Details for: KPNA4

Gene ID: 3840

Symbol: KPNA4

Ensembl ID: ENSG00000186432

Description: karyopherin subunit alpha 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 378.4108
    Cell Significance Index: -58.8600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 229.6334
    Cell Significance Index: -58.2500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 131.2794
    Cell Significance Index: -61.9800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 124.3794
    Cell Significance Index: -50.5300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 113.6891
    Cell Significance Index: -58.4800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 92.4560
    Cell Significance Index: -62.0400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 53.4070
    Cell Significance Index: -50.9900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 49.3124
    Cell Significance Index: -60.8000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 21.7518
    Cell Significance Index: -58.2700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.5371
    Cell Significance Index: -61.3100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.0101
    Cell Significance Index: -39.9600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 10.5867
    Cell Significance Index: -23.1700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.7038
    Cell Significance Index: 186.9800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.4546
    Cell Significance Index: 33.4900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.4952
    Cell Significance Index: 299.9300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.4570
    Cell Significance Index: 81.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4457
    Cell Significance Index: 39.3500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.4436
    Cell Significance Index: 157.0300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4024
    Cell Significance Index: 172.4400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.2037
    Cell Significance Index: 32.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1956
    Cell Significance Index: 215.5400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.1503
    Cell Significance Index: 74.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1390
    Cell Significance Index: 226.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.0716
    Cell Significance Index: 48.5700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9430
    Cell Significance Index: 72.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9277
    Cell Significance Index: 48.1900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8668
    Cell Significance Index: 18.7800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8187
    Cell Significance Index: 293.6600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7712
    Cell Significance Index: 22.2200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7111
    Cell Significance Index: 33.4200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6921
    Cell Significance Index: 306.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6623
    Cell Significance Index: 361.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6451
    Cell Significance Index: 88.5900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6127
    Cell Significance Index: 17.5600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5860
    Cell Significance Index: 95.3000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5475
    Cell Significance Index: 34.5100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4831
    Cell Significance Index: 334.1100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.4517
    Cell Significance Index: 11.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3466
    Cell Significance Index: 16.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3439
    Cell Significance Index: 24.3200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.2844
    Cell Significance Index: 7.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1675
    Cell Significance Index: 4.6800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1665
    Cell Significance Index: 1.9900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1272
    Cell Significance Index: 4.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1174
    Cell Significance Index: 20.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1143
    Cell Significance Index: 14.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0905
    Cell Significance Index: 11.7000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0861
    Cell Significance Index: 54.6700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0704
    Cell Significance Index: 132.5100
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0447
    Cell Significance Index: 0.2700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0302
    Cell Significance Index: 46.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0276
    Cell Significance Index: 2.7400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0241
    Cell Significance Index: 44.4400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0113
    Cell Significance Index: 5.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0091
    Cell Significance Index: 12.3300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0079
    Cell Significance Index: 0.4800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0000
    Cell Significance Index: 0.0200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0002
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0178
    Cell Significance Index: -13.1700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0239
    Cell Significance Index: -14.9600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0308
    Cell Significance Index: -22.5800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0326
    Cell Significance Index: -6.2000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0366
    Cell Significance Index: -2.4600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0512
    Cell Significance Index: -28.8600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0614
    Cell Significance Index: -46.4600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0734
    Cell Significance Index: -8.6600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0996
    Cell Significance Index: -7.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1261
    Cell Significance Index: -12.8900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1311
    Cell Significance Index: -14.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1601
    Cell Significance Index: -33.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1796
    Cell Significance Index: -51.6700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1797
    Cell Significance Index: -26.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1934
    Cell Significance Index: -5.0800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2216
    Cell Significance Index: -25.3900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2799
    Cell Significance Index: -32.6300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2821
    Cell Significance Index: -12.4800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3056
    Cell Significance Index: -7.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3219
    Cell Significance Index: -16.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3691
    Cell Significance Index: -13.9800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4251
    Cell Significance Index: -3.9200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4406
    Cell Significance Index: -8.6000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4512
    Cell Significance Index: -9.3600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.4684
    Cell Significance Index: -3.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5170
    Cell Significance Index: -53.8400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5514
    Cell Significance Index: -15.7400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.5554
    Cell Significance Index: -8.2000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.5588
    Cell Significance Index: -11.9000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6278
    Cell Significance Index: -49.7300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.7027
    Cell Significance Index: -11.7600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7577
    Cell Significance Index: -26.3300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7741
    Cell Significance Index: -16.9500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.7794
    Cell Significance Index: -11.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7956
    Cell Significance Index: -48.7800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7990
    Cell Significance Index: -18.4600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.9007
    Cell Significance Index: -14.4500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.9124
    Cell Significance Index: -15.3700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.9414
    Cell Significance Index: -17.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9634
    Cell Significance Index: -25.8200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.9923
    Cell Significance Index: -21.2100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.9984
    Cell Significance Index: -17.1100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Nuclear Import Complex:** KPNA4 is a component of the nuclear import complex, which recognizes and binds to specific nuclear localization signals (NLS) on proteins. 2. **Antiviral Mechanism:** KPNA4 is involved in the antiviral mechanism of interferon-stimulated genes, which play a crucial role in defending against viral infections. 3. **Cytokine Signaling:** KPNA4 is also involved in cytokine signaling pathways, which regulate the immune response to infection and inflammation. 4. **Interferon Signaling:** KPNA4 interacts with interferon signaling pathways, modulating the expression of interferon-stimulated genes. 5. **NLS-Bearing Proteins:** KPNA4 recognizes and binds to NLS-bearing proteins, facilitating their nuclear import. **Pathways and Functions:** 1. **Antiviral Mechanism by IFN-Stimulated Genes:** KPNA4 is involved in the antiviral mechanism of IFN-stimulated genes, which play a crucial role in defending against viral infections. 2. **Cytokine Signaling in Immune System:** KPNA4 is involved in cytokine signaling pathways, regulating the immune response to infection and inflammation. 3. **Interferon Signaling:** KPNA4 interacts with interferon signaling pathways, modulating the expression of interferon-stimulated genes. 4. **NLS-Dependent Protein Nuclear Import Complex:** KPNA4 is a component of the NLS-dependent protein nuclear import complex, facilitating the transport of NLS-bearing proteins into the nucleus. 5. **Ns1 Mediated Effects on Host Pathways:** KPNA4 interacts with the Ns1 protein, modulating host pathways and influencing the outcome of viral infections. **Clinical Significance:** 1. **Viral Infections:** KPNA4's involvement in antiviral mechanisms and interferon signaling pathways makes it an important target for the development of antiviral therapies. 2. **Immune System Disorders:** Alterations in KPNA4 expression or function may contribute to immune system disorders, such as autoimmune diseases or immunodeficiency. 3. **Cancer:** KPNA4's role in regulating gene expression and responding to environmental stimuli may also be relevant to cancer development and progression. 4. **Neurological Disorders:** KPNA4's expression in neurons and its involvement in dopamine secretion make it a potential target for the treatment of neurological disorders, such as Parkinson's disease. In conclusion, the KPNA4 gene plays a crucial role in immune regulation, viral defense, and gene expression. Its involvement in various cellular processes highlights its importance in maintaining immune homeostasis and defending against viral infections. Further research is needed to fully understand the role of KPNA4 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 2033029855

Symbol: IMA3_HUMAN

Name: Karyopherin subunit alpha-4

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9168958

Title: Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1: discrimination of Qip1 and Rch1 from hSrp1 by their ability to interact with DNA helicase Q1/RecQL.

PubMed ID: 9168958

DOI: 10.1006/bbrc.1997.6535

PubMed ID: 9395085

Title: Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family.

PubMed ID: 9395085

DOI: 10.1016/s0014-5793(97)01265-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10567565

Title: RanBP3 contains an unusual nuclear localization signal that is imported preferentially by importin-alpha3.

PubMed ID: 10567565

DOI: 10.1128/mcb.19.12.8400

PubMed ID: 12610148

Title: A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway.

PubMed ID: 12610148

DOI: 10.1128/jvi.77.6.3734-3748.2003

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20818336

Title: An actin-regulated importin alpha/beta-dependent extended bipartite NLS directs nuclear import of MRTF-A.

PubMed ID: 20818336

DOI: 10.1038/emboj.2010.216

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21454664

Title: Importin alpha protein acts as a negative regulator for Snail protein nuclear import.

PubMed ID: 21454664

DOI: 10.1074/jbc.m110.213579

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23864635

Title: Dissection of the C-terminal region of E1A redefines the roles of CtBP and other cellular targets in oncogenic transformation.

PubMed ID: 23864635

DOI: 10.1128/jvi.00786-13

PubMed ID: 23984714

Title: Chikungunya virus capsid protein contains nuclear import and export signals.

PubMed ID: 23984714

DOI: 10.1186/1743-422x-10-269

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29370303

Title: MERS-CoV 4b protein interferes with the NF-kappaB-dependent innate immune response during infection.

PubMed ID: 29370303

DOI: 10.1371/journal.ppat.1006838

PubMed ID: 38512451

Title: The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer.

PubMed ID: 38512451

DOI: 10.1172/jci174587

PubMed ID: 28760339

Title: Crystal structure of importin-alpha3 bound to the nuclear localization signal of Ran-binding protein 3.

PubMed ID: 28760339

DOI: 10.1016/j.bbrc.2017.07.155

PubMed ID: 29042532

Title: Three-dimensional context rather than NLS amino acid sequence determines importin alpha subtype specificity for RCC1.

PubMed ID: 29042532

DOI: 10.1038/s41467-017-01057-7

Sequence Information:

  • Length: 521
  • Mass: 57887
  • Checksum: D98BC45002C9F57E
  • Sequence:
  • MADNEKLDNQ RLKNFKNKGR DLETMRRQRN EVVVELRKNK RDEHLLKRRN VPHEDICEDS 
    DIDGDYRVQN TSLEAIVQNA SSDNQGIQLS AVQAARKLLS SDRNPPIDDL IKSGILPILV 
    HCLERDDNPS LQFEAAWALT NIASGTSEQT QAVVQSNAVP LFLRLLHSPH QNVCEQAVWA 
    LGNIIGDGPQ CRDYVISLGV VKPLLSFISP SIPITFLRNV TWVMVNLCRH KDPPPPMETI 
    QEILPALCVL IHHTDVNILV DTVWALSYLT DAGNEQIQMV IDSGIVPHLV PLLSHQEVKV 
    QTAALRAVGN IVTGTDEQTQ VVLNCDALSH FPALLTHPKE KINKEAVWFL SNITAGNQQQ 
    VQAVIDANLV PMIIHLLDKG DFGTQKEAAW AISNLTISGR KDQVAYLIQQ NVIPPFCNLL 
    TVKDAQVVQV VLDGLSNILK MAEDEAETIG NLIEECGGLE KIEQLQNHEN EDIYKLAYEI 
    IDQFFSSDDI DEDPSLVPEA IQGGTFGFNS SANVPTEGFQ F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.