Details for: CYP4F3
Associated with
Cells (max top 100)
(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hepatoblast (CL0005026)
Fold Change: 3.07
Marker Score: 10,059 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 2.31
Marker Score: 12,426 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 2
Marker Score: 12,842 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 1.89
Marker Score: 8,153 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 1.17
Marker Score: 4,168 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.04
Marker Score: 798 - Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1
Marker Score: 636 - Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,828 - Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,053 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 510 - Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,408 - Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 463 - Cell Name: type G enteroendocrine cell (CL0000508)
Fold Change: 0.97
Marker Score: 336 - Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
Fold Change: 0.96
Marker Score: 1,031 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,412 - Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5,338 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.93
Marker Score: 1,375 - Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.92
Marker Score: 2,160 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.91
Marker Score: 2,739 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 326 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,296 - Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.87
Marker Score: 339 - Cell Name: hepatocyte (CL0000182)
Fold Change: 0.86
Marker Score: 589 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,262 - Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 397 - Cell Name: brush cell (CL0002204)
Fold Change: 0.76
Marker Score: 694 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.73
Marker Score: 294 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 179 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 0.7
Marker Score: 6,008 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.68
Marker Score: 2,855 - Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.65
Marker Score: 435 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.62
Marker Score: 153 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.6
Marker Score: 680 - Cell Name: precursor B cell (CL0000817)
Fold Change: 0.6
Marker Score: 395 - Cell Name: enterocyte of colon (CL1000347)
Fold Change: 0.59
Marker Score: 906 - Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.56
Marker Score: 149 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.56
Marker Score: 358 - Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.55
Marker Score: 441 - Cell Name: inflammatory macrophage (CL0000863)
Fold Change: 0.53
Marker Score: 165 - Cell Name: hepatic stellate cell (CL0000632)
Fold Change: 0.51
Marker Score: 194 - Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 0.51
Marker Score: 1,028 - Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 0.5
Marker Score: 950 - Cell Name: keratinocyte (CL0000312)
Fold Change: 0.49
Marker Score: 413 - Cell Name: malignant cell (CL0001064)
Fold Change: 0.49
Marker Score: 6,588 - Cell Name: enterocyte (CL0000584)
Fold Change: 0.48
Marker Score: 2,287 - Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.48
Marker Score: 199 - Cell Name: neutrophil (CL0000775)
Fold Change: 0.46
Marker Score: 281 - Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 0.43
Marker Score: 3,202 - Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.42
Marker Score: 288 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.42
Marker Score: 410 - Cell Name: Kupffer cell (CL0000091)
Fold Change: 0.41
Marker Score: 414 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 0.41
Marker Score: 3,210 - Cell Name: type L enteroendocrine cell (CL0002279)
Fold Change: 0.4
Marker Score: 110 - Cell Name: pro-B cell (CL0000826)
Fold Change: 0.4
Marker Score: 384 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.39
Marker Score: 413 - Cell Name: enteroendocrine cell (CL0000164)
Fold Change: 0.37
Marker Score: 192 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.37
Marker Score: 2,346 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.35
Marker Score: 353 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.34
Marker Score: 126 - Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
Fold Change: 0.33
Marker Score: 91 - Cell Name: intestine goblet cell (CL0019031)
Fold Change: 0.31
Marker Score: 296 - Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.31
Marker Score: 310 - Cell Name: paneth cell (CL0000510)
Fold Change: 0.31
Marker Score: 213 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.3
Marker Score: 4,754 - Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 0.3
Marker Score: 114 - Cell Name: respiratory goblet cell (CL0002370)
Fold Change: 0.3
Marker Score: 87 - Cell Name: precursor cell (CL0011115)
Fold Change: 0.28
Marker Score: 69 - Cell Name: duct epithelial cell (CL0000068)
Fold Change: 0.28
Marker Score: 131 - Cell Name: large intestine goblet cell (CL1000320)
Fold Change: 0.27
Marker Score: 72 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.27
Marker Score: 188 - Cell Name: astrocyte (CL0000127)
Fold Change: 0.27
Marker Score: 231 - Cell Name: myelocyte (CL0002193)
Fold Change: 0.26
Marker Score: 114 - Cell Name: basal cell (CL0000646)
Fold Change: 0.25
Marker Score: 329 - Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.25
Marker Score: 153 - Cell Name: P/D1 enteroendocrine cell (CL0002268)
Fold Change: 0.25
Marker Score: 93 - Cell Name: secretory cell (CL0000151)
Fold Change: 0.25
Marker Score: 454 - Cell Name: podocyte (CL0000653)
Fold Change: 0.24
Marker Score: 90 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.24
Marker Score: 160 - Cell Name: intermediate monocyte (CL0002393)
Fold Change: 0.23
Marker Score: 81 - Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.23
Marker Score: 74 - Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 0.22
Marker Score: 68 - Cell Name: blood vessel endothelial cell (CL0000071)
Fold Change: 0.22
Marker Score: 219 - Cell Name: lung goblet cell (CL1000143)
Fold Change: 0.21
Marker Score: 61 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.21
Marker Score: 60 - Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 0.21
Marker Score: 163 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.21
Marker Score: 4,408 - Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.2
Marker Score: 64 - Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.2
Marker Score: 52 - Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.2
Marker Score: 118 - Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 0.19
Marker Score: 205 - Cell Name: papillary tips cell (CL1000597)
Fold Change: 0.19
Marker Score: 39 - Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.19
Marker Score: 68 - Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 0.17
Marker Score: 86 - Cell Name: immature neutrophil (CL0000776)
Fold Change: 0.17
Marker Score: 58 - Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
Fold Change: 0.17
Marker Score: 49 - Cell Name: M cell of gut (CL0000682)
Fold Change: 0.17
Marker Score: 43 - Cell Name: myeloid cell (CL0000763)
Fold Change: 0.17
Marker Score: 265 - Cell Name: kidney interstitial fibroblast (CL1000692)
Fold Change: 0.16
Marker Score: 309 - Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.16
Marker Score: 72 - Cell Name: granulocyte (CL0000094)
Fold Change: 0.16
Marker Score: 71
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3743542694
Symbol: CP4F3_HUMAN
Name: Cytochrome P450 4F3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8486631
Title: A novel form of cytochrome P-450 family 4 in human polymorphonuclear leukocytes. cDNA cloning and expression of leukotriene B4 omega-hydroxylase.
PubMed ID: 8486631
PubMed ID: 9539102
Title: Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular cloning and chromosomal localization.
PubMed ID: 9539102
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9675028
Title: Purification and characterization of recombinant human neutrophil leukotriene B4 omega-hydroxylase (cytochrome P450 4F3).
PubMed ID: 9675028
PubMed ID: 10409674
Title: Expression of the CYP4F3 gene. tissue-specific splicing and alternative promoters generate high and low K(m) forms of leukotriene B(4) omega-hydroxylase.
PubMed ID: 10409674
PubMed ID: 11461919
Title: Alternative splicing determines the function of CYP4F3 by switching substrate specificity.
PubMed ID: 11461919
PubMed ID: 15145985
Title: Human CYP4F3s are the main catalysts in the oxidation of fatty acid epoxides.
PubMed ID: 15145985
PubMed ID: 15364545
Title: Expression and characterization of human cytochrome P450 4F11: Putative role in the metabolism of therapeutic drugs and eicosanoids.
PubMed ID: 15364545
PubMed ID: 16547005
Title: Omega-oxidation of very long-chain fatty acids in human liver microsomes. Implications for X-linked adrenoleukodystrophy.
PubMed ID: 16547005
PubMed ID: 16820285
Title: Oxygenation of omega-3 fatty acids by human cytochrome P450 4F3B: effect on 20-hydroxyeicosatetraenoic acid production.
PubMed ID: 16820285
PubMed ID: 18182499
Title: Characterization of the human omega-oxidation pathway for omega-hydroxy-very-long-chain fatty acids.
PubMed ID: 18182499
DOI: 10.1096/fj.07-099150
PubMed ID: 18065749
Title: Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11.
PubMed ID: 18065749
PubMed ID: 18577768
Title: Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism.
PubMed ID: 18577768
Sequence Information:
- Length: 520
- Mass: 59847
- Checksum: 2519D875280CF9DC
- Sequence:
MPQLSLSSLG LWPMAASPWL LLLLVGASWL LARILAWTYT FYDNCCRLRC FPQPPKRNWF LGHLGLIHSS EEGLLYTQSL ACTFGDMCCW WVGPWHAIVR IFHPTYIKPV LFAPAAIVPK DKVFYSFLKP WLGDGLLLSA GEKWSRHRRM LTPAFHFNIL KPYMKIFNES VNIMHAKWQL LASEGSARLD MFEHISLMTL DSLQKCVFSF DSHCQEKPSE YIAAILELSA LVTKRHQQIL LYIDFLYYLT PDGQRFRRAC RLVHDFTDAV IQERRRTLPS QGVDDFLQAK AKSKTLDFID VLLLSKDEDG KKLSDEDIRA EADTFMFEGH DTTASGLSWV LYHLAKHPEY QERCRQEVQE LLKDREPKEI EWDDLAQLPF LTMCIKESLR LHPPVPAVSR CCTQDIVLPD GRVIPKGIIC LISVFGTHHN PAVWPDPEVY DPFRFDPKNI KERSPLAFIP FSAGPRNCIG QAFAMAEMKV VLGLTLLRFR VLPDHTEPRR KPELVLRAEG GLWLRVEPLS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.