Details for: MBP

Gene ID: 4155

Symbol: MBP

Ensembl ID: ENSG00000197971

Description: myelin basic protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 351.2805
    Cell Significance Index: -54.6400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 206.0373
    Cell Significance Index: -52.2600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 128.9331
    Cell Significance Index: -52.3800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 111.2979
    Cell Significance Index: -57.2500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 54.9153
    Cell Significance Index: -52.4300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 46.3115
    Cell Significance Index: -57.1000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 23.2007
    Cell Significance Index: -71.2600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 21.6761
    Cell Significance Index: -47.4400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 17.6232
    Cell Significance Index: -47.2100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.1975
    Cell Significance Index: -59.9700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.4974
    Cell Significance Index: 407.5800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.1601
    Cell Significance Index: 388.5700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.4786
    Cell Significance Index: 446.8200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.6481
    Cell Significance Index: 179.2600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4722
    Cell Significance Index: 94.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.3664
    Cell Significance Index: 274.0900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.3461
    Cell Significance Index: 31.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.2423
    Cell Significance Index: 678.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9752
    Cell Significance Index: 193.5300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.9159
    Cell Significance Index: 24.9300
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.8529
    Cell Significance Index: 20.8100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8313
    Cell Significance Index: 55.9000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.8039
    Cell Significance Index: 15.6900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.7991
    Cell Significance Index: 55.2700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7315
    Cell Significance Index: 13.5200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.7064
    Cell Significance Index: 253.3800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.7020
    Cell Significance Index: 1321.7500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6737
    Cell Significance Index: 35.0000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6655
    Cell Significance Index: 19.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6075
    Cell Significance Index: 46.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5791
    Cell Significance Index: 26.2500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5329
    Cell Significance Index: 25.0500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4686
    Cell Significance Index: 46.3600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4591
    Cell Significance Index: 291.5800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.4197
    Cell Significance Index: 11.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4129
    Cell Significance Index: 25.3800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3309
    Cell Significance Index: 298.7700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2828
    Cell Significance Index: 14.2900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2728
    Cell Significance Index: 5.9100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2132
    Cell Significance Index: 6.2600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2031
    Cell Significance Index: 38.6600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1944
    Cell Significance Index: 264.3400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1787
    Cell Significance Index: 79.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1660
    Cell Significance Index: 19.5800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.1371
    Cell Significance Index: 1.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0919
    Cell Significance Index: 14.9500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0892
    Cell Significance Index: 3.1400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0807
    Cell Significance Index: 55.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0693
    Cell Significance Index: 11.8300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0371
    Cell Significance Index: 57.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0157
    Cell Significance Index: -11.6400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0159
    Cell Significance Index: -29.3500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0312
    Cell Significance Index: -22.9100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0393
    Cell Significance Index: -29.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0541
    Cell Significance Index: -33.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0681
    Cell Significance Index: -30.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0703
    Cell Significance Index: -39.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0740
    Cell Significance Index: -9.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1027
    Cell Significance Index: -10.4900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1158
    Cell Significance Index: -3.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1459
    Cell Significance Index: -30.7300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1529
    Cell Significance Index: -7.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1820
    Cell Significance Index: -26.4500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1861
    Cell Significance Index: -53.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1909
    Cell Significance Index: -26.2100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2279
    Cell Significance Index: -26.1100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2463
    Cell Significance Index: -5.2500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.3540
    Cell Significance Index: -3.2600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3874
    Cell Significance Index: -6.5300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3958
    Cell Significance Index: -45.1800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4430
    Cell Significance Index: -9.1900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4462
    Cell Significance Index: -28.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.4474
    Cell Significance Index: -57.3600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4515
    Cell Significance Index: -6.1600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4805
    Cell Significance Index: -50.0300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5066
    Cell Significance Index: -35.8300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5360
    Cell Significance Index: -39.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6136
    Cell Significance Index: -48.6000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.6568
    Cell Significance Index: -17.5700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7891
    Cell Significance Index: -20.1600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.8584
    Cell Significance Index: -12.6700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.9043
    Cell Significance Index: -19.8000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.9152
    Cell Significance Index: -21.9500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.9155
    Cell Significance Index: -19.5700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.9345
    Cell Significance Index: -29.9300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.9498
    Cell Significance Index: -58.2300
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.9848
    Cell Significance Index: -15.8900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.0014
    Cell Significance Index: -52.1600
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -1.0142
    Cell Significance Index: -8.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.0799
    Cell Significance Index: -60.6000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.1123
    Cell Significance Index: -58.4000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -1.2047
    Cell Significance Index: -17.3000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.2489
    Cell Significance Index: -55.2400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.2740
    Cell Significance Index: -36.5200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.2976
    Cell Significance Index: -27.5400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.3016
    Cell Significance Index: -47.7800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -1.3681
    Cell Significance Index: -43.2700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.4122
    Cell Significance Index: -35.3000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.4187
    Cell Significance Index: -49.3000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.4810
    Cell Significance Index: -56.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MBP is a small, hydrophobic protein that is expressed in oligodendrocytes, the cells responsible for myelinating axons in the CNS. It is composed of four alpha-helical domains that are arranged in a specific sequence, allowing for specific interactions with other proteins and lipids. MBP is highly conserved across species, suggesting its importance in maintaining the structural and functional integrity of myelinated axons. **Pathways and Functions:** MBP is involved in various cellular processes, including: 1. **Axon ensheathment:** MBP plays a crucial role in the formation of the myelin sheath, where it interacts with other proteins and lipids to maintain the structural integrity of the myelin membrane. 2. **Cell surface interactions:** MBP is involved in cell-cell interactions, including negative regulation of heterotypic cell-cell adhesion, which is essential for maintaining the integrity of the blood-brain barrier. 3. **Immune responses:** MBP is recognized by the immune system as a self-protein, and its expression is upregulated in response to immune activation. This suggests that MBP may play a role in regulating immune responses in the CNS. 4. **Neurotransmission:** MBP is involved in the regulation of neurotransmitter release, including the regulation of chemokine (C-X-C motif) ligand 2 (CXCL2) production, which is essential for synaptic transmission. **Clinical Significance:** Dysregulation of MBP expression has been implicated in various neurological disorders, including: 1. **Multiple sclerosis:** MBP is a target for immunotherapeutic interventions in multiple sclerosis, a chronic autoimmune disease characterized by demyelination and axonal damage. 2. **Neurodegenerative diseases:** MBP has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and amyotrophic lateral sclerosis, where dysregulation of MBP expression is thought to contribute to neuronal damage and death. 3. **Myelin disorders:** MBP is essential for maintaining the structural integrity of the myelin sheath, and dysregulation of MBP expression can lead to myelin disorders, including demyelinating diseases. In conclusion, MBP is a multifaceted protein that plays a critical role in maintaining the structural and functional integrity of myelinated axons in the CNS. Its dysregulation has been implicated in various neurological disorders, highlighting the importance of MBP as a therapeutic target for the treatment of CNS diseases.

Genular Protein ID: 2976375321

Symbol: MBP_HUMAN

Name: Myelin basic protein

UniProtKB Accession Codes:

P02686 A4FU54 A6NI84 A8MY86 A8MYL4 B3KY66 B7ZKS2 B7ZKS4 Q15337 Q15338 Q15339 Q15340 Q59GX3 Q65ZS4 Q6AI64 Q6FH37 Q6FI04 Q6PK23

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DisProt 2 EMBL 32 Ensembl 8 EvolutionaryTrace 1 ExpressionAtlas 1 GO 30 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 2 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 Reactome 1 RefSeq 7 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 4108501

Title: Amino acid sequence of the encephalitogenic basic protein from human myelin.

PubMed ID: 4108501

DOI: 10.1042/bj1230057

PubMed ID: 2427738

Title: Isolation and characterization of a cDNA coding for a novel human 17.3K myelin basic protein (MBP) variant.

PubMed ID: 2427738

DOI: 10.1002/jnr.490160120

PubMed ID: 2425357

Title: Identification of three forms of human myelin basic protein by cDNA cloning.

PubMed ID: 2425357

DOI: 10.1073/pnas.83.13.4962

PubMed ID: 2442403

Title: Evidence for the expression of four myelin basic protein variants in the developing human spinal cord through cDNA cloning.

PubMed ID: 2442403

DOI: 10.1002/jnr.490170402

PubMed ID: 2472816

Title: The organization of the human myelin basic protein gene. Comparison with the mouse gene.

PubMed ID: 2472816

DOI: 10.1515/bchm3.1989.370.1.503

PubMed ID: 7504278

Title: The human myelin basic protein gene is included within a 179-kilobase transcription unit: expression in the immune and central nervous systems.

PubMed ID: 7504278

DOI: 10.1073/pnas.90.22.10695

PubMed ID: 8544862

Title: Purification of immunologically active recombinant 21.5 kDa isoform of human myelin basic protein.

PubMed ID: 8544862

DOI: 10.1016/0161-5890(95)00066-6

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1689270

Title: Repetitive DNA (TGGA)n 5' to the human myelin basic protein gene: a new form of oligonucleotide repetitive sequence showing length polymorphism.

PubMed ID: 1689270

DOI: 10.1016/0888-7543(90)90443-x

PubMed ID: 2426402

Title: Analysis of the primary sequence of human myelin basic protein peptides 1-44 and 90-170 by fast atom bombardment mass spectrometry.

PubMed ID: 2426402

DOI: 10.1111/j.1471-4159.1986.tb04544.x

PubMed ID: 2466844

Title: The isolation, characterization, and lipid-aggregating properties of a citrulline containing myelin basic protein.

PubMed ID: 2466844

DOI: 10.1016/s0021-9258(18)83707-3

PubMed ID: 7574672

Title: The isolation and characterization of four myelin basic proteins from the unbound fraction during CM52 chromatography.

PubMed ID: 7574672

DOI: 10.1006/abbi.1995.1449

PubMed ID: 6201481

Title: Amino acid sequence of human myelin basic protein peptide 45-89 as determined by mass spectrometry.

PubMed ID: 6201481

DOI: 10.1016/s0021-9258(17)42950-4

PubMed ID: 4099924

Title: Immunologic properties of the main encephalitogenic peptide from the basic protein of human myelin.

PubMed ID: 4099924

PubMed ID: 7685161

Title: Leukocyte gelatinase B cleavage releases encephalitogens from human myelin basic protein.

PubMed ID: 7685161

DOI: 10.1006/bbrc.1993.1540

PubMed ID: 5128665

Title: Isolation and partial characterization of methylated arginines from the encephalitogenic basic protein of myelin.

PubMed ID: 5128665

DOI: 10.1042/bj1230069

PubMed ID: 9430721

Title: Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6.

PubMed ID: 9430721

DOI: 10.1074/jbc.273.3.1741

PubMed ID: 10880969

Title: Specific Ser-Pro phosphorylation by the RNA-recognition motif containing kinase KIS.

PubMed ID: 10880969

DOI: 10.1046/j.1432-1327.2000.01493.x

PubMed ID: 10660600

Title: PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the JNK MAPK pathway and regulates actin cytoskeletal organisation.

PubMed ID: 10660600

DOI: 10.1074/jbc.275.6.4311

PubMed ID: 15100291

Title: Cathepsin G, and not the asparagine-specific endoprotease, controls the processing of myelin basic protein in lysosomes from human B lymphocytes.

PubMed ID: 15100291

DOI: 10.4049/jimmunol.172.9.5495

PubMed ID: 16337592

Title: Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells.

PubMed ID: 16337592

DOI: 10.1016/j.molcel.2005.10.038

PubMed ID: 16704422

Title: The subcellular localization of vaccinia-related kinase-2 (VRK2) isoforms determines their different effect on p53 stability in tumour cell lines.

PubMed ID: 16704422

DOI: 10.1111/j.1742-4658.2006.05256.x

PubMed ID: 17158878

Title: Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK- and caspase-dependent nuclear localization is a requirement for membrane blebbing.

PubMed ID: 17158878

DOI: 10.1074/jbc.m608336200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 22609403

Title: The 21.5-kDa isoform of myelin basic protein has a non-traditional PY-nuclear-localization signal.

PubMed ID: 22609403

DOI: 10.1016/j.bbrc.2012.05.051

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23828821

Title: Identification and Characterization of citrulline-modified brain proteins by combining HCD and CID fragmentation.

PubMed ID: 23828821

DOI: 10.1002/pmic.201300064

PubMed ID: 7544282

Title: Conformation of a tetradecapeptide epitope of myelin basic protein.

PubMed ID: 7544282

DOI: 10.1111/j.1432-1033.1995.tb20745.x

PubMed ID: 9020143

Title: Three-dimensional structure of myelin basic protein. II. Molecular modeling and considerations of predicted structures in multiple sclerosis.

PubMed ID: 9020143

DOI: 10.1074/jbc.272.7.4269

PubMed ID: 11080454

Title: Structural basis for the binding of an immunodominant peptide from myelin basic protein in different registers by two HLA-DR2 proteins.

PubMed ID: 11080454

DOI: 10.1006/jmbi.2000.4198

PubMed ID: 11163233

Title: Crystal structure of a superantigen bound to the high-affinity, zinc-dependent site on MHC class II.

PubMed ID: 11163233

DOI: 10.1016/s1074-7613(01)00092-9

PubMed ID: 16079912

Title: Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule.

PubMed ID: 16079912

DOI: 10.1038/sj.emboj.7600771

Sequence Information:

  • Length: 304
  • Mass: 33117
  • Checksum: 4AD7305C1D5434C4
  • Sequence:
    • MGNHAGKREL NAEKASTNSE TNRGESEKKR NLGELSRTTS EDNEVFGEAD ANQNNGTSSQ 
DTAVTDSKRT ADPKNAWQDA HPADPGSRPH LIRLFSRDAP GREDNTFKDR PSESDELQTI 
QEDSAATSES LDVMASQKRP SQRHGSKYLA TASTMDHARH GFLPRHRDTG ILDSIGRFFG 
GDRGAPKRGS GKDSHHPART AHYGSLPQKS HGRTQDENPV VHFFKNIVTP RTPPPSQGKG 
RGLSLSRFSW GAEGQRPGFG YGGRASDYKS AHKGFKGVDA QGTLSKIFKL GGRDSRSGSP 
MARR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.