Details for: LDHC

Gene ID: 3948

Symbol: LDHC

Ensembl ID: ENSG00000166796

Description: lactate dehydrogenase C

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 19.9942
    Cell Significance Index: -3.1100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 12.0248
    Cell Significance Index: -3.0500
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 8.1078
    Cell Significance Index: -3.3400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 2.5467
    Cell Significance Index: -3.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0236
    Cell Significance Index: 194.8000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.8581
    Cell Significance Index: 18.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7118
    Cell Significance Index: 70.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5090
    Cell Significance Index: 459.5900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4821
    Cell Significance Index: 28.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.4171
    Cell Significance Index: 21.6700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3944
    Cell Significance Index: 64.1500
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.3708
    Cell Significance Index: 2.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3145
    Cell Significance Index: 56.7000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2380
    Cell Significance Index: 16.4600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1708
    Cell Significance Index: 2.3300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1238
    Cell Significance Index: 2.7100
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.1023
    Cell Significance Index: 1.4200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0985
    Cell Significance Index: 1.4100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0980
    Cell Significance Index: 3.1400
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.0764
    Cell Significance Index: 0.8800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0566
    Cell Significance Index: 1.6300
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.0531
    Cell Significance Index: 0.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0459
    Cell Significance Index: 9.1100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0393
    Cell Significance Index: 2.4800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0344
    Cell Significance Index: 0.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0330
    Cell Significance Index: 4.8000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0317
    Cell Significance Index: 6.3600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.0306
    Cell Significance Index: 0.4300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0302
    Cell Significance Index: 1.4100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0250
    Cell Significance Index: 0.6700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0227
    Cell Significance Index: 2.6400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0218
    Cell Significance Index: 15.0900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0195
    Cell Significance Index: 0.3100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0194
    Cell Significance Index: 0.8800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0175
    Cell Significance Index: 1.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0133
    Cell Significance Index: 7.2800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0128
    Cell Significance Index: 0.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0115
    Cell Significance Index: 0.3200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0079
    Cell Significance Index: 0.1300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0079
    Cell Significance Index: 2.8500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0065
    Cell Significance Index: 12.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0055
    Cell Significance Index: 7.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0049
    Cell Significance Index: 9.0200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0043
    Cell Significance Index: 0.5500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0039
    Cell Significance Index: 6.0100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0028
    Cell Significance Index: 0.0900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0015
    Cell Significance Index: 0.6500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0003
    Cell Significance Index: 0.1800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0010
    Cell Significance Index: -0.1200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0029
    Cell Significance Index: -1.3000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0032
    Cell Significance Index: -2.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0041
    Cell Significance Index: -3.0100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0044
    Cell Significance Index: -0.7500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0044
    Cell Significance Index: -3.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0046
    Cell Significance Index: -1.3100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0052
    Cell Significance Index: -0.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0055
    Cell Significance Index: -3.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0058
    Cell Significance Index: -3.6500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0065
    Cell Significance Index: -0.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0068
    Cell Significance Index: -0.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0069
    Cell Significance Index: -0.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0124
    Cell Significance Index: -1.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0136
    Cell Significance Index: -0.6000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0164
    Cell Significance Index: -1.1600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0171
    Cell Significance Index: -3.6100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0177
    Cell Significance Index: -0.8300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0178
    Cell Significance Index: -2.4500
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0198
    Cell Significance Index: -0.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0200
    Cell Significance Index: -2.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0208
    Cell Significance Index: -1.4000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0210
    Cell Significance Index: -0.4100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0222
    Cell Significance Index: -0.4600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0229
    Cell Significance Index: -2.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0231
    Cell Significance Index: -1.7700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0232
    Cell Significance Index: -0.8800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0262
    Cell Significance Index: -2.7300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0282
    Cell Significance Index: -1.8200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0290
    Cell Significance Index: -2.3000
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0312
    Cell Significance Index: -0.5000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0320
    Cell Significance Index: -1.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0321
    Cell Significance Index: -2.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0339
    Cell Significance Index: -1.7800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0479
    Cell Significance Index: -1.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0479
    Cell Significance Index: -1.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0481
    Cell Significance Index: -1.3100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0496
    Cell Significance Index: -3.0500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0531
    Cell Significance Index: -1.6900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0537
    Cell Significance Index: -2.3400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0542
    Cell Significance Index: -3.0400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0547
    Cell Significance Index: -2.8500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0554
    Cell Significance Index: -1.9400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0555
    Cell Significance Index: -0.6300
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0568
    Cell Significance Index: -1.6200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0589
    Cell Significance Index: -1.9300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0630
    Cell Significance Index: -0.9500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0631
    Cell Significance Index: -1.3200
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0690
    Cell Significance Index: -1.1600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0693
    Cell Significance Index: -1.6900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0754
    Cell Significance Index: -1.6000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** LDHC is a subunit of the lactate dehydrogenase enzyme complex, which consists of two identical subunits (LDHC and LDHB). LDHC is responsible for the C-terminal domain of the enzyme, which plays a crucial role in the enzyme's substrate specificity and activity. LDHC is highly expressed in various cell types, including retinal bipolar neurons, colon goblet cells, and enterocytes. Its expression is also observed in early T lineage precursors, cerebral cortex GABAergic interneurons, and forebrain radial glial cells. **Pathways and Functions:** LDHC is involved in several key metabolic pathways, including: 1. **Glycolysis:** LDHC facilitates the interconversion of pyruvate and lactate, a critical step in energy metabolism. 2. **Lactate biosynthesis:** LDHC is responsible for the conversion of pyruvate to lactate, a process that occurs in the cytosol and mitochondria. 3. **Pyruvate catabolic process:** LDHC is involved in the breakdown of pyruvate to lactate, which is essential for energy production. 4. **Motile cilium:** LDHC has been implicated in the regulation of motile cilium function, which is critical for cellular movement and signaling. 5. **Extracellular exosome:** LDHC is secreted by cells and regulates extracellular lactate levels, which can impact cellular behavior and signaling. **Clinical Significance:** The dysregulation of LDHC expression and activity has been implicated in various diseases, including: 1. **Cancer:** Altered LDHC expression has been observed in various types of cancer, including colon and breast cancer. 2. **Neurodegenerative diseases:** LDHC has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 3. **Metabolic disorders:** LDHC has been linked to metabolic disorders, including type 2 diabetes and obesity. 4. **Gastrointestinal disorders:** LDHC has been implicated in gastrointestinal disorders, including inflammatory bowel disease and irritable bowel syndrome. In conclusion, LDHC is a multifunctional protein that plays a critical role in cellular metabolism and extracellular processes. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying LDHC function and regulation.

Genular Protein ID: 2009251770

Symbol: LDHC_HUMAN

Name: L-lactate dehydrogenase C chain

UniProtKB Accession Codes:

P07864 D3DQY4 Q6GSG8 Q7Z7J4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 9 Ensembl 2 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2440048

Title: Epitopes of human testis-specific lactate dehydrogenase deduced from a cDNA sequence.

PubMed ID: 2440048

DOI: 10.1073/pnas.84.15.5311

PubMed ID: 2930531

Title: Human testicular lactate dehydrogenase-C gene is interrupted by six introns at positions homologous to those of LDH-A (muscle) and LDH-B (heart) genes.

PubMed ID: 2930531

DOI: 10.1016/0006-291x(89)90033-8

PubMed ID: 14985855

Title: A spermatogenesis-related gene expression profile in human spermatozoa and its potential clinical applications.

PubMed ID: 14985855

DOI: 10.1007/s00109-004-0526-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

Sequence Information:

  • Length: 332
  • Mass: 36311
  • Checksum: DF7047FF5BCB101B
  • Sequence:
    • MSTVKEQLIE KLIEDDENSQ CKITIVGTGA VGMACAISIL LKDLADELAL VDVALDKLKG 
EMMDLQHGSL FFSTSKITSG KDYSVSANSR IVIVTAGARQ QEGETRLALV QRNVAIMKSI 
IPAIVHYSPD CKILVVSNPV DILTYIVWKI SGLPVTRVIG SGCNLDSARF RYLIGEKLGV 
HPTSCHGWII GEHGDSSVPL WSGVNVAGVA LKTLDPKLGT DSDKEHWKNI HKQVIQSAYE 
IIKLKGYTSW AIGLSVMDLV GSILKNLRRV HPVSTMVKGL YGIKEELFLS IPCVLGRNGV 
SDVVKINLNS EEEALFKKSA ETLWNIQKDL IF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.