Details for: KCNN1

Gene ID: 3780

Symbol: KCNN1

Ensembl ID: ENSG00000105642

Description: potassium calcium-activated channel subfamily N member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 46.2245
    Cell Significance Index: -7.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 28.3469
    Cell Significance Index: -7.1900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.8558
    Cell Significance Index: -7.2200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.7459
    Cell Significance Index: 38.2300
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.7280
    Cell Significance Index: 10.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5639
    Cell Significance Index: 113.1200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.5600
    Cell Significance Index: 7.4700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.5172
    Cell Significance Index: 14.7600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.3560
    Cell Significance Index: 4.9400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1970
    Cell Significance Index: 8.9300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1849
    Cell Significance Index: 3.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1523
    Cell Significance Index: 54.6500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.1505
    Cell Significance Index: 4.7600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.1468
    Cell Significance Index: 2.2300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1291
    Cell Significance Index: 89.2900
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.1041
    Cell Significance Index: 1.4600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0980
    Cell Significance Index: 6.5900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.0931
    Cell Significance Index: 0.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0600
    Cell Significance Index: 3.6900
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: 0.0598
    Cell Significance Index: 0.6600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0497
    Cell Significance Index: 2.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0473
    Cell Significance Index: 2.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0343
    Cell Significance Index: 1.3000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0259
    Cell Significance Index: 0.9000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0203
    Cell Significance Index: 0.5100
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0150
    Cell Significance Index: 0.3600
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0148
    Cell Significance Index: 0.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0113
    Cell Significance Index: 2.0300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0098
    Cell Significance Index: 1.2500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0082
    Cell Significance Index: 1.6200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0016
    Cell Significance Index: -2.8800
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0017
    Cell Significance Index: -0.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0017
    Cell Significance Index: -0.7800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0021
    Cell Significance Index: -3.1600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0029
    Cell Significance Index: -3.9600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0046
    Cell Significance Index: -2.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0073
    Cell Significance Index: -4.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0075
    Cell Significance Index: -0.8700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0076
    Cell Significance Index: -4.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0097
    Cell Significance Index: -7.1600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0108
    Cell Significance Index: -8.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0126
    Cell Significance Index: -7.0800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0131
    Cell Significance Index: -8.1700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0152
    Cell Significance Index: -0.2600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0172
    Cell Significance Index: -4.9400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0186
    Cell Significance Index: -1.9000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0194
    Cell Significance Index: -2.6600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0209
    Cell Significance Index: -0.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0290
    Cell Significance Index: -3.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0297
    Cell Significance Index: -4.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0316
    Cell Significance Index: -5.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0371
    Cell Significance Index: -7.8200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.0406
    Cell Significance Index: -0.5200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0418
    Cell Significance Index: -1.3300
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.0439
    Cell Significance Index: -0.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0481
    Cell Significance Index: -6.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0526
    Cell Significance Index: -6.0300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0564
    Cell Significance Index: -2.9600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0638
    Cell Significance Index: -2.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0650
    Cell Significance Index: -6.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0731
    Cell Significance Index: -5.6100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0743
    Cell Significance Index: -0.8100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0824
    Cell Significance Index: -0.7000
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0835
    Cell Significance Index: -1.1700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0878
    Cell Significance Index: -6.5500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0884
    Cell Significance Index: -2.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0912
    Cell Significance Index: -4.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0924
    Cell Significance Index: -5.9600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0925
    Cell Significance Index: -3.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0949
    Cell Significance Index: -4.9300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0950
    Cell Significance Index: -1.3600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0971
    Cell Significance Index: -1.3800
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1005
    Cell Significance Index: -1.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1009
    Cell Significance Index: -4.7400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1040
    Cell Significance Index: -1.7400
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.1061
    Cell Significance Index: -0.6900
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1210
    Cell Significance Index: -1.1000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1231
    Cell Significance Index: -2.6600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1280
    Cell Significance Index: -2.5700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1323
    Cell Significance Index: -3.4000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1356
    Cell Significance Index: -1.5400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1423
    Cell Significance Index: -3.0200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1462
    Cell Significance Index: -2.8900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1499
    Cell Significance Index: -3.7400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1510
    Cell Significance Index: -4.3500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1597
    Cell Significance Index: -4.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1642
    Cell Significance Index: -5.7700
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1684
    Cell Significance Index: -1.3900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1700
    Cell Significance Index: -2.1500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1717
    Cell Significance Index: -2.1300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1735
    Cell Significance Index: -5.1100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1751
    Cell Significance Index: -1.6600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1813
    Cell Significance Index: -3.8800
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -0.1839
    Cell Significance Index: -1.7500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1844
    Cell Significance Index: -2.3000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1994
    Cell Significance Index: -4.3200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2010
    Cell Significance Index: -7.3800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2020
    Cell Significance Index: -6.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Channel Function**: KCNN1 encodes a small conductance calcium-activated potassium channel, which is activated by an increase in intracellular calcium levels. This channel conducts potassium ions out of the cell, leading to hyperpolarization and reduced excitability. 2. **Cellular Localization**: The KCNN1 protein is primarily localized to the plasma membrane, where it forms channels that regulate potassium ion flux. 3. **Regulatory Mechanisms**: KCNN1 channels are regulated by various mechanisms, including calcium-dependent phosphorylation, calmodulin binding, and interactions with other proteins. 4. **Expression Patterns**: KCNN1 is highly expressed in neuronal cells, particularly in cortical and hippocampal neurons, as well as in epithelial cells, such as goblet cells in the colon. **Pathways and Functions** 1. **Neuronal Function**: KCNN1 channels play a critical role in regulating neuronal excitability, synaptic transmission, and neurotransmitter release. They are involved in the modulation of neuronal firing patterns, particularly in the context of calcium-dependent signaling. 2. **Muscle Contraction**: KCNN1 channels are also expressed in smooth muscle cells, where they contribute to the regulation of muscle contraction and relaxation. 3. **Calcium Signaling**: KCNN1 channels interact with calmodulin, a calcium-binding protein, to regulate calcium-dependent signaling pathways. 4. **Gene Regulation**: KCNN1 is involved in the regulation of gene expression, particularly in the context of neuronal development and plasticity. **Clinical Significance** 1. **Neurological Disorders**: KCNN1 mutations have been implicated in various neurological disorders, including epilepsy, schizophrenia, and autism spectrum disorder. These mutations can disrupt normal KCNN1 function, leading to aberrant neuronal excitability and synaptic transmission. 2. **Cardiac Arrhythmias**: KCNN1 channels are also expressed in cardiac tissue, where they contribute to the regulation of cardiac rhythm. Mutations in KCNN1 can lead to cardiac arrhythmias, including long QT syndrome. 3. **Gastrointestinal Disorders**: KCNN1 is expressed in epithelial cells, where it regulates potassium ion flux and calcium signaling. Mutations in KCNN1 have been implicated in gastrointestinal disorders, including diarrhea and constipation. 4. **Cancer**: KCNN1 is also expressed in cancer cells, where it contributes to the regulation of cell growth, migration, and invasion. Mutations in KCNN1 can lead to cancer progression and metastasis. In conclusion, the KCNN1 gene plays a critical role in various cellular processes, including neuronal function, muscle contraction, and calcium signaling. Its dysregulation has been implicated in various diseases, including neurological disorders, cardiac arrhythmias, gastrointestinal disorders, and cancer. Further research is needed to fully understand the complex functions of KCNN1 and its role in human disease.

Genular Protein ID: 3905649212

Symbol: KCNN1_HUMAN

Name: KCa2.1

UniProtKB Accession Codes:

Q92952 Q5KR10 Q6DJU4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 7 DrugCentral 1 EMBL 12 Ensembl 2 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 PANTHER 2 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 1 Rhea 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8781233

Title: Small-conductance, calcium-activated potassium channels from mammalian brain.

PubMed ID: 8781233

DOI: 10.1126/science.273.5282.1709

PubMed ID: 10516439

Title: Gene structure and chromosome mapping of the human small-conductance calcium-activated potassium channel SK1 gene (KCNN1).

PubMed ID: 10516439

DOI: 10.1159/000015415

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9287325

Title: Determinants of apamin and d-tubocurarine block in SK potassium channels.

PubMed ID: 9287325

DOI: 10.1074/jbc.272.37.23195

PubMed ID: 17142458

Title: An amino acid outside the pore region influences apamin sensitivity in small conductance Ca2+-activated K+ channels.

PubMed ID: 17142458

DOI: 10.1074/jbc.m607213200

PubMed ID: 20689065

Title: Cardiac small conductance Ca2+-activated K+ channel subunits form heteromultimers via the coiled-coil domains in the C termini of the channels.

PubMed ID: 20689065

DOI: 10.1161/circresaha.109.215269

Sequence Information:

  • Length: 543
  • Mass: 59987
  • Checksum: 13EFF47C263BCB11
  • Sequence:
    • MNSHSYNGSV GRPLGSGPGA LGRDPPDPEA GHPPQPPHSP GLQVVVAKSE PARPSPGSPR 
GQPQDQDDDE DDEEDEAGRQ RASGKPSNVG HRLGHRRALF EKRKRLSDYA LIFGMFGIVV 
MVTETELSWG VYTKESLYSF ALKCLISLST AILLGLVVLY HAREIQLFMV DNGADDWRIA 
MTCERVFLIS LELAVCAIHP VPGHYRFTWT ARLAFTYAPS VAEADVDVLL SIPMFLRLYL 
LGRVMLLHSK IFTDASSRSI GALNKITFNT RFVMKTLMTI CPGTVLLVFS ISSWIIAAWT 
VRVCERYHDK QEVTSNFLGA MWLISITFLS IGYGDMVPHT YCGKGVCLLT GIMGAGCTAL 
VVAVVARKLE LTKAEKHVHN FMMDTQLTKR VKNAAANVLR ETWLIYKHTR LVKKPDQARV 
RKHQRKFLQA IHQAQKLRSV KIEQGKLNDQ ANTLTDLAKT QTVMYDLVSE LHAQHEELEA 
RLATLESRLD ALGASLQALP GLIAQAIRPP PPPLPPRPGP GPQDQAARSS PCRWTPVAPS 
DCG

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.