Details for: KCND3

Gene ID: 3752

Symbol: KCND3

Ensembl ID: ENSG00000171385

Description: potassium voltage-gated channel subfamily D member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 226.4936
    Cell Significance Index: -35.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 140.0391
    Cell Significance Index: -35.5200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 28.5898
    Cell Significance Index: -35.2500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.0090
    Cell Significance Index: -35.5500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 5.2809
    Cell Significance Index: 90.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.7631
    Cell Significance Index: 1349.7600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 2.9430
    Cell Significance Index: 197.8900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.8051
    Cell Significance Index: 215.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.7928
    Cell Significance Index: 123.5300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 2.5337
    Cell Significance Index: 72.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4951
    Cell Significance Index: 500.5200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.4726
    Cell Significance Index: 93.6300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.8474
    Cell Significance Index: 31.1200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.5949
    Cell Significance Index: 38.2500
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 1.5738
    Cell Significance Index: 20.4100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.5568
    Cell Significance Index: 95.6900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.4517
    Cell Significance Index: 75.4100
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 1.4468
    Cell Significance Index: 19.3000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.2365
    Cell Significance Index: 855.1800
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 1.2195
    Cell Significance Index: 9.4000
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.4101
    Cell Significance Index: 3.6400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4010
    Cell Significance Index: 76.3200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3302
    Cell Significance Index: 65.5300
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 0.2428
    Cell Significance Index: 2.3100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2376
    Cell Significance Index: 214.5200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1645
    Cell Significance Index: 309.7000
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.1208
    Cell Significance Index: 1.0000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1192
    Cell Significance Index: 162.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1008
    Cell Significance Index: 9.9700
  • Cell Name: granule cell (CL0000120)
    Fold Change: 0.0755
    Cell Significance Index: 0.8600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0443
    Cell Significance Index: 28.1700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0105
    Cell Significance Index: 1.8900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0096
    Cell Significance Index: 1.5600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0036
    Cell Significance Index: 5.5500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0024
    Cell Significance Index: -0.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0026
    Cell Significance Index: -0.3200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0028
    Cell Significance Index: -0.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0034
    Cell Significance Index: -0.3500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0047
    Cell Significance Index: -0.6900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0071
    Cell Significance Index: -13.1400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0091
    Cell Significance Index: -0.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0132
    Cell Significance Index: -6.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0347
    Cell Significance Index: -25.7200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0370
    Cell Significance Index: -16.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0411
    Cell Significance Index: -30.1500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0448
    Cell Significance Index: -33.9400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0489
    Cell Significance Index: -1.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0568
    Cell Significance Index: -32.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0602
    Cell Significance Index: -32.8800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0633
    Cell Significance Index: -39.5300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0649
    Cell Significance Index: -1.4200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0681
    Cell Significance Index: -1.6500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0682
    Cell Significance Index: -11.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0787
    Cell Significance Index: -10.8100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0868
    Cell Significance Index: -4.5600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1040
    Cell Significance Index: -29.9200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1088
    Cell Significance Index: -2.7200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1141
    Cell Significance Index: -2.2900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1236
    Cell Significance Index: -1.7700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1382
    Cell Significance Index: -2.0400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1393
    Cell Significance Index: -15.1600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1478
    Cell Significance Index: -6.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1632
    Cell Significance Index: -4.5600
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1714
    Cell Significance Index: -3.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1758
    Cell Significance Index: -37.0300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1762
    Cell Significance Index: -3.7400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1777
    Cell Significance Index: -3.8400
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1886
    Cell Significance Index: -2.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2522
    Cell Significance Index: -32.5900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2549
    Cell Significance Index: -6.2200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2706
    Cell Significance Index: -31.5300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.2983
    Cell Significance Index: -35.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3027
    Cell Significance Index: -20.9300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3128
    Cell Significance Index: -40.1000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3167
    Cell Significance Index: -3.4500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3188
    Cell Significance Index: -36.5200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3209
    Cell Significance Index: -32.7800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3251
    Cell Significance Index: -4.8000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3309
    Cell Significance Index: -10.5400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3772
    Cell Significance Index: -12.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3785
    Cell Significance Index: -28.2100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4141
    Cell Significance Index: -32.8000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4228
    Cell Significance Index: -25.3800
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.4478
    Cell Significance Index: -11.1700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.4858
    Cell Significance Index: -6.2300
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.4900
    Cell Significance Index: -5.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4930
    Cell Significance Index: -13.4200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5008
    Cell Significance Index: -35.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5217
    Cell Significance Index: -32.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5458
    Cell Significance Index: -30.6300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5462
    Cell Significance Index: -35.2400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5636
    Cell Significance Index: -12.2100
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.5829
    Cell Significance Index: -6.8000
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.5882
    Cell Significance Index: -6.4900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.6043
    Cell Significance Index: -7.3300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.6105
    Cell Significance Index: -9.8000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.6109
    Cell Significance Index: -21.4000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6178
    Cell Significance Index: -15.8800
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.6235
    Cell Significance Index: -5.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.6287
    Cell Significance Index: -29.5500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit composition:** KCND3 is a subunit of the A-type potassium channel, which is composed of four subunits (KCND1-4). The KCND3 subunit is essential for the assembly and function of the channel. 2. **Expression:** KCND3 is highly expressed in the heart and brain, with significant expression in cardiac myocytes, neurons, and glial cells. 3. **Function:** KCND3 regulates membrane repolarization, heart rate, and neuronal excitability by controlling the flow of potassium ions across the plasma membrane. 4. **Regulation:** KCND3 is regulated by various mechanisms, including phosphorylation, ubiquitination, and interaction with other proteins. **Pathways and Functions:** 1. **Cardiac Conduction:** KCND3 plays a crucial role in regulating cardiac conduction by controlling the repolarization phase of the cardiac action potential. 2. **Neuronal Excitability:** KCND3 is involved in regulating neuronal excitability by controlling the flow of potassium ions across the neuronal membrane. 3. **Membrane Repolarization:** KCND3 regulates membrane repolarization by controlling the efflux of potassium ions from the cell. 4. **Muscle Contraction:** KCND3 has been implicated in regulating muscle contraction by controlling the repolarization phase of the cardiac action potential. **Clinical Significance:** 1. **Cardiac Disorders:** KCND3 has been implicated in various cardiac disorders, including long QT syndrome, atrial fibrillation, and heart failure. 2. **Neurological Disorders:** KCND3 has been implicated in various neurological disorders, including epilepsy, anxiety disorders, and depression. 3. **Therapeutic Targets:** KCND3 has emerged as a potential therapeutic target for the treatment of cardiac and neurological disorders. 4. **Disease Association:** KCND3 has been associated with various diseases, including arrhythmias, seizures, and psychiatric disorders. In conclusion, KCND3 is a critical gene that plays a vital role in regulating cardiac conduction and neuronal function. Dysregulation of KCND3 has been implicated in various cardiac and neurological disorders, highlighting the importance of this gene in maintaining proper physiological function. Further research is needed to fully understand the mechanisms by which KCND3 regulates cardiac conduction and neuronal excitability, and to identify potential therapeutic targets for the treatment of these disorders.

Genular Protein ID: 3069972644

Symbol: KCND3_HUMAN

Name: Potassium voltage-gated channel subfamily D member 3

UniProtKB Accession Codes:

Q9UK17 O60576 O60577 Q14D71 Q5T0M0 Q9UH85 Q9UH86 Q9UK16

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 10 DrugCentral 1 EMBL 19 EMDB 4 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRINTS 4 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 6 Rhea 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9843794

Title: Isolation and characterization of the human gene encoding Ito: further diversity by alternative mRNA splicing.

PubMed ID: 9843794

DOI: 10.1152/ajpheart.1998.275.6.h1963

PubMed ID: 10200233

Title: Cloning and expression of the human Kv4.3 potassium channel.

PubMed ID: 10200233

DOI: 10.1152/jn.1999.81.4.1974

PubMed ID: 10729221

Title: Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA).

PubMed ID: 10729221

DOI: 10.1006/geno.2000.6117

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12297301

Title: Modulation of Kv4.3 current by accessory subunits.

PubMed ID: 12297301

DOI: 10.1016/s0014-5793(02)03296-9

PubMed ID: 19213956

Title: Kv4 potassium channels form a tripartite complex with the anchoring protein SAP97 and CaMKII in cardiac myocytes.

PubMed ID: 19213956

DOI: 10.1161/circresaha.108.191007

PubMed ID: 21349352

Title: Transient outward current (I(to)) gain-of-function mutations in the KCND3-encoded Kv4.3 potassium channel and Brugada syndrome.

PubMed ID: 21349352

DOI: 10.1016/j.hrthm.2011.02.021

PubMed ID: 22457051

Title: Novel mutations in the KCND3-encoded Kv4.3 K+ channel associated with autopsy-negative sudden unexplained death.

PubMed ID: 22457051

DOI: 10.1002/humu.22058

PubMed ID: 14980207

Title: Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1.

PubMed ID: 14980207

DOI: 10.1016/s0896-6273(04)00049-2

PubMed ID: 17187064

Title: Structural basis for modulation of Kv4 K+ channels by auxiliary KChIP subunits.

PubMed ID: 17187064

DOI: 10.1038/nn1822

PubMed ID: 34997220

Title: Structural basis for the gating modulation of Kv4.3 by auxiliary subunits.

PubMed ID: 34997220

DOI: 10.1038/s41422-021-00608-4

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 23280837

Title: Mutations in KCND3 cause spinocerebellar ataxia type 22.

PubMed ID: 23280837

DOI: 10.1002/ana.23701

PubMed ID: 23280838

Title: Mutations in potassium channel kcnd3 cause spinocerebellar ataxia type 19.

PubMed ID: 23280838

DOI: 10.1002/ana.23700

PubMed ID: 28895081

Title: Novel de novo KCND3 mutation in a Japanese patient with intellectual disability, cerebellar ataxia, myoclonus, and dystonia.

PubMed ID: 28895081

DOI: 10.1007/s12311-017-0883-4

Sequence Information:

  • Length: 655
  • Mass: 73451
  • Checksum: ADD1402A97204764
  • Sequence:
    • MAAGVAAWLP FARAAAIGWM PVANCPMPLA PADKNKRQDE LIVLNVSGRR FQTWRTTLER 
YPDTLLGSTE KEFFFNEDTK EYFFDRDPEV FRCVLNFYRT GKLHYPRYEC ISAYDDELAF 
YGILPEIIGD CCYEEYKDRK RENAERLMDD NDSENNQESM PSLSFRQTMW RAFENPHTST 
LALVFYYVTG FFIAVSVITN VVETVPCGTV PGSKELPCGE RYSVAFFCLD TACVMIFTVE 
YLLRLFAAPS RYRFIRSVMS IIDVVAIMPY YIGLVMTNNE DVSGAFVTLR VFRVFRIFKF 
SRHSQGLRIL GYTLKSCASE LGFLLFSLTM AIIIFATVMF YAEKGSSASK FTSIPASFWY 
TIVTMTTLGY GDMVPKTIAG KIFGSICSLS GVLVIALPVP VIVSNFSRIY HQNQRADKRR 
AQKKARLARI RVAKTGSSNA YLHSKRNGLL NEALELTGTP EEEHMGKTTS LIESQHHHLL 
HCLEKTTGLS YLVDDPLLSV RTSTIKNHEF IDEQMFEQNC MESSMQNYPS TRSPSLSSHP 
GLTTTCCSRR SKKTTHLPNS NLPATRLRSM QELSTIHIQG SEQPSLTTSR SSLNLKADDG 
LRPNCKTSQI TTAIISIPTP PALTPEGESR PPPASPGPNT NIPSIASNVV KVSAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.