Details for: ARHGAP1

Gene ID: 392

Symbol: ARHGAP1

Ensembl ID: ENSG00000175220

Description: Rho GTPase activating protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.57
    Marker Score: 916.5
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.57
    Marker Score: 631
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.3
    Marker Score: 1241
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.27
    Marker Score: 3048
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.17
    Marker Score: 1719.5
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.13
    Marker Score: 802
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.08
    Marker Score: 16889
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.08
    Marker Score: 266
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.06
    Marker Score: 270.5
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.05
    Marker Score: 22342.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71670
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47895
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.99
    Marker Score: 1235
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30386
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.98
    Marker Score: 225
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.97
    Marker Score: 8316
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.97
    Marker Score: 59423
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.96
    Marker Score: 1320
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.96
    Marker Score: 9117.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2390
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.94
    Marker Score: 297
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.93
    Marker Score: 34444
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 479
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.93
    Marker Score: 346
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.92
    Marker Score: 970.5
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.92
    Marker Score: 9479
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.92
    Marker Score: 1601
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.91
    Marker Score: 470
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.9
    Marker Score: 315
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.9
    Marker Score: 255
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2693
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.9
    Marker Score: 589
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.89
    Marker Score: 595
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.89
    Marker Score: 280
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.87
    Marker Score: 548
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.86
    Marker Score: 1115
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.86
    Marker Score: 475
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 308
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.85
    Marker Score: 245
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.85
    Marker Score: 937
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.84
    Marker Score: 1587
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.84
    Marker Score: 3519
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.84
    Marker Score: 772
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.84
    Marker Score: 489
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.83
    Marker Score: 7821.5
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.83
    Marker Score: 4715
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.83
    Marker Score: 9603
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.82
    Marker Score: 1269
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.82
    Marker Score: 942
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.81
    Marker Score: 6063
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 325
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.81
    Marker Score: 3279
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.8
    Marker Score: 328
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 609
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.8
    Marker Score: 580
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.79
    Marker Score: 460
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.78
    Marker Score: 944
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.78
    Marker Score: 445
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.77
    Marker Score: 1270.5
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.77
    Marker Score: 1490.5
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.77
    Marker Score: 194
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.77
    Marker Score: 1949
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.76
    Marker Score: 264
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.76
    Marker Score: 4871
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.76
    Marker Score: 942
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.76
    Marker Score: 636
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.76
    Marker Score: 1662.5
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.75
    Marker Score: 28597
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.75
    Marker Score: 652
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.75
    Marker Score: 261
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.75
    Marker Score: 213
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.75
    Marker Score: 510
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.75
    Marker Score: 1701
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.74
    Marker Score: 403
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.74
    Marker Score: 3206
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.74
    Marker Score: 3185
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.74
    Marker Score: 467
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.74
    Marker Score: 4732
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.74
    Marker Score: 10998
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.73
    Marker Score: 753
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.72
    Marker Score: 3037.5
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 373
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.71
    Marker Score: 6140
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.71
    Marker Score: 2741
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.71
    Marker Score: 719
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.71
    Marker Score: 2511
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.71
    Marker Score: 39512
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.7
    Marker Score: 1381
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.7
    Marker Score: 371
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.7
    Marker Score: 341
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.7
    Marker Score: 678
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.7
    Marker Score: 478
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.7
    Marker Score: 463
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.7
    Marker Score: 623.5
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7
    Marker Score: 7857
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.7
    Marker Score: 197
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.69
    Marker Score: 166

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Other Information

**Key characteristics:** - ARHGAP1 is a protein of the Rho GTPase family, which are involved in signal transduction pathways. - It is a key regulator of the Cdc42 gtpase cycle, which is essential for cell cycle regulation and proliferation. - It also plays a role in the Gtpase activator activity pathway, which is involved in the regulation of cell growth and differentiation. **Pathways and functions:** - ARHGAP1 is involved in multiple cellular processes, including cell cycle regulation, proliferation, differentiation, and apoptosis. - It promotes cell cycle progression by activating the Cdc42 gtpase cycle, which is essential for the initiation of cell cycle checkpoints. - It also promotes the activation of the Gtpase activator activity pathway, which is involved in cell growth and differentiation. - In addition, it plays a role in the regulation of cell migration, adhesion, and signaling pathways. **Clinical significance:** - Mutations in ARHGAP1 have been linked to several eye diseases, including retinal disorders, diabetic retinopathy, and cataracts. - Therefore, ARHGAP1 is a potential therapeutic target for these eye diseases. **Additional notes:** - ARHGAP1 is a highly conserved protein, with similar sequences found in organisms from yeast to humans. - It is a ubiquitin-dependent protein, meaning that it is degraded when it is no longer needed. - It is a multifunctional protein that can interact with various proteins involved in signal transduction pathways.

Genular Protein ID: 1062726588

Symbol: RHG01_HUMAN

Name: Rho GTPase-activating protein 1

UniProtKB Accession Codes:

Q07960 D3DQQ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 11 PIR 1 PRIDE 1 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 2 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8253717

Title: Cloning and expression of a human CDC42 GTPase-activating protein reveals a functional SH3-binding domain.

PubMed ID: 8253717

DOI: 10.1016/s0021-9258(19)74277-x

PubMed ID: 8288572

Title: Characterization of rhoGAP. A GTPase-activating protein for rho-related small GTPases.

PubMed ID: 8288572

DOI: 10.1016/s0021-9258(17)42232-0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1905930

Title: Purification and N-terminal sequence of the p21rho GTPase-activating protein, rho GAP.

PubMed ID: 1905930

DOI: 10.1042/bj2760833

PubMed ID: 1903516

Title: Bcr encodes a GTPase-activating protein for p21rac.

PubMed ID: 1903516

DOI: 10.1038/351400a0

PubMed ID: 12901880

Title: BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis.

PubMed ID: 12901880

DOI: 10.1016/s0006-291x(03)01387-1

PubMed ID: 15282546

Title: Exportin 7 defines a novel general nuclear export pathway.

PubMed ID: 15282546

DOI: 10.1038/sj.emboj.7600338

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 9009196

Title: The structure of the GTPase-activating domain from p50rhoGAP.

PubMed ID: 9009196

DOI: 10.1038/385458a0

PubMed ID: 9262406

Title: Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP.

PubMed ID: 9262406

DOI: 10.1038/41805

Sequence Information:

  • Length: 439
  • Mass: 50436
  • Checksum: 4DD0CC4419849C35
  • Sequence:
    • MDPLSELQDD LTLDDTSEAL NQLKLASIDE KNWPSDEMPD FPKSDDSKSS SPELVTHLKW 
DDPYYDIARH QIVEVAGDDK YGRKIIVFSA CRMPPSHQLD HSKLLGYLKH TLDQYVESDY 
TLLYLHHGLT SDNKPSLSWL RDAYREFDRK YKKNIKALYI VHPTMFIKTL LILFKPLISF 
KFGQKIFYVN YLSELSEHVK LEQLGIPRQV LKYDDFLKST QKSPATAPKP MPPRPPLPNQ 
QFGVSLQHLQ EKNPEQEPIP IVLRETVAYL QAHALTTEGI FRRSANTQVV REVQQKYNMG 
LPVDFDQYNE LHLPAVILKT FLRELPEPLL TFDLYPHVVG FLNIDESQRV PATLQVLQTL 
PEENYQVLRF LTAFLVQISA HSDQNKMTNT NLAVVFGPNL LWAKDAAITL KAINPINTFT 
KFLLDHQGEL FPSPDPSGL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.