Details for: CYP4F3

Gene ID: 4051

Symbol: CYP4F3

Ensembl ID: ENSG00000186529

Description: cytochrome P450 family 4 subfamily F member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 27.0018
    Cell Significance Index: -4.2000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 16.3221
    Cell Significance Index: -4.1400
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 15.1799
    Cell Significance Index: 19.6400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 9.5526
    Cell Significance Index: -4.5100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 6.6168
    Cell Significance Index: -4.4400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 5.3847
    Cell Significance Index: 90.7100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.3983
    Cell Significance Index: -4.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4640
    Cell Significance Index: 290.5400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.4311
    Cell Significance Index: 24.0700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.3069
    Cell Significance Index: 18.9800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.2568
    Cell Significance Index: 18.5500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1283
    Cell Significance Index: 58.6100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0962
    Cell Significance Index: 65.8100
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.9970
    Cell Significance Index: 7.5600
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.9758
    Cell Significance Index: 3.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9545
    Cell Significance Index: 20.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8785
    Cell Significance Index: 24.5500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7753
    Cell Significance Index: 700.0700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7329
    Cell Significance Index: 79.7200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6934
    Cell Significance Index: 9.4600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6249
    Cell Significance Index: 118.9200
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.5956
    Cell Significance Index: 3.4300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.4904
    Cell Significance Index: 7.3900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4622
    Cell Significance Index: 31.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4413
    Cell Significance Index: 71.7700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4332
    Cell Significance Index: 12.4800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2832
    Cell Significance Index: 9.9500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2832
    Cell Significance Index: 7.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1758
    Cell Significance Index: 17.3900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1194
    Cell Significance Index: 13.9100
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.1167
    Cell Significance Index: 0.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1150
    Cell Significance Index: 20.7300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.1140
    Cell Significance Index: 1.0500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1047
    Cell Significance Index: 2.2300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0951
    Cell Significance Index: 4.3100
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.0920
    Cell Significance Index: 0.6000
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: 0.0844
    Cell Significance Index: 1.1800
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.0776
    Cell Significance Index: 0.1800
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.0770
    Cell Significance Index: 0.7600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0277
    Cell Significance Index: 0.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0146
    Cell Significance Index: 1.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0127
    Cell Significance Index: 5.6200
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.0118
    Cell Significance Index: 0.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0116
    Cell Significance Index: 6.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0018
    Cell Significance Index: 0.6400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0005
    Cell Significance Index: -0.1000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0019
    Cell Significance Index: -3.5000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0023
    Cell Significance Index: -4.2000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0032
    Cell Significance Index: -4.9900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0038
    Cell Significance Index: -2.8200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0038
    Cell Significance Index: -5.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0048
    Cell Significance Index: -3.4900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0055
    Cell Significance Index: -4.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0063
    Cell Significance Index: -3.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0073
    Cell Significance Index: -4.6400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0074
    Cell Significance Index: -0.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0110
    Cell Significance Index: -5.0100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0125
    Cell Significance Index: -3.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0145
    Cell Significance Index: -0.4000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0216
    Cell Significance Index: -4.5600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0242
    Cell Significance Index: -0.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0257
    Cell Significance Index: -4.3800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0260
    Cell Significance Index: -1.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0273
    Cell Significance Index: -2.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0273
    Cell Significance Index: -3.7500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0286
    Cell Significance Index: -0.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0327
    Cell Significance Index: -4.7600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0360
    Cell Significance Index: -2.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0363
    Cell Significance Index: -4.1600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0380
    Cell Significance Index: -0.9500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0384
    Cell Significance Index: -1.1300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0400
    Cell Significance Index: -4.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0419
    Cell Significance Index: -2.9600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0496
    Cell Significance Index: -3.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0538
    Cell Significance Index: -4.1300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0546
    Cell Significance Index: -1.7500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0589
    Cell Significance Index: -3.7100
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0633
    Cell Significance Index: -0.4200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0748
    Cell Significance Index: -4.6000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0777
    Cell Significance Index: -2.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0796
    Cell Significance Index: -3.7100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0800
    Cell Significance Index: -4.4900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0810
    Cell Significance Index: -1.4000
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0838
    Cell Significance Index: -0.5200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0892
    Cell Significance Index: -2.1600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0899
    Cell Significance Index: -3.3000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.0908
    Cell Significance Index: -1.5700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0977
    Cell Significance Index: -1.1100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0993
    Cell Significance Index: -2.0600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0999
    Cell Significance Index: -1.3900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1006
    Cell Significance Index: -4.4500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1026
    Cell Significance Index: -4.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1042
    Cell Significance Index: -4.9000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1086
    Cell Significance Index: -2.5100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1124
    Cell Significance Index: -1.6100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1127
    Cell Significance Index: -3.6900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1143
    Cell Significance Index: -3.6400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.1157
    Cell Significance Index: -1.2200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1177
    Cell Significance Index: -3.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1186
    Cell Significance Index: -4.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Substrate specificity:** CYP4F3 exhibits specificity for arachidonic acid, converting it into 20-hydroxy-leukotriene B4 (20-HETE), a potent leukotriene metabolite. 2. **Monooxygenase activity:** CYP4F3 catalyzes the monooxygenation of arachidonic acid, resulting in the production of 20-HETE. 3. **Oxidative activity:** The enzyme exhibits oxidative activity, utilizing oxygen to facilitate the conversion of arachidonic acid into 20-HETE. 4. **Expression in various tissues:** CYP4F3 is expressed in multiple tissues, including the liver, kidneys, immune cells, and the brain, highlighting its broad functional significance. **Pathways and Functions:** 1. **Arachidonic acid metabolism:** CYP4F3 plays a critical role in the metabolism of arachidonic acid, converting it into 20-HETE, which is involved in various physiological and pathological processes, including inflammation, immune regulation, and lipid metabolism. 2. **Leukotriene metabolism:** The enzyme is involved in the catabolism of leukotrienes, such as leukotriene B4 (LTB4), which is a potent pro-inflammatory mediator. 3. **Eicosanoid synthesis:** CYP4F3 contributes to the synthesis of eicosanoids, including leukotrienes and prostaglandins, which play essential roles in various physiological and pathological processes. 4. **Immune regulation:** The enzyme is expressed in immune cells, such as granulocytes and monocytes, and is involved in the regulation of immune responses, including the production of pro-inflammatory and anti-inflammatory cytokines. **Clinical Significance:** 1. **Inflammatory diseases:** Dysregulation of CYP4F3 has been implicated in various inflammatory diseases, including asthma, rheumatoid arthritis, and inflammatory bowel disease. 2. **Cancer:** The enzyme is involved in the metabolism of arachidonic acid, which is a key player in cancer progression and metastasis. 3. **Neurological disorders:** CYP4F3 is expressed in the brain and is involved in the regulation of neuroinflammation, highlighting its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Toxicity and pharmacogenomics:** The enzyme is involved in the metabolism of various toxins and drugs, and its expression and activity can influence an individual's susceptibility to toxicity and response to pharmacotherapy. In conclusion, CYP4F3 is a critical enzyme involved in various biological processes, including lipid metabolism, immune regulation, and eicosanoid synthesis. Its dysregulation has been implicated in various diseases, including inflammatory disorders and cancer. Further research into the role of CYP4F3 in human health and disease will provide valuable insights into the development of novel therapeutic strategies and the understanding of its clinical significance.

Genular Protein ID: 3743542694

Symbol: CP4F3_HUMAN

Name: Cytochrome P450 4F3

UniProtKB Accession Codes:

Q08477 B7Z8Z3 O60634 Q5U740

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 100 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 4 EMBL 11 Ensembl 4 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 4 Rhea 100 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissLipids 2 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8486631

Title: A novel form of cytochrome P-450 family 4 in human polymorphonuclear leukocytes. cDNA cloning and expression of leukotriene B4 omega-hydroxylase.

PubMed ID: 8486631

DOI: 10.1016/s0021-9258(18)98360-2

PubMed ID: 9539102

Title: Human leukotriene B4 omega-hydroxylase (CYP4F3) gene: molecular cloning and chromosomal localization.

PubMed ID: 9539102

DOI: 10.1089/dna.1998.17.221

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9675028

Title: Purification and characterization of recombinant human neutrophil leukotriene B4 omega-hydroxylase (cytochrome P450 4F3).

PubMed ID: 9675028

DOI: 10.1006/abbi.1998.0724

PubMed ID: 10409674

Title: Expression of the CYP4F3 gene. tissue-specific splicing and alternative promoters generate high and low K(m) forms of leukotriene B(4) omega-hydroxylase.

PubMed ID: 10409674

DOI: 10.1074/jbc.274.30.21191

PubMed ID: 11461919

Title: Alternative splicing determines the function of CYP4F3 by switching substrate specificity.

PubMed ID: 11461919

DOI: 10.1074/jbc.m104818200

PubMed ID: 15145985

Title: Human CYP4F3s are the main catalysts in the oxidation of fatty acid epoxides.

PubMed ID: 15145985

DOI: 10.1194/jlr.m300463-jlr200

PubMed ID: 15364545

Title: Expression and characterization of human cytochrome P450 4F11: Putative role in the metabolism of therapeutic drugs and eicosanoids.

PubMed ID: 15364545

DOI: 10.1016/j.taap.2003.12.033

PubMed ID: 16547005

Title: Omega-oxidation of very long-chain fatty acids in human liver microsomes. Implications for X-linked adrenoleukodystrophy.

PubMed ID: 16547005

DOI: 10.1074/jbc.m513481200

PubMed ID: 16820285

Title: Oxygenation of omega-3 fatty acids by human cytochrome P450 4F3B: effect on 20-hydroxyeicosatetraenoic acid production.

PubMed ID: 16820285

DOI: 10.1016/j.plefa.2006.05.005

PubMed ID: 18182499

Title: Characterization of the human omega-oxidation pathway for omega-hydroxy-very-long-chain fatty acids.

PubMed ID: 18182499

DOI: 10.1096/fj.07-099150

PubMed ID: 18065749

Title: Omega oxidation of 3-hydroxy fatty acids by the human CYP4F gene subfamily enzyme CYP4F11.

PubMed ID: 18065749

DOI: 10.1194/jlr.m700450-jlr200

PubMed ID: 18577768

Title: Cytochromes P450 from family 4 are the main omega hydroxylating enzymes in humans: CYP4F3B is the prominent player in PUFA metabolism.

PubMed ID: 18577768

DOI: 10.1194/jlr.m800199-jlr200

Sequence Information:

  • Length: 520
  • Mass: 59847
  • Checksum: 2519D875280CF9DC
  • Sequence:
    • MPQLSLSSLG LWPMAASPWL LLLLVGASWL LARILAWTYT FYDNCCRLRC FPQPPKRNWF 
LGHLGLIHSS EEGLLYTQSL ACTFGDMCCW WVGPWHAIVR IFHPTYIKPV LFAPAAIVPK 
DKVFYSFLKP WLGDGLLLSA GEKWSRHRRM LTPAFHFNIL KPYMKIFNES VNIMHAKWQL 
LASEGSARLD MFEHISLMTL DSLQKCVFSF DSHCQEKPSE YIAAILELSA LVTKRHQQIL 
LYIDFLYYLT PDGQRFRRAC RLVHDFTDAV IQERRRTLPS QGVDDFLQAK AKSKTLDFID 
VLLLSKDEDG KKLSDEDIRA EADTFMFEGH DTTASGLSWV LYHLAKHPEY QERCRQEVQE 
LLKDREPKEI EWDDLAQLPF LTMCIKESLR LHPPVPAVSR CCTQDIVLPD GRVIPKGIIC 
LISVFGTHHN PAVWPDPEVY DPFRFDPKNI KERSPLAFIP FSAGPRNCIG QAFAMAEMKV 
VLGLTLLRFR VLPDHTEPRR KPELVLRAEG GLWLRVEPLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.