Details for: KCNN1

Gene ID: 3780

Symbol: KCNN1

Ensembl ID: ENSG00000105642

Description: potassium calcium-activated channel subfamily N member 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1169
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.36
    Marker Score: 2093
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 853
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.24
    Marker Score: 2354
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.2
    Marker Score: 2434
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.05
    Marker Score: 9999
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 794
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71827
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48052
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.96
    Marker Score: 432
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.96
    Marker Score: 1983
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5331
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.91
    Marker Score: 377
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.91
    Marker Score: 545
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.81
    Marker Score: 49954
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.8
    Marker Score: 366
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.79
    Marker Score: 6751
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.77
    Marker Score: 12123
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.77
    Marker Score: 1020
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.77
    Marker Score: 3213
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 459
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.65
    Marker Score: 22066
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.64
    Marker Score: 205
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.59
    Marker Score: 283
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.56
    Marker Score: 2327
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.56
    Marker Score: 673
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.54
    Marker Score: 2216
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.5
    Marker Score: 374
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.49
    Marker Score: 155
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.43
    Marker Score: 4061
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.42
    Marker Score: 3233
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.4
    Marker Score: 706
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.4
    Marker Score: 2345
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.4
    Marker Score: 108
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.39
    Marker Score: 417
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.38
    Marker Score: 5679
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.37
    Marker Score: 1434
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.37
    Marker Score: 153
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.35
    Marker Score: 153
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.33
    Marker Score: 183
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.32
    Marker Score: 543
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.32
    Marker Score: 12085
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.31
    Marker Score: 1216
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.31
    Marker Score: 97
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.3
    Marker Score: 508
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.3
    Marker Score: 620
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.29
    Marker Score: 3013
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.29
    Marker Score: 84
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.28
    Marker Score: 932
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.28
    Marker Score: 2809
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.28
    Marker Score: 346
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.27
    Marker Score: 293
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.26
    Marker Score: 1712
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.26
    Marker Score: 100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.25
    Marker Score: 2531
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.25
    Marker Score: 158
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.25
    Marker Score: 104
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.24
    Marker Score: 63
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.23
    Marker Score: 335
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.23
    Marker Score: 511
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.23
    Marker Score: 531
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.22
    Marker Score: 148
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.22
    Marker Score: 91
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.22
    Marker Score: 125
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.22
    Marker Score: 4394
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.22
    Marker Score: 4684
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.22
    Marker Score: 69
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.22
    Marker Score: 903
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.21
    Marker Score: 991
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.21
    Marker Score: 151
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.21
    Marker Score: 180
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.2
    Marker Score: 98
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.2
    Marker Score: 69
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.2
    Marker Score: 221
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.19
    Marker Score: 127
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.19
    Marker Score: 189
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.19
    Marker Score: 208
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.19
    Marker Score: 110
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.19
    Marker Score: 127
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.18
    Marker Score: 106
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.18
    Marker Score: 97
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.18
    Marker Score: 86

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Other Information

**Key characteristics:** - KCNN1 is a large protein (130 kDa) that is expressed in high levels in the plasma membrane of neurons and epithelial cells. - It is a calcium-activated potassium channel, which means that it opens when calcium ions bind to it. - KCNN1 is a non-selective cation channel, which means that it allows both potassium and chloride ions to flow down their concentration gradients. **Pathways and functions:** - KCNN1 is involved in a variety of cellular processes, including: - Calcium signaling: KCNN1 is a key calcium-activated potassium channel in the plasma membrane of neurons and epithelial cells. It is involved in a variety of cellular processes, including neuronal excitability, muscle contraction, and fluid transport. - Neuronal excitability: KCNN1 is also involved in the regulation of neuronal excitability. It is a key component of the voltage-gated potassium channel complex, which is responsible for generating and propagating action potentials. - Fluid transport: KCNN1 is involved in the regulation of fluid transport across cell membranes. It is a key component of the sodium-potassium pump, which is responsible for maintaining the resting potential of cells. **Clinical significance:** - Mutations in KCNN1 have been linked to a number of human diseases, including: - Cardiac arrhythmias: Mutations in KCNN1 have been linked to a number of cardiac arrhythmias, such as atrial fibrillation and ventricular tachycardia. - Renal failure: Mutations in KCNN1 have also been linked to renal failure. - Epilepsy: Mutations in KCNN1 have been linked to epilepsy. **Additional information:** - KCNN1 is a relatively new channel, and there is still much that is unknown about its function. - It is a promising target for the treatment of a variety of diseases, including cardiac arrhythmias, renal failure, and epilepsy.

Genular Protein ID: 3905649212

Symbol: KCNN1_HUMAN

Name: Small conductance calcium-activated potassium channel protein 1

UniProtKB Accession Codes:

Q92952 Q5KR10 Q6DJU4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 DrugCentral 1 EMBL 12 Ensembl 2 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 PANTHER 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8781233

Title: Small-conductance, calcium-activated potassium channels from mammalian brain.

PubMed ID: 8781233

DOI: 10.1126/science.273.5282.1709

PubMed ID: 10516439

Title: Gene structure and chromosome mapping of the human small-conductance calcium-activated potassium channel SK1 gene (KCNN1).

PubMed ID: 10516439

DOI: 10.1159/000015415

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9287325

Title: Determinants of apamin and d-tubocurarine block in SK potassium channels.

PubMed ID: 9287325

DOI: 10.1074/jbc.272.37.23195

PubMed ID: 17142458

Title: An amino acid outside the pore region influences apamin sensitivity in small conductance Ca2+-activated K+ channels.

PubMed ID: 17142458

DOI: 10.1074/jbc.m607213200

Sequence Information:

  • Length: 543
  • Mass: 59987
  • Checksum: 13EFF47C263BCB11
  • Sequence:
    • MNSHSYNGSV GRPLGSGPGA LGRDPPDPEA GHPPQPPHSP GLQVVVAKSE PARPSPGSPR 
GQPQDQDDDE DDEEDEAGRQ RASGKPSNVG HRLGHRRALF EKRKRLSDYA LIFGMFGIVV 
MVTETELSWG VYTKESLYSF ALKCLISLST AILLGLVVLY HAREIQLFMV DNGADDWRIA 
MTCERVFLIS LELAVCAIHP VPGHYRFTWT ARLAFTYAPS VAEADVDVLL SIPMFLRLYL 
LGRVMLLHSK IFTDASSRSI GALNKITFNT RFVMKTLMTI CPGTVLLVFS ISSWIIAAWT 
VRVCERYHDK QEVTSNFLGA MWLISITFLS IGYGDMVPHT YCGKGVCLLT GIMGAGCTAL 
VVAVVARKLE LTKAEKHVHN FMMDTQLTKR VKNAAANVLR ETWLIYKHTR LVKKPDQARV 
RKHQRKFLQA IHQAQKLRSV KIEQGKLNDQ ANTLTDLAKT QTVMYDLVSE LHAQHEELEA 
RLATLESRLD ALGASLQALP GLIAQAIRPP PPPLPPRPGP GPQDQAARSS PCRWTPVAPS 
DCG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.