Details for: MDM2

Gene ID: 4193

Symbol: MDM2

Ensembl ID: ENSG00000135679

Description: MDM2 proto-oncogene

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 264.6176
    Cell Significance Index: -41.1600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 168.5831
    Cell Significance Index: -42.7600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 108.2905
    Cell Significance Index: -44.6100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 90.5273
    Cell Significance Index: -42.7400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 80.7566
    Cell Significance Index: -41.5400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 63.7237
    Cell Significance Index: -42.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 35.4352
    Cell Significance Index: -43.6900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.5999
    Cell Significance Index: -41.7900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.9813
    Cell Significance Index: -36.8000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.1973
    Cell Significance Index: -44.1900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.5450
    Cell Significance Index: -20.8900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.3331
    Cell Significance Index: 89.0000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 3.0831
    Cell Significance Index: 160.1600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.6115
    Cell Significance Index: 518.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.4664
    Cell Significance Index: 243.9900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 2.2179
    Cell Significance Index: 37.3600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.0092
    Cell Significance Index: 1814.1600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3000
    Cell Significance Index: 141.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.2693
    Cell Significance Index: 254.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.2366
    Cell Significance Index: 56.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0878
    Cell Significance Index: 196.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.0088
    Cell Significance Index: 124.0400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8545
    Cell Significance Index: 306.5000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.8450
    Cell Significance Index: 21.7200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7389
    Cell Significance Index: 403.5200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.6943
    Cell Significance Index: 44.8000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.6847
    Cell Significance Index: 15.8200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.6216
    Cell Significance Index: 17.9100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4948
    Cell Significance Index: 10.7200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3983
    Cell Significance Index: 46.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.3498
    Cell Significance Index: 19.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3318
    Cell Significance Index: 45.5600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3233
    Cell Significance Index: 8.8000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3068
    Cell Significance Index: 21.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2685
    Cell Significance Index: 118.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2556
    Cell Significance Index: 19.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.2466
    Cell Significance Index: 15.1600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2210
    Cell Significance Index: 2.0400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1890
    Cell Significance Index: 5.0700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1807
    Cell Significance Index: 5.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1723
    Cell Significance Index: 22.0900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.1293
    Cell Significance Index: 2.0000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1249
    Cell Significance Index: 21.3200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1218
    Cell Significance Index: 5.6800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0900
    Cell Significance Index: 17.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0890
    Cell Significance Index: 167.5800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0851
    Cell Significance Index: 5.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0789
    Cell Significance Index: 50.1400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0777
    Cell Significance Index: 2.7300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0639
    Cell Significance Index: 3.0100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.0460
    Cell Significance Index: 0.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0385
    Cell Significance Index: 17.4900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0338
    Cell Significance Index: 0.6600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0119
    Cell Significance Index: 0.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0107
    Cell Significance Index: 16.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0102
    Cell Significance Index: 13.9100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0093
    Cell Significance Index: 17.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0055
    Cell Significance Index: -0.2400
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0079
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0154
    Cell Significance Index: -11.4300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0274
    Cell Significance Index: -20.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0347
    Cell Significance Index: -26.2700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0364
    Cell Significance Index: -22.7100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0505
    Cell Significance Index: -3.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0507
    Cell Significance Index: -1.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0547
    Cell Significance Index: -2.0700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0550
    Cell Significance Index: -31.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0779
    Cell Significance Index: -7.9600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1096
    Cell Significance Index: -7.7500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1240
    Cell Significance Index: -26.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1302
    Cell Significance Index: -37.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1375
    Cell Significance Index: -17.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1393
    Cell Significance Index: -1.9000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1438
    Cell Significance Index: -16.7600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1498
    Cell Significance Index: -21.7800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1611
    Cell Significance Index: -2.7600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1877
    Cell Significance Index: -2.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2383
    Cell Significance Index: -27.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2384
    Cell Significance Index: -17.7700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2469
    Cell Significance Index: -3.7000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2658
    Cell Significance Index: -27.6800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2802
    Cell Significance Index: -31.9800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3105
    Cell Significance Index: -6.4400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3575
    Cell Significance Index: -2.1600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3757
    Cell Significance Index: -9.0100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.3949
    Cell Significance Index: -3.2200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.4124
    Cell Significance Index: -5.8700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4290
    Cell Significance Index: -12.6000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4405
    Cell Significance Index: -34.8900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.4631
    Cell Significance Index: -11.5800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4792
    Cell Significance Index: -8.0200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5091
    Cell Significance Index: -31.2100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.5773
    Cell Significance Index: -29.1800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5782
    Cell Significance Index: -16.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5970
    Cell Significance Index: -19.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6166
    Cell Significance Index: -32.3800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6392
    Cell Significance Index: -7.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7133
    Cell Significance Index: -19.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.8081
    Cell Significance Index: -21.2500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8305
    Cell Significance Index: -28.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **E3 ubiquitin-protein ligase**: MDM2 is an E3 ubiquitin-protein ligase that binds to and ubiquitinates target proteins, signaling them for degradation. 2. **p53 regulation**: MDM2 is a primary regulator of p53 activity, binding to and ubiquitinating it, leading to its degradation and preventing tumor suppression. 3. **Cell cycle regulation**: MDM2 regulates cell cycle progression by inhibiting p53-mediated cell cycle arrest. 4. **Apoptosis regulation**: MDM2 regulates apoptosis by inhibiting p53-mediated apoptosis. 5. **Tumor suppressor**: MDM2 acts as a tumor suppressor by preventing p53-mediated tumor suppression. **Pathways and Functions** 1. **p53 signaling pathway**: MDM2 regulates p53 activity, leading to cell cycle arrest, apoptosis, or senescence. 2. **Cell cycle regulation**: MDM2 regulates cell cycle progression by inhibiting p53-mediated cell cycle arrest. 3. **Apoptosis regulation**: MDM2 regulates apoptosis by inhibiting p53-mediated apoptosis. 4. **Stress response**: MDM2 regulates stress response by inhibiting p53-mediated stress response. 5. **Cancer development**: MDM2 is implicated in cancer development by promoting tumor growth and preventing p53-mediated tumor suppression. **Clinical Significance** 1. **Cancer**: MDM2 is overexpressed in various cancers, including breast, lung, and colon cancer, and is associated with poor prognosis. 2. **Neurodegenerative diseases**: MDM2 is implicated in neurodegenerative diseases, including Alzheimer's and Parkinson's disease, by regulating p53 activity and apoptosis. 3. **Infectious diseases**: MDM2 is involved in the regulation of immune responses to infections, including HIV and tuberculosis. 4. **Regenerative medicine**: MDM2 is being explored as a potential therapeutic target for regenerative medicine, including tissue engineering and stem cell therapy. In conclusion, MDM2 is a complex gene that plays a critical role in regulating cell cycle, apoptosis, and p53 activity. Its dysregulation is implicated in various diseases, including cancer, neurodegenerative diseases, and infectious diseases. Further research is needed to fully understand the role of MDM2 in human disease and to develop effective therapeutic strategies.

Genular Protein ID: 3580826718

Symbol: MDM2_HUMAN

Name: E3 ubiquitin-protein ligase Mdm2

UniProtKB Accession Codes:

Q00987 A6NL51 A8K2S6 Q13226 Q13297 Q13298 Q13299 Q13300 Q13301 Q53XW0 Q71TW9 Q8WYJ1 Q8WYJ2 Q9UGI3 Q9UMT8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 2 CORUM 1 CPTAC 1 CPTC 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 2 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 2 DrugBank 6 DrugCentral 1 EC 1 ELM 1 EMBL 18 EMDB 1 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 89 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 4 MINT 1 MalaCards 1 MassIVE 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PIRSF 2 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 9 RNAct 1 Reactome 15 RefSeq 5 SIGNOR 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1614537

Title: Amplification of a gene encoding a p53-associated protein in human sarcomas.

PubMed ID: 1614537

DOI: 10.1038/358080a0

PubMed ID: 8705862

Title: Alternatively spliced mdm2 transcripts with loss of p53 binding domain sequences: transforming ability and frequent detection in human cancer.

PubMed ID: 8705862

DOI: 10.1038/nm0896-912

PubMed ID: 10597303

Title: A novel exon within the mdm2 gene modulates translation initiation in vitro and disrupts the p53-binding domain of mdm2 protein.

PubMed ID: 10597303

DOI: 10.1038/sj.onc.1203182

PubMed ID: 11351297

Title: Analysis of the molecular species generated by MDM2 gene amplification in liposarcomas.

PubMed ID: 11351297

DOI: 10.1002/ijc.1271

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7651818

Title: A functional p53-responsive intronic promoter is contained within the human mdm2 gene.

PubMed ID: 7651818

DOI: 10.1093/nar/23.14.2584

PubMed ID: 9270029

Title: Translational enhancement of mdm2 oncogene expression in human tumor cells containing a stabilized wild-type p53 protein.

PubMed ID: 9270029

PubMed ID: 15315825

Title: Genomic organisation of the human MDM2 oncogene and relationship to its alternatively spliced mRNAs.

PubMed ID: 15315825

DOI: 10.1016/j.gene.2004.05.015

PubMed ID: 11087894

Title: A MboII polymorphism in exon 11 of the human MDM2 gene occurring in normal blood donors and in soft tissue sarcoma patients: an indication for an increased cancer susceptibility?

PubMed ID: 11087894

DOI: 10.1016/s0027-5107(00)00112-3

PubMed ID: 7689721

Title: Identification and characterization of multiple mdm-2 proteins and mdm-2-p53 protein complexes.

PubMed ID: 7689721

PubMed ID: 9450543

Title: Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53.

PubMed ID: 9450543

DOI: 10.1016/s0014-5793(97)01480-4

PubMed ID: 10608892

Title: Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein.

PubMed ID: 10608892

DOI: 10.1074/jbc.274.53.38189

PubMed ID: 10611322

Title: Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage.

PubMed ID: 10611322

DOI: 10.1073/pnas.96.26.14973

PubMed ID: 10722742

Title: Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53.

PubMed ID: 10722742

DOI: 10.1074/jbc.275.12.8945

PubMed ID: 10707090

Title: Identification of a cryptic nucleolar-localization signal in MDM2.

PubMed ID: 10707090

DOI: 10.1038/35004057

PubMed ID: 10723139

Title: Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase.

PubMed ID: 10723139

DOI: 10.1038/sj.onc.1203464

PubMed ID: 12167711

Title: Hypophosphorylation of Mdm2 augments p53 stability.

PubMed ID: 12167711

DOI: 10.1128/mcb.22.17.6170-6182.2002

PubMed ID: 12883554

Title: A non-proteolytic role for ubiquitin in Tat-mediated transactivation of the HIV-1 promoter.

PubMed ID: 12883554

DOI: 10.1038/ncb1023

PubMed ID: 12821780

Title: Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor.

PubMed ID: 12821780

DOI: 10.1073/pnas.1431613100

PubMed ID: 15313915

Title: Synergistic tumor suppression by coexpression of FHIT and p53 coincides with FHIT-mediated MDM2 inactivation and p53 stabilization in human non-small cell lung cancer cells.

PubMed ID: 15313915

DOI: 10.1158/0008-5472.can-04-0195

PubMed ID: 15550242

Title: A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans.

PubMed ID: 15550242

DOI: 10.1016/j.cell.2004.11.022

PubMed ID: 15364927

Title: Negative regulation of p53 functions by Daxx and the involvement of MDM2.

PubMed ID: 15364927

DOI: 10.1074/jbc.m406743200

PubMed ID: 15053880

Title: A dynamic role of HAUSP in the p53-Mdm2 pathway.

PubMed ID: 15053880

DOI: 10.1016/s1097-2765(04)00157-1

PubMed ID: 15195100

Title: PML regulates p53 stability by sequestering Mdm2 to the nucleolus.

PubMed ID: 15195100

DOI: 10.1038/ncb1147

PubMed ID: 15878855

Title: {beta}-Arrestin is crucial for ubiquitination and down-regulation of the insulin-like growth factor-1 receptor by acting as adaptor for the MDM2 E3 ligase.

PubMed ID: 15878855

DOI: 10.1074/jbc.m501129200

PubMed ID: 16219768

Title: WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53.

PubMed ID: 16219768

DOI: 10.1074/jbc.m505590200

PubMed ID: 16337594

Title: MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein.

PubMed ID: 16337594

DOI: 10.1016/j.molcel.2005.10.017

PubMed ID: 15632057

Title: Regulation of p53 and MDM2 activity by MTBP.

PubMed ID: 15632057

DOI: 10.1128/mcb.25.2.545-553.2005

PubMed ID: 16173922

Title: A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2.

PubMed ID: 16173922

DOI: 10.1042/bj20050960

PubMed ID: 16479015

Title: Interferon-inducible protein IFIXalpha1 functions as a negative regulator of HDM2.

PubMed ID: 16479015

DOI: 10.1128/mcb.26.5.1979-1996.2006

PubMed ID: 16845383

Title: Critical role for Daxx in regulating Mdm2.

PubMed ID: 16845383

DOI: 10.1038/ncb1442

PubMed ID: 17460193

Title: CARF binds to three members (ARF, p53, and HDM2) of the p53 tumor-suppressor pathway.

PubMed ID: 17460193

DOI: 10.1196/annals.1395.033

PubMed ID: 17290220

Title: The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2.

PubMed ID: 17290220

DOI: 10.1038/sj.emboj.7601567

PubMed ID: 17003841

Title: The single-nucleotide polymorphism 309 in the MDM2 gene contributes to the Li-Fraumeni syndrome and related phenotypes.

PubMed ID: 17003841

DOI: 10.1038/sj.ejhg.5201715

PubMed ID: 17110379

Title: A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains chromosomal stability.

PubMed ID: 17110379

DOI: 10.1074/jbc.m609612200

PubMed ID: 17470788

Title: PACT is a negative regulator of p53 and essential for cell growth and embryonic development.

PubMed ID: 17470788

DOI: 10.1073/pnas.0701916104

PubMed ID: 18382127

Title: CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2.

PubMed ID: 18382127

DOI: 10.4161/cc.7.5.5701

PubMed ID: 18566590

Title: The tumour suppressor RASSF1A promotes MDM2 self-ubiquitination by disrupting the MDM2-DAXX-HAUSP complex.

PubMed ID: 18566590

DOI: 10.1038/emboj.2008.115

PubMed ID: 19816404

Title: ATM activates p53 by regulating MDM2 oligomerization and E3 processivity.

PubMed ID: 19816404

DOI: 10.1038/emboj.2009.294

PubMed ID: 19098711

Title: RYBP stabilizes p53 by modulating MDM2.

PubMed ID: 19098711

DOI: 10.1038/embor.2008.231

PubMed ID: 19837670

Title: MTA1 coregulator regulates p53 stability and function.

PubMed ID: 19837670

DOI: 10.1074/jbc.m109.056499

PubMed ID: 19756449

Title: Sgk1 activates MDM2-dependent p53 degradation and affects cell proliferation, survival, and differentiation.

PubMed ID: 19756449

DOI: 10.1007/s00109-009-0525-5

PubMed ID: 19369353

Title: Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor 4 targets MDM2 to deregulate the p53 tumor suppressor pathway.

PubMed ID: 19369353

DOI: 10.1128/jvi.02353-08

PubMed ID: 19219073

Title: Ubiquitination of mammalian AP endonuclease (APE1) regulated by the p53-MDM2 signaling pathway.

PubMed ID: 19219073

DOI: 10.1038/onc.2009.5

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20385133

Title: p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma.

PubMed ID: 20385133

DOI: 10.1016/j.febslet.2010.04.006

PubMed ID: 19965871

Title: ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage.

PubMed ID: 19965871

DOI: 10.1074/jbc.m109.042341

PubMed ID: 20858735

Title: Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways.

PubMed ID: 20858735

DOI: 10.1158/1541-7786.mcr-10-0042

PubMed ID: 20173098

Title: RFWD3-Mdm2 ubiquitin ligase complex positively regulates p53 stability in response to DNA damage.

PubMed ID: 20173098

DOI: 10.1073/pnas.0912094107

PubMed ID: 19838211

Title: MdmX is a substrate for the deubiquitinating enzyme USP2a.

PubMed ID: 19838211

DOI: 10.1038/onc.2009.330

PubMed ID: 22128911

Title: Notch1 binds and induces degradation of Snail in hepatocellular carcinoma.

PubMed ID: 22128911

DOI: 10.1186/1741-7007-9-83

PubMed ID: 21333377

Title: Ret finger protein 2 enhances ionizing radiation-induced apoptosis via degradation of AKT and MDM2.

PubMed ID: 21333377

DOI: 10.1016/j.ejcb.2010.12.001

PubMed ID: 24120868

Title: The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress.

PubMed ID: 24120868

DOI: 10.1016/j.celrep.2013.08.049

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 22869143

Title: BMK1 is involved in the regulation of p53 through disrupting the PML-MDM2 interaction.

PubMed ID: 22869143

DOI: 10.1038/onc.2012.332

PubMed ID: 26203195

Title: Nucleolar GTP-binding protein-1 (NGP-1) promotes G1 to S phase transition by activating cyclin-dependent kinase inhibitor p21 Cip1/Waf1.

PubMed ID: 26203195

DOI: 10.1074/jbc.m115.637280

PubMed ID: 29681526

Title: A Designed Peptide Targets Two Types of Modifications of p53 with Anti-cancer Activity.

PubMed ID: 29681526

DOI: 10.1016/j.chembiol.2018.03.010

PubMed ID: 30879903

Title: MDM2 Integrates Cellular Respiration and Apoptotic Signaling through NDUFS1 and the Mitochondrial Network.

PubMed ID: 30879903

DOI: 10.1016/j.molcel.2019.02.012

PubMed ID: 28846075

Title: Dysfunction of the MDM2/p53 axis is linked to premature aging.

PubMed ID: 28846075

DOI: 10.1172/jci92171

PubMed ID: 8875929

Title: Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.

PubMed ID: 8875929

DOI: 10.1126/science.274.5289.948

PubMed ID: 16402859

Title: Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway.

PubMed ID: 16402859

DOI: 10.1371/journal.pbio.0040027

PubMed ID: 16474402

Title: Molecular recognition of p53 and MDM2 by USP7/HAUSP.

PubMed ID: 16474402

DOI: 10.1038/nsmb1067

Sequence Information:

  • Length: 491
  • Mass: 55233
  • Checksum: F37CE163876BC983
  • Sequence:
    • MCNTNMSVPT DGAVTTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM KEVLFYLGQY 
IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY TMIYRNLVVV NQQESSDSGT 
SVSENRCHLE GGSDQKDLVQ ELQEEKPSSS HLVSRPSTSS RRRAISETEE NSDELSGERQ 
RKRHKSDSIS LSFDESLALC VIREICCERS SSSESTGTPS NPDLDAGVSE HSGDWLDQDS 
VSDQFSVEFE VESLDSEDYS LSEEGQELSD EDDEVYQVTV YQAGESDTDS FEEDPEISLA 
DYWKCTSCNE MNPPLPSHCN RCWALRENWL PEDKGKDKGE ISEKAKLENS TQAEEGFDVP 
DCKKTIVNDS RESCVEENDD KITQASQSQE SEDYSQPSTS SSIIYSSQED VKEFEREETQ 
DKEESVESSL PLNAIEPCVI CQGRPKNGCI VHGKTGHLMA CFTCAKKLKK RNKPCPVCRQ 
PIQMIVLTYF P

Genular Protein ID: 1515208056

Symbol: A7UKX8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A7UKX8 E7EPE3

Database IDs:

ARBA 3 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 2 GO 4 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PROSITE 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 256
  • Mass: 28730
  • Checksum: 680FB46549DE2469
  • Sequence:
    • MCNTNMSVPT DGAVTTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM KEVLFYLGQY 
IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY TMIYRNLVVV NQQESSDSGT 
SVSENRCHLE GGSDQKDLVQ ELQEEKPSSS HLVSRPSTSS RRRAISETEE NSDELSGERQ 
RKRHKSDSIS LSFDESLALC VIREICCERS SSSESTGTPS NPDLDAGVYQ VTVYQAGESD 
TDSFEEDPEI SLADYW

Genular Protein ID: 916966709

Symbol: A0A0A8KB75_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0A8KB75

Database IDs:

ARBA 16 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 2 GO 9 Gene3D 3 InterPro 9 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 2 PROSITE 7 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 1 SMR 1 SUPFAM 3

Sequence Information:

  • Length: 444
  • Mass: 49907
  • Checksum: 652DA584061064A0
  • Sequence:
    • MCNTNMSVPT DGAVTTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM KEVLFYLGQY 
IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY TMIYRNLVVV NQQESSDSGT 
SVSENRCHLE GGSDQKDLVQ ELQEEKPSSS HLVSRPSTSS RRRAISETEE NSDELSGERQ 
RKRHKSDSIS LSFDESLALC VIREICCERS SSSESTGTPS NPDLDAGVYQ VTVYQAGESD 
TDSFEEDPEI SLADYWKCTS CNEMNPPLPS HCNRCWALRE NWLPEDKGKD KGEISEKAKL 
ENSTQAEEGF DVPDCKKTIV NDSRESCVEE NDDKITQASQ SQESEDYSQP STSSSIIYSS 
QEDVKEFERE ETQDKEESVE SSLPLNAIEP CVICQGRPKN GCIVHGKTGH LMACFTCAKK 
LKKRNKPCPV CRQPIQMIVL TYFP

Genular Protein ID: 189650531

Symbol: A7UKX9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A7UKX9

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PeptideAtlas 1 RefSeq 2 SAM 1 SMR 1 SUPFAM 2

Sequence Information:

  • Length: 144
  • Mass: 15992
  • Checksum: 11E605286A3CB147
  • Sequence:
    • MCNTNMSVPT DGAVTTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM KEDLDAGVSE 
HSGDWLDQDS VSDQFSVEFE VESLDSEDYS LSEEGQELSD EDDEVYQVTV YQAGESDTDS 
FEEDPEISLA DYWKCTACNE MNPP

Genular Protein ID: 3214238504

Symbol: Q96DS0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q96DS0

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PeptideAtlas 1 RefSeq 2 SUPFAM 1

Sequence Information:

  • Length: 159
  • Mass: 17890
  • Checksum: 97C9E39B46B6F9A7
  • Sequence:
    • MCNTNMSVPT DGAVTTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM KEDLDAGVSE 
HSGDWLDQDS VSDQFSVEFE VESLDSEDYS LSEEGQELSD EDDEVYQVTV YQAGESDTDS 
FEEDPEISLA DYWKCLKKRN KPCPVCRQPI QMIVLTYFP

Genular Protein ID: 3670804717

Symbol: G3XA89_HUMAN

Name: N/A

UniProtKB Accession Codes:

G3XA89

Database IDs:

ARBA 16 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 3 Ensembl 2 GO 9 Gene3D 3 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 9 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 2 PROSITE 7 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 3 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SUPFAM 3 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 442
  • Mass: 50006
  • Checksum: 3A785D132314D9BB
  • Sequence:
    • MVRSRQMCNT NMSVPTDGAV TTSQIPASEQ ETLVRPKPLL LKLLKSVGAQ KDTYTMKEVL 
FYLGQYIMTK RLYDEKQQHI VYCSNDLLGD LFGVPSFSVK EHRKIYTMIY RNLVVVNQQE 
ENSDELSGER QRKRHKSDSI SLSFDESLAL CVIREICCER SSSSESTGTP SNPDLDAGVS 
EHSGDWLDQD SVSDQFSVEF EVESLDSEDY SLSEEGQELS DEDDEVYQVT VYQAGESDTD 
SFEEDPEISL ADYWKCTSCN EMNPPLPSHC NRCWALRENW LPEDKGKDKG EISEKAKLEN 
STQAEEGFDV PDCKKTIVND SRESCVEEND DKITQASQSQ ESEDYSQPST SSSIIYSSQE 
DVKEFEREET QDKEESVESS LPLNAIEPCV ICQGRPKNGC IVHGKTGHLM ACFTCAKKLK 
KRNKPCPVCR QPIQMIVLTY FP

Genular Protein ID: 1071867859

Symbol: A7UKX7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A7UKX7 A0A0A6YYM9 A0A0K0K1B6 F6RKA8

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 2 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PIRSF 1 PeptideAtlas 1 RefSeq 1 SAM 1 SUPFAM 1 UCSC 1

Sequence Information:

  • Length: 118
  • Mass: 13133
  • Checksum: 2A82DE153A1189FF
  • Sequence:
    • MCNTNMSVPT DGAVTTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM KEDLDAGVSE 
HSGDWLDQDS VSDQFSVEFE VESLDSEDYS LSEEGQELSD EDDEDYWKCT SCNEMNPP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.