Details for: LGALS8

Gene ID: 3964

Symbol: LGALS8

Ensembl ID: ENSG00000116977

Description: galectin 8

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.78
    Marker Score: 1191
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.6
    Marker Score: 1682
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.59
    Marker Score: 11828
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.57
    Marker Score: 4283
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167344
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.38
    Marker Score: 84989
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.34
    Marker Score: 5554
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.33
    Marker Score: 2330.5
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.33
    Marker Score: 48883
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.31
    Marker Score: 5155
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 1.26
    Marker Score: 1247
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.25
    Marker Score: 1255
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.23
    Marker Score: 1280
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.21
    Marker Score: 349
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.21
    Marker Score: 387
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.19
    Marker Score: 1754
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.18
    Marker Score: 11089
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.16
    Marker Score: 1789
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.16
    Marker Score: 4714
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.15
    Marker Score: 426
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.15
    Marker Score: 22811
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.14
    Marker Score: 10872
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.13
    Marker Score: 621
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.13
    Marker Score: 2804
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.11
    Marker Score: 465
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.1
    Marker Score: 11402
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.1
    Marker Score: 624
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.1
    Marker Score: 41843
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.1
    Marker Score: 9419
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.07
    Marker Score: 8189
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.06
    Marker Score: 493
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.05
    Marker Score: 16491
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.05
    Marker Score: 15740
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.04
    Marker Score: 3560
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.01
    Marker Score: 1845
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.01
    Marker Score: 589
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71630
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47854
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.98
    Marker Score: 1270
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30378
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.98
    Marker Score: 3787
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.97
    Marker Score: 11317
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.97
    Marker Score: 6198
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.95
    Marker Score: 1681
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.94
    Marker Score: 5737
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2384
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.93
    Marker Score: 8113
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 474
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.92
    Marker Score: 453
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.91
    Marker Score: 1858
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 431
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.91
    Marker Score: 617
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.9
    Marker Score: 601
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.9
    Marker Score: 969
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.89
    Marker Score: 2680
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.89
    Marker Score: 442
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.88
    Marker Score: 1063
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.88
    Marker Score: 306
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.87
    Marker Score: 210
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.87
    Marker Score: 208
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.87
    Marker Score: 8742
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.87
    Marker Score: 1046
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.87
    Marker Score: 592
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.86
    Marker Score: 955
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.86
    Marker Score: 4501
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.86
    Marker Score: 196
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.85
    Marker Score: 185
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.85
    Marker Score: 7465
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.85
    Marker Score: 18940
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.84
    Marker Score: 746
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.83
    Marker Score: 748
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.83
    Marker Score: 903.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.82
    Marker Score: 329
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.82
    Marker Score: 727
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.82
    Marker Score: 960
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.82
    Marker Score: 956
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.82
    Marker Score: 389
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 0.82
    Marker Score: 209
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.82
    Marker Score: 208
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.82
    Marker Score: 45633
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.82
    Marker Score: 4656
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.81
    Marker Score: 329
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.81
    Marker Score: 1837
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.8
    Marker Score: 1699
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.8
    Marker Score: 918
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.8
    Marker Score: 723
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.8
    Marker Score: 835
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.8
    Marker Score: 752
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.8
    Marker Score: 203
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 607
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.79
    Marker Score: 297
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.79
    Marker Score: 1582
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.79
    Marker Score: 792
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.79
    Marker Score: 176
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.78
    Marker Score: 843
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.78
    Marker Score: 315
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.78
    Marker Score: 187
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259

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Other Information

**Key characteristics:** - LGALS8 is a type I transmembrane protein with a molecular weight of approximately 120 kDa. - It is highly expressed in epithelial cells, particularly in tissues such as the nasal mucosa, conjunctiva, trachea, and placenta. - It is also expressed in immune cells, including macrophages, dendritic cells, and lymphocytes. **Pathways and functions:** - LGALS8 is involved in a variety of cellular processes, including cell adhesion, migration, and signaling. - It is a key regulator of epithelial cell migration and invasion. - It also plays a role in the regulation of immune cell function. - LGALS8 is a potential therapeutic target for a variety of diseases, including cancer and inflammatory diseases. **Clinical significance:** - Mutations in the LGALS8 gene have been linked to several human diseases, including cancer, asthma, and inflammatory bowel disease. - LGALS8 is a promising target for cancer immunotherapy. - Agents that block LGALS8 have been shown to be effective in inhibiting cancer growth and metastasis. **Additional information:** - LGALS8 is a highly conserved protein, with a similar gene found in mammals, birds, and reptiles. - It is a member of the galectin family of cell adhesion molecules, which are involved in cell-cell and cell-extracellular matrix interactions. - LGALS8 is a multi-functional protein that has a variety of cellular functions.

Genular Protein ID: 4209093841

Symbol: LEG8_HUMAN

Name: Po66 carbohydrate-binding protein

UniProtKB Accession Codes:

O00214 O15215 Q5T3P5 Q5T3Q4 Q8TEV1 Q96B92 Q9BXC8 Q9H584 Q9H585 Q9UEZ6 Q9UP32 Q9UP33 Q9UP34

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 13 EPD 1 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 2 Genevisible 1 GenomeRNAi 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 41 PDBsum 35 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 4 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8692978

Title: Surface-epitope masking and expression cloning identifies the human prostate carcinoma tumor antigen gene PCTA-1 a member of the galectin gene family.

PubMed ID: 8692978

DOI: 10.1073/pnas.93.14.7252

PubMed ID: 10980616

Title: Molecular characterization of prostate carcinoma tumor antigen-1, PCTA-1, a human galectin-8 related gene.

PubMed ID: 10980616

DOI: 10.1038/sj.onc.1203767

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19268462

Title: Galectin-8 interacts with podoplanin and modulates lymphatic endothelial cell functions.

PubMed ID: 19268462

DOI: 10.1016/j.yexcr.2009.02.021

PubMed ID: 22246324

Title: Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion.

PubMed ID: 22246324

DOI: 10.1038/nature10744

PubMed ID: 28077878

Title: PLA2G16 represents a switch between entry and clearance of Picornaviridae.

PubMed ID: 28077878

DOI: 10.1038/nature21032

PubMed ID: 21288902

Title: Galectin-8-N-domain recognition mechanism for sialylated and sulfated glycans.

PubMed ID: 21288902

DOI: 10.1074/jbc.m110.195925

Sequence Information:

  • Length: 317
  • Mass: 35808
  • Checksum: AA13116AC5C0D69A
  • Sequence:
    • MMLSLNNLQN IIYNPVIPFV GTIPDQLDPG TLIVIRGHVP SDADRFQVDL QNGSSMKPRA 
DVAFHFNPRF KRAGCIVCNT LINEKWGREE ITYDTPFKRE KSFEIVIMVL KDKFQVAVNG 
KHTLLYGHRI GPEKIDTLGI YGKVNIHSIG FSFSSDLQST QASSLELTEI SRENVPKSGT 
PQLRLPFAAR LNTPMGPGRT VVVKGEVNAN AKSFNVDLLA GKSKDIALHL NPRLNIKAFV 
RNSFLQESWG EEERNITSFP FSPGMYFEMI IYCDVREFKV AVNGVHSLEY KHRFKELSSI 
DTLEINGDIH LLEVRSW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.