Details for: LGALS8

Gene ID: 3964

Symbol: LGALS8

Ensembl ID: ENSG00000116977

Description: galectin 8

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 189.5912
    Cell Significance Index: -29.4900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 111.8302
    Cell Significance Index: -28.3700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 82.2677
    Cell Significance Index: -33.8900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 71.8881
    Cell Significance Index: -33.9400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 69.3157
    Cell Significance Index: -28.1600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 62.7545
    Cell Significance Index: -32.2800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.7672
    Cell Significance Index: -28.4200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 26.2297
    Cell Significance Index: -32.3400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.7177
    Cell Significance Index: -31.3900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.1618
    Cell Significance Index: -28.1400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.3628
    Cell Significance Index: -33.0000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.7075
    Cell Significance Index: -14.6800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6466
    Cell Significance Index: 162.8900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.3823
    Cell Significance Index: 36.9100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.1369
    Cell Significance Index: 225.6200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0174
    Cell Significance Index: 204.0900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9339
    Cell Significance Index: 101.5800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8822
    Cell Significance Index: 796.5300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8410
    Cell Significance Index: 136.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6999
    Cell Significance Index: 49.5000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6775
    Cell Significance Index: 83.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6616
    Cell Significance Index: 18.4900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.6271
    Cell Significance Index: 277.2600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6193
    Cell Significance Index: 32.2600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5918
    Cell Significance Index: 30.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5581
    Cell Significance Index: 15.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5467
    Cell Significance Index: 98.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5044
    Cell Significance Index: 38.7100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4477
    Cell Significance Index: 160.5900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.4127
    Cell Significance Index: 12.1200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.3546
    Cell Significance Index: 9.3300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3264
    Cell Significance Index: 44.8200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3130
    Cell Significance Index: 6.7800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2885
    Cell Significance Index: 157.5600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.2880
    Cell Significance Index: 15.1200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2392
    Cell Significance Index: 15.4400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2113
    Cell Significance Index: 15.7500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1881
    Cell Significance Index: 8.7700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1654
    Cell Significance Index: 7.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1428
    Cell Significance Index: 9.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1313
    Cell Significance Index: 22.4200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1109
    Cell Significance Index: 76.7100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1054
    Cell Significance Index: 2.6400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0926
    Cell Significance Index: 4.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0700
    Cell Significance Index: 4.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0633
    Cell Significance Index: 2.8000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0475
    Cell Significance Index: 1.6700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0375
    Cell Significance Index: 7.1400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0303
    Cell Significance Index: 46.5900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0254
    Cell Significance Index: 0.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0219
    Cell Significance Index: 40.3200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0210
    Cell Significance Index: 0.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0205
    Cell Significance Index: 27.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0148
    Cell Significance Index: 1.7400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0082
    Cell Significance Index: 15.4900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0043
    Cell Significance Index: 0.4900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0006
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0072
    Cell Significance Index: -5.3100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0102
    Cell Significance Index: -6.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0116
    Cell Significance Index: -6.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0122
    Cell Significance Index: -1.5700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0181
    Cell Significance Index: -13.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0182
    Cell Significance Index: -11.5600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0227
    Cell Significance Index: -16.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0259
    Cell Significance Index: -11.7600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0277
    Cell Significance Index: -1.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0358
    Cell Significance Index: -2.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0407
    Cell Significance Index: -4.1500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0677
    Cell Significance Index: -8.7500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0693
    Cell Significance Index: -1.8600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0791
    Cell Significance Index: -16.6600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0800
    Cell Significance Index: -5.0400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0938
    Cell Significance Index: -1.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0954
    Cell Significance Index: -27.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1047
    Cell Significance Index: -12.2100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1118
    Cell Significance Index: -1.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1308
    Cell Significance Index: -19.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1417
    Cell Significance Index: -16.2300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2052
    Cell Significance Index: -4.3700
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2507
    Cell Significance Index: -3.1100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2521
    Cell Significance Index: -4.9200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2580
    Cell Significance Index: -5.6500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2976
    Cell Significance Index: -30.9900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3226
    Cell Significance Index: -9.2100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3557
    Cell Significance Index: -28.1700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3654
    Cell Significance Index: -6.1600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3902
    Cell Significance Index: -6.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3937
    Cell Significance Index: -24.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4033
    Cell Significance Index: -11.5600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4233
    Cell Significance Index: -7.4800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4440
    Cell Significance Index: -15.4300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.4463
    Cell Significance Index: -4.1100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4603
    Cell Significance Index: -11.7600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4714
    Cell Significance Index: -10.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4804
    Cell Significance Index: -15.3900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4974
    Cell Significance Index: -11.9300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4990
    Cell Significance Index: -25.2200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5065
    Cell Significance Index: -7.5900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5926
    Cell Significance Index: -7.3900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6484
    Cell Significance Index: -9.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Carbohydrate-binding protein:** Galectin 8 exhibits high affinity for beta-galactosides, a class of sugars found in cell surface glycoproteins and glycolipids. 2. **Cell surface expression:** Galectin 8 is primarily expressed on the cell surface, where it interacts with various ligands, including integrins, CD44, and hyaluronic acid. 3. **Multifunctional protein:** Galectin 8 has been implicated in numerous biological processes, including cell proliferation, differentiation, adhesion, migration, and apoptosis. 4. **Expression in various tissues:** Galectin 8 is expressed in epithelial cells, neurons, immune cells, and placental trophoblasts, indicating its involvement in tissue homeostasis and development. **Pathways and Functions:** 1. **Immune response:** Galectin 8 modulates immune responses by interacting with immune cells, such as macrophages and T cells, and regulating cytokine production and cell activation. 2. **Cell migration:** Galectin 8 plays a role in cell migration, particularly in the migration of lymphatic endothelial cells and neurons. 3. **Xenophagy:** Galectin 8 is involved in the recognition and degradation of extracellular pathogens and foreign substances through the xenophagy pathway. 4. **Cell adhesion and proliferation:** Galectin 8 interacts with integrins and other adhesion molecules, regulating cell adhesion, proliferation, and differentiation. **Clinical Significance:** Galectin 8 has been implicated in various diseases, including: 1. **Autoimmune disorders:** Galectin 8 has been linked to autoimmune diseases, such as multiple sclerosis and type 1 diabetes, where it regulates immune cell function and tissue homeostasis. 2. **Cancer:** Galectin 8 has been found to be overexpressed in various types of cancer, including breast, lung, and colon cancer, where it promotes tumor growth, invasion, and metastasis. 3. **Infectious diseases:** Galectin 8 has been implicated in the recognition and clearance of pathogens, such as viruses and bacteria, through the xenophagy pathway. 4. **Neurological disorders:** Galectin 8 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease, where it regulates neuronal function and survival. In conclusion, galectin 8 is a multifunctional protein involved in immune response, cell migration, and tissue homeostasis. Its dysregulation has been implicated in various diseases, highlighting the need for further research into the mechanisms of galectin 8 and its role in human health and disease.

Genular Protein ID: 4209093841

Symbol: LEG8_HUMAN

Name: Po66 carbohydrate-binding protein

UniProtKB Accession Codes:

O00214 O15215 Q5T3P5 Q5T3Q4 Q8TEV1 Q96B92 Q9BXC8 Q9H584 Q9H585 Q9UEZ6 Q9UP32 Q9UP33 Q9UP34

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugCentral 1 EMBL 13 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 2 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 36 PDBsum 36 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 4 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8692978

Title: Surface-epitope masking and expression cloning identifies the human prostate carcinoma tumor antigen gene PCTA-1 a member of the galectin gene family.

PubMed ID: 8692978

DOI: 10.1073/pnas.93.14.7252

PubMed ID: 10980616

Title: Molecular characterization of prostate carcinoma tumor antigen-1, PCTA-1, a human galectin-8 related gene.

PubMed ID: 10980616

DOI: 10.1038/sj.onc.1203767

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19268462

Title: Galectin-8 interacts with podoplanin and modulates lymphatic endothelial cell functions.

PubMed ID: 19268462

DOI: 10.1016/j.yexcr.2009.02.021

PubMed ID: 22246324

Title: Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion.

PubMed ID: 22246324

DOI: 10.1038/nature10744

PubMed ID: 28077878

Title: PLA2G16 represents a switch between entry and clearance of Picornaviridae.

PubMed ID: 28077878

DOI: 10.1038/nature21032

PubMed ID: 21288902

Title: Galectin-8-N-domain recognition mechanism for sialylated and sulfated glycans.

PubMed ID: 21288902

DOI: 10.1074/jbc.m110.195925

Sequence Information:

  • Length: 317
  • Mass: 35808
  • Checksum: AA13116AC5C0D69A
  • Sequence:
    • MMLSLNNLQN IIYNPVIPFV GTIPDQLDPG TLIVIRGHVP SDADRFQVDL QNGSSMKPRA 
DVAFHFNPRF KRAGCIVCNT LINEKWGREE ITYDTPFKRE KSFEIVIMVL KDKFQVAVNG 
KHTLLYGHRI GPEKIDTLGI YGKVNIHSIG FSFSSDLQST QASSLELTEI SRENVPKSGT 
PQLRLPFAAR LNTPMGPGRT VVVKGEVNAN AKSFNVDLLA GKSKDIALHL NPRLNIKAFV 
RNSFLQESWG EEERNITSFP FSPGMYFEMI IYCDVREFKV AVNGVHSLEY KHRFKELSSI 
DTLEINGDIH LLEVRSW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.