KIF2A | ENSG00000068796 | NCBI 3796

Details for: KIF2A

Gene ID: 3796

Symbol: KIF2A

Ensembl ID: ENSG00000068796

Description: kinesin family member 2A

Associated with

Adaptive immune system
(R-HSA-1280218)
Amplification of signal from the kinetochores
(R-HSA-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-HSA-141444)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Cell cycle checkpoints
(R-HSA-69620)
Copi-dependent golgi-to-er retrograde traffic
(R-HSA-6811434)
Eml4 and nudc in mitotic spindle formation
(R-HSA-9648025)
Factors involved in megakaryocyte development and platelet production
(R-HSA-983231)
Golgi-to-er retrograde transport
(R-HSA-8856688)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Intra-golgi and retrograde golgi-to-er traffic
(R-HSA-6811442)
Kinesins
(R-HSA-983189)
Membrane trafficking
(R-HSA-199991)
Mhc class ii antigen presentation
(R-HSA-2132295)
Mitotic anaphase
(R-HSA-68882)
Mitotic metaphase and anaphase
(R-HSA-2555396)
Mitotic prometaphase
(R-HSA-68877)
Mitotic spindle checkpoint
(R-HSA-69618)
M phase
(R-HSA-68886)
Resolution of sister chromatid cohesion
(R-HSA-2500257)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate formins
(R-HSA-5663220)
Separation of sister chromatids
(R-HSA-2467813)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Vesicle-mediated transport
(R-HSA-5653656)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Cell differentiation
(GO:0030154)
Cell division
(GO:0051301)
Centriolar subdistal appendage
(GO:0120103)
Centriole
(GO:0005814)
Centrosome
(GO:0005813)
Cytoplasm
(GO:0005737)
Cytoskeletal motor activity
(GO:0003774)
Cytosol
(GO:0005829)
Kinesin complex
(GO:0005871)
Membrane
(GO:0016020)
Microtubule
(GO:0005874)
Microtubule-based movement
(GO:0007018)
Microtubule binding
(GO:0008017)
Microtubule cytoskeleton organization
(GO:0000226)
Microtubule depolymerization
(GO:0007019)
Microtubule motor activity
(GO:0003777)
Mitotic spindle assembly
(GO:0090307)
Mitotic spindle organization
(GO:0007052)
Nervous system development
(GO:0007399)
Nuclear body
(GO:0016604)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Protein binding
(GO:0005515)
Regulation of cell migration
(GO:0030334)
Spindle
(GO:0005819)
Spindle microtubule
(GO:0005876)
Spindle pole
(GO:0000922)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 310.3277
Cell Significance Index: -48.2700
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 167.8735
Cell Significance Index: -42.5800
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 110.9828
Cell Significance Index: -52.4000
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 107.6412
Cell Significance Index: -43.7300
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 96.2897
Cell Significance Index: -49.5300
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 46.3476
Cell Significance Index: -44.2500
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 40.2285
Cell Significance Index: -49.6000
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 17.6418
Cell Significance Index: -47.2600
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 15.5041
Cell Significance Index: -47.6200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 12.6962
Cell Significance Index: -50.1000
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 11.4686
Cell Significance Index: -25.1000
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 2.5058
Cell Significance Index: 154.0200
Cell Name: retinal rod cell (CL0000604)
Fold Change: 2.3149
Cell Significance Index: 27.6000
Cell Name: cortical interneuron (CL0008031)
Fold Change: 2.3071
Cell Significance Index: 55.3300
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.9341
Cell Significance Index: 108.5300
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 1.8322
Cell Significance Index: 126.7100
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.6259
Cell Significance Index: 84.6900
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.6167
Cell Significance Index: 320.8400
Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.5922
Cell Significance Index: 157.5100
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 1.5809
Cell Significance Index: 99.6400
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.5523
Cell Significance Index: 252.4600
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.3884
Cell Significance Index: 498.0100
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 1.3605
Cell Significance Index: 16.8800
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.3025
Cell Significance Index: 34.7800
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 1.1565
Cell Significance Index: 1044.2600
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.1145
Cell Significance Index: 770.8300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.0897
Cell Significance Index: 196.4400
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.9936
Cell Significance Index: 29.1800
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.9614
Cell Significance Index: 104.5700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.9492
Cell Significance Index: 63.8300
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.9427
Cell Significance Index: 115.9200
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.8559
Cell Significance Index: 23.9200
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.8544
Cell Significance Index: 466.5900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.7209
Cell Significance Index: 85.0200
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.6459
Cell Significance Index: 28.5700
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.6193
Cell Significance Index: 23.4500
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.5991
Cell Significance Index: 38.6500
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.5875
Cell Significance Index: 16.7700
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.5574
Cell Significance Index: 7.6100
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.5019
Cell Significance Index: 10.9900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.4356
Cell Significance Index: 59.8200
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.4315
Cell Significance Index: 190.7900
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.4249
Cell Significance Index: 22.3100
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3592
Cell Significance Index: 18.6600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.2305
Cell Significance Index: 17.6900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1463
Cell Significance Index: 3.1700
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.1424
Cell Significance Index: 2.4400
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0878
Cell Significance Index: 17.6100
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.0219
Cell Significance Index: 1.0300
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.0061
Cell Significance Index: 0.1600
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.0050
Cell Significance Index: 0.0300
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.0130
Cell Significance Index: -2.4800
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0191
Cell Significance Index: -35.8900
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0247
Cell Significance Index: -45.6400
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0275
Cell Significance Index: -20.3500
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0298
Cell Significance Index: -45.9200
Cell Name: peg cell (CL4033014)
Fold Change: -0.0327
Cell Significance Index: -0.7600
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0365
Cell Significance Index: -6.2400
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0378
Cell Significance Index: -51.3900
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0379
Cell Significance Index: -27.7900
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0472
Cell Significance Index: -29.4600
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0605
Cell Significance Index: -45.8000
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.0635
Cell Significance Index: -1.2400
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0678
Cell Significance Index: -43.0900
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0716
Cell Significance Index: -40.3700
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0809
Cell Significance Index: -5.7200
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1060
Cell Significance Index: -48.1100
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1542
Cell Significance Index: -44.3700
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1587
Cell Significance Index: -33.4300
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1653
Cell Significance Index: -16.8900
Cell Name: odontoblast (CL0000060)
Fold Change: -0.1739
Cell Significance Index: -22.2900
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.1783
Cell Significance Index: -8.0800
Cell Name: lactocyte (CL0002325)
Fold Change: -0.1866
Cell Significance Index: -24.1100
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1948
Cell Significance Index: -22.7000
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2004
Cell Significance Index: -22.8800
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.2367
Cell Significance Index: -2.1800
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -0.2376
Cell Significance Index: -6.8500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2482
Cell Significance Index: -8.7200
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.2734
Cell Significance Index: -39.7400
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.3103
Cell Significance Index: -35.5500
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.3207
Cell Significance Index: -23.9000
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3557
Cell Significance Index: -12.3600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.3601
Cell Significance Index: -16.7900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3625
Cell Significance Index: -7.7200
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.3659
Cell Significance Index: -9.8100
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.4679
Cell Significance Index: -12.5200
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4810
Cell Significance Index: -50.0800
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5590
Cell Significance Index: -44.2700
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.5655
Cell Significance Index: -14.8700
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: -0.5813
Cell Significance Index: -5.1600
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6421
Cell Significance Index: -20.5700
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.6581
Cell Significance Index: -16.4500
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.7149
Cell Significance Index: -11.9700
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.7831
Cell Significance Index: -16.7400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.8269
Cell Significance Index: -50.7000
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.8544
Cell Significance Index: -12.2400
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.8607
Cell Significance Index: -28.1800
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.9192
Cell Significance Index: -26.3500
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.9445
Cell Significance Index: -30.0800
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.9471
Cell Significance Index: -24.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** KIF2A is a kinesin-like protein that exhibits microtubule-dependent movement. It is characterized by its ability to bind to microtubules and undergo ATP-dependent hydrolysis, which drives its movement along the microtubule track. KIF2A is also known to interact with other proteins, including Mad2, which modulates its activity. The protein is highly conserved across species, suggesting its essential role in cellular processes. **Pathways and Functions** KIF2A is involved in various cellular pathways, including: 1. **Cell Cycle**: KIF2A plays a crucial role in regulating cell cycle progression, particularly during the mitotic phase. It is involved in the separation of sister chromatids and the regulation of the mitotic spindle. 2. **Immune System**: KIF2A is involved in antigen presentation and the regulation of T-cell responses. It is expressed in immune cells, including double-negative T regulatory cells, central memory CD8-positive T cells, and T-helper 22 cells. 3. **Neurodevelopment**: KIF2A is expressed in neurons, particularly in Purkinje cells and VIP GABAergic cortical interneurons. 4. **Hemostasis**: KIF2A is involved in the regulation of platelet production and megakaryocyte development. KIF2A's functions include: 1. **Microtubule organization**: KIF2A regulates microtubule organization and cytoskeletal dynamics, which is essential for cell migration and division. 2. **Antigen presentation**: KIF2A is involved in the presentation of antigens to T-cells, which is crucial for immune responses. 3. **Cell migration**: KIF2A regulates cell migration, particularly during immune responses and tissue development. **Clinical Significance** Dysregulation of KIF2A has been implicated in various diseases, including: 1. **Cancer**: KIF2A is overexpressed in several types of cancer, including breast, lung, and colon cancer. Its overexpression is associated with poor prognosis and metastasis. 2. **Neurological disorders**: KIF2A mutations have been linked to neurological disorders, including spinocerebellar ataxia and frontotemporal dementia. 3. **Immune disorders**: KIF2A is involved in immune responses, and its dysregulation has been implicated in autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. In conclusion, KIF2A is a multifunctional protein that plays a crucial role in various cellular processes, including cell division, migration, and immune responses. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its functions and pathways. Further research is necessary to elucidate the mechanisms underlying KIF2A's role in human disease.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 834707083

Symbol: KIF2A_HUMAN

Name: Kinesin-like protein KIF2A

UniProtKB Accession Codes:

O00139 A5YM42 A5YM54 B4DY54 D3DW97 E9PB70 Q7Z5I3 Q8N5Q7

Database IDs:

Citations:

PubMed ID: 9177777

Title: Identification of a novel human kinesin-related gene (HK2) by the cDNA differential display technique.

PubMed ID: 9177777

DOI: 10.1006/geno.1997.4720

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15843429

Title: Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference.

PubMed ID: 15843429

DOI: 10.1091/mbc.e05-02-0167

PubMed ID: 17538014

Title: The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells.

PubMed ID: 17538014

DOI: 10.1091/mbc.e07-02-0110

PubMed ID: 18411309

Title: DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement.

PubMed ID: 18411309

DOI: 10.1083/jcb.200711032

PubMed ID: 19351716

Title: Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a.

PubMed ID: 19351716

DOI: 10.1242/jcs.044321

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23603762

Title: Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly.

PubMed ID: 23603762

DOI: 10.1038/ng.2613

Sequence Information:

Length: 706
Mass: 79955
Checksum: A407D84B6BD04ACF
Sequence:

MATANFGKIQ IGIYVEIKRS DGRIHQAMVT SLNEDNESVT VEWIENGDTK GKEIDLESIF 
SLNPDLVPDE EIEPSPETPP PPASSAKVNK IVKNRRTVAS IKNDPPSRDN RVVGSARARP 
SQFPEQSSSA QQNGSVSDIS PVQAAKKEFG PPSRRKSNCV KEVEKLQEKR EKRRLQQQEL 
REKRAQDVDA TNPNYEIMCM IRDFRGSLDY RPLTTADPID EHRICVCVRK RPLNKKETQM 
KDLDVITIPS KDVVMVHEPK QKVDLTRYLE NQTFRFDYAF DDSAPNEMVY RFTARPLVET 
IFERGMATCF AYGQTGSGKT HTMGGDFSGK NQDCSKGIYA LAARDVFLML KKPNYKKLEL 
QVYATFFEIY SGKVFDLLNR KTKLRVLEDG KQQVQVVGLQ EREVKCVEDV LKLIDIGNSC 
RTSGQTSANA HSSRSHAVFQ IILRRKGKLH GKFSLIDLAG NERGADTSSA DRQTRLEGAE 
INKSLLALKE CIRALGRNKP HTPFRASKLT QVLRDSFIGE NSRTCMIATI SPGMASCENT 
LNTLRYANRV KELTVDPTAA GDVRPIMHHP PNQIDDLETQ WGVGSSPQRD DLKLLCEQNE 
EEVSPQLFTF HEAVSQMVEM EEQVVEDHRA VFQESIRWLE DEKALLEMTE EVDYDVDSYA 
TQLEAILEQK IDILTELRDK VKSFRAALQE EEQASKQINP KRPRAL

Genular Protein ID: 872120852

Symbol: B0AZS5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B0AZS5

Database IDs:

Sequence Information:

Length: 660
Mass: 75029
Checksum: 6B5AC95C44B959E3
Sequence:

MVTSLNEDNE SVTVEWIENG DTKGKEIDLE SIFSLNPDLV PDEEIEPSPE TPPPPASSAK 
VNKIVKNRRT VASIKNDPPS RDNRVVGSAR ARPSQFPEQS SSAQQNARRK SNCVKEVEKL 
QEKREKRRLQ QQELREKRAQ DVDATNPNYE IMCMIRDFRG SLDYRPLTTA DPIDEHRICV 
CVRKRPLNKK ETQMKDLDVI TIPSKDVVMV HEPKQKVDLT RYLENQTFRF DYAFDDSAPN 
EMVYRFTARP LVETIFERGM ATCFAYGQTG SGKTHTMGGD FSGKNQDCSK GVYALAARDV 
FLMLKKPNYK KLELQVYATF FEIYSGKVFD LLNRKTKLRV LEDGKQQVQV VGLQEREVKC 
VEDVLKLIDI GNSCRTSGQT SANAHSSRSH AVFQIILRRK GKLHGKFSLI DLAGNERGAD 
TSSADRQTRL EGAEINKSLL ALKECIRALG RNKPHTPFRA SKLTQVLRDS FIGENSRTCM 
IATISPGMAS CENTLNTLRY ANRVKELTVD PTAAGDVRPI MHHPPNQIDD LETQWGVGSS 
PQRDDLKLLC EQNEEEVSPQ LFTFHEAVSQ MVEMEEQVVE DHRAVFQESI RWLEDEKALL 
EMTEEVDYDV DSYATQLEAI LEQKIDILTE LRDKVKSFRA ALQEEEQASK QINPKRPRAL

Genular Protein ID: 2747318214

Symbol: A0A6Q8PFA6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A6Q8PFA6

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

Length: 687
Mass: 78042
Checksum: DB1C55C74C5C0A47
Sequence:

MATANFGKIQ IGIYVEIKRS DGRIHQAMVT SLNEDNESVT VEWIENGDTK GKEIDLESIF 
SLNPDLVPDE EIEPSPETPP PPASSAKVNK IVKNRRTVAS IKNDPPSRDN RVVGSARARP 
SQFPEQSSSA QQNARRKSNC VKEVEKLQEK REKRRLQQQE LREKRAQDVD ATNPNYEIMC 
MIRDFRGSLD YRPLTTADPI DEHRICVCVR KRPLNKKETQ MKDLDVITIP SKDVVMVHEP 
KQKVDLTRYL ENQTFRFDYA FDDSAPNEMV YRFTARPLVE TIFERGMATC FAYGQTGSGK 
THTMGGDFSG KNQDCSKGIY ALAARDVFLM LKKPNYKKLE LQVYATFFEI YSGKVFDLLN 
RKTKLRVLED GKQQVQVVGL QEREVKCVED VLKLIDIGNS CRTSGQTSAN AHSSRSHAVF 
QIILRRKGKL HGKFSLIDLA GNERGADTSS ADRQTRLEGA EINKSLLALK ECIRALGRNK 
PHTPFRASKL TQVLRDSFIG ENSRTCMIAT ISPGMASCEN TLNTLRYANR VKELTVDPTA 
AGDVRPIMHH PPNQIDDLET QWGVGSSPQR DDLKLLCEQN EEEVSPQLFT FHEAVSQMVE 
MEEQVVEDHR AVFQESIRWL EDEKALLEMT EEVDYDVDSY ATQLEAILEQ KIDILTELRD 
KVKSFRAALQ EEEQASKQIN PKRPRAL

Database document:

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Details for: KIF2A

Associated with

Cells (max top 100)

Other Information

Identification of a novel human kinesin-related gene (HK2) by the cDNA differential display technique. PubMed ID: 9177777

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference. PubMed ID: 15843429

The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells. PubMed ID: 17538014

DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement. PubMed ID: 18411309

Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a. PubMed ID: 19351716

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly. PubMed ID: 23603762

Initial sequencing and analysis of the human genome. PubMed ID: 11237011

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

Finishing the euchromatic sequence of the human genome. PubMed ID: 15496913

Database document:

PubMed ID: 9177777

PubMed ID: 14702039

PubMed ID: 17974005

PubMed ID: 15372022

PubMed ID: 15489334

PubMed ID: 15843429

PubMed ID: 17538014

PubMed ID: 18411309

PubMed ID: 19351716

PubMed ID: 19690332

PubMed ID: 21269460

PubMed ID: 23186163

PubMed ID: 23603762

PubMed ID: 11237011

PubMed ID: 15372022

PubMed ID: 15496913