Details for: MAGEA10

Gene ID: 4109

Symbol: MAGEA10

Ensembl ID: ENSG00000124260

Description: MAGE family member A10

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 4.0179
    Cell Significance Index: 141.1900
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 2.8579
    Cell Significance Index: 20.5900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.9725
    Cell Significance Index: 49.3100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 1.7764
    Cell Significance Index: 108.9100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.2833
    Cell Significance Index: 26.6200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9672
    Cell Significance Index: 20.9600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.8403
    Cell Significance Index: 20.3600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.7916
    Cell Significance Index: 11.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.6632
    Cell Significance Index: 30.0600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.6521
    Cell Significance Index: 20.8900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.6168
    Cell Significance Index: 5.3000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.4917
    Cell Significance Index: 7.4100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4852
    Cell Significance Index: 92.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3478
    Cell Significance Index: 34.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2890
    Cell Significance Index: 260.9600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2003
    Cell Significance Index: 4.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1823
    Cell Significance Index: 29.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1598
    Cell Significance Index: 17.3900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0956
    Cell Significance Index: 6.6100
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.0934
    Cell Significance Index: 1.3300
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.0825
    Cell Significance Index: 0.9300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0755
    Cell Significance Index: 4.5300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0667
    Cell Significance Index: 4.2100
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.0269
    Cell Significance Index: 0.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0135
    Cell Significance Index: 0.3900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0019
    Cell Significance Index: -0.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0025
    Cell Significance Index: -0.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0025
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0038
    Cell Significance Index: -0.6500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0043
    Cell Significance Index: -0.2200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0050
    Cell Significance Index: -2.7400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0079
    Cell Significance Index: -2.8400
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.0094
    Cell Significance Index: -0.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0098
    Cell Significance Index: -1.7700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0105
    Cell Significance Index: -2.0800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0120
    Cell Significance Index: -0.4900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0122
    Cell Significance Index: -0.3300
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.0126
    Cell Significance Index: -0.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0143
    Cell Significance Index: -1.7600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0147
    Cell Significance Index: -2.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0174
    Cell Significance Index: -0.8100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0189
    Cell Significance Index: -2.1700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0209
    Cell Significance Index: -0.5200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0211
    Cell Significance Index: -2.9000
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0218
    Cell Significance Index: -0.2900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0239
    Cell Significance Index: -1.1300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0248
    Cell Significance Index: -0.6900
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0257
    Cell Significance Index: -0.3700
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0268
    Cell Significance Index: -0.6700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0271
    Cell Significance Index: -0.3300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0364
    Cell Significance Index: -1.5800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0370
    Cell Significance Index: -1.0600
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0398
    Cell Significance Index: -0.4200
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: -0.0432
    Cell Significance Index: -0.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0473
    Cell Significance Index: -3.1800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0506
    Cell Significance Index: -0.9400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0520
    Cell Significance Index: -1.8200
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.0538
    Cell Significance Index: -0.5300
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: -0.0549
    Cell Significance Index: -0.6400
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: -0.0559
    Cell Significance Index: -0.3500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0580
    Cell Significance Index: -0.9300
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0584
    Cell Significance Index: -0.7100
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.0600
    Cell Significance Index: -0.5800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0603
    Cell Significance Index: -1.7800
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: -0.0613
    Cell Significance Index: -0.6700
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0623
    Cell Significance Index: -0.6500
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.0656
    Cell Significance Index: -0.4700
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.0659
    Cell Significance Index: -0.7000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0676
    Cell Significance Index: -0.8700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0676
    Cell Significance Index: -1.3200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0700
    Cell Significance Index: -0.7300
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.0764
    Cell Significance Index: -1.1600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0780
    Cell Significance Index: -0.9100
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.0785
    Cell Significance Index: -0.8500
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0788
    Cell Significance Index: -1.0300
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0791
    Cell Significance Index: -0.7400
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0801
    Cell Significance Index: -1.0200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0826
    Cell Significance Index: -1.0400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0829
    Cell Significance Index: -1.8200
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: -0.0831
    Cell Significance Index: -0.8600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0836
    Cell Significance Index: -2.1300
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: -0.0839
    Cell Significance Index: -0.8900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0896
    Cell Significance Index: -2.4000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0901
    Cell Significance Index: -2.9500
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0916
    Cell Significance Index: -1.0900
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0922
    Cell Significance Index: -0.9200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0936
    Cell Significance Index: -1.8300
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.0944
    Cell Significance Index: -1.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0945
    Cell Significance Index: -3.0100
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.0957
    Cell Significance Index: -0.7300
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0971
    Cell Significance Index: -1.4200
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.0973
    Cell Significance Index: -1.1500
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0978
    Cell Significance Index: -1.3300
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: -0.0979
    Cell Significance Index: -1.0600
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0981
    Cell Significance Index: -1.1700
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.1009
    Cell Significance Index: -0.7000
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: -0.1019
    Cell Significance Index: -1.0100
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: -0.1041
    Cell Significance Index: -1.2300
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.1042
    Cell Significance Index: -1.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MAGEA10 is a non-coding gene that belongs to the MAGE family, which is known for its expression in malignant melanoma cells. However, MAGEA10 is also expressed in normal cells, including endothelial cells, plasma cells, and immune cells. This unique expression pattern suggests that MAGEA10 may play a role in regulating immune responses and maintaining tissue homeostasis. The gene is characterized by its ability to bind to histone deacetylases, which are enzymes involved in chromatin remodeling and transcription regulation. **Pathways and Functions:** MAGEA10 has been implicated in several cellular pathways, including: 1. **Negative regulation of transcription by RNA polymerase II**: MAGEA10 has been shown to inhibit the activity of RNA polymerase II, a key enzyme involved in the transcription of genes. This inhibition can lead to the suppression of gene expression, suggesting that MAGEA10 may play a role in regulating the expression of genes involved in immune responses. 2. **Histone deacetylase binding**: MAGEA10 has been shown to bind to histone deacetylases, which can lead to the suppression of gene expression. This binding can also modulate chromatin structure and facilitate the recruitment of transcriptional repressors. 3. **Cytosol and nucleoplasm localization**: MAGEA10 is localized to the cytosol and nucleoplasm, suggesting that it may play a role in regulating cellular processes that occur in these compartments. **Clinical Significance:** The expression of MAGEA10 in various cell types has significant implications for our understanding of immune-related disorders. For example: 1. **Cancer immunotherapy**: MAGEA10 has been identified as a potential target for cancer immunotherapy. The gene's expression in tumor cells suggests that it may be a useful biomarker for identifying patients who may benefit from immunotherapeutic interventions. 2. **Autoimmune diseases**: The expression of MAGEA10 in immune cells such as B cells and CD8-positive, alpha-beta T cells suggests that it may play a role in regulating immune responses and maintaining tissue homeostasis. Dysregulation of MAGEA10 expression may contribute to the development of autoimmune diseases. 3. **Infectious diseases**: MAGEA10 has been implicated in the regulation of immune responses to infections. The gene's expression in immune cells such as plasma cells and CD8-positive, alpha-beta T cells suggests that it may play a role in regulating the adaptive immune response to pathogens. In conclusion, MAGEA10 is a gene with significant implications for our understanding of immune-related disorders. Its expression in various cell types and its involvement in regulating transcription and chromatin structure make it a valuable target for further research. The clinical significance of MAGEA10 is multifaceted, with potential applications in cancer immunotherapy, autoimmune disease, and infectious disease.

Genular Protein ID: 2087328964

Symbol: MAGAA_HUMAN

Name: Melanoma-associated antigen 10

UniProtKB Accession Codes:

P43363

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 3 SMART 2 SMR 1 STRING 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7927540

Title: Structure, chromosomal localization, and expression of 12 genes of the MAGE family.

PubMed ID: 7927540

DOI: 10.1007/bf01246677

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21710496

Title: MAGE-A10 is a nuclear protein frequently expressed in high percentages of tumor cells in lung, skin and urothelial malignancies.

PubMed ID: 21710496

DOI: 10.1002/ijc.25777

Sequence Information:

  • Length: 369
  • Mass: 40780
  • Checksum: 64FC72BBAF6F2DE6
  • Sequence:
    • MPRAPKRQRC MPEEDLQSQS ETQGLEGAQA PLAVEEDASS STSTSSSFPS SFPSSSSSSS 
SSCYPLIPST PEEVSADDET PNPPQSAQIA CSSPSVVASL PLDQSDEGSS SQKEESPSTL 
QVLPDSESLP RSEIDEKVTD LVQFLLFKYQ MKEPITKAEI LESVIRNYED HFPLLFSEAS 
ECMLLVFGID VKEVDPTGHS FVLVTSLGLT YDGMLSDVQS MPKTGILILI LSIVFIEGYC 
TPEEVIWEAL NMMGLYDGME HLIYGEPRKL LTQDWVQENY LEYRQVPGSD PARYEFLWGP 
RAHAEIRKMS LLKFLAKVNG SDPRSFPLWY EEALKDEEER AQDRIATTDD TTAMASASSS 
ATGSFSYPE

Genular Protein ID: 2473991182

Symbol: B2RAE8_HUMAN

Name: N/A

UniProtKB Accession Codes:

B2RAE8

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 Gene3D 2 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 RefSeq 3 SAM 1 SMART 2

Sequence Information:

  • Length: 369
  • Mass: 40708
  • Checksum: 5F1FF2B6CDC6D54F
  • Sequence:
    • MPRAPKRQRC MPEEDLQSQS ETQGLEGAQA PLAVEEDASS STSTSSSFPS SFPSSSSSSS 
SSCYPLIPST PEEVSADDAT PNPPQSAQIA CSSPSVVASL PLDQSDEGSS SQKEESPSTL 
QVLPDSESLP RSEIDEKVTD LVQFLLFKYQ MKEPITKAEI LESVIKNYED HFPLLFSEAS 
ECMLLVFGID VKEVDPTGHS FVLVTSLGLT YDGMLSDVQS MPKTGILILI LSIIFIEGYC 
TPEEVIWEAL NMMGLYDGME HLIYGEPRKL LTQDWVQENY LEYRQVPGSD PARYEFLWGP 
RAHAEIRKMS LLKFLAKVNG SDPRSFPLWY EEALKDEEER AQDRIATTDD TTAMASASSS 
ATGSFSYPE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.