Details for: MCC

Gene ID: 4163

Symbol: MCC

Ensembl ID: ENSG00000171444

Description: MCC regulator of WNT signaling pathway

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 282.2973
    Cell Significance Index: -43.9100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 173.6296
    Cell Significance Index: -44.0400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 116.9627
    Cell Significance Index: -48.1800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 92.6666
    Cell Significance Index: -43.7500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 85.9923
    Cell Significance Index: -34.9400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.6217
    Cell Significance Index: -43.9200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.9546
    Cell Significance Index: -42.7400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.8550
    Cell Significance Index: -34.7000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.1453
    Cell Significance Index: -43.9800
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 10.6729
    Cell Significance Index: 94.7400
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 4.6972
    Cell Significance Index: 28.9800
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 4.3511
    Cell Significance Index: 62.5800
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 3.3513
    Cell Significance Index: 71.6400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 3.1297
    Cell Significance Index: 42.7000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.9126
    Cell Significance Index: 22.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.6934
    Cell Significance Index: 75.2700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.1772
    Cell Significance Index: 780.9100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.0531
    Cell Significance Index: 40.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.7895
    Cell Significance Index: 137.3200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.6064
    Cell Significance Index: 27.0600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.5117
    Cell Significance Index: 84.8300
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: 1.2911
    Cell Significance Index: 12.9200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.2680
    Cell Significance Index: 27.7700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9680
    Cell Significance Index: 119.0300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.9419
    Cell Significance Index: 651.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7739
    Cell Significance Index: 40.2000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7367
    Cell Significance Index: 33.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6949
    Cell Significance Index: 95.4300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6215
    Cell Significance Index: 112.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5651
    Cell Significance Index: 112.1500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5322
    Cell Significance Index: 101.2800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.4423
    Cell Significance Index: 6.5300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3670
    Cell Significance Index: 331.4100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3631
    Cell Significance Index: 683.7600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3141
    Cell Significance Index: 8.5500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3065
    Cell Significance Index: 61.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.3059
    Cell Significance Index: 415.9300
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.2983
    Cell Significance Index: 4.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2922
    Cell Significance Index: 17.9600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2518
    Cell Significance Index: 24.9100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.2382
    Cell Significance Index: 3.4200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.2281
    Cell Significance Index: 15.3400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2089
    Cell Significance Index: 92.3400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1491
    Cell Significance Index: 67.6600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1403
    Cell Significance Index: 215.9700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0858
    Cell Significance Index: 13.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0749
    Cell Significance Index: 138.1100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0722
    Cell Significance Index: 3.7600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0714
    Cell Significance Index: 2.5100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0649
    Cell Significance Index: 41.2400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0583
    Cell Significance Index: 7.4700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.0179
    Cell Significance Index: 0.4600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0037
    Cell Significance Index: -0.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0130
    Cell Significance Index: -8.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0212
    Cell Significance Index: -15.7200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0471
    Cell Significance Index: -26.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0492
    Cell Significance Index: -36.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0582
    Cell Significance Index: -31.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0621
    Cell Significance Index: -47.0100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0627
    Cell Significance Index: -1.7900
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0651
    Cell Significance Index: -0.9100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0684
    Cell Significance Index: -1.9700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0688
    Cell Significance Index: -1.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0698
    Cell Significance Index: -4.2800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0828
    Cell Significance Index: -17.4500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0950
    Cell Significance Index: -2.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1034
    Cell Significance Index: -17.6500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1074
    Cell Significance Index: -1.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1092
    Cell Significance Index: -11.8800
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.1230
    Cell Significance Index: -1.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1286
    Cell Significance Index: -37.0000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.1304
    Cell Significance Index: -1.6700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1395
    Cell Significance Index: -7.0500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1477
    Cell Significance Index: -2.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1675
    Cell Significance Index: -19.1900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1713
    Cell Significance Index: -3.4400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1845
    Cell Significance Index: -3.1900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2168
    Cell Significance Index: -10.1900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2172
    Cell Significance Index: -4.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2205
    Cell Significance Index: -25.7000
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.2209
    Cell Significance Index: -3.3600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2278
    Cell Significance Index: -16.1100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2486
    Cell Significance Index: -4.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2549
    Cell Significance Index: -26.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2553
    Cell Significance Index: -32.9800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2751
    Cell Significance Index: -3.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2808
    Cell Significance Index: -13.0900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2969
    Cell Significance Index: -30.9100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3242
    Cell Significance Index: -22.4200
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3482
    Cell Significance Index: -39.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3562
    Cell Significance Index: -42.0100
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.4018
    Cell Significance Index: -4.8700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.4715
    Cell Significance Index: -35.1400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4782
    Cell Significance Index: -15.2300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4836
    Cell Significance Index: -29.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4841
    Cell Significance Index: -38.3400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5368
    Cell Significance Index: -11.6300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5711
    Cell Significance Index: -18.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6049
    Cell Significance Index: -31.7600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6115
    Cell Significance Index: -16.0800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Negative Regulation of WNT Signaling:** MCC acts as a negative regulator of the canonical WNT signaling pathway, which is characterized by the activation of β-catenin-mediated transcription. 2. **Cellular Localization:** MCC is primarily localized to the nucleus and cytosol, where it interacts with key components of the WNT signaling pathway, including β-catenin and GSK3β. 3. **Tissue-Specific Expression:** MCC is significantly expressed in basal epithelial cells of the prostate, interneurons, photoreceptor cells, and astrocytes of the cerebral cortex, among other cell types. 4. **Protein-Protein Interactions:** MCC interacts with several proteins, including CRCM_HUMAN (Colorectal mutant cancer protein), which may contribute to its regulatory function. **Pathways and Functions:** 1. **WNT Signaling Pathway:** MCC negatively regulates the canonical WNT signaling pathway, which is involved in cell proliferation, differentiation, and migration. 2. **Epithelial Cell Migration and Proliferation:** MCC's negative regulation of WNT signaling may also impact epithelial cell migration and proliferation, which are critical processes in tissue development and homeostasis. 3. **Neurological Function:** MCC's expression in interneurons and astrocytes of the cerebral cortex suggests its involvement in neurological function and potentially in neurological disorders. **Clinical Significance:** 1. **Cancer:** Disruption of MCC's negative regulation of WNT signaling has been implicated in various cancers, including colorectal cancer, where CRCM_HUMAN has been identified as a key player. 2. **Neurological Disorders:** MCC's expression in interneurons and astrocytes of the cerebral cortex may contribute to its role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Prostate Cancer:** MCC's significant expression in basal epithelial cells of the prostate may contribute to its role in prostate cancer development and progression. 4. **Therapeutic Potential:** Targeting MCC's regulatory function may provide a novel therapeutic strategy for treating cancers and neurological disorders associated with WNT signaling dysregulation. In conclusion, MCC is a critical regulator of the WNT signaling pathway, and its dysregulation has been implicated in various disease states, including cancer and neurological disorders. Further research is needed to fully elucidate MCC's role in these processes and to explore its therapeutic potential.

Genular Protein ID: 1292916211

Symbol: CRCM_HUMAN

Name: Colorectal mutant cancer protein

UniProtKB Accession Codes:

P23508 D3DT05 Q6ZR04

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1848370

Title: Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers.

PubMed ID: 1848370

DOI: 10.1126/science.1848370

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 18591935

Title: Mutated in colorectal cancer, a putative tumor suppressor for serrated colorectal cancer, selectively represses beta-catenin-dependent transcription.

PubMed ID: 18591935

DOI: 10.1038/onc.2008.204

PubMed ID: 19555689

Title: MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells.

PubMed ID: 19555689

DOI: 10.1016/j.febslet.2009.06.034

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 22480440

Title: The PDZ-binding motif of MCC is phosphorylated at position -1 and controls lamellipodia formation in colon epithelial cells.

PubMed ID: 22480440

DOI: 10.1016/j.bbamcr.2012.03.011

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 1651563

Title: Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients.

PubMed ID: 1651563

DOI: 10.1126/science.1651563

PubMed ID: 24824780

Title: MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm.

PubMed ID: 24824780

DOI: 10.1002/ijc.28967

PubMed ID: 27932480

Title: MAGI2 mutations cause congenital nephrotic syndrome.

PubMed ID: 27932480

DOI: 10.1681/asn.2016040387

Sequence Information:

  • Length: 829
  • Mass: 93027
  • Checksum: C90611B2E91A7F60
  • Sequence:
    • MNSGVAMKYG NDSSAELSEL HSAALASLKG DIVELNKRLQ QTERERDLLE KKLAKAQCEQ 
SHLMREHEDV QERTTLRYEE RITELHSVIA ELNKKIDRLQ GTTIREEDEY SELRSELSQS 
QHEVNEDSRS MDQDQTSVSI PENQSTMVTA DMDNCSDLNS ELQRVLTGLE NVVCGRKKSS 
CSLSVAEVDK HIEQLTTASE HCDLAIKTVE EIEGVLGRDL YPNLAEERSR WEKELAGLRE 
ENESLTAMLC SKEEELNRTK ATMNAIREER DRLRRRVREL QTRLQSVQAT GPSSPGRLTS 
TNRPINPSTG ELSTSSSSND IPIAKIAERV KLSKTRSESS SSDRPVLGSE ISSIGVSSSV 
AEHLAHSLQD CSNIQEIFQT LYSHGSAISE SKIREFEVET ERLNSRIEHL KSQNDLLTIT 
LEECKSNAER MSMLVGKYES NATALRLALQ YSEQCIEAYE LLLALAESEQ SLILGQFRAA 
GVGSSPGDQS GDENITQMLK RAHDCRKTAE NAAKALLMKL DGSCGGAFAV AGCSVQPWES 
LSSNSHTSTT SSTASSCDTE FTKEDEQRLK DYIQQLKNDR AAVKLTMLEL ESIHIDPLSY 
DVKPRGDSQR LDLENAVLMQ ELMAMKEEMA ELKAQLYLLE KEKKALELKL STREAQEQAY 
LVHIEHLKSE VEEQKEQRMR SLSSTSSGSK DKPGKECADA ASPALSLAEL RTTCSENELA 
AEFTNAIRRE KKLKARVQEL VSALERLTKS SEIRHQQSAE FVNDLKRANS NLVAAYEKAK 
KKHQNKLKKL ESQMMAMVER HETQVRMLKQ RIALLEEENS RPHTNETSL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.