Details for: KPNA4
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 378.4108
Cell Significance Index: -58.8600 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 229.6334
Cell Significance Index: -58.2500 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 131.2794
Cell Significance Index: -61.9800 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 124.3794
Cell Significance Index: -50.5300 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 113.6891
Cell Significance Index: -58.4800 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 92.4560
Cell Significance Index: -62.0400 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 53.4070
Cell Significance Index: -50.9900 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 49.3124
Cell Significance Index: -60.8000 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 21.7518
Cell Significance Index: -58.2700 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 15.5371
Cell Significance Index: -61.3100 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 13.0101
Cell Significance Index: -39.9600 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 10.5867
Cell Significance Index: -23.1700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.7038
Cell Significance Index: 186.9800 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.4546
Cell Significance Index: 33.4900 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.4952
Cell Significance Index: 299.9300 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.4570
Cell Significance Index: 81.7600 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.4457
Cell Significance Index: 39.3500 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.4436
Cell Significance Index: 157.0300 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.4024
Cell Significance Index: 172.4400 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.2037
Cell Significance Index: 32.1400 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.1956
Cell Significance Index: 215.5400 - Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.1503
Cell Significance Index: 74.2100 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.1390
Cell Significance Index: 226.0300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 1.0716
Cell Significance Index: 48.5700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.9430
Cell Significance Index: 72.3700 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.9277
Cell Significance Index: 48.1900 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.8668
Cell Significance Index: 18.7800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.8187
Cell Significance Index: 293.6600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.7712
Cell Significance Index: 22.2200 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.7111
Cell Significance Index: 33.4200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.6921
Cell Significance Index: 306.0100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.6623
Cell Significance Index: 361.7100 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.6451
Cell Significance Index: 88.5900 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.6127
Cell Significance Index: 17.5600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.5860
Cell Significance Index: 95.3000 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.5475
Cell Significance Index: 34.5100 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.4831
Cell Significance Index: 334.1100 - Cell Name: type I muscle cell (CL0002211)
Fold Change: 0.4517
Cell Significance Index: 11.0200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.3466
Cell Significance Index: 16.1600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.3439
Cell Significance Index: 24.3200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.2844
Cell Significance Index: 7.3100 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1675
Cell Significance Index: 4.6800 - Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.1665
Cell Significance Index: 1.9900 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1272
Cell Significance Index: 4.4700 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1174
Cell Significance Index: 20.0400 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.1143
Cell Significance Index: 14.6500 - Cell Name: lactocyte (CL0002325)
Fold Change: 0.0905
Cell Significance Index: 11.7000 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0861
Cell Significance Index: 54.6700 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0704
Cell Significance Index: 132.5100 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.0447
Cell Significance Index: 0.2700 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0302
Cell Significance Index: 46.5000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0276
Cell Significance Index: 2.7400 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0241
Cell Significance Index: 44.4400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0113
Cell Significance Index: 5.1200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0091
Cell Significance Index: 12.3300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.0079
Cell Significance Index: 0.4800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0000
Cell Significance Index: 0.0200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.0002
Cell Significance Index: -0.0100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0178
Cell Significance Index: -13.1700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0239
Cell Significance Index: -14.9600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0308
Cell Significance Index: -22.5800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.0326
Cell Significance Index: -6.2000 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0366
Cell Significance Index: -2.4600 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0512
Cell Significance Index: -28.8600 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0614
Cell Significance Index: -46.4600 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.0734
Cell Significance Index: -8.6600 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0996
Cell Significance Index: -7.4200 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1261
Cell Significance Index: -12.8900 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1311
Cell Significance Index: -14.9600 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1601
Cell Significance Index: -33.7300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1796
Cell Significance Index: -51.6700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1797
Cell Significance Index: -26.1200 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1934
Cell Significance Index: -5.0800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2216
Cell Significance Index: -25.3900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2799
Cell Significance Index: -32.6300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2821
Cell Significance Index: -12.4800 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.3056
Cell Significance Index: -7.6400 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.3219
Cell Significance Index: -16.9000 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.3691
Cell Significance Index: -13.9800 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.4251
Cell Significance Index: -3.9200 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.4406
Cell Significance Index: -8.6000 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.4512
Cell Significance Index: -9.3600 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.4684
Cell Significance Index: -3.6100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5170
Cell Significance Index: -53.8400 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.5514
Cell Significance Index: -15.7400 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.5554
Cell Significance Index: -8.2000 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.5588
Cell Significance Index: -11.9000 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.6278
Cell Significance Index: -49.7300 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.7027
Cell Significance Index: -11.7600 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.7577
Cell Significance Index: -26.3300 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.7741
Cell Significance Index: -16.9500 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.7794
Cell Significance Index: -11.2100 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.7956
Cell Significance Index: -48.7800 - Cell Name: peg cell (CL4033014)
Fold Change: -0.7990
Cell Significance Index: -18.4600 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.9007
Cell Significance Index: -14.4500 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.9124
Cell Significance Index: -15.3700 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: -0.9414
Cell Significance Index: -17.4000 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.9634
Cell Significance Index: -25.8200 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.9923
Cell Significance Index: -21.2100 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.9984
Cell Significance Index: -17.1100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2033029855
Symbol: IMA3_HUMAN
Name: Karyopherin subunit alpha-4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9168958
Title: Cloning of a cDNA encoding a novel importin-alpha homologue, Qip1: discrimination of Qip1 and Rch1 from hSrp1 by their ability to interact with DNA helicase Q1/RecQL.
PubMed ID: 9168958
PubMed ID: 9395085
Title: Cloning of two novel human importin-alpha subunits and analysis of the expression pattern of the importin-alpha protein family.
PubMed ID: 9395085
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10567565
Title: RanBP3 contains an unusual nuclear localization signal that is imported preferentially by importin-alpha3.
PubMed ID: 10567565
PubMed ID: 12610148
Title: A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway.
PubMed ID: 12610148
PubMed ID: 14654843
Title: Proteomic characterization of the human centrosome by protein correlation profiling.
PubMed ID: 14654843
DOI: 10.1038/nature02166
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20818336
Title: An actin-regulated importin alpha/beta-dependent extended bipartite NLS directs nuclear import of MRTF-A.
PubMed ID: 20818336
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21454664
Title: Importin alpha protein acts as a negative regulator for Snail protein nuclear import.
PubMed ID: 21454664
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23864635
Title: Dissection of the C-terminal region of E1A redefines the roles of CtBP and other cellular targets in oncogenic transformation.
PubMed ID: 23864635
DOI: 10.1128/jvi.00786-13
PubMed ID: 23984714
Title: Chikungunya virus capsid protein contains nuclear import and export signals.
PubMed ID: 23984714
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 29370303
Title: MERS-CoV 4b protein interferes with the NF-kappaB-dependent innate immune response during infection.
PubMed ID: 29370303
PubMed ID: 38512451
Title: The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer.
PubMed ID: 38512451
DOI: 10.1172/jci174587
PubMed ID: 28760339
Title: Crystal structure of importin-alpha3 bound to the nuclear localization signal of Ran-binding protein 3.
PubMed ID: 28760339
PubMed ID: 29042532
Title: Three-dimensional context rather than NLS amino acid sequence determines importin alpha subtype specificity for RCC1.
PubMed ID: 29042532
Sequence Information:
- Length: 521
- Mass: 57887
- Checksum: D98BC45002C9F57E
- Sequence:
MADNEKLDNQ RLKNFKNKGR DLETMRRQRN EVVVELRKNK RDEHLLKRRN VPHEDICEDS DIDGDYRVQN TSLEAIVQNA SSDNQGIQLS AVQAARKLLS SDRNPPIDDL IKSGILPILV HCLERDDNPS LQFEAAWALT NIASGTSEQT QAVVQSNAVP LFLRLLHSPH QNVCEQAVWA LGNIIGDGPQ CRDYVISLGV VKPLLSFISP SIPITFLRNV TWVMVNLCRH KDPPPPMETI QEILPALCVL IHHTDVNILV DTVWALSYLT DAGNEQIQMV IDSGIVPHLV PLLSHQEVKV QTAALRAVGN IVTGTDEQTQ VVLNCDALSH FPALLTHPKE KINKEAVWFL SNITAGNQQQ VQAVIDANLV PMIIHLLDKG DFGTQKEAAW AISNLTISGR KDQVAYLIQQ NVIPPFCNLL TVKDAQVVQV VLDGLSNILK MAEDEAETIG NLIEECGGLE KIEQLQNHEN EDIYKLAYEI IDQFFSSDDI DEDPSLVPEA IQGGTFGFNS SANVPTEGFQ F
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.