Details for: MCM2

Gene ID: 4171

Symbol: MCM2

Ensembl ID: ENSG00000073111

Description: minichromosome maintenance complex component 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 17.1812
    Cell Significance Index: -6.9800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 14.6465
    Cell Significance Index: -3.7200
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 12.8457
    Cell Significance Index: 5.8500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.2313
    Cell Significance Index: -6.4500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 2.8520
    Cell Significance Index: -7.6400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.0967
    Cell Significance Index: -6.4400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.9779
    Cell Significance Index: -7.8100
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.8721
    Cell Significance Index: 12.4200
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 1.8203
    Cell Significance Index: 11.6200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6825
    Cell Significance Index: 166.4400
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.4264
    Cell Significance Index: 10.7700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.3365
    Cell Significance Index: 14.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.2892
    Cell Significance Index: 34.4900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1995
    Cell Significance Index: 72.0100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.1249
    Cell Significance Index: 39.0900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.0834
    Cell Significance Index: 31.9100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9264
    Cell Significance Index: 100.7700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8625
    Cell Significance Index: 101.7200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.8108
    Cell Significance Index: 13.5700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.7916
    Cell Significance Index: 6.3200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7807
    Cell Significance Index: 126.9800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4180
    Cell Significance Index: 8.7500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4097
    Cell Significance Index: 10.9400
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.3968
    Cell Significance Index: 1.9300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.3475
    Cell Significance Index: 4.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3400
    Cell Significance Index: 10.8900
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.3102
    Cell Significance Index: 2.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2980
    Cell Significance Index: 16.7200
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.2903
    Cell Significance Index: 1.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2883
    Cell Significance Index: 18.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2842
    Cell Significance Index: 33.1200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2761
    Cell Significance Index: 54.8000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2517
    Cell Significance Index: 17.4100
  • Cell Name: glioblast (CL0000030)
    Fold Change: 0.1911
    Cell Significance Index: 1.2000
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.1561
    Cell Significance Index: 2.1900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1548
    Cell Significance Index: 4.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1266
    Cell Significance Index: 69.1400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1261
    Cell Significance Index: 55.7700
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.1148
    Cell Significance Index: 0.7100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1128
    Cell Significance Index: 3.2500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1028
    Cell Significance Index: 2.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1012
    Cell Significance Index: 19.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0786
    Cell Significance Index: 1.9700
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.0769
    Cell Significance Index: 0.7300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0700
    Cell Significance Index: 1.8800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0611
    Cell Significance Index: 55.1800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0518
    Cell Significance Index: 1.4500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0471
    Cell Significance Index: 1.0200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0398
    Cell Significance Index: 4.8900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0326
    Cell Significance Index: 1.7000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0270
    Cell Significance Index: 3.7100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0269
    Cell Significance Index: 1.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0168
    Cell Significance Index: 1.0600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0127
    Cell Significance Index: 0.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0123
    Cell Significance Index: 2.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0123
    Cell Significance Index: 0.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0045
    Cell Significance Index: 0.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0004
    Cell Significance Index: 0.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0004
    Cell Significance Index: -0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0022
    Cell Significance Index: -4.1300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0023
    Cell Significance Index: -1.5700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0027
    Cell Significance Index: -0.0700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0029
    Cell Significance Index: -0.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0049
    Cell Significance Index: -3.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0052
    Cell Significance Index: -9.5700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0066
    Cell Significance Index: -10.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0082
    Cell Significance Index: -11.1600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0089
    Cell Significance Index: -6.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0104
    Cell Significance Index: -6.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0114
    Cell Significance Index: -8.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0129
    Cell Significance Index: -8.0300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.0133
    Cell Significance Index: -0.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0149
    Cell Significance Index: -8.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0170
    Cell Significance Index: -7.7200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0212
    Cell Significance Index: -2.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0218
    Cell Significance Index: -2.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0229
    Cell Significance Index: -6.5800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0262
    Cell Significance Index: -0.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0329
    Cell Significance Index: -5.6200
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0404
    Cell Significance Index: -0.2400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0428
    Cell Significance Index: -9.0100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0462
    Cell Significance Index: -6.7200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0474
    Cell Significance Index: -5.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0621
    Cell Significance Index: -3.8100
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.0623
    Cell Significance Index: -0.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0692
    Cell Significance Index: -3.6400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0732
    Cell Significance Index: -7.6200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0747
    Cell Significance Index: -1.0700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0814
    Cell Significance Index: -6.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0869
    Cell Significance Index: -5.3400
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0879
    Cell Significance Index: -0.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0880
    Cell Significance Index: -4.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0897
    Cell Significance Index: -4.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0919
    Cell Significance Index: -7.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0980
    Cell Significance Index: -7.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1034
    Cell Significance Index: -6.9500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1266
    Cell Significance Index: -1.6000
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: -0.1360
    Cell Significance Index: -1.1300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1543
    Cell Significance Index: -3.2000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1744
    Cell Significance Index: -2.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MCM2 is a highly conserved protein that belongs to the minichromosome maintenance family of proteins. It is characterized by its ability to bind to single-stranded DNA, unwind DNA, and form the pre-replicative complex. MCM2 is also involved in the regulation of the cell cycle, particularly during the G1/S transition and the G2/M checkpoint. The gene is highly expressed in cells that undergo rapid proliferation, such as those found in hematopoiesis, placental development, and oogenesis. **Pathways and Functions:** MCM2 is involved in several critical pathways, including: 1. **DNA Replication Initiation:** MCM2 forms the pre-replicative complex, which is essential for the unwinding of DNA and the initiation of DNA replication. 2. **Cell Cycle Regulation:** MCM2 is involved in the regulation of the G1/S transition and the G2/M checkpoint, ensuring that DNA replication occurs only once per cell cycle. 3. **DNA Unwinding:** MCM2 unwinds DNA, creating a replication fork that allows the replication machinery to access the DNA template. 4. **Single-Stranded DNA Binding:** MCM2 binds to single-stranded DNA, stabilizing it and preventing degradation. **Clinical Significance:** Dysregulation of the MCM2 gene has been implicated in various diseases, including: 1. **Cancer:** Overexpression of MCM2 has been observed in several types of cancer, including leukemia, lymphoma, and breast cancer. 2. **Neurodegenerative Diseases:** MCM2 has been implicated in neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. 3. **Reproductive Diseases:** MCM2 is essential for oogenesis, and dysregulation of the gene has been implicated in infertility and reproductive abnormalities. In conclusion, the MCM2 gene plays a critical role in DNA replication, cell cycle regulation, and the maintenance of genome stability. Dysregulation of the gene has been implicated in various diseases, highlighting the importance of understanding its function and regulation. **Significantly Expressed Cells:** The MCM2 gene is highly expressed in cells that undergo rapid proliferation, including: 1. **Early Promyelocyte:** A stage of hematopoiesis characterized by rapid cell division. 2. **Extravillous Trophoblast:** A type of placental cell involved in implantation and placental development. 3. **Placental Villous Trophoblast:** A type of placental cell involved in placental development and function. 4. **Late Promyelocyte:** A stage of hematopoiesis characterized by rapid cell division. 5. **Primitive Red Blood Cell:** A type of red blood cell involved in oxygen transport. 6. **Large Pre-B-II Cell:** A stage of B cell development. 7. **Oogonial Cell:** A type of female germ cell involved in oogenesis. 8. **Fraction A Pre-Pro B Cell:** A stage of B cell development. 9. **Pro-T Cell:** A stage of T cell development. 10. **Mesenchymal Cell:** A type of stem cell involved in tissue development and repair. **Proteins:** The MCM2 gene encodes for the Minichromosome Maintenance Protein 2 (MCM2), a highly conserved protein that plays a critical role in DNA replication and cell cycle regulation.

Genular Protein ID: 3396235385

Symbol: MCM2_HUMAN

Name: Minichromosome maintenance protein 2 homolog

UniProtKB Accession Codes:

P49736 Q14577 Q15023 Q8N2V1 Q969W7 Q96AE1 Q9BRM7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CPTAC 1 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 EC 1 ELM 1 EMBL 12 EMDB 6 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 27 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 18 PDBsum 18 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 5 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 1 Rhea 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8175912

Title: A human nuclear protein with sequence homology to a family of early S phase proteins is required for entry into S phase and for cell division.

PubMed ID: 8175912

DOI: 10.1242/jcs.107.1.253

PubMed ID: 7584026

Title: Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1.

PubMed ID: 7584026

DOI: 10.1093/dnares/1.1.27

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8258304

Title: The human gene for nuclear protein BM28 (CDCL1), a new member of the early S-phase family of proteins, maps to chromosome band 3q21.

PubMed ID: 8258304

DOI: 10.1159/000133647

PubMed ID: 9305914

Title: A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.

PubMed ID: 9305914

DOI: 10.1074/jbc.272.39.24508

PubMed ID: 11095689

Title: The human homolog of Saccharomyces cerevisiae Mcm10 interacts with replication factors and dissociates from nuclease-resistant nuclear structures in G(2) phase.

PubMed ID: 11095689

DOI: 10.1093/nar/28.23.4769

PubMed ID: 15210935

Title: Minichromosome maintenance proteins are direct targets of the ATM and ATR checkpoint kinases.

PubMed ID: 15210935

DOI: 10.1073/pnas.0403410101

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16899510

Title: Essential role of phosphorylation of MCM2 by Cdc7/Dbf4 in the initiation of DNA replication in mammalian cells.

PubMed ID: 16899510

DOI: 10.1091/mbc.e06-03-0241

PubMed ID: 16387653

Title: ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.

PubMed ID: 16387653

DOI: 10.1016/j.molcel.2005.12.007

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17487921

Title: Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.

PubMed ID: 17487921

DOI: 10.1002/elps.200600782

PubMed ID: 17062569

Title: Cdc7 is an active kinase in human cancer cells undergoing replication stress.

PubMed ID: 17062569

DOI: 10.1074/jbc.m604457200

PubMed ID: 17296731

Title: Identification and characterization of a novel component of the human minichromosome maintenance complex.

PubMed ID: 17296731

DOI: 10.1128/mcb.02384-06

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27401717

Title: Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells.

PubMed ID: 27401717

DOI: 10.1038/ncomms12135

PubMed ID: 28191891

Title: Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism.

PubMed ID: 28191891

DOI: 10.1038/ng.3790

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 35585232

Title: Fast and efficient DNA replication with purified human proteins.

PubMed ID: 35585232

DOI: 10.1038/s41586-022-04759-1

PubMed ID: 32453425

Title: CryoEM structures of human CMG-ATPgammaS-DNA and CMG-AND-1 complexes.

PubMed ID: 32453425

DOI: 10.1093/nar/gkaa429

PubMed ID: 33857403

Title: DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network.

PubMed ID: 33857403

DOI: 10.1016/j.molcel.2021.03.041

PubMed ID: 34694004

Title: Structure of a human replisome shows the organisation and interactions of a DNA replication machine.

PubMed ID: 34694004

DOI: 10.15252/embj.2021108819

PubMed ID: 34700328

Title: A conserved mechanism for regulating replisome disassembly in eukaryotes.

PubMed ID: 34700328

DOI: 10.1038/s41586-021-04145-3

PubMed ID: 26196677

Title: Whole exome sequencing identified MCM2 as a novel causative gene for autosomal dominant nonsyndromic deafness in a chinese family.

PubMed ID: 26196677

DOI: 10.1371/journal.pone.0133522

Sequence Information:

  • Length: 904
  • Mass: 101896
  • Checksum: 52C6DC61F128B404
  • Sequence:
    • MAESSESFTM ASSPAQRRRG NDPLTSSPGR SSRRTDALTS SPGRDLPPFE DESEGLLGTE 
GPLEEEEDGE ELIGDGMERD YRAIPELDAY EAEGLALDDE DVEELTASQR EAAERAMRQR 
DREAGRGLGR MRRGLLYDSD EEDEERPARK RRQVERATED GEEDEEMIES IENLEDLKGH 
SVREWVSMAG PRLEIHHRFK NFLRTHVDSH GHNVFKERIS DMCKENRESL VVNYEDLAAR 
EHVLAYFLPE APAELLQIFD EAALEVVLAM YPKYDRITNH IHVRISHLPL VEELRSLRQL 
HLNQLIRTSG VVTSCTGVLP QLSMVKYNCN KCNFVLGPFC QSQNQEVKPG SCPECQSAGP 
FEVNMEETIY QNYQRIRIQE SPGKVAAGRL PRSKDAILLA DLVDSCKPGD EIELTGIYHN 
NYDGSLNTAN GFPVFATVIL ANHVAKKDNK VAVGELTDED VKMITSLSKD QQIGEKIFAS 
IAPSIYGHED IKRGLALALF GGEPKNPGGK HKVRGDINVL LCGDPGTAKS QFLKYIEKVS 
SRAIFTTGQG ASAVGLTAYV QRHPVSREWT LEAGALVLAD RGVCLIDEFD KMNDQDRTSI 
HEAMEQQSIS ISKAGIVTSL QARCTVIAAA NPIGGRYDPS LTFSENVDLT EPIISRFDIL 
CVVRDTVDPV QDEMLARFVV GSHVRHHPSN KEEEGLANGS AAEPAMPNTY GVEPLPQEVL 
KKYIIYAKER VHPKLNQMDQ DKVAKMYSDL RKESMATGSI PITVRHIESM IRMAEAHARI 
HLRDYVIEDD VNMAIRVMLE SFIDTQKFSV MRSMRKTFAR YLSFRRDNNE LLLFILKQLV 
AEQVTYQRNR FGAQQDTIEV PEKDLVDKAR QINIHNLSAF YDSELFRMNK FSHDLKRKMI 
LQQF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.