Details for: M6PR

Gene ID: 4074

Symbol: M6PR

Ensembl ID: ENSG00000003056

Description: mannose-6-phosphate receptor, cation dependent

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 230.2546
    Cell Significance Index: -35.8200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 137.7525
    Cell Significance Index: -34.9400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 105.7951
    Cell Significance Index: -42.9800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 98.8726
    Cell Significance Index: -46.6800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 91.1768
    Cell Significance Index: -46.9000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 69.7592
    Cell Significance Index: -46.8100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 45.2268
    Cell Significance Index: -43.1800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.5227
    Cell Significance Index: -42.5700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 11.2361
    Cell Significance Index: -30.1000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.1833
    Cell Significance Index: -44.1300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 9.9660
    Cell Significance Index: -30.6100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.9954
    Cell Significance Index: -15.3100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.0068
    Cell Significance Index: 207.9400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.4185
    Cell Significance Index: 38.6100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3194
    Cell Significance Index: 214.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1802
    Cell Significance Index: 212.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0565
    Cell Significance Index: 129.9100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.0211
    Cell Significance Index: 29.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9398
    Cell Significance Index: 48.8200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8165
    Cell Significance Index: 38.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7855
    Cell Significance Index: 155.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7469
    Cell Significance Index: 149.8200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.7026
    Cell Significance Index: 33.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6727
    Cell Significance Index: 79.3300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6639
    Cell Significance Index: 12.2700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6457
    Cell Significance Index: 17.2400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6004
    Cell Significance Index: 38.7400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5981
    Cell Significance Index: 326.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.5940
    Cell Significance Index: 81.5700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.5714
    Cell Significance Index: 4.8000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.5657
    Cell Significance Index: 42.1600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5593
    Cell Significance Index: 55.3300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4981
    Cell Significance Index: 220.2400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4636
    Cell Significance Index: 12.4000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4379
    Cell Significance Index: 30.9700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4281
    Cell Significance Index: 386.5800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.4089
    Cell Significance Index: 282.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.3913
    Cell Significance Index: 50.5500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3811
    Cell Significance Index: 20.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3641
    Cell Significance Index: 130.6100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3448
    Cell Significance Index: 3.1800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2782
    Cell Significance Index: 35.6600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1661
    Cell Significance Index: 7.5300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1536
    Cell Significance Index: 3.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1322
    Cell Significance Index: 8.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1302
    Cell Significance Index: 2.8200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1254
    Cell Significance Index: 23.8600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0336
    Cell Significance Index: 63.2900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0209
    Cell Significance Index: 0.6000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0202
    Cell Significance Index: 15.3100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0062
    Cell Significance Index: 11.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0013
    Cell Significance Index: -0.0400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0018
    Cell Significance Index: -1.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0037
    Cell Significance Index: -5.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0109
    Cell Significance Index: -1.1100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0185
    Cell Significance Index: -0.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0216
    Cell Significance Index: -13.6900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0230
    Cell Significance Index: -31.2600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0505
    Cell Significance Index: -8.6200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0509
    Cell Significance Index: -37.7100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0527
    Cell Significance Index: -23.9100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0555
    Cell Significance Index: -1.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0677
    Cell Significance Index: -2.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0710
    Cell Significance Index: -40.0500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0795
    Cell Significance Index: -2.0900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0815
    Cell Significance Index: -50.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0864
    Cell Significance Index: -12.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1164
    Cell Significance Index: -8.9400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1294
    Cell Significance Index: -37.2400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1315
    Cell Significance Index: -15.3300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1676
    Cell Significance Index: -2.8100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1740
    Cell Significance Index: -4.0200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2155
    Cell Significance Index: -4.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2366
    Cell Significance Index: -49.8400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2443
    Cell Significance Index: -16.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2691
    Cell Significance Index: -15.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2708
    Cell Significance Index: -16.6500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2713
    Cell Significance Index: -31.0800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2994
    Cell Significance Index: -9.5900
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: -0.3437
    Cell Significance Index: -2.2800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3468
    Cell Significance Index: -12.0500
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3496
    Cell Significance Index: -8.9300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3828
    Cell Significance Index: -39.8600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4068
    Cell Significance Index: -5.5500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4654
    Cell Significance Index: -12.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5460
    Cell Significance Index: -43.2400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.5910
    Cell Significance Index: -12.3700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.6101
    Cell Significance Index: -26.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6286
    Cell Significance Index: -32.7500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6666
    Cell Significance Index: -33.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6725
    Cell Significance Index: -41.2300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.7452
    Cell Significance Index: -28.2200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.7901
    Cell Significance Index: -20.3100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.8365
    Cell Significance Index: -23.8700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.8730
    Cell Significance Index: -35.7700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.0004
    Cell Significance Index: -31.8600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.0052
    Cell Significance Index: -35.2200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.0081
    Cell Significance Index: -17.8200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.0299
    Cell Significance Index: -33.7200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.0674
    Cell Significance Index: -18.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural Features:** The M6PR is a transmembrane receptor with a cytoplasmic domain that contains a ubiquitin-like protein (ULP) domain. This domain is responsible for the recognition of mannose-6-phosphate (M6P) residues on proteins. 2. **Function:** The M6PR mediates the transport of M6P-tagged proteins and lipids from the endoplasmic reticulum to lysosomes, where they are degraded and recycled. 3. **Regulation:** The M6PR is regulated by a complex interplay of signals, including the ubiquitination of M6P-tagged proteins and the binding of adaptor proteins. 4. **Cellular Localization:** The M6PR is primarily expressed on the surface of immune cells, including macrophages, dendritic cells, and T cells. **Pathways and Functions:** 1. **Lysosomal Trafficking:** The M6PR mediates the transport of M6P-tagged proteins and lipids from the endoplasmic reticulum to lysosomes, ensuring their degradation and recycling. 2. **Protein Targeting:** The M6PR regulates the targeting of proteins to lysosomes, including lysosomal enzymes and receptors. 3. **Immune Regulation:** The M6PR plays a critical role in the regulation of immune cell function, particularly in the context of phagocytosis and antigen presentation. 4. **Antigen Presentation:** The M6PR is involved in the processing and presentation of antigens to T cells, promoting immune responses. **Clinical Significance:** Dysregulation of the M6PR gene has been implicated in various diseases, including: 1. **Lysosomal Storage Disorders:** Mutations in the M6PR gene can lead to lysosomal storage disorders, such as I-cell disease and Hermansky-Pudlak syndrome. 2. **Autoimmune Conditions:** Abnormalities in the M6PR gene have been linked to autoimmune conditions, such as rheumatoid arthritis and lupus. 3. **Cancer:** The M6PR has been implicated in the development and progression of certain cancers, including breast and lung cancer. In conclusion, the M6PR gene plays a critical role in the regulation of lysosomal trafficking, protein targeting, and immune function. Abnormalities in this gene have significant clinical implications, highlighting the importance of further research into the molecular mechanisms underlying lysosomal function and immune regulation.

Genular Protein ID: 2231238979

Symbol: MPRD_HUMAN

Name: Cation-dependent mannose-6-phosphate receptor

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2441386

Title: Cloning of a cDNA encoding the human cation-dependent mannose 6-phosphate-specific receptor.

PubMed ID: 2441386

DOI: 10.1073/pnas.84.16.5575

PubMed ID: 1849818

Title: Isolation and analysis of the human 46-kDa mannose 6-phosphate receptor gene.

PubMed ID: 1849818

DOI: 10.1111/j.1432-1033.1991.tb15877.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11387475

Title: Sorting of mannose 6-phosphate receptors mediated by the GGAs.

PubMed ID: 11387475

DOI: 10.1126/science.1060750

PubMed ID: 11886874

Title: Interaction of the cation-dependent mannose 6-phosphate receptor with GGA proteins.

PubMed ID: 11886874

DOI: 10.1074/jbc.m201879200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 277
  • Mass: 30993
  • Checksum: 1093FE25DEB6C8E8
  • Sequence:
  • MFPFYSCWRT GLLLLLLAVA VRESWQTEEK TCDLVGEKGK ESEKELALVK RLKPLFNKSF 
    ESTVGQGSDT YIYIFRVCRE AGNHTSGAGL VQINKSNGKE TVVGRLNETH IFNGSNWIML 
    IYKGGDEYDN HCGKEQRRAV VMISCNRHTL ADNFNPVSEE RGKVQDCFYL FEMDSSLACS 
    PEISHLSVGS ILLVTFASLV AVYVVGGFLY QRLVVGAKGM EQFPHLAFWQ DLGNLVADGC 
    DFVCRSKPRN VPAAYRGVGD DQLGEESEER DDHLLPM

Genular Protein ID: 4001212168

Symbol: F5GX30_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

Sequence Information:

  • Length: 191
  • Mass: 21538
  • Checksum: 82BC34033B6B42D8
  • Sequence:
  • MFPFYSCWRT GLLLLLLAVA VRESWQTEEK TCDLVGEKGK ESEKELALVK RLKPLFNKSF 
    ESTVGQGSDT YIYIFRVCRE AGNHTSGAGL VQINKSNGKE TVVGRLNETH IFNGSNWIML 
    IYKGGDEYDN HCGKEQRRAV VMISCNRHTL ADGCDFVCRS KPRNVPAAYR GVGDDQLGEE 
    SEERDDHLLP M

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.