Details for: LRP3

Gene ID: 4037

Symbol: LRP3

Ensembl ID: ENSG00000130881

Description: LDL receptor related protein 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 2.97
    Marker Score: 6145
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.5
    Marker Score: 1468
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.02
    Marker Score: 1933.5
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.01
    Marker Score: 2129
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71798
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48022
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30406
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.97
    Marker Score: 15185
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 498
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.97
    Marker Score: 1964
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 452
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2732
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.9
    Marker Score: 5116
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.85
    Marker Score: 1992
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.82
    Marker Score: 265
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.81
    Marker Score: 253
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 601
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1271
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.78
    Marker Score: 47838
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.77
    Marker Score: 7261
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 389
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 299
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.74
    Marker Score: 1147
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 672
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.73
    Marker Score: 463.5
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.73
    Marker Score: 6972
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.72
    Marker Score: 26460
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.71
    Marker Score: 6103
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.69
    Marker Score: 4174
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.67
    Marker Score: 1173
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.66
    Marker Score: 13189
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.66
    Marker Score: 25118
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2761
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.66
    Marker Score: 2726
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.64
    Marker Score: 2613
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.63
    Marker Score: 7110
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.62
    Marker Score: 6424.5
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.61
    Marker Score: 390
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.6
    Marker Score: 590
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.59
    Marker Score: 2295
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.59
    Marker Score: 133
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.59
    Marker Score: 354
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.56
    Marker Score: 4323
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.55
    Marker Score: 229
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.52
    Marker Score: 3391
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.52
    Marker Score: 248
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.51
    Marker Score: 5083
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.5
    Marker Score: 2070
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.5
    Marker Score: 239
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.49
    Marker Score: 205
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.47
    Marker Score: 206
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.46
    Marker Score: 6898
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.46
    Marker Score: 300
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.45
    Marker Score: 435
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.44
    Marker Score: 1205
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.43
    Marker Score: 532
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.43
    Marker Score: 272
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.41
    Marker Score: 465
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.41
    Marker Score: 582
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.41
    Marker Score: 103.5
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.41
    Marker Score: 115
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.4
    Marker Score: 215
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.4
    Marker Score: 104
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.4
    Marker Score: 254
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.4
    Marker Score: 423.5
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.4
    Marker Score: 365
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.39
    Marker Score: 342
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.39
    Marker Score: 661
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.39
    Marker Score: 164
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.39
    Marker Score: 147
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.39
    Marker Score: 415
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.38
    Marker Score: 207
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.37
    Marker Score: 1426
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.36
    Marker Score: 918
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.36
    Marker Score: 351
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.36
    Marker Score: 99
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.35
    Marker Score: 157
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.35
    Marker Score: 119
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.35
    Marker Score: 186
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.34
    Marker Score: 139
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.34
    Marker Score: 525
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.34
    Marker Score: 574.5
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.33
    Marker Score: 350
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.33
    Marker Score: 1413
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.32
    Marker Score: 113
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.32
    Marker Score: 184
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.32
    Marker Score: 803
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.32
    Marker Score: 394
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.32
    Marker Score: 321.5
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.31
    Marker Score: 183
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.31
    Marker Score: 293
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.31
    Marker Score: 82
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.3
    Marker Score: 782
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.3
    Marker Score: 426
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.3
    Marker Score: 147

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Other Information

**Key characteristics:** * The LRP3 gene is a large protein (370 amino acids) that is expressed in a variety of cell types. * It is a member of the LDL receptor family of proteins, which are involved in the uptake and processing of cholesterol. * LRP3 is a negative regulator of fat cell differentiation, and its overexpression leads to the development of obesity and insulin resistance. * It is also a positive regulator of osteoblast differentiation, and its overexpression leads to the development of osteoporosis. * LRP3 is a negative regulator of gene expression, and its overexpression leads to the upregulation of genes involved in cell proliferation, survival, and differentiation. * It is a positive regulator of osteoblast differentiation, and its overexpression leads to the development of osteoporosis. **Pathways and functions:** * LRP3 is involved in the regulation of lipid metabolism through its interaction with other proteins in the LDL receptor complex. * It also plays a role in the regulation of cell growth, differentiation, and migration. * It is involved in the regulation of inflammation, and its overexpression has been linked to the development of atherosclerosis and other inflammatory diseases. * LRP3 is also involved in the regulation of blood-brain barrier function, and its overexpression has been linked to the development of brain tumors. **Clinical significance:** * Mutations in the LRP3 gene have been linked to the development of a variety of diseases, including obesity, diabetes, cancer, and cardiovascular disease. * LRP3 is a potential target for the treatment of these diseases, as its inhibition has been shown to be effective in reducing inflammation and cell growth.

Genular Protein ID: 892758541

Symbol: LRP3_HUMAN

Name: Low-density lipoprotein receptor-related protein 3

UniProtKB Accession Codes:

O75074 B3KQD6 B4DKF2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9693042

Title: cDNA cloning of a new low-density lipoprotein receptor-related protein and mapping of its gene (LRP3) to chromosome bands 19q12-q13. 2.

PubMed ID: 9693042

DOI: 10.1006/geno.1998.5339

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

Sequence Information:

  • Length: 770
  • Mass: 82884
  • Checksum: 5175EDCB7A7D22EE
  • Sequence:
    • MEKRAAAGLE GAPGARAQLA VVCLVNIFLT GRLSSAVPAL AACSGKLEQH TERRGVIYSP 
AWPLNYPPGT NCSWYIQGDR GDMITISFRN FDVEESHQCS LDWLLLGPAA PPRQEAFRLC 
GSAIPPAFIS ARDHVWIFFH SDASSSGQAQ GFRLSYIRGK LGQASCQADE FRCDNGKCLP 
GPWQCNTVDE CGDGSDEGNC SAPASEPPGS LCPGGTFPCS GARSTRCLPV ERRCDGLQDC 
GDGSDEAGCP DLACGRRLGS FYGSFASPDL FGAARGPSDL HCTWLVDTQD SRRVLLQLEL 
RLGYDDYVQV YEGLGERGDR LLQTLSYRSN HRPVSLEAAQ GRLTVAYHAR ARSAGHGFNA 
TYQVKGYCLP WEQPCGSSSD SDGGSLGDQG CFSEPQRCDG WWHCASGRDE QGCPACPPDQ 
YPCEGGSGLC YTPADRCNNQ KSCPDGADEK NCFSCQPGTF HCGTNLCIFE TWRCDGQEDC 
QDGSDEHGCL AAVPRKVITA ALIGSLVCGL LLVIALGCAF KLYSLRTQEY RAFETQMTRL 
EAEFVRREAP PSYGQLIAQG LIPPVEDFPV YSASQASVLQ NLRTAMRRQM RRHASRRGPS 
RRRLGRLWNR LFHRPRAPRG QIPLLTAARP SQTVLGDGFL QPAPGAAPDP PAPLMDTGST 
RAAGDRPPSA PGRAPEVGPS GPPLPSGLRD PECRPVDKDR KVCREPLVDG PAPADAPREP 
CSAQDPHPQV STASSTLGPH SPEPLGVCRN PPPPCSPMLE ASDDEALLVC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.