Gene LIMK2 - ENSG00000182541 | NCBI Gene ID: 3985

Details for: LIMK2

Gene ID: 3985

Symbol: LIMK2

Ensembl ID: ENSG00000182541

Description: LIM domain kinase 2

Associated with

Axon guidance
(R-HSA-422475)
Developmental biology
(R-HSA-1266738)
Eph-ephrin signaling
(R-HSA-2682334)
Ephb-mediated forward signaling
(R-HSA-3928662)
Nervous system development
(R-HSA-9675108)
Rho gtpase effectors
(R-HSA-195258)
Rho gtpases activate rocks
(R-HSA-5627117)
Sema4d induced cell migration and growth-cone collapse
(R-HSA-416572)
Sema4d in semaphorin signaling
(R-HSA-400685)
Semaphorin interactions
(R-HSA-373755)
Signaling by rho gtpases
(R-HSA-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-HSA-9716542)
Signal transduction
(R-HSA-162582)
Actin cytoskeleton organization
(GO:0030036)
Astral microtubule organization
(GO:0030953)
Atp binding
(GO:0005524)
Centrosome
(GO:0005813)
Cis-golgi network
(GO:0005801)
Cornea development in camera-type eye
(GO:0061303)
Cytoplasm
(GO:0005737)
Establishment of vesicle localization
(GO:0051650)
Head development
(GO:0060322)
Metal ion binding
(GO:0046872)
Mitotic spindle
(GO:0072686)
Negative regulation of cilium assembly
(GO:1902018)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Phosphorylation
(GO:0016310)
Positive regulation of protein localization to nucleus
(GO:1900182)
Positive regulation of protein phosphorylation
(GO:0001934)
Protein binding
(GO:0005515)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Spermatogenesis
(GO:0007283)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: lens epithelial cell (CL0002224)
Fold Change: 2.1
Marker Score: 2545
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 1.94
Marker Score: 1134
Cell Name: anterior lens cell (CL0002223)
Fold Change: 1.85
Marker Score: 2492
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 1.69
Marker Score: 1128
Cell Name: endothelial cell of vascular tree (CL0002139)
Fold Change: 1.68
Marker Score: 2434
Cell Name: germ cell (CL0000586)
Fold Change: 1.59
Marker Score: 2770
Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.53
Marker Score: 1064
Cell Name: lung goblet cell (CL1000143)
Fold Change: 1.5
Marker Score: 431.5
Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 1.49
Marker Score: 1321
Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167984
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.39
Marker Score: 5448
Cell Name: mature microglial cell (CL0002629)
Fold Change: 1.39
Marker Score: 501
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 1.38
Marker Score: 14278
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 1.37
Marker Score: 29277
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 1.33
Marker Score: 418
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.31
Marker Score: 2670
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 1.29
Marker Score: 773
Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 1.23
Marker Score: 355
Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: 1.22
Marker Score: 1001
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 1.16
Marker Score: 570
Cell Name: corneal epithelial cell (CL0000575)
Fold Change: 1.15
Marker Score: 1272
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.11
Marker Score: 1259
Cell Name: ciliated cell (CL0000064)
Fold Change: 1.1
Marker Score: 3792
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 1.1
Marker Score: 2588
Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
Fold Change: 1.07
Marker Score: 9315
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.06
Marker Score: 16615
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 1.06
Marker Score: 7898
Cell Name: basal cell (CL0000646)
Fold Change: 1.06
Marker Score: 1368
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.01
Marker Score: 9562
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71727
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 47951
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30396
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.95
Marker Score: 489
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2403
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.94
Marker Score: 3940
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.94
Marker Score: 443
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.93
Marker Score: 8019
Cell Name: secretory cell (CL0000151)
Fold Change: 0.93
Marker Score: 1696
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.92
Marker Score: 629
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.92
Marker Score: 5251
Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
Fold Change: 0.92
Marker Score: 991
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.92
Marker Score: 1492
Cell Name: myoepithelial cell of mammary gland (CL0002324)
Fold Change: 0.92
Marker Score: 4505
Cell Name: lung ciliated cell (CL1000271)
Fold Change: 0.92
Marker Score: 435
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 0.91
Marker Score: 8602
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2715
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.9
Marker Score: 326
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.9
Marker Score: 5727
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.89
Marker Score: 890.5
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.89
Marker Score: 939
Cell Name: podocyte (CL0000653)
Fold Change: 0.88
Marker Score: 327
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5295
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.87
Marker Score: 313
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.86
Marker Score: 276
Cell Name: lactocyte (CL0002325)
Fold Change: 0.86
Marker Score: 13756
Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.85
Marker Score: 560
Cell Name: neuron (CL0000540)
Fold Change: 0.85
Marker Score: 3459
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.85
Marker Score: 509
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 0.84
Marker Score: 2649
Cell Name: endothelial cell of lymphatic vessel (CL0002138)
Fold Change: 0.83
Marker Score: 520
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.83
Marker Score: 388
Cell Name: oogonial cell (CL0000024)
Fold Change: 0.83
Marker Score: 1194
Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.83
Marker Score: 885
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.82
Marker Score: 627
Cell Name: club cell (CL0000158)
Fold Change: 0.82
Marker Score: 958
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.81
Marker Score: 304
Cell Name: pulmonary artery endothelial cell (CL1001568)
Fold Change: 0.81
Marker Score: 695
Cell Name: multi-ciliated epithelial cell (CL0005012)
Fold Change: 0.81
Marker Score: 1532
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 0.8
Marker Score: 6151
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.79
Marker Score: 317
Cell Name: stem cell (CL0000034)
Fold Change: 0.78
Marker Score: 1860
Cell Name: type EC enteroendocrine cell (CL0000577)
Fold Change: 0.78
Marker Score: 734
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 0.78
Marker Score: 11623
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.77
Marker Score: 1762
Cell Name: OFF retinal ganglion cell (CL4023033)
Fold Change: 0.77
Marker Score: 321
Cell Name: corneal endothelial cell (CL0000132)
Fold Change: 0.76
Marker Score: 445
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.76
Marker Score: 1178
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 0.76
Marker Score: 2799
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.75
Marker Score: 2896
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 0.74
Marker Score: 1320
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.74
Marker Score: 6362
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.73
Marker Score: 3080
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.73
Marker Score: 380
Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
Fold Change: 0.73
Marker Score: 1865
Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.73
Marker Score: 148
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.73
Marker Score: 6426
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.72
Marker Score: 459
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.72
Marker Score: 5590
Cell Name: primordial germ cell (CL0000670)
Fold Change: 0.7
Marker Score: 883.5
Cell Name: choroid plexus epithelial cell (CL0000706)
Fold Change: 0.7
Marker Score: 643.5
Cell Name: ciliated epithelial cell (CL0000067)
Fold Change: 0.7
Marker Score: 320
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.7
Marker Score: 1530.5
Cell Name: astrocyte (CL0000127)
Fold Change: 0.69
Marker Score: 601
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.69
Marker Score: 42568
Cell Name: brush cell (CL0002204)
Fold Change: 0.69
Marker Score: 630
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.69
Marker Score: 4136
Cell Name: male germ cell (CL0000015)
Fold Change: 0.68
Marker Score: 197
Cell Name: mucous neck cell (CL0000651)
Fold Change: 0.68
Marker Score: 1542
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.68
Marker Score: 996
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.68
Marker Score: 173

Hover over a box to see details here...

**Key characteristics:** * LIMK2 is a transmembrane protein with a transmembrane domain and two intracellular LIM domains. * It is expressed in a wide variety of cell types, including epithelial cells, endothelial cells, and germ cells. * LIMK2 is a key regulator of epithelial cell migration and is also involved in the development of the nervous system. * It is a downstream target for various growth factors and cytokines. **Pathways and functions:** * LIMK2 is involved in a variety of cellular processes, including cell migration, growth, and signaling. * It is a key regulator of epithelial cell migration and is also involved in the development of the nervous system. * It is a downstream target for various growth factors and cytokines. * LIMK2 is also involved in the regulation of cell cycle progression and apoptosis. **Clinical significance:** * Mutations in the LIMK2 gene have been linked to a number of human diseases, including cataracts, glaucoma, and retinal vascular abnormalities. * LIMK2 inhibitors are being investigated as a treatment for these diseases. **Additional information:** * LIMK2 is a member of the LIMK family of kinase inhibitors. * It is a highly conserved protein that is found in organisms from yeast to humans. * LIMK2 is a promising target for cancer therapy.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

LIM domain kinase 2

Genular Protein ID: 2564083435

Symbol: LIMK2_HUMAN

Name: LIM domain kinase 2

UniProtKB Accession Codes:

P53671 A8K6H5 Q7KZ80 Q7L3H5 Q96E10 Q99464 Q9UFU0

Database IDs:

Citations:

PubMed ID: 8537403

Title: Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs.

PubMed ID: 8537403

DOI: 10.1074/jbc.270.52.31321

PubMed ID: 8954941

Title: Subcellular localization and protein interaction of the human LIMK2 gene expressing alternative transcripts with tissue-specific regulation.

PubMed ID: 8954941

DOI: 10.1006/bbrc.1996.1847

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10436159

Title: Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase.

PubMed ID: 10436159

DOI: 10.1126/science.285.5429.895

PubMed ID: 11018042

Title: Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase.

PubMed ID: 11018042

DOI: 10.1074/jbc.m007074200

PubMed ID: 11340065

Title: Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha.

PubMed ID: 11340065

DOI: 10.1074/jbc.c100196200

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 22328514

Title: TPPP acts downstream of RhoA-ROCK-LIMK2 to regulate astral microtubule organization and spindle orientation.

PubMed ID: 22328514

DOI: 10.1242/jcs.096818

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25849865

Title: Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking.

PubMed ID: 25849865

DOI: 10.1038/ncomms7781

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

Length: 638
Mass: 72232
Checksum: FB51813D99AFAC18
Sequence:

MSALAGEDVW RCPGCGDHIA PSQIWYRTVN ETWHGSCFRC SECQDSLTNW YYEKDGKLYC 
PKDYWGKFGE FCHGCSLLMT GPFMVAGEFK YHPECFACMS CKVIIEDGDA YALVQHATLY 
CGKCHNEVVL APMFERLSTE SVQEQLPYSV TLISMPATTE GRRGFSVSVE SACSNYATTV 
QVKEVNRMHI SPNNRNAIHP GDRILEINGT PVRTLRVEEV EDAISQTSQT LQLLIEHDPV 
SQRLDQLRLE ARLAPHMQNA GHPHALSTLD TKENLEGTLR RRSLRRSNSI SKSPGPSSPK 
EPLLFSRDIS RSESLRCSSS YSQQIFRPCD LIHGEVLGKG FFGQAIKVTH KATGKVMVMK 
ELIRCDEETQ KTFLTEVKVM RSLDHPNVLK FIGVLYKDKK LNLLTEYIEG GTLKDFLRSM 
DPFPWQQKVR FAKGIASGMA YLHSMCIIHR DLNSHNCLIK LDKTVVVADF GLSRLIVEER 
KRAPMEKATT KKRTLRKNDR KKRYTVVGNP YWMAPEMLNG KSYDETVDIF SFGIVLCEII 
GQVYADPDCL PRTLDFGLNV KLFWEKFVPT DCPPAFFPLA AICCRLEPES RPAFSKLEDS 
FEALSLYLGE LGIPLPAELE ELDHTVSMQY GLTRDSPP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: LIMK2

Associated with

Cells (max top 100)

Other Information

Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs. PubMed ID: 8537403

Subcellular localization and protein interaction of the human LIMK2 gene expressing alternative transcripts with tissue-specific regulation. PubMed ID: 8954941

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. PubMed ID: 11230166

A genome annotation-driven approach to cloning the human ORFeome. PubMed ID: 15461802

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence of human chromosome 22. PubMed ID: 10591208

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. PubMed ID: 10436159

Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase. PubMed ID: 11018042

Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha. PubMed ID: 11340065

Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. PubMed ID: 18691976

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Large-scale proteomics analysis of the human kinome. PubMed ID: 19369195

TPPP acts downstream of RhoA-ROCK-LIMK2 to regulate astral microtubule organization and spindle orientation. PubMed ID: 22328514

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking. PubMed ID: 25849865

Patterns of somatic mutation in human cancer genomes. PubMed ID: 17344846