNKRQDE LIVLNVSGRR FQTWRTTLER 
YPDTLLGSTE KEFFFNEDTK EYFFDRDPEV FRCVLNFYRT GKLHYPRYEC ISAYDDELAF 
YGILPEIIGD CCYEEYKDRK RENAERLMDD NDSENNQESM PSLSFRQTMW RAFENPHTST 
LALVFYYVTG FFIAVSVITN VVETVPCGTV PGSKELPCGE RYSVAFFCLD TACVMIFTVE 
YLLRLFAAPS RYRFIRSVMS IIDVVAIMPY YIGLVMTNNE DVSGAFVTLR VFRVFRIFKF 
SRHSQGLRIL GYTLKSCASE LGFLLFSLTM AIIIFATVMF YAEKGSSASK FTSIPASFWY 
TIVTMTTLGY GDMVPKTIAG KIFGSICSLS GVLVIALPVP VIVSNFSRIY HQNQRADKRR 
AQKKARLARI RVAKTGSSNA YLHSKRNGLL NEALELTGTP EEEHMGKTTS LIESQHHHLL 
HCLEKTTGLS YLVDDPLLSV RTSTIKNHEF IDEQMFEQNC MESSMQNYPS TRSPSLSSHP 
GLTTTCCSRR SKKTTHLPNS NLPATRLRSM QELSTIHIQG SEQPSLTTSR SSLNLKADDG 
LRPNCKTSQI TTAIISIPTP PALTPEGESR PPPASPGPNT NIPSIASNVV KVSAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.