Details for: SMAD2

Gene ID: 4087

Symbol: SMAD2

Ensembl ID: ENSG00000175387

Description: SMAD family member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 378.0251
    Cell Significance Index: -58.8000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 227.8396
    Cell Significance Index: -57.7900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 133.8000
    Cell Significance Index: -63.1700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 129.3516
    Cell Significance Index: -52.5500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 115.5165
    Cell Significance Index: -59.4200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 94.1847
    Cell Significance Index: -63.2000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 55.0934
    Cell Significance Index: -52.6000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 49.9045
    Cell Significance Index: -61.5300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 22.0878
    Cell Significance Index: -59.1700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 17.0408
    Cell Significance Index: -52.3400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.7525
    Cell Significance Index: -62.1600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 14.3243
    Cell Significance Index: -31.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 6.3894
    Cell Significance Index: 358.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.9326
    Cell Significance Index: 383.5300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.7759
    Cell Significance Index: 21.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7411
    Cell Significance Index: 349.2600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.6984
    Cell Significance Index: 130.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.6263
    Cell Significance Index: 45.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.2746
    Cell Significance Index: 34.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9905
    Cell Significance Index: 178.5500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.9559
    Cell Significance Index: 607.0900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9038
    Cell Significance Index: 111.1300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.8668
    Cell Significance Index: 16.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8420
    Cell Significance Index: 302.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8245
    Cell Significance Index: 37.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7613
    Cell Significance Index: 47.9800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.7451
    Cell Significance Index: 1374.0900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7075
    Cell Significance Index: 20.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7057
    Cell Significance Index: 96.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6595
    Cell Significance Index: 45.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.6136
    Cell Significance Index: 335.1100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.6120
    Cell Significance Index: 15.7300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5739
    Cell Significance Index: 396.9000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4842
    Cell Significance Index: 214.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.4369
    Cell Significance Index: 822.6900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.4067
    Cell Significance Index: 11.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3926
    Cell Significance Index: 604.3300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3911
    Cell Significance Index: 17.3000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3615
    Cell Significance Index: 326.3800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3347
    Cell Significance Index: 15.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.3298
    Cell Significance Index: 448.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3074
    Cell Significance Index: 15.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.3004
    Cell Significance Index: 14.1200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2944
    Cell Significance Index: 11.1500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2851
    Cell Significance Index: 54.2600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.2318
    Cell Significance Index: 6.2100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2215
    Cell Significance Index: 14.2900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.2203
    Cell Significance Index: 4.3000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2200
    Cell Significance Index: 21.7600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1891
    Cell Significance Index: 4.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1707
    Cell Significance Index: 10.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1065
    Cell Significance Index: 18.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0913
    Cell Significance Index: 6.1400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0909
    Cell Significance Index: 41.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0577
    Cell Significance Index: 6.8100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0480
    Cell Significance Index: 0.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0041
    Cell Significance Index: 0.5200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0074
    Cell Significance Index: -0.2600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0076
    Cell Significance Index: -0.9800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0244
    Cell Significance Index: -15.2100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0345
    Cell Significance Index: -25.3100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0388
    Cell Significance Index: -1.0200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0417
    Cell Significance Index: -31.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0434
    Cell Significance Index: -32.1400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0552
    Cell Significance Index: -31.1100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0687
    Cell Significance Index: -11.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1240
    Cell Significance Index: -12.6700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1332
    Cell Significance Index: -14.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1788
    Cell Significance Index: -26.0000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1808
    Cell Significance Index: -52.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1822
    Cell Significance Index: -3.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1877
    Cell Significance Index: -13.9900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1927
    Cell Significance Index: -40.5800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2036
    Cell Significance Index: -14.4000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2622
    Cell Significance Index: -30.0400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3261
    Cell Significance Index: -1.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3706
    Cell Significance Index: -43.1900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4108
    Cell Significance Index: -3.3500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4200
    Cell Significance Index: -5.7300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4201
    Cell Significance Index: -7.2000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4279
    Cell Significance Index: -14.8700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4353
    Cell Significance Index: -45.3300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4363
    Cell Significance Index: -49.8000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4531
    Cell Significance Index: -12.9300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4702
    Cell Significance Index: -7.9200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4861
    Cell Significance Index: -15.5700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.5344
    Cell Significance Index: -11.0900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5553
    Cell Significance Index: -12.1600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5944
    Cell Significance Index: -31.2100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.6268
    Cell Significance Index: -32.6500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.6534
    Cell Significance Index: -10.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6602
    Cell Significance Index: -52.2900
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.6657
    Cell Significance Index: -9.3500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7112
    Cell Significance Index: -10.5000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7219
    Cell Significance Index: -15.4300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7245
    Cell Significance Index: -18.1100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.7449
    Cell Significance Index: -17.2100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.7678
    Cell Significance Index: -7.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.8570
    Cell Significance Index: -25.1700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.8621
    Cell Significance Index: -20.6800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** SMAD2 is a phosphorylated serine protein that belongs to the SMAD family, which consists of approximately 20 members. It is characterized by its unique MH2 domain, which is essential for its interaction with other SMAD proteins and transcription factors. SMAD2 is highly conserved across species, with high sequence identity to its human ortholog. It is primarily expressed in the liver, lungs, and kidneys, and its expression is regulated by TGF-β signaling. **Pathways and Functions** SMAD2 is a key component of the TGF-β signaling pathway, which is involved in regulating cell growth, differentiation, and apoptosis. The TGF-β pathway is activated by the binding of TGF-β ligands to their receptors, which triggers the phosphorylation and activation of SMAD2 and SMAD3. SMAD2 then forms a complex with SMAD4, a common co-receptor, and translocates to the nucleus to regulate gene expression. SMAD2 can also interact with other transcription factors, such as BMPs and FoxO, to modulate gene expression. In addition to its role in the TGF-β pathway, SMAD2 is involved in other signaling pathways, including the activin and nodal pathways. These pathways are essential for embryonic development, tissue homeostasis, and cancer suppression. SMAD2 is also involved in the regulation of cell differentiation, as it can interact with transcription factors to regulate the expression of genes involved in cell fate determination. **Clinical Significance** Dysregulation of SMAD2 has been implicated in various diseases, including cancer, fibrosis, and autoimmune disorders. Mutations in the SMAD2 gene have been associated with several diseases, including: 1. **Lung cancer**: SMAD2 mutations have been identified in a subset of lung cancer patients, suggesting a role for SMAD2 in cancer suppression. 2. **Fibrosis**: SMAD2 dysregulation has been implicated in the pathogenesis of fibrosis, including idiopathic pulmonary fibrosis and liver cirrhosis. 3. **Autoimmune disorders**: SMAD2 has been implicated in the regulation of immune responses, and dysregulation of SMAD2 has been associated with autoimmune disorders, such as rheumatoid arthritis and lupus. 4. **Neurological disorders**: SMAD2 has been implicated in the regulation of neural development and function, and dysregulation of SMAD2 has been associated with neurological disorders, such as Alzheimer's disease and Parkinson's disease. In summary, SMAD2 is a crucial gene involved in the regulation of various cellular processes, including cell differentiation, development, and signaling pathways. Its dysregulation has been implicated in various diseases, including cancer, fibrosis, and autoimmune disorders, highlighting the importance of SMAD2 in human health and disease.

Genular Protein ID: 1940880482

Symbol: SMAD2_HUMAN

Name: Mothers against decapentaplegic homolog 2

UniProtKB Accession Codes:

Q15796

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 1 EMBL 13 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 79 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 17 RefSeq 6 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8673135

Title: Mad-related genes in the human.

PubMed ID: 8673135

DOI: 10.1038/ng0796-347

PubMed ID: 8774881

Title: Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.

PubMed ID: 8774881

DOI: 10.1038/383168a0

PubMed ID: 8752209

Title: MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma.

PubMed ID: 8752209

DOI: 10.1016/s0092-8674(00)80128-2

PubMed ID: 9389648

Title: Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes.

PubMed ID: 9389648

DOI: 10.1101/gad.11.23.3157

PubMed ID: 9503010

Title: Characterization of the MADH2/Smad2 gene, a human Mad homolog responsible for the transforming growth factor-beta and activin signal transduction pathway.

PubMed ID: 9503010

DOI: 10.1006/geno.1997.5149

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8980228

Title: MADR2 is a substrate of the TGFbeta receptor and its phosphorylation is required for nuclear accumulation and signaling.

PubMed ID: 8980228

DOI: 10.1016/s0092-8674(00)81817-6

PubMed ID: 9865696

Title: SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor.

PubMed ID: 9865696

DOI: 10.1016/s0092-8674(00)81701-8

PubMed ID: 9670020

Title: Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors.

PubMed ID: 9670020

DOI: 10.1093/emboj/17.14.4056

PubMed ID: 9873005

Title: Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3.

PubMed ID: 9873005

DOI: 10.1074/jbc.274.2.703

PubMed ID: 9136927

Title: The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.

PubMed ID: 9136927

DOI: 10.1101/gad.11.8.984

PubMed ID: 9346908

Title: TbetaRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling.

PubMed ID: 9346908

DOI: 10.1074/jbc.272.44.27678

PubMed ID: 9702198

Title: Characterization of human FAST-1, a TGF beta and activin signal transducer.

PubMed ID: 9702198

DOI: 10.1016/s1097-2765(00)80120-3

PubMed ID: 9892009

Title: Roles of pathway-specific and inhibitory Smads in activin receptor signaling.

PubMed ID: 9892009

DOI: 10.1210/mend.13.1.0218

PubMed ID: 10835638

Title: Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination.

PubMed ID: 10835638

DOI: 10.1038/76074

PubMed ID: 11387212

Title: The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway.

PubMed ID: 11387212

DOI: 10.1093/emboj/20.11.2789

PubMed ID: 11278756

Title: Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription.

PubMed ID: 11278756

DOI: 10.1074/jbc.m010815200

PubMed ID: 11389444

Title: TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation.

PubMed ID: 11389444

DOI: 10.1038/35078562

PubMed ID: 11879191

Title: Decorin suppresses transforming growth factor-beta-induced expression of plasminogen activator inhibitor-1 in human mesangial cells through a mechanism that involves Ca2+-dependent phosphorylation of Smad2 at serine-240.

PubMed ID: 11879191

DOI: 10.1042/0264-6021:3620643

PubMed ID: 12193595

Title: Modulation of Smad2-mediated signaling by extracellular signal-regulated kinase.

PubMed ID: 12193595

DOI: 10.1074/jbc.m204597200

PubMed ID: 15601644

Title: MAN1, an integral protein of the inner nuclear membrane, binds Smad2 and Smad3 and antagonizes transforming growth factor-beta signaling.

PubMed ID: 15601644

DOI: 10.1093/hmg/ddi040

PubMed ID: 15647271

Title: The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-{beta} superfamily of cytokines.

PubMed ID: 15647271

DOI: 10.1074/jbc.m411234200

PubMed ID: 16200078

Title: Cloning and functional characterization of a new Ski homolog, Fussel-18, specifically expressed in neuronal tissues.

PubMed ID: 16200078

DOI: 10.1038/labinvest.3700344

PubMed ID: 16751101

Title: PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling.

PubMed ID: 16751101

DOI: 10.1016/j.cell.2006.03.044

PubMed ID: 16751102

Title: Hematopoiesis controlled by distinct TIF1gamma and Smad4 branches of the TGFbeta pathway.

PubMed ID: 16751102

DOI: 10.1016/j.cell.2006.03.045

PubMed ID: 17074756

Title: The DNA binding activities of Smad2 and Smad3 are regulated by coactivator-mediated acetylation.

PubMed ID: 17074756

DOI: 10.1074/jbc.m607868200

PubMed ID: 17099224

Title: Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS.

PubMed ID: 17099224

DOI: 10.1093/nar/gkl914

PubMed ID: 17327236

Title: 3-Phosphoinositide-dependent PDK1 negatively regulates transforming growth factor-beta-induced signaling in a kinase-dependent manner through physical interaction with Smad proteins.

PubMed ID: 17327236

DOI: 10.1074/jbc.m609279200

PubMed ID: 17292623

Title: Fussel-15, a novel Ski/Sno homolog protein, antagonizes BMP signaling.

PubMed ID: 17292623

DOI: 10.1016/j.mcn.2007.01.002

PubMed ID: 16862174

Title: Smad3 is acetylated by p300/CBP to regulate its transactivation activity.

PubMed ID: 16862174

DOI: 10.1038/sj.onc.1209826

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18568018

Title: TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal.

PubMed ID: 18568018

DOI: 10.1038/ncb1748

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19289081

Title: Nuclear export of Smad2 and Smad3 by RanBP3 facilitates termination of TGF-beta signaling.

PubMed ID: 19289081

DOI: 10.1016/j.devcel.2009.01.022

PubMed ID: 19049980

Title: SKI and MEL1 cooperate to inhibit transforming growth factor-beta signal in gastric cancer cells.

PubMed ID: 19049980

DOI: 10.1074/jbc.m808989200

PubMed ID: 21145499

Title: The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway.

PubMed ID: 21145499

DOI: 10.1016/j.devcel.2010.11.012

PubMed ID: 20061380

Title: MTMR4 attenuates transforming growth factor beta (TGFbeta) signaling by dephosphorylating R-Smads in endosomes.

PubMed ID: 20061380

DOI: 10.1074/jbc.m109.075036

PubMed ID: 20129061

Title: TMEPAI, a transmembrane TGF-beta-inducible protein, sequesters Smad proteins from active participation in TGF-beta signaling.

PubMed ID: 20129061

DOI: 10.1016/j.molcel.2009.10.028

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21599657

Title: ZNF580, a novel C2H2 zinc-finger transcription factor, interacts with the TGF-beta signal molecule Smad2.

PubMed ID: 21599657

DOI: 10.1042/cbi20110050

PubMed ID: 21947082

Title: USP15 is a deubiquitylating enzyme for receptor-activated SMADs.

PubMed ID: 21947082

DOI: 10.1038/ncb2346

PubMed ID: 22781750

Title: Protein phosphatase 5 modulates SMAD3 function in the transforming growth factor-beta pathway.

PubMed ID: 22781750

DOI: 10.1016/j.cellsig.2012.07.003

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23478445

Title: CRL1-FBXO11 promotes Cdt2 ubiquitylation and degradation and regulates Pr-Set7/Set8-mediated cellular migration.

PubMed ID: 23478445

DOI: 10.1016/j.molcel.2013.02.003

PubMed ID: 24324267

Title: Zinc finger protein 451 is a novel Smad corepressor in transforming growth factor-beta signaling.

PubMed ID: 24324267

DOI: 10.1074/jbc.m113.526905

PubMed ID: 24627487

Title: C18 ORF1, a novel negative regulator of transforming growth factor-beta signaling.

PubMed ID: 24627487

DOI: 10.1074/jbc.m114.558981

PubMed ID: 9759503

Title: TGF-beta signal transduction.

PubMed ID: 9759503

DOI: 10.1146/annurev.biochem.67.1.753

PubMed ID: 10647776

Title: Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells.

PubMed ID: 10647776

DOI: 10.1016/s1359-6101(99)00012-x

PubMed ID: 10708948

Title: The Smad pathway.

PubMed ID: 10708948

DOI: 10.1016/s1359-6101(99)00024-6

PubMed ID: 10708949

Title: TGF-beta signaling by Smad proteins.

PubMed ID: 10708949

DOI: 10.1016/s1359-6101(99)00025-8

PubMed ID: 23665959

Title: De novo mutations in histone-modifying genes in congenital heart disease.

PubMed ID: 23665959

DOI: 10.1038/nature12141

PubMed ID: 25105025

Title: TGF-beta signaling cooperates with AT motif-binding factor-1 for repression of the alpha -fetoprotein promoter.

PubMed ID: 25105025

DOI: 10.1155/2014/970346

PubMed ID: 26247899

Title: SMAD2 Mutations Are Associated with Arterial Aneurysms and Dissections.

PubMed ID: 26247899

DOI: 10.1002/humu.22854

PubMed ID: 10615055

Title: Structural basis of Smad2 recognition by the Smad anchor for receptor activation.

PubMed ID: 10615055

DOI: 10.1126/science.287.5450.92

PubMed ID: 15350224

Title: Structural basis of heteromeric smad protein assembly in TGF-beta signaling.

PubMed ID: 15350224

DOI: 10.1016/j.molcel.2004.07.016

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 28283438

Title: Exome sequencing identified a novel SMAD2 mutation in a Chinese family with early onset aortic aneurysms.

PubMed ID: 28283438

DOI: 10.1016/j.cca.2017.03.007

PubMed ID: 30157302

Title: Variable cardiovascular phenotypes associated with SMAD2 pathogenic variants.

PubMed ID: 30157302

DOI: 10.1002/humu.23627

PubMed ID: 29967133

Title: Novel pathogenic SMAD2 variants in five families with arterial aneurysm and dissection: further delineation of the phenotype.

PubMed ID: 29967133

DOI: 10.1136/jmedgenet-2018-105304

Sequence Information:

  • Length: 467
  • Mass: 52306
  • Checksum: 95406DB5FC0AA4C9
  • Sequence:
    • MSSILPFTPP VVKRLLGWKK SAGGSGGAGG GEQNGQEEKW CEKAVKSLVK KLKKTGRLDE 
LEKAITTQNC NTKCVTIPST CSEIWGLSTP NTIDQWDTTG LYSFSEQTRS LDGRLQVSHR 
KGLPHVIYCR LWRWPDLHSH HELKAIENCE YAFNLKKDEV CVNPYHYQRV ETPVLPPVLV 
PRHTEILTEL PPLDDYTHSI PENTNFPAGI EPQSNYIPET PPPGYISEDG ETSDQQLNQS 
MDTGSPAELS PTTLSPVNHS LDLQPVTYSE PAFWCSIAYY ELNQRVGETF HASQPSLTVD 
GFTDPSNSER FCLGLLSNVN RNATVEMTRR HIGRGVRLYY IGGEVFAECL SDSAIFVQSP 
NCNQRYGWHP ATVCKIPPGC NLKIFNNQEF AALLAQSVNQ GFEAVYQLTR MCTIRMSFVK 
GWGAEYRRQT VTSTPCWIEL HLNGPLQWLD KVLTQMGSPS VRCSSMS

Genular Protein ID: 2762793963

Symbol: B7Z5N5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z5N5

Database IDs:

ARBA 7 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 2 GO 6 Gene3D 2 GeneTree 1 HGNC 1 IntAct 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PROSITE 4 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 2 SMART 2 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.M111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Title: Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-beta signaling.

DOI: 10.1101/gad.330837.119

Sequence Information:

  • Length: 431
  • Mass: 48669
  • Checksum: AB3BEA35AACAECDC
  • Sequence:
    • MSSILPFTPP VVKRLLGWKK SAGGSGGAGG GEQNGQEEKW CEKAVKSLVK KLKKTGRLDE 
LEKAITTQNC NTKCVTIPRS LDGRLQVSHR KGLPHVIYCR LWRWPDLHSH HELKAIENCE 
YAFNLKKDEV CVNPYHYQRV ETPVLPPVLV PRHTEILTEL PPLDDYTHSI PENTNFPAGI 
EPQSNYIPET PPPGYISEDG ETSDQQLNQS MDTGSPAELS PTTLSPVNHS LDLQPVTYSE 
PAFWCSIAYY ELNQRVGETF HASQPSLTVD GFTDPSNSER FCLGLLSNVN RNATVEMTRR 
HIGRGVRLYY IGGEVFAECL SDSAIFVQSP NCNQRYGWHP ATVCKIPPGC NLKIFNNQEF 
AALLAQSVNQ GFEAVYQLTR MCTIRMSFVK GWGAEYRYEI HIWFLNFHSV IMFHCILAYS 
GVHLYLFSMR L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.