Details for: KIF2A

Gene ID: 3796

Symbol: KIF2A

Ensembl ID: ENSG00000068796

Description: kinesin family member 2A

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 3.11
    Marker Score: 5436
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.18
    Marker Score: 73601
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.17
    Marker Score: 2094
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.15
    Marker Score: 5254
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.1
    Marker Score: 24406
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.06
    Marker Score: 4028
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.96
    Marker Score: 74575
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.96
    Marker Score: 8386
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.94
    Marker Score: 2729
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.94
    Marker Score: 810
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.92
    Marker Score: 40946
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.91
    Marker Score: 1501
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.9
    Marker Score: 818
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.86
    Marker Score: 9754
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.85
    Marker Score: 2724
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.82
    Marker Score: 5105
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.81
    Marker Score: 18684
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.81
    Marker Score: 1309
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.8
    Marker Score: 627
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.77
    Marker Score: 93638
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.76
    Marker Score: 1549
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 1.76
    Marker Score: 1568
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.75
    Marker Score: 6781
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.74
    Marker Score: 13336
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.73
    Marker Score: 7174
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.73
    Marker Score: 25824
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.73
    Marker Score: 63693
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.71
    Marker Score: 511
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.7
    Marker Score: 33872
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.7
    Marker Score: 5371.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.69
    Marker Score: 103699
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.68
    Marker Score: 1226
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.68
    Marker Score: 2022
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.67
    Marker Score: 832
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.65
    Marker Score: 15681
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.64
    Marker Score: 14100
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.63
    Marker Score: 8758
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.62
    Marker Score: 14255
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.62
    Marker Score: 15220
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.61
    Marker Score: 1625
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.6
    Marker Score: 12050
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.6
    Marker Score: 1169
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.57
    Marker Score: 7269
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.56
    Marker Score: 5373
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.55
    Marker Score: 2136
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.52
    Marker Score: 472
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.52
    Marker Score: 936
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.51
    Marker Score: 9686
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.51
    Marker Score: 2705
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 1.51
    Marker Score: 1336
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.51
    Marker Score: 631
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.5
    Marker Score: 792
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.49
    Marker Score: 4057
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.48
    Marker Score: 2134
  • Cell Name: platelet (CL0000233)
    Fold Change: 1.48
    Marker Score: 671
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.47
    Marker Score: 471
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.47
    Marker Score: 14520
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.45
    Marker Score: 2238
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.45
    Marker Score: 166189
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.45
    Marker Score: 5359
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.44
    Marker Score: 4829
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.44
    Marker Score: 2037.5
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.44
    Marker Score: 998
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.43
    Marker Score: 10616
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.41
    Marker Score: 48761
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.41
    Marker Score: 958
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.39
    Marker Score: 12032
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.38
    Marker Score: 2813.5
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.38
    Marker Score: 482
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.37
    Marker Score: 477
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.37
    Marker Score: 415
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.37
    Marker Score: 1279
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.37
    Marker Score: 3141
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.37
    Marker Score: 24237
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.33
    Marker Score: 429
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: 1.32
    Marker Score: 3768.5
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.31
    Marker Score: 1746
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.31
    Marker Score: 1261
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.29
    Marker Score: 1907
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.29
    Marker Score: 1060.5
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.28
    Marker Score: 1360
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.28
    Marker Score: 2431
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.27
    Marker Score: 1591
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.27
    Marker Score: 397
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 1.26
    Marker Score: 286
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.26
    Marker Score: 1088
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.26
    Marker Score: 3089.5
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.25
    Marker Score: 3574.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.25
    Marker Score: 2053.5
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.24
    Marker Score: 853
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.24
    Marker Score: 1042
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.23
    Marker Score: 1158
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.23
    Marker Score: 3637
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.22
    Marker Score: 1287.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.22
    Marker Score: 2872
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.22
    Marker Score: 351
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.22
    Marker Score: 630
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.21
    Marker Score: 705
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.2
    Marker Score: 680
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.19
    Marker Score: 584

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Other Information

**Key characteristics:** - KIF2A is a large protein with a molecular weight of approximately 120 kDa. - It is a member of the kinesin family of microtubule-associated proteins. - KIF2A is involved in the regulation of cell cycle progression, cell cycle checkpoints, and the assembly of the mitotic spindle apparatus. - It also plays a role in the regulation of immune responses, including the activation of macrophages and dendritic cells. **Pathways and functions:** - KIF2A is involved in the regulation of cell cycle progression by interacting with cyclin-dependent kinase 1 (CDK1). - It is also involved in the regulation of cell cycle checkpoints by interacting with the CDK inhibitor protein p53. - In the mitotic phase, KIF2A is involved in the assembly of the mitotic spindle apparatus. - In the G1/S transition, KIF2A is involved in the regulation of cell cycle checkpoints. - It also plays a role in the regulation of immune responses by interacting with the MHC class II antigen presentation complex. - KIF2A is also involved in the regulation of the development and function of megakaryocytes and erythroid progenitor cells. **Clinical significance:** - Mutations in KIF2A have been linked to several human diseases, including cancer and autoimmune disorders. - Targeting KIF2A has been investigated as a therapeutic strategy for these diseases. - However, the clinical efficacy of KIF2A inhibitors is still uncertain.

Genular Protein ID: 834707083

Symbol: KIF2A_HUMAN

Name: Kinesin-like protein KIF2A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9177777

Title: Identification of a novel human kinesin-related gene (HK2) by the cDNA differential display technique.

PubMed ID: 9177777

DOI: 10.1006/geno.1997.4720

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15843429

Title: Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference.

PubMed ID: 15843429

DOI: 10.1091/mbc.e05-02-0167

PubMed ID: 17538014

Title: The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells.

PubMed ID: 17538014

DOI: 10.1091/mbc.e07-02-0110

PubMed ID: 18411309

Title: DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement.

PubMed ID: 18411309

DOI: 10.1083/jcb.200711032

PubMed ID: 19351716

Title: Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a.

PubMed ID: 19351716

DOI: 10.1242/jcs.044321

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23603762

Title: Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly.

PubMed ID: 23603762

DOI: 10.1038/ng.2613

Sequence Information:

  • Length: 706
  • Mass: 79955
  • Checksum: A407D84B6BD04ACF
  • Sequence:
  • MATANFGKIQ IGIYVEIKRS DGRIHQAMVT SLNEDNESVT VEWIENGDTK GKEIDLESIF 
    SLNPDLVPDE EIEPSPETPP PPASSAKVNK IVKNRRTVAS IKNDPPSRDN RVVGSARARP 
    SQFPEQSSSA QQNGSVSDIS PVQAAKKEFG PPSRRKSNCV KEVEKLQEKR EKRRLQQQEL 
    REKRAQDVDA TNPNYEIMCM IRDFRGSLDY RPLTTADPID EHRICVCVRK RPLNKKETQM 
    KDLDVITIPS KDVVMVHEPK QKVDLTRYLE NQTFRFDYAF DDSAPNEMVY RFTARPLVET 
    IFERGMATCF AYGQTGSGKT HTMGGDFSGK NQDCSKGIYA LAARDVFLML KKPNYKKLEL 
    QVYATFFEIY SGKVFDLLNR KTKLRVLEDG KQQVQVVGLQ EREVKCVEDV LKLIDIGNSC 
    RTSGQTSANA HSSRSHAVFQ IILRRKGKLH GKFSLIDLAG NERGADTSSA DRQTRLEGAE 
    INKSLLALKE CIRALGRNKP HTPFRASKLT QVLRDSFIGE NSRTCMIATI SPGMASCENT 
    LNTLRYANRV KELTVDPTAA GDVRPIMHHP PNQIDDLETQ WGVGSSPQRD DLKLLCEQNE 
    EEVSPQLFTF HEAVSQMVEM EEQVVEDHRA VFQESIRWLE DEKALLEMTE EVDYDVDSYA 
    TQLEAILEQK IDILTELRDK VKSFRAALQE EEQASKQINP KRPRAL

Genular Protein ID: 872120852

Symbol: B0AZS5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 660
  • Mass: 75029
  • Checksum: 6B5AC95C44B959E3
  • Sequence:
  • MVTSLNEDNE SVTVEWIENG DTKGKEIDLE SIFSLNPDLV PDEEIEPSPE TPPPPASSAK 
    VNKIVKNRRT VASIKNDPPS RDNRVVGSAR ARPSQFPEQS SSAQQNARRK SNCVKEVEKL 
    QEKREKRRLQ QQELREKRAQ DVDATNPNYE IMCMIRDFRG SLDYRPLTTA DPIDEHRICV 
    CVRKRPLNKK ETQMKDLDVI TIPSKDVVMV HEPKQKVDLT RYLENQTFRF DYAFDDSAPN 
    EMVYRFTARP LVETIFERGM ATCFAYGQTG SGKTHTMGGD FSGKNQDCSK GVYALAARDV 
    FLMLKKPNYK KLELQVYATF FEIYSGKVFD LLNRKTKLRV LEDGKQQVQV VGLQEREVKC 
    VEDVLKLIDI GNSCRTSGQT SANAHSSRSH AVFQIILRRK GKLHGKFSLI DLAGNERGAD 
    TSSADRQTRL EGAEINKSLL ALKECIRALG RNKPHTPFRA SKLTQVLRDS FIGENSRTCM 
    IATISPGMAS CENTLNTLRY ANRVKELTVD PTAAGDVRPI MHHPPNQIDD LETQWGVGSS 
    PQRDDLKLLC EQNEEEVSPQ LFTFHEAVSQ MVEMEEQVVE DHRAVFQESI RWLEDEKALL 
    EMTEEVDYDV DSYATQLEAI LEQKIDILTE LRDKVKSFRA ALQEEEQASK QINPKRPRAL

Genular Protein ID: 2747318214

Symbol: A0A6Q8PFA6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

Sequence Information:

  • Length: 687
  • Mass: 78042
  • Checksum: DB1C55C74C5C0A47
  • Sequence:
  • MATANFGKIQ IGIYVEIKRS DGRIHQAMVT SLNEDNESVT VEWIENGDTK GKEIDLESIF 
    SLNPDLVPDE EIEPSPETPP PPASSAKVNK IVKNRRTVAS IKNDPPSRDN RVVGSARARP 
    SQFPEQSSSA QQNARRKSNC VKEVEKLQEK REKRRLQQQE LREKRAQDVD ATNPNYEIMC 
    MIRDFRGSLD YRPLTTADPI DEHRICVCVR KRPLNKKETQ MKDLDVITIP SKDVVMVHEP 
    KQKVDLTRYL ENQTFRFDYA FDDSAPNEMV YRFTARPLVE TIFERGMATC FAYGQTGSGK 
    THTMGGDFSG KNQDCSKGIY ALAARDVFLM LKKPNYKKLE LQVYATFFEI YSGKVFDLLN 
    RKTKLRVLED GKQQVQVVGL QEREVKCVED VLKLIDIGNS CRTSGQTSAN AHSSRSHAVF 
    QIILRRKGKL HGKFSLIDLA GNERGADTSS ADRQTRLEGA EINKSLLALK ECIRALGRNK 
    PHTPFRASKL TQVLRDSFIG ENSRTCMIAT ISPGMASCEN TLNTLRYANR VKELTVDPTA 
    AGDVRPIMHH PPNQIDDLET QWGVGSSPQR DDLKLLCEQN EEEVSPQLFT FHEAVSQMVE 
    MEEQVVEDHR AVFQESIRWL EDEKALLEMT EEVDYDVDSY ATQLEAILEQ KIDILTELRD 
    KVKSFRAALQ EEEQASKQIN PKRPRAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.