Details for: KLC1

Gene ID: 3831

Symbol: KLC1

Ensembl ID: ENSG00000126214

Description: kinesin light chain 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.94
    Marker Score: 5966
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.81
    Marker Score: 3394
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.76
    Marker Score: 14503
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.61
    Marker Score: 55653
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.58
    Marker Score: 2971
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.45
    Marker Score: 2315.5
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.37
    Marker Score: 10945
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.21
    Marker Score: 2486
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.21
    Marker Score: 33077
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.18
    Marker Score: 82825
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.16
    Marker Score: 16545
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.14
    Marker Score: 42508
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.06
    Marker Score: 7982
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.04
    Marker Score: 1218
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.96
    Marker Score: 72246
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.96
    Marker Score: 8113
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.91
    Marker Score: 117464
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.87
    Marker Score: 19284
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.86
    Marker Score: 62925
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.85
    Marker Score: 777
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.82
    Marker Score: 612
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.81
    Marker Score: 17038
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.79
    Marker Score: 17003
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.77
    Marker Score: 15174
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.76
    Marker Score: 7156
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.75
    Marker Score: 548
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 1.75
    Marker Score: 972
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 1.68
    Marker Score: 2363
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.64
    Marker Score: 812
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.63
    Marker Score: 857
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.59
    Marker Score: 2291
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.59
    Marker Score: 2312
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.58
    Marker Score: 827.5
  • Cell Name: granule cell (CL0000120)
    Fold Change: 1.54
    Marker Score: 11594
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.53
    Marker Score: 8203
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.52
    Marker Score: 891
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.52
    Marker Score: 7464
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.51
    Marker Score: 2326
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.51
    Marker Score: 1160
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.5
    Marker Score: 1864
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.5
    Marker Score: 50876
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.48
    Marker Score: 6209
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.48
    Marker Score: 1783
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.45
    Marker Score: 1252
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.44
    Marker Score: 1406
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.43
    Marker Score: 1239
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.43
    Marker Score: 3416
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.42
    Marker Score: 3335
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.41
    Marker Score: 420
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.38
    Marker Score: 378
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.34
    Marker Score: 668
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.32
    Marker Score: 625
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.32
    Marker Score: 4437
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.32
    Marker Score: 870
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.31
    Marker Score: 1250
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.29
    Marker Score: 668
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.28
    Marker Score: 475
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 1.27
    Marker Score: 1543
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.27
    Marker Score: 408
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.26
    Marker Score: 2422
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.26
    Marker Score: 19663
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.26
    Marker Score: 362
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.25
    Marker Score: 2745
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.25
    Marker Score: 2865
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.22
    Marker Score: 352.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.22
    Marker Score: 1800
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.22
    Marker Score: 723.5
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.21
    Marker Score: 1564
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.19
    Marker Score: 481
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.18
    Marker Score: 5086
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.18
    Marker Score: 571
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.17
    Marker Score: 1073
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.14
    Marker Score: 1259
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.13
    Marker Score: 280
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.12
    Marker Score: 355
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.1
    Marker Score: 1160
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.1
    Marker Score: 322
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.1
    Marker Score: 3136
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.1
    Marker Score: 288.5
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.1
    Marker Score: 1181
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.09
    Marker Score: 2054
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.08
    Marker Score: 630
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.08
    Marker Score: 1154
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.08
    Marker Score: 1224
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.08
    Marker Score: 1830
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.07
    Marker Score: 435
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.07
    Marker Score: 570
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.07
    Marker Score: 2175
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.07
    Marker Score: 255
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.06
    Marker Score: 637
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.06
    Marker Score: 384
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.05
    Marker Score: 16839
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.04
    Marker Score: 2171
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.04
    Marker Score: 328
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.04
    Marker Score: 423
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.03
    Marker Score: 2066
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.02
    Marker Score: 1267
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.02
    Marker Score: 1374
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.02
    Marker Score: 443
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.01
    Marker Score: 907

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Other Information

**Key characteristics:** * KLC1 is a transmembrane protein that is expressed in the ER and the Golgi apparatus. * It is a member of the kinesin family of proteins, which are involved in the transport of proteins between the ER and the Golgi apparatus. * KLC1 is a ubiquitously expressed protein, meaning that it is expressed in all cells. * It is a highly conserved protein, with a sequence that is similar in humans and mice. **Pathways and functions:** * KLC1 is a key component of the endosomal recycling pathway, which is responsible for the trafficking of proteins between the endoplasmic reticulum (ER) and the Golgi apparatus. * This pathway is involved in the production of membrane proteins, which are synthesized in the ER and then transported to the Golgi apparatus for processing and packaging. * KLC1 is also involved in the sorting of proteins for secretion from the cell. * It is involved in the regulation of cell growth, differentiation, and apoptosis. **Clinical significance:** * Mutations in KLC1 have been linked to a number of human diseases, including cancer and neurodegenerative disorders. * In cancer, KLC1 mutations can lead to the formation of tumors that are resistant to therapy. * KLC1 mutations can also lead to the development of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. **Additional information:** * KLC1 is a highly conserved protein, with a sequence that is similar in humans and mice. * It is a well-characterized protein that has been extensively studied in both in vitro and in vivo models of cancer and neurodegenerative disorders. * KLC1 is a promising target for cancer therapy, as it is frequently mutated in cancer cells.

Genular Protein ID: 1984237713

Symbol: KLC1_HUMAN

Name: Kinesin light chain 1

UniProtKB Accession Codes:

Q07866 A6NF62 F8VTM4 Q7RTM2 Q7RTM3 Q7RTM5 Q7RTP9 Q7RTQ3 Q7RTQ5 Q7RTQ6 Q86SF5 Q86TF5 Q86V74 Q86V75 Q86V76 Q86V77 Q86V78 Q86V79 Q96H62

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 7 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 36 EPD 1 Ensembl 10 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 4 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 10 Pumba 1 RNAct 1 Reactome 5 RefSeq 3 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8274221

Title: Cloning and genetic characterization of the human kinesin light-chain (KLC) gene.

PubMed ID: 8274221

DOI: 10.1089/dna.1993.12.881

PubMed ID: 12839500

Title: Alternatively spliced products of the human kinesin light chain 1 (KNS2) gene.

PubMed ID: 12839500

DOI: 10.1034/j.1600-0854.2003.00113.x

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14970196

Title: The early onset dystonia protein torsinA interacts with kinesin light chain 1.

PubMed ID: 14970196

DOI: 10.1074/jbc.m401332200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20074060

Title: Cell-wide analysis of secretory granule dynamics in three dimensions in living pancreatic beta-cells: evidence against a role for AMPK-dependent phosphorylation of KLC1 at Ser517/Ser520 in glucose-stimulated insulin granule movement.

PubMed ID: 20074060

DOI: 10.1042/bst0380205

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21925109

Title: Kinesin-1-mediated capsid disassembly and disruption of the nuclear pore complex promote virus infection.

PubMed ID: 21925109

DOI: 10.1016/j.chom.2011.08.010

PubMed ID: 21385839

Title: Phosphorylation of kinesin light chain 1 at serine 460 modulates binding and trafficking of calsyntenin-1.

PubMed ID: 21385839

DOI: 10.1242/jcs.075168

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25898167

Title: BORC, a multisubunit complex that regulates lysosome positioning.

PubMed ID: 25898167

DOI: 10.1016/j.devcel.2015.02.011

Sequence Information:

  • Length: 573
  • Mass: 65310
  • Checksum: A66E3915C57C2764
  • Sequence:
    • MYDNMSTMVY IKEDKLEKLT QDEIISKTKQ VIQGLEALKN EHNSILQSLL ETLKCLKKDD 
ESNLVEEKSN MIRKSLEMLE LGLSEAQVMM ALSNHLNAVE SEKQKLRAQV RRLCQENQWL 
RDELANTQQK LQKSEQSVAQ LEEEKKHLEF MNQLKKYDDD ISPSEDKDTD STKEPLDDLF 
PNDEDDPGQG IQQQHSSAAA AAQQGGYEIP ARLRTLHNLV IQYASQGRYE VAVPLCKQAL 
EDLEKTSGHD HPDVATMLNI LALVYRDQNK YKDAANLLND ALAIREKTLG KDHPAVAATL 
NNLAVLYGKR GKYKEAEPLC KRALEIREKV LGKDHPDVAK QLNNLALLCQ NQGKYEEVEY 
YYQRALEIYQ TKLGPDDPNV AKTKNNLASC YLKQGKFKQA ETLYKEILTR AHEREFGSVD 
DENKPIWMHA EEREECKGKQ KDGTSFGEYG GWYKACKVDS PTVTTTLKNL GALYRRQGKF 
EAAETLEEAA MRSRKQGLDN VHKQRVAEVL NDPENMEKRR SRESLNVDVV KYESGPDGGE 
EVSMSVEWNG GVSGRASFCG KRQQQQWPGR RHR

Genular Protein ID: 300703577

Symbol: Q7RTQ2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q7RTQ2

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 1 RuleBase 1 SAM 2 SMART 1 SUPFAM 1

Citations:

PubMed ID: 12839500

Title: Alternatively spliced products of the human kinesin light chain 1 (KNS2) gene.

PubMed ID: 12839500

Sequence Information:

  • Length: 609
  • Mass: 68762
  • Checksum: CC42D0ADB681B8C7
  • Sequence:
    • MYDTMSTMVY IKEDKLEKLT QDEIISKTKQ VIQGLEALKN EHNSILQSLL ETLKCLKKDD 
ESNLVEEKSN MIRKSLEMLE LGLSEAQVMM ALSNHLNAVE SEKQKLRAQV RRLCQENQWL 
RDELANTQQK LQKSEQSVAQ LEEEKKHLEF MNQLKKYDDD ISPSEDKDTD STKEPLDDLF 
PNDEDDPGQG IQQQHSSAAA AAQQGGYEIP ARLRTLHNLV IQYASQGRYE VAVPLCKQAL 
EDLEKTSGHD HPDVATMLNI LALVYRDQNK YKDAANLLND ALAIREKTLG KDHPAVAATL 
NNLAVLYGKR GKYKEAEPLC KRALEIREKV LGKDHPDVAK QLNNLALLCQ NQGKYEEVEY 
YYQRALEIYQ TKLGPDDPNV AKTKNNLASC YLKQGKFKQA ETLYKEILTR AHEREFGSVD 
DENKPIWMHA EEREECKGKQ KDGTSFGEYG GWYKACKVDS PTVTTTLKNL GALYRRQGKF 
EAAETLEEAA MRSRKQGLDN VHKQRVAEVL NDPENMEKRR SRESLNVDVV KYESGPDGGE 
EDGTGSLKRS GSFSKLRASI RRSSEKLVRK LKGGSSRESE PKNPGASLAE PLFVENDSSS 
SGLEDATAN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.