Details for: CYP4F3
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 27.0018
Cell Significance Index: -4.2000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 16.3221
Cell Significance Index: -4.1400 - Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 15.1799
Cell Significance Index: 19.6400 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 9.5526
Cell Significance Index: -4.5100 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 6.6168
Cell Significance Index: -4.4400 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 5.3847
Cell Significance Index: 90.7100 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 3.3983
Cell Significance Index: -4.1900 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.4640
Cell Significance Index: 290.5400 - Cell Name: hepatoblast (CL0005026)
Fold Change: 1.4311
Cell Significance Index: 24.0700 - Cell Name: early T lineage precursor (CL0002425)
Fold Change: 1.3069
Cell Significance Index: 18.9800 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: 1.2568
Cell Significance Index: 18.5500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 1.1283
Cell Significance Index: 58.6100 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.0962
Cell Significance Index: 65.8100 - Cell Name: precursor cell (CL0011115)
Fold Change: 0.9970
Cell Significance Index: 7.5600 - Cell Name: intrahepatic cholangiocyte (CL0002538)
Fold Change: 0.9758
Cell Significance Index: 3.6800 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.9545
Cell Significance Index: 20.6800 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.8785
Cell Significance Index: 24.5500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7753
Cell Significance Index: 700.0700 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7329
Cell Significance Index: 79.7200 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.6934
Cell Significance Index: 9.4600 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.6249
Cell Significance Index: 118.9200 - Cell Name: midzonal region hepatocyte (CL0019028)
Fold Change: 0.5956
Cell Significance Index: 3.4300 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: 0.4904
Cell Significance Index: 7.3900 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4622
Cell Significance Index: 31.9600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4413
Cell Significance Index: 71.7700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.4332
Cell Significance Index: 12.4800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.2832
Cell Significance Index: 9.9500 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.2832
Cell Significance Index: 7.0800 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1758
Cell Significance Index: 17.3900 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 0.1194
Cell Significance Index: 13.9100 - Cell Name: epithelial cell of prostate (CL0002231)
Fold Change: 0.1167
Cell Significance Index: 0.7200 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1150
Cell Significance Index: 20.7300 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.1140
Cell Significance Index: 1.0500 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.1047
Cell Significance Index: 2.2300 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.0951
Cell Significance Index: 4.3100 - Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 0.0920
Cell Significance Index: 0.6000 - Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: 0.0844
Cell Significance Index: 1.1800 - Cell Name: epidermal cell (CL0000362)
Fold Change: 0.0776
Cell Significance Index: 0.1800 - Cell Name: cholangiocyte (CL1000488)
Fold Change: 0.0770
Cell Significance Index: 0.7600 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.0277
Cell Significance Index: 0.7400 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0146
Cell Significance Index: 1.8000 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0127
Cell Significance Index: 5.6200 - Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 0.0118
Cell Significance Index: 0.0900 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0116
Cell Significance Index: 6.3300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0018
Cell Significance Index: 0.6400 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.0005
Cell Significance Index: -0.1000 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0019
Cell Significance Index: -3.5000 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0023
Cell Significance Index: -4.2000 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0032
Cell Significance Index: -4.9900 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0038
Cell Significance Index: -2.8200 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0038
Cell Significance Index: -5.1600 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0048
Cell Significance Index: -3.4900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0055
Cell Significance Index: -4.1900 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0063
Cell Significance Index: -3.5300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0073
Cell Significance Index: -4.6400 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0074
Cell Significance Index: -0.4600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0110
Cell Significance Index: -5.0100 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0125
Cell Significance Index: -3.6100 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.0145
Cell Significance Index: -0.4000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0216
Cell Significance Index: -4.5600 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.0242
Cell Significance Index: -0.9900 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0257
Cell Significance Index: -4.3800 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0260
Cell Significance Index: -1.3100 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0273
Cell Significance Index: -2.7900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0273
Cell Significance Index: -3.7500 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.0286
Cell Significance Index: -0.7300 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0327
Cell Significance Index: -4.7600 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.0360
Cell Significance Index: -2.4200 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0363
Cell Significance Index: -4.1600 - Cell Name: keratinocyte (CL0000312)
Fold Change: -0.0380
Cell Significance Index: -0.9500 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0384
Cell Significance Index: -1.1300 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0400
Cell Significance Index: -4.1600 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0419
Cell Significance Index: -2.9600 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.0496
Cell Significance Index: -3.9300 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.0538
Cell Significance Index: -4.1300 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0546
Cell Significance Index: -1.7500 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0589
Cell Significance Index: -3.7100 - Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: -0.0633
Cell Significance Index: -0.4200 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0748
Cell Significance Index: -4.6000 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.0777
Cell Significance Index: -2.7200 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0796
Cell Significance Index: -3.7100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0800
Cell Significance Index: -4.4900 - Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -0.0810
Cell Significance Index: -1.4000 - Cell Name: enterocyte (CL0000584)
Fold Change: -0.0838
Cell Significance Index: -0.5200 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.0892
Cell Significance Index: -2.1600 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.0899
Cell Significance Index: -3.3000 - Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: -0.0908
Cell Significance Index: -1.5700 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0977
Cell Significance Index: -1.1100 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0993
Cell Significance Index: -2.0600 - Cell Name: hepatocyte (CL0000182)
Fold Change: -0.0999
Cell Significance Index: -1.3900 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1006
Cell Significance Index: -4.4500 - Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.1026
Cell Significance Index: -4.4600 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1042
Cell Significance Index: -4.9000 - Cell Name: peg cell (CL4033014)
Fold Change: -0.1086
Cell Significance Index: -2.5100 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1124
Cell Significance Index: -1.6100 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.1127
Cell Significance Index: -3.6900 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1143
Cell Significance Index: -3.6400 - Cell Name: epithelial cell (CL0000066)
Fold Change: -0.1157
Cell Significance Index: -1.2200 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.1177
Cell Significance Index: -3.1600 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1186
Cell Significance Index: -4.4900
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3743542694
Symbol: CP4F3_HUMAN
Name: Cytochrome P450 4F3
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8486631
Title: A novel form of cytochrome P-450 family 4 in human polymorphonuclear leukocytes. cDNA cloning and expression of leukotriene B4 omega-hydroxylase.
PubMed ID: 8486631
PubMed ID: 9539102
Title: Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular cloning and chromosomal localization.
PubMed ID: 9539102
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15057824
Title: The DNA sequence and biology of human chromosome 19.
PubMed ID: 15057824
DOI: 10.1038/nature02399
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9675028
Title: Purification and characterization of recombinant human neutrophil leukotriene B4 omega-hydroxylase (cytochrome P450 4F3).
PubMed ID: 9675028
PubMed ID: 10409674
Title: Expression of the CYP4F3 gene. tissue-specific splicing and alternative promoters generate high and low K(m) forms of leukotriene B(4) omega-hydroxylase.
PubMed ID: 10409674
PubMed ID: 11461919
Title: Alternative splicing determines the function of CYP4F3 by switching substrate specificity.
PubMed ID: 11461919
PubMed ID: 15145985
Title: Human CYP4F3s are the main catalysts in the oxidation of fatty acid epoxides.
PubMed ID: 15145985
PubMed ID: 15364545
Title: Expression and characterization of human cytochrome P450 4F11: Putative role in the metabolism of therapeutic drugs and eicosanoids.
PubMed ID: 15364545
PubMed ID: 16547005
Title: Omega-oxidation of very long-chain fatty acids in human liver microsomes. Implications for X-linked adrenoleukodystrophy.
PubMed ID: 16547005
PubMed ID: 16820285
Title: Oxygenation of omega-3 fatty acids by human cytochrome P450 4F3B: effect on 20-hydroxyeicosatetraenoic acid production.
PubMed ID: 16820285
PubMed ID: 18182499
Title: Characterization of the human omega-oxidation pathway for omega-hydroxy-very-long-chain fatty acids.
PubMed ID: 18182499
DOI: 10.1096/fj.07-099150
PubMed ID: 18065749
Title: Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11.
PubMed ID: 18065749
PubMed ID: 18577768
Title: Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism.
PubMed ID: 18577768
Sequence Information:
- Length: 520
- Mass: 59847
- Checksum: 2519D875280CF9DC
- Sequence:
MPQLSLSSLG LWPMAASPWL LLLLVGASWL LARILAWTYT FYDNCCRLRC FPQPPKRNWF LGHLGLIHSS EEGLLYTQSL ACTFGDMCCW WVGPWHAIVR IFHPTYIKPV LFAPAAIVPK DKVFYSFLKP WLGDGLLLSA GEKWSRHRRM LTPAFHFNIL KPYMKIFNES VNIMHAKWQL LASEGSARLD MFEHISLMTL DSLQKCVFSF DSHCQEKPSE YIAAILELSA LVTKRHQQIL LYIDFLYYLT PDGQRFRRAC RLVHDFTDAV IQERRRTLPS QGVDDFLQAK AKSKTLDFID VLLLSKDEDG KKLSDEDIRA EADTFMFEGH DTTASGLSWV LYHLAKHPEY QERCRQEVQE LLKDREPKEI EWDDLAQLPF LTMCIKESLR LHPPVPAVSR CCTQDIVLPD GRVIPKGIIC LISVFGTHHN PAVWPDPEVY DPFRFDPKNI KERSPLAFIP FSAGPRNCIG QAFAMAEMKV VLGLTLLRFR VLPDHTEPRR KPELVLRAEG GLWLRVEPLS
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.