Details for: CYP4F3

Gene ID: 4051

Symbol: CYP4F3

Ensembl ID: ENSG00000186529

Description: cytochrome P450 family 4 subfamily F member 3

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 3.07
    Marker Score: 10,059
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.31
    Marker Score: 12,426
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2
    Marker Score: 12,842
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.89
    Marker Score: 8,153
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.17
    Marker Score: 4,168
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 798
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1
    Marker Score: 636
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,828
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,053
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.97
    Marker Score: 336
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.96
    Marker Score: 1,031
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,338
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.93
    Marker Score: 1,375
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.92
    Marker Score: 2,160
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,296
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.87
    Marker Score: 339
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.86
    Marker Score: 589
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,262
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 694
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 294
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.7
    Marker Score: 6,008
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2,855
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.65
    Marker Score: 435
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.62
    Marker Score: 153
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.6
    Marker Score: 680
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.6
    Marker Score: 395
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.59
    Marker Score: 906
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.56
    Marker Score: 358
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.53
    Marker Score: 165
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.51
    Marker Score: 194
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.51
    Marker Score: 1,028
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.5
    Marker Score: 950
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.49
    Marker Score: 413
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.49
    Marker Score: 6,588
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.48
    Marker Score: 2,287
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.48
    Marker Score: 199
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.46
    Marker Score: 281
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.43
    Marker Score: 3,202
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.42
    Marker Score: 288
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.42
    Marker Score: 410
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.41
    Marker Score: 414
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.41
    Marker Score: 3,210
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.4
    Marker Score: 110
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.4
    Marker Score: 384
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.39
    Marker Score: 413
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.37
    Marker Score: 192
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.37
    Marker Score: 2,346
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.35
    Marker Score: 353
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.34
    Marker Score: 126
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.33
    Marker Score: 91
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.31
    Marker Score: 296
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.31
    Marker Score: 310
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.31
    Marker Score: 213
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.3
    Marker Score: 4,754
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.3
    Marker Score: 114
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.3
    Marker Score: 87
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.28
    Marker Score: 69
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.28
    Marker Score: 131
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.27
    Marker Score: 72
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.27
    Marker Score: 188
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.27
    Marker Score: 231
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.26
    Marker Score: 114
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.25
    Marker Score: 329
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.25
    Marker Score: 153
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.25
    Marker Score: 93
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.25
    Marker Score: 454
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.24
    Marker Score: 90
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.24
    Marker Score: 160
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.23
    Marker Score: 81
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.23
    Marker Score: 74
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.22
    Marker Score: 68
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.22
    Marker Score: 219
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.21
    Marker Score: 61
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.21
    Marker Score: 60
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.21
    Marker Score: 163
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.21
    Marker Score: 4,408
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.2
    Marker Score: 64
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.2
    Marker Score: 52
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.2
    Marker Score: 118
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.19
    Marker Score: 205
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.19
    Marker Score: 39
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.19
    Marker Score: 68
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.17
    Marker Score: 86
  • Cell Name: immature neutrophil (CL0000776)
    Fold Change: 0.17
    Marker Score: 58
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.17
    Marker Score: 49
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.17
    Marker Score: 265
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.16
    Marker Score: 309
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.16
    Marker Score: 72
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.16
    Marker Score: 71

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Substrate specificity:** CYP4F3 exhibits specificity for arachidonic acid, converting it into 20-hydroxy-leukotriene B4 (20-HETE), a potent leukotriene metabolite. 2. **Monooxygenase activity:** CYP4F3 catalyzes the monooxygenation of arachidonic acid, resulting in the production of 20-HETE. 3. **Oxidative activity:** The enzyme exhibits oxidative activity, utilizing oxygen to facilitate the conversion of arachidonic acid into 20-HETE. 4. **Expression in various tissues:** CYP4F3 is expressed in multiple tissues, including the liver, kidneys, immune cells, and the brain, highlighting its broad functional significance. **Pathways and Functions:** 1. **Arachidonic acid metabolism:** CYP4F3 plays a critical role in the metabolism of arachidonic acid, converting it into 20-HETE, which is involved in various physiological and pathological processes, including inflammation, immune regulation, and lipid metabolism. 2. **Leukotriene metabolism:** The enzyme is involved in the catabolism of leukotrienes, such as leukotriene B4 (LTB4), which is a potent pro-inflammatory mediator. 3. **Eicosanoid synthesis:** CYP4F3 contributes to the synthesis of eicosanoids, including leukotrienes and prostaglandins, which play essential roles in various physiological and pathological processes. 4. **Immune regulation:** The enzyme is expressed in immune cells, such as granulocytes and monocytes, and is involved in the regulation of immune responses, including the production of pro-inflammatory and anti-inflammatory cytokines. **Clinical Significance:** 1. **Inflammatory diseases:** Dysregulation of CYP4F3 has been implicated in various inflammatory diseases, including asthma, rheumatoid arthritis, and inflammatory bowel disease. 2. **Cancer:** The enzyme is involved in the metabolism of arachidonic acid, which is a key player in cancer progression and metastasis. 3. **Neurological disorders:** CYP4F3 is expressed in the brain and is involved in the regulation of neuroinflammation, highlighting its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Toxicity and pharmacogenomics:** The enzyme is involved in the metabolism of various toxins and drugs, and its expression and activity can influence an individual's susceptibility to toxicity and response to pharmacotherapy. In conclusion, CYP4F3 is a critical enzyme involved in various biological processes, including lipid metabolism, immune regulation, and eicosanoid synthesis. Its dysregulation has been implicated in various diseases, including inflammatory disorders and cancer. Further research into the role of CYP4F3 in human health and disease will provide valuable insights into the development of novel therapeutic strategies and the understanding of its clinical significance.

Genular Protein ID: 3743542694

Symbol: CP4F3_HUMAN

Name: Cytochrome P450 4F3

UniProtKB Accession Codes:

Q08477 B7Z8Z3 O60634 Q5U740

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 100 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 4 EMBL 11 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 4 Rhea 100 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 2 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 2 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8486631

Title: A novel form of cytochrome P-450 family 4 in human polymorphonuclear leukocytes. cDNA cloning and expression of leukotriene B4 omega-hydroxylase.

PubMed ID: 8486631

DOI: 10.1016/s0021-9258(18)98360-2

PubMed ID: 9539102

Title: Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular cloning and chromosomal localization.

PubMed ID: 9539102

DOI: 10.1089/dna.1998.17.221

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9675028

Title: Purification and characterization of recombinant human neutrophil leukotriene B4 omega-hydroxylase (cytochrome P450 4F3).

PubMed ID: 9675028

DOI: 10.1006/abbi.1998.0724

PubMed ID: 10409674

Title: Expression of the CYP4F3 gene. tissue-specific splicing and alternative promoters generate high and low K(m) forms of leukotriene B(4) omega-hydroxylase.

PubMed ID: 10409674

DOI: 10.1074/jbc.274.30.21191

PubMed ID: 11461919

Title: Alternative splicing determines the function of CYP4F3 by switching substrate specificity.

PubMed ID: 11461919

DOI: 10.1074/jbc.m104818200

PubMed ID: 15145985

Title: Human CYP4F3s are the main catalysts in the oxidation of fatty acid epoxides.

PubMed ID: 15145985

DOI: 10.1194/jlr.m300463-jlr200

PubMed ID: 15364545

Title: Expression and characterization of human cytochrome P450 4F11: Putative role in the metabolism of therapeutic drugs and eicosanoids.

PubMed ID: 15364545

DOI: 10.1016/j.taap.2003.12.033

PubMed ID: 16547005

Title: Omega-oxidation of very long-chain fatty acids in human liver microsomes. Implications for X-linked adrenoleukodystrophy.

PubMed ID: 16547005

DOI: 10.1074/jbc.m513481200

PubMed ID: 16820285

Title: Oxygenation of omega-3 fatty acids by human cytochrome P450 4F3B: effect on 20-hydroxyeicosatetraenoic acid production.

PubMed ID: 16820285

DOI: 10.1016/j.plefa.2006.05.005

PubMed ID: 18182499

Title: Characterization of the human omega-oxidation pathway for omega-hydroxy-very-long-chain fatty acids.

PubMed ID: 18182499

DOI: 10.1096/fj.07-099150

PubMed ID: 18065749

Title: Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11.

PubMed ID: 18065749

DOI: 10.1194/jlr.m700450-jlr200

PubMed ID: 18577768

Title: Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism.

PubMed ID: 18577768

DOI: 10.1194/jlr.m800199-jlr200

Sequence Information:

  • Length: 520
  • Mass: 59847
  • Checksum: 2519D875280CF9DC
  • Sequence:
    • MPQLSLSSLG LWPMAASPWL LLLLVGASWL LARILAWTYT FYDNCCRLRC FPQPPKRNWF 
LGHLGLIHSS EEGLLYTQSL ACTFGDMCCW WVGPWHAIVR IFHPTYIKPV LFAPAAIVPK 
DKVFYSFLKP WLGDGLLLSA GEKWSRHRRM LTPAFHFNIL KPYMKIFNES VNIMHAKWQL 
LASEGSARLD MFEHISLMTL DSLQKCVFSF DSHCQEKPSE YIAAILELSA LVTKRHQQIL 
LYIDFLYYLT PDGQRFRRAC RLVHDFTDAV IQERRRTLPS QGVDDFLQAK AKSKTLDFID 
VLLLSKDEDG KKLSDEDIRA EADTFMFEGH DTTASGLSWV LYHLAKHPEY QERCRQEVQE 
LLKDREPKEI EWDDLAQLPF LTMCIKESLR LHPPVPAVSR CCTQDIVLPD GRVIPKGIIC 
LISVFGTHHN PAVWPDPEVY DPFRFDPKNI KERSPLAFIP FSAGPRNCIG QAFAMAEMKV 
VLGLTLLRFR VLPDHTEPRR KPELVLRAEG GLWLRVEPLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.