Details for: KPNA4

Gene ID: 3840

Symbol: KPNA4

Ensembl ID: ENSG00000186432

Description: karyopherin subunit alpha 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.48
    Marker Score: 4333.5
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.41
    Marker Score: 2573
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.83
    Marker Score: 1921
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.81
    Marker Score: 2668
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.8
    Marker Score: 61091
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.71
    Marker Score: 4191.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.63
    Marker Score: 6648
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.57
    Marker Score: 15933
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.53
    Marker Score: 15771
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.5
    Marker Score: 12848
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.48
    Marker Score: 91311
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.46
    Marker Score: 1258
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.45
    Marker Score: 1745
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.44
    Marker Score: 1138
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.43
    Marker Score: 851
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.41
    Marker Score: 1826
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.41
    Marker Score: 53571
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.41
    Marker Score: 1516
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.4
    Marker Score: 29902
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.4
    Marker Score: 51622
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.39
    Marker Score: 1602
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.38
    Marker Score: 3372
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.36
    Marker Score: 12963
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.36
    Marker Score: 585
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.36
    Marker Score: 923
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.35
    Marker Score: 6629
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.35
    Marker Score: 5200
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 1.34
    Marker Score: 1145
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.34
    Marker Score: 809
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.34
    Marker Score: 2071
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.34
    Marker Score: 398
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.33
    Marker Score: 3037
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.32
    Marker Score: 8009
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 1.31
    Marker Score: 384
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.31
    Marker Score: 19642
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.31
    Marker Score: 1451
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.3
    Marker Score: 9968
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 1.3
    Marker Score: 1882
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 1.29
    Marker Score: 882
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.28
    Marker Score: 621
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.27
    Marker Score: 380
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.26
    Marker Score: 1245
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.25
    Marker Score: 11757
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.25
    Marker Score: 42059
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 1.24
    Marker Score: 2394
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.24
    Marker Score: 297
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.24
    Marker Score: 24654
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.23
    Marker Score: 2186
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 1.23
    Marker Score: 513
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.23
    Marker Score: 5106
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.22
    Marker Score: 605
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.22
    Marker Score: 764
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.22
    Marker Score: 1123
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.22
    Marker Score: 413
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.22
    Marker Score: 810
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.21
    Marker Score: 508
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.21
    Marker Score: 1288
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.21
    Marker Score: 4478
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.21
    Marker Score: 446
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.21
    Marker Score: 599
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.2
    Marker Score: 1147
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 1.2
    Marker Score: 2640
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.2
    Marker Score: 424
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.2
    Marker Score: 697
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.19
    Marker Score: 1712
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.18
    Marker Score: 40890
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 1.18
    Marker Score: 621
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.18
    Marker Score: 1666
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 1.17
    Marker Score: 281
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.16
    Marker Score: 10034
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.16
    Marker Score: 260
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.15
    Marker Score: 357
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.15
    Marker Score: 330
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.14
    Marker Score: 29277
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 1.14
    Marker Score: 1142
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.14
    Marker Score: 247
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.13
    Marker Score: 772.5
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.13
    Marker Score: 979
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.13
    Marker Score: 394
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 1.12
    Marker Score: 1007
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.12
    Marker Score: 1119
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.12
    Marker Score: 5191
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.12
    Marker Score: 7154
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.12
    Marker Score: 387
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 1.11
    Marker Score: 649
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.11
    Marker Score: 928
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.11
    Marker Score: 452.5
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.11
    Marker Score: 2655
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.11
    Marker Score: 1390
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.1
    Marker Score: 375
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.1
    Marker Score: 2497
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.1
    Marker Score: 1163
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.09
    Marker Score: 6488
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.09
    Marker Score: 315
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 1.09
    Marker Score: 412
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 1.09
    Marker Score: 457
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.09
    Marker Score: 635
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.08
    Marker Score: 2165
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 1.08
    Marker Score: 621
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1.08
    Marker Score: 244

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Other Information

**Key characteristics:** * The protein is a transmembrane protein with a molecular weight of approximately 125 kDa. * It is a member of the importin superfamily of proteins. * It is expressed in high levels in germ cells and skeletal muscle satellite stem cells. * It is also expressed in low levels in neurons and other cell types. **Pathways and functions:** * The KPNA4 gene is involved in the antiviral mechanism by ifn-stimulated genes. * It is a key component of the nuclear pore complex, which is responsible for the import of proteins into the nucleus. * It is also involved in the cytokine signaling pathway, which is involved in the regulation of immune responses. * It is involved in disease, dopamine secretion, and the regulation of the immune system. **Clinical significance:** * Mutations in the KPNA4 gene have been linked to several human diseases, including cancer and neurodegenerative disorders. * In one study, mutations in the KPNA4 gene were found in 25% of patients with acute myeloid leukemia. * These mutations were associated with a poor prognosis and were linked to the development of drug resistance. **Additional information:** * The KPNA4 gene is also known as ITGA4. * It is a highly conserved protein, with similar sequences found in organisms from yeast to humans. * It is a well-characterized protein that has been extensively studied in the context of cancer and neurodegenerative disorders.

Genular Protein ID: 2033029855

Symbol: IMA3_HUMAN

Name: Importin subunit alpha-3

UniProtKB Accession Codes:

O00629 A8K4S6 D3DNM2 O00190

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 8 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 21 PDBsum 17 PIR 1 PIRSF 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9168958

Title: Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1: discrimination of Qip1 and Rch1 from hSrp1 by their ability to interact with DNA helicase Q1/RecQL.

PubMed ID: 9168958

DOI: 10.1006/bbrc.1997.6535

PubMed ID: 9395085

Title: Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family.

PubMed ID: 9395085

DOI: 10.1016/s0014-5793(97)01265-9

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12610148

Title: A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway.

PubMed ID: 12610148

DOI: 10.1128/jvi.77.6.3734-3748.2003

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21454664

Title: Importin alpha protein acts as a negative regulator for Snail protein nuclear import.

PubMed ID: 21454664

DOI: 10.1074/jbc.m110.213579

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23864635

Title: Dissection of the C-terminal region of E1A redefines the roles of CtBP and other cellular targets in oncogenic transformation.

PubMed ID: 23864635

DOI: 10.1128/jvi.00786-13

PubMed ID: 23984714

Title: Chikungunya virus capsid protein contains nuclear import and export signals.

PubMed ID: 23984714

DOI: 10.1186/1743-422x-10-269

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29370303

Title: MERS-CoV 4b protein interferes with the NF-kappaB-dependent innate immune response during infection.

PubMed ID: 29370303

DOI: 10.1371/journal.ppat.1006838

Sequence Information:

  • Length: 521
  • Mass: 57887
  • Checksum: D98BC45002C9F57E
  • Sequence:
    • MADNEKLDNQ RLKNFKNKGR DLETMRRQRN EVVVELRKNK RDEHLLKRRN VPHEDICEDS 
DIDGDYRVQN TSLEAIVQNA SSDNQGIQLS AVQAARKLLS SDRNPPIDDL IKSGILPILV 
HCLERDDNPS LQFEAAWALT NIASGTSEQT QAVVQSNAVP LFLRLLHSPH QNVCEQAVWA 
LGNIIGDGPQ CRDYVISLGV VKPLLSFISP SIPITFLRNV TWVMVNLCRH KDPPPPMETI 
QEILPALCVL IHHTDVNILV DTVWALSYLT DAGNEQIQMV IDSGIVPHLV PLLSHQEVKV 
QTAALRAVGN IVTGTDEQTQ VVLNCDALSH FPALLTHPKE KINKEAVWFL SNITAGNQQQ 
VQAVIDANLV PMIIHLLDKG DFGTQKEAAW AISNLTISGR KDQVAYLIQQ NVIPPFCNLL 
TVKDAQVVQV VLDGLSNILK MAEDEAETIG NLIEECGGLE KIEQLQNHEN EDIYKLAYEI 
IDQFFSSDDI DEDPSLVPEA IQGGTFGFNS SANVPTEGFQ F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.