Details for: LRP3

Gene ID: 4037

Symbol: LRP3

Ensembl ID: ENSG00000130881

Description: LDL receptor related protein 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 108.5215
    Cell Significance Index: -16.8800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 66.6290
    Cell Significance Index: -16.9000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 35.2978
    Cell Significance Index: -14.3400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 15.0616
    Cell Significance Index: -14.3800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 13.7150
    Cell Significance Index: -16.9100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.2701
    Cell Significance Index: -16.8500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 2.1797
    Cell Significance Index: 414.8200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.3976
    Cell Significance Index: 138.2500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9909
    Cell Significance Index: 894.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8159
    Cell Significance Index: 132.7100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7844
    Cell Significance Index: 85.3200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5618
    Cell Significance Index: 33.7300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5560
    Cell Significance Index: 111.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4620
    Cell Significance Index: 91.6800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.3546
    Cell Significance Index: 10.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3501
    Cell Significance Index: 24.2100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2675
    Cell Significance Index: 36.7300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2363
    Cell Significance Index: 84.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2255
    Cell Significance Index: 13.8600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2170
    Cell Significance Index: 150.1000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1703
    Cell Significance Index: 75.3100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1656
    Cell Significance Index: 7.7200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1174
    Cell Significance Index: 8.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1041
    Cell Significance Index: 3.0000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0879
    Cell Significance Index: 5.9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0865
    Cell Significance Index: 3.9200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0529
    Cell Significance Index: 1.8600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0503
    Cell Significance Index: 27.4900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0385
    Cell Significance Index: 0.8200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0374
    Cell Significance Index: 1.9500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0288
    Cell Significance Index: 0.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0194
    Cell Significance Index: 2.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0084
    Cell Significance Index: 0.3700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0040
    Cell Significance Index: 0.6900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0007
    Cell Significance Index: 1.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0067
    Cell Significance Index: -4.9100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0090
    Cell Significance Index: -16.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0109
    Cell Significance Index: -16.7500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0130
    Cell Significance Index: -1.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0134
    Cell Significance Index: -8.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0140
    Cell Significance Index: -19.0500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0145
    Cell Significance Index: -10.9800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0194
    Cell Significance Index: -0.5100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0199
    Cell Significance Index: -14.7400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0205
    Cell Significance Index: -9.3000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0267
    Cell Significance Index: -15.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0307
    Cell Significance Index: -19.1500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0365
    Cell Significance Index: -0.7900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0457
    Cell Significance Index: -1.7300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0478
    Cell Significance Index: -13.7500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0586
    Cell Significance Index: -1.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0587
    Cell Significance Index: -8.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0675
    Cell Significance Index: -12.1600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0683
    Cell Significance Index: -8.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0754
    Cell Significance Index: -3.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0856
    Cell Significance Index: -6.3800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0859
    Cell Significance Index: -1.2300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0895
    Cell Significance Index: -18.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0932
    Cell Significance Index: -7.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0951
    Cell Significance Index: -9.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0966
    Cell Significance Index: -2.7000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1003
    Cell Significance Index: -6.1500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1023
    Cell Significance Index: -11.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1089
    Cell Significance Index: -13.3900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1144
    Cell Significance Index: -6.4200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1548
    Cell Significance Index: -2.5900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1577
    Cell Significance Index: -16.4200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1679
    Cell Significance Index: -7.8900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1717
    Cell Significance Index: -3.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1795
    Cell Significance Index: -5.7500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1806
    Cell Significance Index: -4.8300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1844
    Cell Significance Index: -21.7500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1854
    Cell Significance Index: -14.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1858
    Cell Significance Index: -11.9900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2021
    Cell Significance Index: -4.2900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2022
    Cell Significance Index: -2.5900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2149
    Cell Significance Index: -2.2300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2331
    Cell Significance Index: -14.6900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2405
    Cell Significance Index: -2.0200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2419
    Cell Significance Index: -3.0000
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.2435
    Cell Significance Index: -2.0700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.2508
    Cell Significance Index: -5.2500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2560
    Cell Significance Index: -13.3000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2746
    Cell Significance Index: -5.3600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2754
    Cell Significance Index: -8.7700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2824
    Cell Significance Index: -5.6700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2960
    Cell Significance Index: -9.6900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3060
    Cell Significance Index: -6.0500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3177
    Cell Significance Index: -11.1300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3237
    Cell Significance Index: -8.3200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3305
    Cell Significance Index: -4.9800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3316
    Cell Significance Index: -9.5100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3571
    Cell Significance Index: -3.8900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3577
    Cell Significance Index: -12.4300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3648
    Cell Significance Index: -9.1000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.3668
    Cell Significance Index: -7.9300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.3801
    Cell Significance Index: -6.0300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4044
    Cell Significance Index: -11.9100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4113
    Cell Significance Index: -8.5900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4148
    Cell Significance Index: -11.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** LRP3 is a transmembrane receptor composed of 12 immunoglobulin-like domains, which enable it to interact with various ligands and modulate signaling pathways. 2. **Expression:** LRP3 is highly expressed in cells involved in immune regulation, such as innate lymphoid cells, GABAergic interneurons, and osteoblasts. 3. **Function:** LRP3 regulates gene expression, differentiation, and immune responses through its interactions with various ligands and signaling pathways. 4. **Cellular localization:** LRP3 is primarily located on the plasma membrane, but it can also be found in the endoplasmic reticulum and Golgi apparatus. **Pathways and Functions:** 1. **Receptor-mediated endocytosis:** LRP3 participates in the internalization of various ligands, including lipids, proteins, and RNA, which can modulate signaling pathways and gene expression. 2. **Transport across the blood-brain barrier:** LRP3 facilitates the transport of lipids and proteins across the blood-brain barrier, which is essential for brain development and function. 3. **Negative regulation of gene expression:** LRP3 can repress the expression of certain genes involved in immune responses, such as the production of pro-inflammatory cytokines. 4. **Positive regulation of gene expression:** LRP3 can also activate the expression of genes involved in immune responses, such as the production of anti-inflammatory cytokines. 5. **Regulation of osteoblast differentiation:** LRP3 plays a crucial role in the regulation of osteoblast differentiation, which is essential for bone development and remodeling. **Clinical Significance:** 1. **Immune-related disorders:** Alterations in LRP3 expression and function have been implicated in various immune-related disorders, including autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer:** LRP3 has been shown to play a role in cancer progression, particularly in the context of immune evasion and tumor metastasis. 3. **Neurological disorders:** LRP3 has been implicated in the pathogenesis of neurological disorders, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). 4. **Metabolic disorders:** LRP3 has been shown to play a role in metabolic disorders, including obesity and insulin resistance. In conclusion, LRP3 is a complex receptor that plays a critical role in various cellular processes, including gene expression, differentiation, and immune regulation. Its dysregulation has been implicated in various immune-related disorders, including autoimmune diseases, cancer, and neurological disorders. Further research is necessary to fully understand the mechanisms by which LRP3 regulates immune responses and to identify potential therapeutic targets for the treatment of these disorders.

Genular Protein ID: 892758541

Symbol: LRP3_HUMAN

Name: Low-density lipoprotein receptor-related protein 3

UniProtKB Accession Codes:

O75074 B3KQD6 B4DKF2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 ELM 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9693042

Title: cDNA cloning of a new low-density lipoprotein receptor-related protein and mapping of its gene (LRP3) to chromosome bands 19q12-q13. 2.

PubMed ID: 9693042

DOI: 10.1006/geno.1998.5339

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

Sequence Information:

  • Length: 770
  • Mass: 82884
  • Checksum: 5175EDCB7A7D22EE
  • Sequence:
    • MEKRAAAGLE GAPGARAQLA VVCLVNIFLT GRLSSAVPAL AACSGKLEQH TERRGVIYSP 
AWPLNYPPGT NCSWYIQGDR GDMITISFRN FDVEESHQCS LDWLLLGPAA PPRQEAFRLC 
GSAIPPAFIS ARDHVWIFFH SDASSSGQAQ GFRLSYIRGK LGQASCQADE FRCDNGKCLP 
GPWQCNTVDE CGDGSDEGNC SAPASEPPGS LCPGGTFPCS GARSTRCLPV ERRCDGLQDC 
GDGSDEAGCP DLACGRRLGS FYGSFASPDL FGAARGPSDL HCTWLVDTQD SRRVLLQLEL 
RLGYDDYVQV YEGLGERGDR LLQTLSYRSN HRPVSLEAAQ GRLTVAYHAR ARSAGHGFNA 
TYQVKGYCLP WEQPCGSSSD SDGGSLGDQG CFSEPQRCDG WWHCASGRDE QGCPACPPDQ 
YPCEGGSGLC YTPADRCNNQ KSCPDGADEK NCFSCQPGTF HCGTNLCIFE TWRCDGQEDC 
QDGSDEHGCL AAVPRKVITA ALIGSLVCGL LLVIALGCAF KLYSLRTQEY RAFETQMTRL 
EAEFVRREAP PSYGQLIAQG LIPPVEDFPV YSASQASVLQ NLRTAMRRQM RRHASRRGPS 
RRRLGRLWNR LFHRPRAPRG QIPLLTAARP SQTVLGDGFL QPAPGAAPDP PAPLMDTGST 
RAAGDRPPSA PGRAPEVGPS GPPLPSGLRD PECRPVDKDR KVCREPLVDG PAPADAPREP 
CSAQDPHPQV STASSTLGPH SPEPLGVCRN PPPPCSPMLE ASDDEALLVC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.