Details for: LDHC

Gene ID: 3948

Symbol: LDHC

Ensembl ID: ENSG00000166796

Description: lactate dehydrogenase C

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 3.39
    Marker Score: 28627
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1167
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.31
    Marker Score: 1303
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 793
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.96
    Marker Score: 1680
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5301
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 371
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.84
    Marker Score: 350
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.81
    Marker Score: 549
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.77
    Marker Score: 1100
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2980
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.71
    Marker Score: 204
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 175
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.64
    Marker Score: 294
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 170
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.53
    Marker Score: 395
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.52
    Marker Score: 333.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.47
    Marker Score: 899
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.4
    Marker Score: 826
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.35
    Marker Score: 87
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.34
    Marker Score: 687
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.34
    Marker Score: 5276
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.28
    Marker Score: 75
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.27
    Marker Score: 680
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.24
    Marker Score: 351
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.23
    Marker Score: 293
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.23
    Marker Score: 73.5
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.21
    Marker Score: 140
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.21
    Marker Score: 146
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.21
    Marker Score: 121
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.2
    Marker Score: 118
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.19
    Marker Score: 289
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.19
    Marker Score: 269
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.18
    Marker Score: 182
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.17
    Marker Score: 104
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.17
    Marker Score: 468
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.17
    Marker Score: 207
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.16
    Marker Score: 53
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.16
    Marker Score: 78
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.16
    Marker Score: 89
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.16
    Marker Score: 71
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.15
    Marker Score: 349
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.15
    Marker Score: 82
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.15
    Marker Score: 59
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.14
    Marker Score: 56
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.14
    Marker Score: 60
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.14
    Marker Score: 102
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.14
    Marker Score: 59
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.14
    Marker Score: 432
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.14
    Marker Score: 41
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.14
    Marker Score: 133.5
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.14
    Marker Score: 34
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.13
    Marker Score: 216
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.13
    Marker Score: 62
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.13
    Marker Score: 58
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.13
    Marker Score: 109
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.12
    Marker Score: 191
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.12
    Marker Score: 24
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.12
    Marker Score: 94
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 0.12
    Marker Score: 36
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.12
    Marker Score: 124
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.12
    Marker Score: 34
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.12
    Marker Score: 397
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.11
    Marker Score: 78
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.11
    Marker Score: 133
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.11
    Marker Score: 71
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.11
    Marker Score: 35
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.11
    Marker Score: 317
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.11
    Marker Score: 462
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.11
    Marker Score: 44
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.11
    Marker Score: 158
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.11
    Marker Score: 148
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.11
    Marker Score: 53
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.11
    Marker Score: 23
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1
    Marker Score: 140
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.1
    Marker Score: 160
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.1
    Marker Score: 37
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.1
    Marker Score: 59
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.1
    Marker Score: 192
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.1
    Marker Score: 27
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.1
    Marker Score: 1017
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.1
    Marker Score: 23
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.1
    Marker Score: 96
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.1
    Marker Score: 94

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Other Information

**Key characteristics:** * The LDHC gene is located on chromosome 19p13.2. * It is a single-exon gene that encodes a protein of 134 amino acids. * The protein is expressed in high levels in the liver and other tissues with high energy demand, such as muscle and brain. * LDHC is a key enzyme in the citric acid (TCA) cycle, a metabolic pathway that produces energy for cells. **Pathways and functions:** * LDHC is involved in the following metabolic pathways: * Atp biosynthetic process * Cytosol * Extracellular exosome * Flagellated sperm motility * L-lactate dehydrogenase activity * Lactate biosynthetic process from pyruvate * Lactate metabolic process * Lactate oxidation * Metabolism * Mitochondrion * Motile cilium * Nucleus * Oxidoreductase complex * Pyruvate catabolic process * Pyruvate metabolic process * Pyruvate metabolism * Pyruvate metabolism and citric acid (tca) cycle * LDHC is also involved in the regulation of cell migration and differentiation. **Clinical significance:** * Mutations in the LDHC gene have been linked to several human diseases, including lactic acidosis, which is a condition in which the blood contains high levels of lactate. * LDHC inhibitors are being investigated as potential treatments for lactic acidosis and other diseases that are caused by abnormalities in the TCA cycle.

Genular Protein ID: 2009251770

Symbol: LDHC_HUMAN

Name: L-lactate dehydrogenase C chain

UniProtKB Accession Codes:

P07864 D3DQY4 Q6GSG8 Q7Z7J4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 8 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 9 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 Rhea 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2440048

Title: Epitopes of human testis-specific lactate dehydrogenase deduced from a cDNA sequence.

PubMed ID: 2440048

DOI: 10.1073/pnas.84.15.5311

PubMed ID: 2930531

Title: Human testicular lactate dehydrogenase-C gene is interrupted by six introns at positions homologous to those of LDH-A (muscle) and LDH-B (heart) genes.

PubMed ID: 2930531

DOI: 10.1016/0006-291x(89)90033-8

PubMed ID: 14985855

Title: A spermatogenesis-related gene expression profile in human spermatozoa and its potential clinical applications.

PubMed ID: 14985855

DOI: 10.1007/s00109-004-0526-3

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

Sequence Information:

  • Length: 332
  • Mass: 36311
  • Checksum: DF7047FF5BCB101B
  • Sequence:
    • MSTVKEQLIE KLIEDDENSQ CKITIVGTGA VGMACAISIL LKDLADELAL VDVALDKLKG 
EMMDLQHGSL FFSTSKITSG KDYSVSANSR IVIVTAGARQ QEGETRLALV QRNVAIMKSI 
IPAIVHYSPD CKILVVSNPV DILTYIVWKI SGLPVTRVIG SGCNLDSARF RYLIGEKLGV 
HPTSCHGWII GEHGDSSVPL WSGVNVAGVA LKTLDPKLGT DSDKEHWKNI HKQVIQSAYE 
IIKLKGYTSW AIGLSVMDLV GSILKNLRRV HPVSTMVKGL YGIKEELFLS IPCVLGRNGV 
SDVVKINLNS EEEALFKKSA ETLWNIQKDL IF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.