Details for: LIMK2
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 150.4386
Cell Significance Index: -23.4000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 92.1372
Cell Significance Index: -23.3700 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 64.3286
Cell Significance Index: -26.5000 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 54.8586
Cell Significance Index: -25.9000 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 54.3744
Cell Significance Index: -22.0900 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 23.2157
Cell Significance Index: -22.1700 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 19.6357
Cell Significance Index: -24.2100 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 9.3697
Cell Significance Index: -25.1000 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 8.3341
Cell Significance Index: -18.2400 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 6.2163
Cell Significance Index: -24.5300 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.8238
Cell Significance Index: 75.4000 - Cell Name: basal epithelial cell of prostatic duct (CL0002236)
Fold Change: 1.9996
Cell Significance Index: 17.7500 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 1.8234
Cell Significance Index: 11.2500 - Cell Name: tuft cell of small intestine (CL0009080)
Fold Change: 1.5234
Cell Significance Index: 15.3700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 1.4754
Cell Significance Index: 171.9400 - Cell Name: decidual cell (CL2000002)
Fold Change: 1.4373
Cell Significance Index: 23.0600 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 1.1307
Cell Significance Index: 31.6000 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.1222
Cell Significance Index: 16.1400 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.1192
Cell Significance Index: 67.1900 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 1.0463
Cell Significance Index: 170.1700 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.9105
Cell Significance Index: 22.7600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.8313
Cell Significance Index: 164.9800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.7710
Cell Significance Index: 34.9500 - Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
Fold Change: 0.6575
Cell Significance Index: 6.5800 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.6078
Cell Significance Index: 31.6600 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.5860
Cell Significance Index: 15.9500 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.5816
Cell Significance Index: 12.6000 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.5272
Cell Significance Index: 15.1900 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.4964
Cell Significance Index: 61.0400 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4235
Cell Significance Index: 41.8900 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3898
Cell Significance Index: 172.3500 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.3623
Cell Significance Index: 16.8900 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.3523
Cell Significance Index: 67.0500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.3481
Cell Significance Index: 62.7600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.3441
Cell Significance Index: 69.0200 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3421
Cell Significance Index: 23.6600 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.3326
Cell Significance Index: 119.3200 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.3295
Cell Significance Index: 18.4900 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.3087
Cell Significance Index: 23.6900 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2478
Cell Significance Index: 12.8700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2437
Cell Significance Index: 133.1000 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.2327
Cell Significance Index: 160.9800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.2226
Cell Significance Index: 342.7300 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2165
Cell Significance Index: 195.5200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1637
Cell Significance Index: 301.9800 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.1589
Cell Significance Index: 11.2400 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.1515
Cell Significance Index: 1.4000 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1439
Cell Significance Index: 19.7700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.1369
Cell Significance Index: 186.1100 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.1322
Cell Significance Index: 8.8900 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.1126
Cell Significance Index: 5.2900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0942
Cell Significance Index: 16.0800 - Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.0927
Cell Significance Index: 0.5600 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0747
Cell Significance Index: 140.7100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0557
Cell Significance Index: 3.5100 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0485
Cell Significance Index: 5.7200 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0225
Cell Significance Index: 0.4800 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0198
Cell Significance Index: 12.5800 - Cell Name: peg cell (CL4033014)
Fold Change: 0.0151
Cell Significance Index: 0.3500 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0062
Cell Significance Index: 2.8100 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0105
Cell Significance Index: -6.5500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0138
Cell Significance Index: -10.2500 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0163
Cell Significance Index: -2.3700 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0171
Cell Significance Index: -2.2100 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0174
Cell Significance Index: -1.3000 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0188
Cell Significance Index: -14.2000 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0243
Cell Significance Index: -13.7300 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0268
Cell Significance Index: -19.6400 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0312
Cell Significance Index: -1.1000 - Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.0331
Cell Significance Index: -0.2700 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.0572
Cell Significance Index: -0.9800 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0652
Cell Significance Index: -6.6600 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0739
Cell Significance Index: -21.2700 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0761
Cell Significance Index: -16.0300 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.0814
Cell Significance Index: -10.4400 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0889
Cell Significance Index: -5.4700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0930
Cell Significance Index: -10.6600 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.1099
Cell Significance Index: -1.3100 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1259
Cell Significance Index: -5.5700 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1301
Cell Significance Index: -1.7800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1516
Cell Significance Index: -5.7400 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2067
Cell Significance Index: -23.6000 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.2093
Cell Significance Index: -21.8000 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.2249
Cell Significance Index: -5.7800 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.2292
Cell Significance Index: -6.5400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.2481
Cell Significance Index: -8.6200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2544
Cell Significance Index: -16.4100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.2912
Cell Significance Index: -23.0600 - Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.2959
Cell Significance Index: -6.4800 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.3043
Cell Significance Index: -4.5600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.3181
Cell Significance Index: -19.5000 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.3382
Cell Significance Index: -10.8300 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.3408
Cell Significance Index: -5.0300 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.3912
Cell Significance Index: -6.5900 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.3932
Cell Significance Index: -6.5800 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.4086
Cell Significance Index: -4.2300 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.4127
Cell Significance Index: -21.6700 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.4321
Cell Significance Index: -12.6900 - Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: -0.4397
Cell Significance Index: -7.7700 - Cell Name: syncytiotrophoblast cell (CL0000525)
Fold Change: -0.4475
Cell Significance Index: -4.2500
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2564083435
Symbol: LIMK2_HUMAN
Name: LIM domain kinase 2
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8537403
Title: Identification and characterization of a novel family of serine/threonine kinases containing two N-terminal LIM motifs.
PubMed ID: 8537403
PubMed ID: 8954941
Title: Subcellular localization and protein interaction of the human LIMK2 gene expressing alternative transcripts with tissue-specific regulation.
PubMed ID: 8954941
PubMed ID: 11230166
Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
PubMed ID: 11230166
DOI: 10.1101/gr.gr1547r
PubMed ID: 15461802
Title: A genome annotation-driven approach to cloning the human ORFeome.
PubMed ID: 15461802
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 10591208
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10436159
Title: Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase.
PubMed ID: 10436159
PubMed ID: 11018042
Title: Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinase.
PubMed ID: 11018042
PubMed ID: 11340065
Title: Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha.
PubMed ID: 11340065
PubMed ID: 18691976
Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
PubMed ID: 18691976
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 22328514
Title: TPPP acts downstream of RhoA-ROCK-LIMK2 to regulate astral microtubule organization and spindle orientation.
PubMed ID: 22328514
DOI: 10.1242/jcs.096818
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25849865
Title: Actin remodelling factors control ciliogenesis by regulating YAP/TAZ activity and vesicle trafficking.
PubMed ID: 25849865
DOI: 10.1038/ncomms7781
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 638
- Mass: 72232
- Checksum: FB51813D99AFAC18
- Sequence:
MSALAGEDVW RCPGCGDHIA PSQIWYRTVN ETWHGSCFRC SECQDSLTNW YYEKDGKLYC PKDYWGKFGE FCHGCSLLMT GPFMVAGEFK YHPECFACMS CKVIIEDGDA YALVQHATLY CGKCHNEVVL APMFERLSTE SVQEQLPYSV TLISMPATTE GRRGFSVSVE SACSNYATTV QVKEVNRMHI SPNNRNAIHP GDRILEINGT PVRTLRVEEV EDAISQTSQT LQLLIEHDPV SQRLDQLRLE ARLAPHMQNA GHPHALSTLD TKENLEGTLR RRSLRRSNSI SKSPGPSSPK EPLLFSRDIS RSESLRCSSS YSQQIFRPCD LIHGEVLGKG FFGQAIKVTH KATGKVMVMK ELIRCDEETQ KTFLTEVKVM RSLDHPNVLK FIGVLYKDKK LNLLTEYIEG GTLKDFLRSM DPFPWQQKVR FAKGIASGMA YLHSMCIIHR DLNSHNCLIK LDKTVVVADF GLSRLIVEER KRAPMEKATT KKRTLRKNDR KKRYTVVGNP YWMAPEMLNG KSYDETVDIF SFGIVLCEII GQVYADPDCL PRTLDFGLNV KLFWEKFVPT DCPPAFFPLA AICCRLEPES RPAFSKLEDS FEALSLYLGE LGIPLPAELE ELDHTVSMQY GLTRDSPP
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.