Details for: MARK1

Gene ID: 4139

Symbol: MARK1

Ensembl ID: ENSG00000116141

Description: microtubule affinity regulating kinase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 54.0879
    Cell Significance Index: -51.6400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 3.3362
    Cell Significance Index: 80.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.8979
    Cell Significance Index: 178.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.8787
    Cell Significance Index: 161.5400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.6936
    Cell Significance Index: 540.3400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.2368
    Cell Significance Index: 802.3000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.0041
    Cell Significance Index: 1386.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.5246
    Cell Significance Index: 117.0000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.3325
    Cell Significance Index: 58.9400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.2768
    Cell Significance Index: 48.3500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.0785
    Cell Significance Index: 72.5200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.0622
    Cell Significance Index: 22.7100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9961
    Cell Significance Index: 13.5900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.9230
    Cell Significance Index: 26.3400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.9066
    Cell Significance Index: 11.2500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6880
    Cell Significance Index: 84.6000
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 0.6672
    Cell Significance Index: 6.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6154
    Cell Significance Index: 110.9400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5981
    Cell Significance Index: 31.0700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3626
    Cell Significance Index: 327.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3575
    Cell Significance Index: 9.9900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2948
    Cell Significance Index: 2.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2469
    Cell Significance Index: 24.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.1749
    Cell Significance Index: 3.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1700
    Cell Significance Index: 4.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1474
    Cell Significance Index: 277.5000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1225
    Cell Significance Index: 2.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1208
    Cell Significance Index: 185.9700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.1199
    Cell Significance Index: 1.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0933
    Cell Significance Index: 15.1800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0693
    Cell Significance Index: 31.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0562
    Cell Significance Index: 103.6300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0098
    Cell Significance Index: 13.2800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0125
    Cell Significance Index: -0.7900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0204
    Cell Significance Index: -9.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0302
    Cell Significance Index: -1.0600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0390
    Cell Significance Index: -24.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0406
    Cell Significance Index: -5.9000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0563
    Cell Significance Index: -10.7200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0660
    Cell Significance Index: -36.0400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0674
    Cell Significance Index: -49.9500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0742
    Cell Significance Index: -54.3900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0933
    Cell Significance Index: -70.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0967
    Cell Significance Index: -2.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1006
    Cell Significance Index: -56.7100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1124
    Cell Significance Index: -70.1800
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.1656
    Cell Significance Index: -2.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1734
    Cell Significance Index: -7.8600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1792
    Cell Significance Index: -51.5600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1920
    Cell Significance Index: -20.8800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2644
    Cell Significance Index: -52.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2836
    Cell Significance Index: -17.3900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3002
    Cell Significance Index: -63.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.3364
    Cell Significance Index: -46.2000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3415
    Cell Significance Index: -43.7800
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.3898
    Cell Significance Index: -4.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.3912
    Cell Significance Index: -66.8000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4000
    Cell Significance Index: -7.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4362
    Cell Significance Index: -56.3500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4422
    Cell Significance Index: -46.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4657
    Cell Significance Index: -11.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4730
    Cell Significance Index: -55.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.5306
    Cell Significance Index: -36.7000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5427
    Cell Significance Index: -63.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5461
    Cell Significance Index: -62.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.5701
    Cell Significance Index: -58.2400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5828
    Cell Significance Index: -19.0800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6018
    Cell Significance Index: -42.5600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6516
    Cell Significance Index: -13.8300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.6800
    Cell Significance Index: -40.8300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6813
    Cell Significance Index: -21.7000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7460
    Cell Significance Index: -14.5600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7480
    Cell Significance Index: -59.2400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.7525
    Cell Significance Index: -15.6100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.7844
    Cell Significance Index: -11.5800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8022
    Cell Significance Index: -42.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.8034
    Cell Significance Index: -37.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.8047
    Cell Significance Index: -59.9700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.8062
    Cell Significance Index: -16.1900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.9165
    Cell Significance Index: -47.7400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.9430
    Cell Significance Index: -20.4300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.9865
    Cell Significance Index: -46.3700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.0180
    Cell Significance Index: -32.6100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -1.0687
    Cell Significance Index: -15.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.1418
    Cell Significance Index: -40.0000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.1854
    Cell Significance Index: -29.5700
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -1.2638
    Cell Significance Index: -16.3900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -1.2703
    Cell Significance Index: -14.8200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.3103
    Cell Significance Index: -28.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.3513
    Cell Significance Index: -36.7800
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.3585
    Cell Significance Index: -14.8000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.3723
    Cell Significance Index: -33.2400
  • Cell Name: neuron (CL0000540)
    Fold Change: -1.4801
    Cell Significance Index: -14.0300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -1.5216
    Cell Significance Index: -66.1600
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: -1.5254
    Cell Significance Index: -11.0900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.5438
    Cell Significance Index: -56.6700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.5729
    Cell Significance Index: -42.0000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.5931
    Cell Significance Index: -33.2500
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -1.6318
    Cell Significance Index: -19.7800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.6487
    Cell Significance Index: -57.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MARK1 exhibits several key characteristics that distinguish it from other kinases. Firstly, its microtubule affinity enables it to interact with microtubules, which are essential components of the cytoskeleton. This interaction allows MARK1 to regulate microtubule dynamics and stability, thereby influencing cellular processes such as cell migration, division, and morphology. MARK1 also exhibits a unique substrate specificity, phosphorylating serine and threonine residues on target proteins. This specificity is critical for regulating cellular processes, as the phosphorylation of these residues can alter protein function, localization, or stability. In addition to its kinase activity, MARK1 has been shown to interact with various proteins, including tau-proteins, which are essential components of microtubules. These interactions enable MARK1 to regulate tau-protein function and localization, which is critical for maintaining microtubule stability and dynamics. MARK1 also exhibits a high degree of specificity for its substrates, with a relatively small number of known targets. This specificity is thought to be mediated by the kinase's unique substrate specificity and its interactions with microtubules. **Pathways and Functions** MARK1 is involved in a wide range of cellular processes, including: 1. **Cytoskeleton organization**: MARK1 regulates microtubule dynamics and stability, which is critical for maintaining cellular morphology and function. 2. **Intracellular signaling**: MARK1 interacts with various signaling molecules, including Wnt proteins, to regulate cellular responses to changes in the cytoskeleton. 3. **Gene expression**: MARK1 regulates gene expression by phosphorylating transcription factors and other regulatory proteins. 4. **Neuron development**: MARK1 is essential for regulating dendrite development, neuron projection development, and the establishment of neuronal morphology. 5. **Cell migration and division**: MARK1 regulates microtubule dynamics and stability, which is critical for cell migration and division. MARK1's involvement in these processes is thought to be mediated by its kinase activity, which phosphorylates serine and threonine residues on target proteins. This phosphorylation can alter protein function, localization, or stability, thereby regulating cellular processes. **Clinical Significance** MARK1 has been implicated in various neurological disorders, including: 1. **Neurodegenerative diseases**: MARK1 has been shown to be involved in the regulation of tau-protein function and localization, which is critical for maintaining microtubule stability and dynamics. Abnormalities in MARK1 function have been implicated in neurodegenerative diseases, including Alzheimer's disease and frontotemporal dementia. 2. **Cancer**: MARK1 has been shown to be involved in the regulation of gene expression and cell migration. Abnormalities in MARK1 function have been implicated in various types of cancer, including breast cancer and colon cancer. 3. **Neurodevelopmental disorders**: MARK1 has been implicated in the regulation of neuron development and function. Abnormalities in MARK1 function have been implicated in neurodevelopmental disorders, including autism spectrum disorder and schizophrenia. In conclusion, MARK1 is a serine/threonine kinase enzyme that plays a critical role in regulating various cellular processes, including cytoskeleton organization, intracellular signaling, and gene expression. Its involvement in neurological disorders, including neurodegenerative diseases and neurodevelopmental disorders, highlights the importance of MARK1 in maintaining cellular homeostasis and function.

Genular Protein ID: 2216677431

Symbol: MARK1_HUMAN

Name: Serine/threonine-protein kinase MARK1

UniProtKB Accession Codes:

Q9P0L2 D3DTB0 D3DTB1 Q2HIY1 Q5VTF9 Q5VTG0 Q96SW9 Q9P251

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 3 CTD 1 CarbonylDB 1 ChEBI 23 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 6 EMBL 10 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 3 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 2 Rhea 12 SASBDB 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14976552

Title: LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1.

PubMed ID: 14976552

DOI: 10.1038/sj.emboj.7600110

PubMed ID: 10819331

Title: Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10819331

DOI: 10.1093/dnares/7.2.143

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9108484

Title: MARK - a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption.

PubMed ID: 9108484

DOI: 10.1016/s0092-8674(00)80208-1

PubMed ID: 11089574

Title: Microtubule-affinity regulating kinase (MARK) is tightly associated with neurofibrillary tangles in Alzheimer brain: a fluorescence resonance energy transfer study.

PubMed ID: 11089574

DOI: 10.1093/jnen/59.11.966

PubMed ID: 11433294

Title: PAR-1 is a Dishevelled-associated kinase and a positive regulator of Wnt signalling.

PubMed ID: 11433294

DOI: 10.1038/35083016

PubMed ID: 17573348

Title: Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling.

PubMed ID: 17573348

DOI: 10.1074/jbc.m700590200

PubMed ID: 18492799

Title: Convergent evidence identifying MAP/microtubule affinity-regulating kinase 1 (MARK1) as a susceptibility gene for autism.

PubMed ID: 18492799

DOI: 10.1093/hmg/ddn154

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19559622

Title: The tau of MARK: a polarized view of the cytoskeleton.

PubMed ID: 19559622

DOI: 10.1016/j.tibs.2009.03.008

PubMed ID: 20071654

Title: Structure and function of polarity-inducing kinase family MARK/Par-1 within the branch of AMPK/Snf1-related kinases.

PubMed ID: 20071654

DOI: 10.1096/fj.09-148064

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23666762

Title: Role of individual MARK isoforms in phosphorylation of tau at Ser262 in Alzheimer's disease.

PubMed ID: 23666762

DOI: 10.1007/s12017-013-8232-3

PubMed ID: 16803889

Title: Structural variations in the catalytic and ubiquitin-associated domains of microtubule-associated protein/microtubule affinity regulating kinase (MARK) 1 and MARK2.

PubMed ID: 16803889

DOI: 10.1074/jbc.m604865200

PubMed ID: 21145462

Title: Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids.

PubMed ID: 21145462

DOI: 10.1016/j.cell.2010.11.028

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 795
  • Mass: 89003
  • Checksum: 71BF6EB76912631B
  • Sequence:
    • MSARTPLPTV NERDTENHTS VDGYTEPHIQ PTKSSSRQNI PRCRNSITSA TDEQPHIGNY 
RLQKTIGKGN FAKVKLARHV LTGREVAVKI IDKTQLNPTS LQKLFREVRI MKILNHPNIV 
KLFEVIETEK TLYLVMEYAS GGEVFDYLVA HGRMKEKEAR AKFRQIVSAV QYCHQKYIVH 
RDLKAENLLL DGDMNIKIAD FGFSNEFTVG NKLDTFCGSP PYAAPELFQG KKYDGPEVDV 
WSLGVILYTL VSGSLPFDGQ NLKELRERVL RGKYRIPFYM STDCENLLKK LLVLNPIKRG 
SLEQIMKDRW MNVGHEEEEL KPYTEPDPDF NDTKRIDIMV TMGFARDEIN DALINQKYDE 
VMATYILLGR KPPEFEGGES LSSGNLCQRS RPSSDLNNST LQSPAHLKVQ RSISANQKQR 
RFSDHAGPSI PPAVSYTKRP QANSVESEQK EEWDKDVARK LGSTTVGSKS EMTASPLVGP 
ERKKSSTIPS NNVYSGGSMA RRNTYVCERT TDRYVALQNG KDSSLTEMSV SSISSAGSSV 
ASAVPSARPR HQKSMSTSGH PIKVTLPTIK DGSEAYRPGT TQRVPAASPS AHSISTATPD 
RTRFPRGSSS RSTFHGEQLR ERRSVAYNGP PASPSHETGA FAHARRGTST GIISKITSKF 
VRRDPSEGEA SGRTDTSRST SGEPKERDKE EGKDSKPRSL RFTWSMKTTS SMDPNDMMRE 
IRKVLDANNC DYEQKERFLL FCVHGDARQD SLVQWEMEVC KLPRLSLNGV RFKRISGTSI 
AFKNIASKIA NELKL

Genular Protein ID: 1929603540

Symbol: A0A087X0I6_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A087X0I6

Database IDs:

ARBA 8 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 11 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 3 GeneTree 1 HGNC 1 InterPro 8 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 8 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 6 SAM 1 SMART 2 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 796
  • Mass: 89090
  • Checksum: A188B96E16BB7C32
  • Sequence:
    • MSARTPLPTV NERDTENHTS VDGYTEPHIQ PTKSSSRQNI PRCRNSITSA TDEQPHIGNY 
RLQKTIGKGN FAKVKLARHV LTGREVAVKI IDKTQLNPTS LQKLFREVRI MKILNHPNIV 
KLFEVIETEK TLYLVMEYAS GGEVFDYLVA HGRMKEKEAR AKFRQIVSAV QYCHQKYIVH 
RDLKAENLLL DGDMNIKIAD FGFSNEFTVG NKLDTFCGSP PYAAPELFQG KKYDGPEVDV 
WSLGVILYTL VSGSLPFDGQ NLKELRERVL RGKYRIPFYM STDCENLLKK LLVLNPIKRG 
SLEQIMKDRW MNVGHEEEEL KPYTEPDPDF NDTKRIDIMV TMGFARDEIN DALINQKYDE 
VMATYILLGR KPPEFEGGES LSSGNLCQRS RPSSDLNNST LQSPAHLKVQ RSISANQKQR 
RFSDHAGPSI PPAVSYTKRP QANSVESEQK EEWDKDVARK LGSTTVGSKS EMTASPLVGP 
ERKKSSTIPS NNVYSGGSMA RRNTYVCERT TDRYVALQNG KDSSLTEMSV SSISSAGSSV 
ASAVPSARPR HQKSMSTSGH PIKVTLPTIK DGSEAYRPGS TTQRVPAASP SAHSISTATP 
DRTRFPRGSS SRSTFHGEQL RERRSVAYNG PPASPSHETG AFAHARRGTS TGIISKITSK 
FVRRDPSEGE ASGRTDTSRS TSGEPKERDK EEGKDSKPRS LRFTWSMKTT SSMDPNDMMR 
EIRKVLDANN CDYEQKERFL LFCVHGDARQ DSLVQWEMEV CKLPRLSLNG VRFKRISGTS 
IAFKNIASKI ANELKL

Genular Protein ID: 2209628026

Symbol: B4DIB3_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DIB3

Database IDs:

ARBA 8 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 11 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 6 Ensembl 2 GO 3 Gene3D 3 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 8 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 1 RefSeq 1 Rhea 6 SAM 1 SMART 2 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.M800588-MCP200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 780
  • Mass: 87456
  • Checksum: BD23F5B6AA3EF287
  • Sequence:
    • MSARTPLPTV NERDTENHTS VDGYTEPHIQ PTKSSSRQNI PRCRNSITSA TDEQPHIGNY 
RLQKTIGKGN FAKVKLARHV LTGREVAVKI IDKTQLNPTS LQKLFREVRI MKILNHPNIV 
KLFEVIETEK TLYLVMEYAS GGEVFDYLVA HGRMKEKEAR AKFRQIVSAV QYCHQKYIVH 
RDLKAENLLL DGDMNIKIAD FGFSNEFTVG NKLDTFCGSP PYAAPELFQG KKYDGPEVDV 
WSLGVILYTL VSGSLPFDGQ NLKELRERVL RGKYRIPFYM STDCENLLKK LLVLNPIKRG 
SLEQIMKDRW MNVGHEEEEL KPYTEPDPDF NDTKRIDIMV TMGFARDEIN DALINQKYDE 
VMATYILLGR KPPEFEGGES LSSGNLCQRS RPSSDLNNST LQSPAHLKVQ RSISANQKQR 
RFSDHAGPSI PPAVSYTKRP QANSVESEQK EEWDKDVARK LGSTTVGSKS EMTASPLVGP 
ERKKSSTIPS NNVYSGGSMA RRNTYVCERT TDRYVALQNG KDSSLTEMSV SSISSAGSSV 
ASAVPSARPR HQKSMSTSGH PIKVTLPTIK DGSEAYRPGT TQRVPAASPS AHSISTATPD 
RTRFPRGSSS RSTFHGEQLR ERRSVAYNGP PASPSHETGA FAHARRGTST GIISKITSKF 
VRRSTSGEPK ERDKEEGKDS KPRSLRFTWS MKTTSSMDPN DMMREIRKVL DANNCDYEQK 
ERFLLFCVHG DARQDSLVQW EMEVCKLPRL SLNGVRFKRI SGTSIAFKNI ASKIANELKL

Genular Protein ID: 3596250173

Symbol: X5D2M4_HUMAN

Name: N/A

UniProtKB Accession Codes:

X5D2M4

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChEBI 11 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 2 EMBL 2 GO 8 Gene3D 3 IntAct 1 InterPro 8 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 8 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 RefSeq 1 Rhea 6 SAM 1 SMART 2 SMR 1 SUPFAM 2

Citations:

PubMed ID: 24722188

Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

PubMed ID: 24722188

Sequence Information:

  • Length: 781
  • Mass: 87543
  • Checksum: 49588B5E16028889
  • Sequence:
    • MSARTPLPTV NERDTENHTS VDGYTEPHIQ PTKSSSRQNI PRCRNSITSA TDEQPHIGNY 
RLQKTIGKGN FAKVKLARHV LTGREVAVKI IDKTQLNPTS LQKLFREVRI MKILNHPNIV 
KLFEVIETEK TLYLVMEYAS GGEVFDYLVA HGRMKEKEAR AKFRQIVSAV QYCHQKYIVH 
RDLKAENLLL DGDMNIKIAD FGFSNEFTVG NKLDTFCGSP PYAAPELFQG KKYDGPEVDV 
WSLGVILYTL VSGSLPFDGQ NLKELRERVL RGKYRIPFYM STDCENLLKK LLVLNPIKRG 
SLEQIMKDRW MNVGHEEEEL KPYTEPDPDF NDTKRIDIMV TMGFARDEIN DALINQKYDE 
VMATYILLGR KPPEFEGGES LSSGNLCQRS RPSSDLNNST LQSPAHLKVQ RSISANQKQR 
RFSDHAGPSI PPAVSYTKRP QANSVESEQK EEWDKDVARK LGSTTVGSKS EMTASPLVGP 
ERKKSSTIPS NNVYSGGSMA RRNTYVCERT TDRYVALQNG KDSSLTEMSV SSISSAGSSV 
ASAVPSARPR HQKSMSTSGH PIKVTLPTIK DGSEAYRPGS TTQRVPAASP SAHSISTATP 
DRTRFPRGSS SRSTFHGEQL RERRSVAYNG PPASPSHETG AFAHARRGTS TGIISKITSK 
FVRRSTSGEP KERDKEEGKD SKPRSLRFTW SMKTTSSMDP NDMMREIRKV LDANNCDYEQ 
KERFLLFCVH GDARQDSLVQ WEMEVCKLPR LSLNGVRFKR ISGTSIAFKN IASKIANELK 
L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.