Details for: MEF2A

Gene ID: 4205

Symbol: MEF2A

Ensembl ID: ENSG00000068305

Description: myocyte enhancer factor 2A

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 625.2844
    Cell Significance Index: -97.2600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 383.2941
    Cell Significance Index: -97.2200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 208.3145
    Cell Significance Index: -98.3500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 196.0827
    Cell Significance Index: -79.6600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 178.9223
    Cell Significance Index: -92.0400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 146.5823
    Cell Significance Index: -98.3600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 83.7712
    Cell Significance Index: -79.9800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 79.8325
    Cell Significance Index: -98.4300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 34.4475
    Cell Significance Index: -92.2800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 32.0239
    Cell Significance Index: -98.3600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 28.1186
    Cell Significance Index: -61.5400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 25.0276
    Cell Significance Index: -98.7600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 7.5240
    Cell Significance Index: 108.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 4.6423
    Cell Significance Index: 356.2400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 4.1934
    Cell Significance Index: 218.4300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.8662
    Cell Significance Index: 99.3800
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 3.1357
    Cell Significance Index: 61.2000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.0194
    Cell Significance Index: 351.8800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.7379
    Cell Significance Index: 549.2300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.5254
    Cell Significance Index: 501.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.3204
    Cell Significance Index: 130.2100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 2.2535
    Cell Significance Index: 33.2700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.8692
    Cell Significance Index: 114.8900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.5544
    Cell Significance Index: 1075.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4944
    Cell Significance Index: 536.0200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.4525
    Cell Significance Index: 93.7100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.3576
    Cell Significance Index: 220.8000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.2935
    Cell Significance Index: 31.5600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.1075
    Cell Significance Index: 30.9500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7069
    Cell Significance Index: 47.5300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6308
    Cell Significance Index: 77.5600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5858
    Cell Significance Index: 1102.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5456
    Cell Significance Index: 98.3600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5160
    Cell Significance Index: 56.1200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.4995
    Cell Significance Index: 11.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4759
    Cell Significance Index: 21.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4448
    Cell Significance Index: 20.1600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4436
    Cell Significance Index: 400.5000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4362
    Cell Significance Index: 59.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.4130
    Cell Significance Index: 15.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3697
    Cell Significance Index: 36.5700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3069
    Cell Significance Index: 36.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3004
    Cell Significance Index: 164.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2990
    Cell Significance Index: 135.6900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2912
    Cell Significance Index: 4.9900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2853
    Cell Significance Index: 181.2000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2698
    Cell Significance Index: 497.5300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2353
    Cell Significance Index: 362.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1800
    Cell Significance Index: 79.6000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0743
    Cell Significance Index: 2.6100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0640
    Cell Significance Index: 87.0900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0579
    Cell Significance Index: 0.3500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0491
    Cell Significance Index: 1.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0343
    Cell Significance Index: -25.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0608
    Cell Significance Index: -44.5600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0913
    Cell Significance Index: -6.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1081
    Cell Significance Index: -67.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1141
    Cell Significance Index: -64.3800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1223
    Cell Significance Index: -92.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.1273
    Cell Significance Index: -24.2300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1388
    Cell Significance Index: -14.1800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2171
    Cell Significance Index: -37.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2261
    Cell Significance Index: -10.6300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2331
    Cell Significance Index: -5.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2650
    Cell Significance Index: -33.9700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2844
    Cell Significance Index: -41.3400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3046
    Cell Significance Index: -87.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3062
    Cell Significance Index: -64.5000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4314
    Cell Significance Index: -44.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.4612
    Cell Significance Index: -59.5900
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -0.4816
    Cell Significance Index: -7.7700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5407
    Cell Significance Index: -61.7200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.6578
    Cell Significance Index: -11.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.6702
    Cell Significance Index: -31.2500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6738
    Cell Significance Index: -19.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6819
    Cell Significance Index: -78.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.7573
    Cell Significance Index: -47.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.8470
    Cell Significance Index: -63.1300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.8828
    Cell Significance Index: -46.3500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.9065
    Cell Significance Index: -64.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0213
    Cell Significance Index: -80.8900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.0329
    Cell Significance Index: -15.2500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.0343
    Cell Significance Index: -27.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -1.1379
    Cell Significance Index: -59.1100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.3125
    Cell Significance Index: -80.4700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.3922
    Cell Significance Index: -39.7300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -1.4369
    Cell Significance Index: -41.4000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.4498
    Cell Significance Index: -19.7800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.4514
    Cell Significance Index: -31.7800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.4804
    Cell Significance Index: -30.7100
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -1.4926
    Cell Significance Index: -15.4600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -1.5009
    Cell Significance Index: -24.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -1.5877
    Cell Significance Index: -42.4000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.6557
    Cell Significance Index: -53.0300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.7607
    Cell Significance Index: -37.3700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.7619
    Cell Significance Index: -21.9700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.7724
    Cell Significance Index: -22.3700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -1.8260
    Cell Significance Index: -23.4200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.8268
    Cell Significance Index: -59.8100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.9026
    Cell Significance Index: -37.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MEF2A is a transcription factor that binds to specific DNA sequences, regulating the expression of target genes. It is a member of the MEF2 family, which consists of four members: MEF2A, MEF2B, MEF2C, and MEF2D. MEF2A is characterized by its ability to bind to specific DNA sequences, known as MEF2 elements, which are found in the promoter regions of target genes. MEF2A also interacts with other transcription factors, such as NFAT and AP-1, to regulate gene expression. Additionally, MEF2A is involved in the regulation of cell differentiation, particularly in the development of cardiac myocytes and muscle cells. **Pathways and Functions** MEF2A is involved in various signaling pathways, including: 1. **Cardiac Conduction**: MEF2A regulates the expression of genes involved in cardiac conduction, including those involved in the development and maintenance of the cardiac conduction system. 2. **Cell Differentiation**: MEF2A is involved in the regulation of cell differentiation, particularly in the development of cardiac myocytes and muscle cells. 3. **Immune Response**: MEF2A is expressed in immune cells, including microglial cells and macrophages, and is involved in the regulation of immune responses, including the production of cytokines and the activation of immune cells. 4. **Cytokine Signaling**: MEF2A interacts with cytokine receptors, including those involved in the signaling pathways of IL-17 and TNF-α. 5. **Cardiac Hypertrophy**: MEF2A regulates the expression of genes involved in cardiac hypertrophy, including those involved in the development and maintenance of cardiac muscle cells. **Clinical Significance** MEF2A has been implicated in various diseases, including: 1. **Cardiac Arrhythmias**: Abnormal expression of MEF2A has been linked to cardiac arrhythmias, including atrial fibrillation and ventricular tachycardia. 2. **Muscular Dystrophy**: MEF2A is involved in the regulation of muscle differentiation, and abnormalities in MEF2A have been linked to muscular dystrophy. 3. **Autoimmune Diseases**: MEF2A is involved in the regulation of immune responses, and abnormalities in MEF2A have been linked to autoimmune diseases, including multiple sclerosis and rheumatoid arthritis. In conclusion, MEF2A is a transcription factor that plays a crucial role in various cellular processes, including cell differentiation, development, and immune response. Its dysregulation has been implicated in various diseases, highlighting the importance of MEF2A in maintaining tissue homeostasis and preventing disease.

Genular Protein ID: 218110147

Symbol: MEF2A_HUMAN

Name: Myocyte-specific enhancer factor 2A

UniProtKB Accession Codes:

Q02078 B4DFQ7 F6XG23 O43814 Q14223 Q14224 Q59GX4 Q7Z6C9 Q96D14

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DisProt 1 EMBL 29 Ensembl 7 EvolutionaryTrace 1 ExpressionAtlas 1 GO 37 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 2 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 8 Pumba 1 RNAct 1 Reactome 2 RefSeq 12 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1748287

Title: Human SRF-related proteins: DNA-binding properties and potential regulatory targets.

PubMed ID: 1748287

DOI: 10.1101/gad.5.12a.2327

PubMed ID: 1516833

Title: Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors.

PubMed ID: 1516833

DOI: 10.1101/gad.6.9.1783

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9753748

Title: Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1.

PubMed ID: 9753748

DOI: 10.1093/nar/26.20.4771

PubMed ID: 10487761

Title: HDAC4 deacetylase associates with and represses the MEF2 transcription factor.

PubMed ID: 10487761

DOI: 10.1093/emboj/18.18.5099

PubMed ID: 9858528

Title: Regulation of the MEF2 family of transcription factors by p38.

PubMed ID: 9858528

DOI: 10.1128/mcb.19.1.21

PubMed ID: 10330143

Title: Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors.

PubMed ID: 10330143

DOI: 10.1128/mcb.19.6.4028

PubMed ID: 10849446

Title: Big mitogen-activated kinase regulates multiple members of the MEF2 protein family.

PubMed ID: 10849446

DOI: 10.1074/jbc.m001573200

PubMed ID: 11904443

Title: Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis.

PubMed ID: 11904443

DOI: 10.1073/pnas.022036399

PubMed ID: 12586839

Title: Phosphorylation motifs regulating the stability and function of myocyte enhancer factor 2A.

PubMed ID: 12586839

DOI: 10.1074/jbc.m211312200

PubMed ID: 12691662

Title: Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis.

PubMed ID: 12691662

DOI: 10.1016/s0896-6273(03)00191-0

PubMed ID: 14630949

Title: Regulation of the human GLUT4 gene promoter: interaction between a transcriptional activator and myocyte enhancer factor 2A.

PubMed ID: 14630949

DOI: 10.1073/pnas.2432756100

PubMed ID: 15834131

Title: Alternative pre-mRNA splicing governs expression of a conserved acidic transactivation domain in myocyte enhancer factor 2 factors of striated muscle and brain.

PubMed ID: 15834131

DOI: 10.1074/jbc.m502491200

PubMed ID: 15888658

Title: Cyclin-dependent kinase 5 mediates neurotoxin-induced degradation of the transcription factor myocyte enhancer factor 2.

PubMed ID: 15888658

DOI: 10.1523/jneurosci.1331-05.2005

PubMed ID: 16563226

Title: SUMO-1 modification of MEF2A regulates its transcriptional activity.

PubMed ID: 16563226

DOI: 10.1111/j.1582-4934.2006.tb00295.x

PubMed ID: 16371476

Title: PDSM, a motif for phosphorylation-dependent SUMO modification.

PubMed ID: 16371476

DOI: 10.1073/pnas.0503698102

PubMed ID: 16484498

Title: A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation.

PubMed ID: 16484498

DOI: 10.1126/science.1122513

PubMed ID: 17785444

Title: Nemo-like kinase-myocyte enhancer factor 2A signaling regulates anterior formation in Xenopus development.

PubMed ID: 17785444

DOI: 10.1128/mcb.01481-07

PubMed ID: 18697823

Title: Quantitative control of adaptive cardiac hypertrophy by acetyltransferase p300.

PubMed ID: 18697823

DOI: 10.1161/circulationaha.107.760488

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21468593

Title: Identification of HZF1 as a novel target gene of the MEF2 transcription factor.

PubMed ID: 21468593

DOI: 10.3892/mmr.2011.465

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 15496429

Title: Transcription factor MEF2A mutations in patients with coronary artery disease.

PubMed ID: 15496429

DOI: 10.1093/hmg/ddh329

PubMed ID: 15958500

Title: The Pro279Leu variant in the transcription factor MEF2A is associated with myocardial infarction.

PubMed ID: 15958500

DOI: 10.1136/jmg.2005.035071

PubMed ID: 18086930

Title: Lack of association between the MEF2A gene and myocardial infarction.

PubMed ID: 18086930

DOI: 10.1161/circulationaha.107.728485

PubMed ID: 10835359

Title: Solution structure of the MEF2A-DNA complex: structural basis for the modulation of DNA bending and specificity by MADS-box transcription factors.

PubMed ID: 10835359

DOI: 10.1093/emboj/19.11.2615

PubMed ID: 10715212

Title: Crystal structure of MEF2A core bound to DNA at 1.5 A resolution.

PubMed ID: 10715212

DOI: 10.1006/jmbi.2000.3568

Sequence Information:

  • Length: 507
  • Mass: 54811
  • Checksum: 362BA4FBCC792CE2
  • Sequence:
    • MGRKKIQITR IMDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS SNKLFQYAST 
DMDKVLLKYT EYNEPHESRT NSDIVEALNK KEHRGCDSPD PDTSYVLTPH TEEKYKKINE 
EFDNMMRNHK IAPGLPPQNF SMSVTVPVTS PNALSYTNPG SSLVSPSLAA SSTLTDSSML 
SPPQTTLHRN VSPGAPQRPP STGNAGGMLS TTDLTVPNGA GSSPVGNGFV NSRASPNLIG 
ATGANSLGKV MPTKSPPPPG GGNLGMNSRK PDLRVVIPPS SKGMMPPLSE EEELELNTQR 
ISSSQATQPL ATPVVSVTTP SLPPQGLVYS AMPTAYNTDY SLTSADLSAL QGFNSPGMLS 
LGQVSAWQQH HLGQAALSSL VAGGQLSQGS NLSINTNQNI SIKSEPISPP RDRMTPSGFQ 
QQQQQQQQQQ PPPPPQPQPQ PPQPQPRQEM GRSPVDSLSS SSSSYDGSDR EDPRGDFHSP 
IVLGRPPNTE DRESPSVKRM RMDAWVT

Genular Protein ID: 610107293

Symbol: A0A0S2Z454_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z454

Database IDs:

ARBA 7 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 ExpressionAtlas 1 GO 7 Gene3D 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 Pfam 2 RefSeq 3 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 499
  • Mass: 53852
  • Checksum: FE3A83DDCE477C27
  • Sequence:
    • MGRKKIQITR IMDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS SNKLFQYAST 
DMDKVLLKYT EYNEPHESRT NSDIVEALNK KEHRGCDSPD PDTSYVLTPH TEEKYKKINE 
EFDNMMRNHK IAPGLPPQNF SMSVTVPVTS PNALSYTNPG SSLVSPSLAA SSTLTDSSML 
SPPQTTLHRN VSPGAPQRPP STGNAGGMLS TTDLTVPNGA GSSPVGNGFV NSRASPNLIG 
ATGANSLGKV MPTKSPPPPG GGNLGMNSRK PDLRVVIPPS SKGMMPPLNT QRISSSQATQ 
PLATPVVSVT TPSLPPQGLV YSAMPTAYNT DYSLTSADLS ALQGFNSPGM LSLGQVSAWQ 
QHHLGQAALS SLVAGGQLSQ GSNLSINTNQ NISIKSEPIS PPRDRMTPSG FQQQQQQQQQ 
QQPPPPPQPQ PQPPQPQPRQ EMGRSPVDSL SSSSSSYDGS DREDPRGDFH SPIVLGRPPN 
TEDRESPSVK RMRMDAWVT

Genular Protein ID: 615192611

Symbol: A0A0S2Z4N0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z4N0

Database IDs:

ARBA 7 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 ExpressionAtlas 1 GO 15 Gene3D 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 Pfam 2 RefSeq 7 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 505
  • Mass: 54442
  • Checksum: E0032FA6F955D7F7
  • Sequence:
    • MGRKKIQITR IMDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS SNKLFQYAST 
DMDKVLLKYT EYNEPHESRT NSDIVETLRK KGLNGCESPD ADDYFEHSPL SEDRFSKLNE 
DSDFIFKRGP PGLPPQNFSM SVTVPVTSPN ALSYTNPGSS LVSPSLAASS TLTDSSMLSP 
PQTTLHRNVS PGAPQRPPST GNAGGMLSTT DLTVPNGAGS SPVGNGFVNS RASPNLIGAT 
GANSLGKVMP TKSPPPPGGG NLGMNSRKPD LRVVIPPSSK GMMPPLSEEE ELELNTQRIS 
SSQATQPLAT PVVSVTTPSL PPQGLVYSAM PTAYNTDYSL TSADLSALQG FNSPGMLSLG 
QVSAWQQHHL GQAALSSLVA GGQLSQGSNL SINTNQNISI KSEPISPPRD RMTPSGFQQQ 
QQQQQQQQPP PPPQPQPQPP QPQPRQEMGR SPVDSLSSSS SSYDGSDRED PRGDFHSPIV 
LGRPPNTEDR ESPSVKRMRM DAWVT

Genular Protein ID: 3240433943

Symbol: A0A8I5KVQ4_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A8I5KVQ4

Database IDs:

ARBA 7 CDD 1 CTD 1 DisGeNET 1 EMBL 2 Ensembl 4 GO 7 Gene3D 1 GeneTree 1 HGNC 1 InterPro 5 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 7 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16572171

Title: Analysis of the DNA sequence and duplication history of human chromosome 15.

PubMed ID: 16572171

DOI: 10.1038/nature04601

Sequence Information:

  • Length: 511
  • Mass: 55227
  • Checksum: 32617CFBEFF14532
  • Sequence:
    • MGRKKIQITR IMDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS SNKLFQYAST 
DMDKVLLKYT EYNEPHESRT NSDIVEALNK KEHRGCDSPD PDTSYVLTPH TEEKYKKINE 
EFDNMMRNHK IAVSTKPGLP PQNFSMSVTV PVTSPNALSY TNPGSSLVSP SLAASSTLTD 
SSMLSPPQTT LHRNVSPGAP QRPPSTGNAG GMLSTTDLTV PNGAGSSPVG NGFVNSRASP 
NLIGATGANS LGKVMPTKSP PPPGGGNLGM NSRKPDLRVV IPPSSKGMMP PLSEEEELEL 
NTQRISSSQA TQPLATPVVS VTTPSLPPQG LVYSAMPTAY NTDYSLTSAD LSALQGFNSP 
GMLSLGQVSA WQQHHLGQAA LSSLVAGGQL SQGSNLSINT NQNISIKSEP ISPPRDRMTP 
SGFQQQQQQQ QQQQPPPPPQ PQPQPPQPQP RQEMGRSPVD SLSSSSSSYD GSDREDPRGD 
FHSPIVLGRP PNTEDRESPS VKRMRMDAWV T

Genular Protein ID: 458520458

Symbol: A0A0S2Z417_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z417

Database IDs:

ARBA 7 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 7 Gene3D 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 Pfam 2 RefSeq 3 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 497
  • Mass: 53483
  • Checksum: F4A61D805AE448AF
  • Sequence:
    • MGRKKIQITR IMDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS SNKLFQYAST 
DMDKVLLKYT EYNEPHESRT NSDIVETLRK KGLNGCESPD ADDYFEHSPL SEDRFSKLNE 
DSDFIFKRGP PGLPPQNFSM SVTVPVTSPN ALSYTNPGSS LVSPSLAASS TLTDSSMLSP 
PQTTLHRNVS PGAPQRPPST GNAGGMLSTT DLTVPNGAGS SPVGNGFVNS RASPNLIGAT 
GANSLGKVMP TKSPPPPGGG NLGMNSRKPD LRVVIPPSSK GMMPPLNTQR ISSSQATQPL 
ATPVVSVTTP SLPPQGLVYS AMPTAYNTDY SLTSADLSAL QGFNSPGMLS LGQVSAWQQH 
HLGQAALSSL VAGGQLSQGS NLSINTNQNI SIKSEPISPP RDRMTPSGFQ QQQQQQQQQQ 
PPPPPQPQPQ PPQPQPRQEM GRSPVDSLSS SSSSYDGSDR EDPRGDFHSP IVLGRPPNTE 
DRESPSVKRM RMDAWVT

Genular Protein ID: 3999949473

Symbol: A8K720_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K720

Database IDs:

ARBA 7 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 495
  • Mass: 53255
  • Checksum: 44EBB2734D63B74C
  • Sequence:
    • MGRRKIQITR IMDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS SNKLFQYAST 
DMDKVLLKYT EYNEPHESRT NSDIVETLRK KGLNGCESPD ADDYFEHSPL SEDRFSKLNE 
DSDFIFKRGP PGLPPQNFSM SVTVPVTSPN ALSYTNPGSS LVSPSLAASS TLTDSSMLSP 
PQTTLHRNVS PGAPQRPPST GNAGGMLSTT DLTVPNGAGS SPVGNGFVNS RASPNLIGAT 
GANSLGKVMP TKSPPPPGGG NLGMNSRKPD LRVVIPPSSK GMMPPLNTQR ISSSQATQPL 
ATPVVSVTTP SLPPQGLVYS AMPTAYNTDY SLTSADLSAL QGFNSPGMLS LGQVSAWQQH 
HLGQAALSSL VAGGQLSQGS NLSINTNQNI SIKSEPISPP RDRMTPSGFQ QQQQQQQQPP 
PPPQPQPQPP QPQPRQEMGR SPVDSLSSSS SSYDGSDRED PRGDFHSPIV LGRPPNTEDR 
ESPSVKRMRM DAWVT

Genular Protein ID: 3468921167

Symbol: A0A0S2Z4C8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z4C8

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 3 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 Pfam 2 RefSeq 2 SAM 1 VEuPathDB 1

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 429
  • Mass: 45570
  • Checksum: B356416F17385FCD
  • Sequence:
    • MGRKKIQITR IMDERNRQTL RKKGLNGCES PDADDYFEHS PLSEDRFSKL NEDSDFIFKR 
GPPGLPPQNF SMSVTVPVTS PNALSYTNPG SSLVSPSLAA SSTLTDSSML SPPQTTLHRN 
VSPGAPQRPP STGNAGGMLS TTDLTVPNGA GSSPVGNGFV NSRASPNLIG ATGANSLGKV 
MPTKSPPPPG GGNLGMNSRK PDLRVVIPPS SKGMMPPLNT QRISSSQATQ PLATPVVSVT 
TPSLPPQGLV YSAMPTAYNT DYSLTSADLS ALQGFNSPGM LSLGQVSAWQ QHHLGQAALS 
SLVAGGQLSQ GSNLSINTNQ NISIKSEPIS PPRDRMTPSG FQQQQQQQQQ QQPPPPPQPQ 
PQPPQPQPRQ EMGRSPVDSL SSSSSSYDGS DREDPRGDFH SPIVLGRPPN TEDRESPSVK 
RMRMDAWVT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.