Details for: ARHGAP1

Gene ID: 392

Symbol: ARHGAP1

Ensembl ID: ENSG00000175220

Description: Rho GTPase activating protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 193.2557
    Cell Significance Index: -30.0600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 109.7604
    Cell Significance Index: -27.8400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 75.1795
    Cell Significance Index: -30.9700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 64.3477
    Cell Significance Index: -30.3800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 63.1866
    Cell Significance Index: -25.6700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 56.5724
    Cell Significance Index: -29.1000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 27.0858
    Cell Significance Index: -25.8600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.7941
    Cell Significance Index: -30.5700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.3440
    Cell Significance Index: -27.7100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 7.8204
    Cell Significance Index: -24.0200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.8103
    Cell Significance Index: -30.8200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.1180
    Cell Significance Index: 146.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.8063
    Cell Significance Index: 293.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0046
    Cell Significance Index: 109.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9123
    Cell Significance Index: 112.1800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8330
    Cell Significance Index: 150.1700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7966
    Cell Significance Index: 78.8100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7170
    Cell Significance Index: 143.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6539
    Cell Significance Index: 129.7600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6387
    Cell Significance Index: 33.1800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6352
    Cell Significance Index: 573.5200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4973
    Cell Significance Index: 94.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4641
    Cell Significance Index: 63.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3432
    Cell Significance Index: 9.5900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2986
    Cell Significance Index: 107.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2975
    Cell Significance Index: 22.8300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2833
    Cell Significance Index: 13.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2771
    Cell Significance Index: 17.8800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2691
    Cell Significance Index: 5.8300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2206
    Cell Significance Index: 97.5300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1906
    Cell Significance Index: 131.8500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1728
    Cell Significance Index: 4.9800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1695
    Cell Significance Index: 92.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1611
    Cell Significance Index: 4.3200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1456
    Cell Significance Index: 18.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1282
    Cell Significance Index: 21.8900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0820
    Cell Significance Index: 111.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0777
    Cell Significance Index: 9.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0580
    Cell Significance Index: 109.1600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.0413
    Cell Significance Index: 0.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0061
    Cell Significance Index: 0.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0026
    Cell Significance Index: 1.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0019
    Cell Significance Index: 0.2200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0000
    Cell Significance Index: -0.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0007
    Cell Significance Index: -1.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0017
    Cell Significance Index: -0.7900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0093
    Cell Significance Index: -7.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0124
    Cell Significance Index: -9.1600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0188
    Cell Significance Index: -11.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0195
    Cell Significance Index: -0.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0227
    Cell Significance Index: -12.8000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0244
    Cell Significance Index: -17.9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0272
    Cell Significance Index: -1.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0494
    Cell Significance Index: -5.0500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0602
    Cell Significance Index: -2.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0627
    Cell Significance Index: -8.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0685
    Cell Significance Index: -14.4400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0728
    Cell Significance Index: -5.1500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0743
    Cell Significance Index: -1.4500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0919
    Cell Significance Index: -6.8500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0931
    Cell Significance Index: -26.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0995
    Cell Significance Index: -14.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1008
    Cell Significance Index: -11.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1069
    Cell Significance Index: -6.5700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1137
    Cell Significance Index: -3.3400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1321
    Cell Significance Index: -1.9500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1574
    Cell Significance Index: -2.6400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1881
    Cell Significance Index: -1.5800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1883
    Cell Significance Index: -6.0300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2050
    Cell Significance Index: -21.3500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2084
    Cell Significance Index: -5.9800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2090
    Cell Significance Index: -5.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2162
    Cell Significance Index: -2.9500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2390
    Cell Significance Index: -5.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2523
    Cell Significance Index: -14.1600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2593
    Cell Significance Index: -29.6000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2673
    Cell Significance Index: -16.8500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3117
    Cell Significance Index: -5.2500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3203
    Cell Significance Index: -25.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3423
    Cell Significance Index: -17.9700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3601
    Cell Significance Index: -7.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3650
    Cell Significance Index: -22.3800
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.3658
    Cell Significance Index: -2.3900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3767
    Cell Significance Index: -19.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3873
    Cell Significance Index: -17.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3988
    Cell Significance Index: -10.2500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.3997
    Cell Significance Index: -5.7400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4273
    Cell Significance Index: -11.2400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.4348
    Cell Significance Index: -16.4700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4758
    Cell Significance Index: -9.9600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4800
    Cell Significance Index: -16.6800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5074
    Cell Significance Index: -14.4800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5089
    Cell Significance Index: -13.0000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5099
    Cell Significance Index: -11.7800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.5345
    Cell Significance Index: -8.4800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5378
    Cell Significance Index: -9.9400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.5393
    Cell Significance Index: -7.9600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5596
    Cell Significance Index: -9.5900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6054
    Cell Significance Index: -12.8500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6330
    Cell Significance Index: -13.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ARHGAP1 is a member of the Rho GTPase-activating protein (GAP) family, which are known to regulate the activity of small GTPases. The gene encodes a protein that contains a SH3 domain and a GTPase-activating domain (GAP). This unique combination enables ARHGAP1 to interact with various GTPases, including Rho, Rac, and Cdc42, and modulate their activity. The protein's ability to bind to SH3 domains and GTPases makes it a versatile regulator of signaling pathways. **Pathways and Functions:** ARHGAP1 is involved in various signaling pathways, including: 1. **Cytoskeleton dynamics:** ARHGAP1 regulates the activity of Rho GTPases, which are essential for cytoskeleton dynamics, including actin polymerization and depolymerization. 2. **Cell migration:** ARHGAP1 modulates the activity of Rac GTPases, which are involved in cell migration and invasion. 3. **Endosomal transport:** ARHGAP1 regulates the activity of Rho GTPases, which are involved in endosomal transport and recycling. 4. **Signaling by Rho GTPases:** ARHGAP1 interacts with Rho GTPases, modulating their activity and influencing downstream signaling pathways. **Clinical Significance:** Dysregulation of ARHGAP1 has been implicated in various diseases, including: 1. **Cancer:** Overexpression of ARHGAP1 has been observed in certain types of cancer, including breast and lung cancer, suggesting its potential role as a tumor suppressor. 2. **Neurological disorders:** ARHGAP1 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease, due to its role in regulating cytoskeleton dynamics and cell migration. 3. **Cardiovascular disease:** ARHGAP1 has been shown to regulate the activity of Rho GTPases, which are involved in vascular smooth muscle cell migration and proliferation, making it a potential target for cardiovascular disease treatment. In conclusion, ARHGAP1 is a complex gene that plays a crucial role in regulating the activity of small GTPases, including Rho, Rac, and Cdc42. Its dysregulation has been implicated in various diseases, highlighting its potential as a therapeutic target. Further research is needed to fully elucidate the mechanisms by which ARHGAP1 regulates cellular signaling and to explore its therapeutic potential in disease.

Genular Protein ID: 1062726588

Symbol: RHG01_HUMAN

Name: Rho GTPase-activating protein 1

UniProtKB Accession Codes:

Q07960 D3DQQ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 15 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PIR 1 PRIDE 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 13 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8253717

Title: Cloning and expression of a human CDC42 GTPase-activating protein reveals a functional SH3-binding domain.

PubMed ID: 8253717

DOI: 10.1016/s0021-9258(19)74277-x

PubMed ID: 8288572

Title: Characterization of rhoGAP. A GTPase-activating protein for rho-related small GTPases.

PubMed ID: 8288572

DOI: 10.1016/s0021-9258(17)42232-0

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1905930

Title: Purification and N-terminal sequence of the p21rho GTPase-activating protein, rho GAP.

PubMed ID: 1905930

DOI: 10.1042/bj2760833

PubMed ID: 1903516

Title: Bcr encodes a GTPase-activating protein for p21rac.

PubMed ID: 1903516

DOI: 10.1038/351400a0

PubMed ID: 12901880

Title: BNIPL-2, a novel homologue of BNIP-2, interacts with Bcl-2 and Cdc42GAP in apoptosis.

PubMed ID: 12901880

DOI: 10.1016/s0006-291x(03)01387-1

PubMed ID: 15282546

Title: Exportin 7 defines a novel general nuclear export pathway.

PubMed ID: 15282546

DOI: 10.1038/sj.emboj.7600338

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 9009196

Title: The structure of the GTPase-activating domain from p50rhoGAP.

PubMed ID: 9009196

DOI: 10.1038/385458a0

PubMed ID: 9262406

Title: Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP.

PubMed ID: 9262406

DOI: 10.1038/41805

Sequence Information:

  • Length: 439
  • Mass: 50436
  • Checksum: 4DD0CC4419849C35
  • Sequence:
    • MDPLSELQDD LTLDDTSEAL NQLKLASIDE KNWPSDEMPD FPKSDDSKSS SPELVTHLKW 
DDPYYDIARH QIVEVAGDDK YGRKIIVFSA CRMPPSHQLD HSKLLGYLKH TLDQYVESDY 
TLLYLHHGLT SDNKPSLSWL RDAYREFDRK YKKNIKALYI VHPTMFIKTL LILFKPLISF 
KFGQKIFYVN YLSELSEHVK LEQLGIPRQV LKYDDFLKST QKSPATAPKP MPPRPPLPNQ 
QFGVSLQHLQ EKNPEQEPIP IVLRETVAYL QAHALTTEGI FRRSANTQVV REVQQKYNMG 
LPVDFDQYNE LHLPAVILKT FLRELPEPLL TFDLYPHVVG FLNIDESQRV PATLQVLQTL 
PEENYQVLRF LTAFLVQISA HSDQNKMTNT NLAVVFGPNL LWAKDAAITL KAINPINTFT 
KFLLDHQGEL FPSPDPSGL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.