Details for: MAP3K4
Gene ID: 4216
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: MAP3K4
Ensembl ID: ENSG00000085511
Description: mitogen-activated protein kinase kinase kinase 4
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 18.38rCSI 57.45%PRS 45.83
-
CSI 14.89rCSI 36.19%PRS 42.79
-
CSI 12.35rCSI 16.88%PRS 64.26
-
CSI 11.92rCSI 13.79%PRS 52.7
-
CSI 11.77rCSI 12.05%PRS 76.68
-
CSI 11.34rCSI 30.09%PRS 73.7
-
CSI 11.06rCSI 8.7%PRS 69.33
-
CSI 10.43rCSI 32.61%PRS 48.3
-
CSI 9.53rCSI 24.11%PRS 70.49
-
CSI 8.91rCSI 7.08%PRS 83.61
-
CSI 8.87rCSI 52.23%PRS 45.39
-
CSI 8.69rCSI 13.73%PRS 64.78
-
CSI 8.12rCSI 29.22%PRS 42.56
-
CSI 7.18rCSI 15.87%PRS 48.63
-
CSI 7.17rCSI 9%PRS 72.98
-
CSI 6.53rCSI 3.85%PRS 79.9
-
CSI 6.5rCSI 14.4%PRS 60.55
-
CSI 6.08rCSI 10.21%PRS 44.17
-
CSI 5.74rCSI 7.97%PRS 61.09
-
CSI 5.31rCSI 3.93%PRS 55.01
-
CSI 5.23rCSI 38.47%PRS 48.99
-
CSI 5.08rCSI 13.56%PRS 53.41
-
CSI 4.95rCSI 3.45%PRS 77.74
-
CSI 4.91rCSI 12.46%PRS 51.96
-
CSI 4.89rCSI 6.09%PRS 73.39
-
CSI 4.87rCSI 18.85%PRS 76.79
-
CSI 4.63rCSI 3.12%PRS 75.79
-
CSI 4.27rCSI 3.45%PRS 72.87
-
CSI 4.19rCSI 5.22%PRS 42.27
-
CSI 4.12rCSI 3.21%PRS 80.21
-
CSI 4rCSI 2.87%PRS 76.76
-
CSI 3.95rCSI 3.27%PRS 64.75
-
CSI 3.9rCSI 2.95%PRS 76.49
-
CSI 3.81rCSI 3.1%PRS 62.98
-
CSI 3.79rCSI 23.7%PRS 54.16
-
CSI 3.79rCSI 6.09%PRS 46.17
-
CSI 3.72rCSI 32.74%PRS 49.54
-
CSI 3.55rCSI 6.08%PRS 71.42
-
CSI 3.53rCSI 8.06%PRS 58.88
-
CSI 3.48rCSI 5.12%PRS 55.9
-
CSI 3.43rCSI 6.43%PRS 50.74
-
CSI 3.4rCSI 12.09%PRS 71.11
-
CSI 3.33rCSI 7.7%PRS 51.52
-
CSI 3.33rCSI 5.46%PRS 51.69
-
CSI 3.33rCSI 3.9%PRS 78.98
-
CSI 3.31rCSI 19.07%PRS 60.91
-
CSI 3.29rCSI 9.25%PRS 59.13
-
CSI 3.2rCSI 3.7%PRS 55.59
-
CSI 3.17rCSI 3.32%PRS 66.18
-
CSI 3.15rCSI 2.49%PRS 49.35
-
CSI 3.15rCSI 2.19%PRS 73.83
-
CSI 3.12rCSI 2.62%PRS 79.51
-
CSI 3.1rCSI 2.51%PRS 63.96
-
CSI 3.08rCSI 5.4%PRS 54.31
-
CSI 3.06rCSI 2.76%PRS 59.45
-
CSI 2.98rCSI 2.23%PRS 77.87
-
CSI 2.98rCSI 2.26%PRS 75.68
-
CSI 2.97rCSI 8.01%PRS 69.55
-
CSI 2.94rCSI 3.53%PRS 60.66
-
CSI 2.86rCSI 4.05%PRS 58.77
-
CSI 2.81rCSI 6.42%PRS 54.18
-
CSI 2.79rCSI 2.44%PRS 72.04
-
CSI 2.78rCSI 3.58%PRS 45.49
-
CSI 2.69rCSI 4.76%PRS 43.24
-
CSI 2.67rCSI 10.77%PRS 61.19
-
CSI 2.65rCSI 4.23%PRS 55.02
-
CSI 2.62rCSI 5.27%PRS 51.55
-
CSI 2.62rCSI 4%PRS 66.77
-
CSI 2.5rCSI 2.46%PRS 65.22
-
CSI 2.4rCSI 57.58%PRS 43.17
-
CSI 2.4rCSI 2.7%PRS 78.77
-
CSI 2.4rCSI 9.37%PRS 39.06
-
CSI 2.36rCSI 4.22%PRS 61.56
-
CSI 2.35rCSI 2.03%PRS 67.58
-
CSI 2.34rCSI 1.82%PRS 64.55
-
CSI 2.33rCSI 2.17%PRS 63.08
-
CSI 2.32rCSI 3.71%PRS 66.66
-
CSI 2.3rCSI 11.02%PRS 62.4
-
CSI 2.3rCSI 4.67%PRS 41.74
-
CSI 2.3rCSI 46.78%PRS 54.58
-
CSI 2.29rCSI 55.28%PRS 44.01
-
CSI 2.25rCSI 45.91%PRS 53.2
-
CSI 2.24rCSI 3.63%PRS 59.16
-
CSI 2.22rCSI 8.4%PRS 44.9
-
CSI 2.21rCSI 3.38%PRS 63.18
-
CSI 2.18rCSI 4.98%PRS 62.4
-
CSI 2.18rCSI 3.58%PRS 67.74
-
CSI 2.17rCSI 2.38%PRS 66.29
-
CSI 2.16rCSI 2.51%PRS 70.11
-
CSI 2.15rCSI 4.47%PRS 59.64
-
CSI 2.1rCSI 2.19%PRS 62.83
-
CSI 2.08rCSI 4.66%PRS 44.9
-
CSI 2.07rCSI 3.76%PRS 54.23
-
CSI 2.05rCSI 5.35%PRS 62.22
-
CSI 2.05rCSI 7.67%PRS 54.41
-
CSI 2.02rCSI 1.87%PRS 81.79
-
CSI 2.01rCSI 1.77%PRS 50.44
-
CSI 1.98rCSI 4.33%PRS 70.48
-
CSI 1.96rCSI 5.1%PRS 59.86
-
CSI 1.95rCSI 3.44%PRS 59.32
-
CSI 0.2rCSI 1.7%PRS 60.6%
-
CSI 0.3rCSI 2.8%PRS 49.7%
-
CSI 0.4rCSI 1.8%PRS 73.5%
-
CSI 0.5rCSI 2.5%PRS 59.7%
-
CSI 0.6rCSI 5.0%PRS 53.9%
-
CSI 0.6rCSI 3.4%PRS 47.6%
-
CSI 0.6rCSI 3.3%PRS 77.9%
-
CSI 0.7rCSI 2.3%PRS 51.2%
-
CSI 0.7rCSI 2.2%PRS 49.4%
-
CSI 0.7rCSI 9.7%PRS 53.4%
-
CSI 0.8rCSI 3.1%PRS 53.2%
-
CSI 0.9rCSI 2.1%PRS 49.7%
-
CSI 0.9rCSI 7.3%PRS 55.7%
-
CSI 0.9rCSI 2.9%PRS 60.5%
-
CSI 0.9rCSI 1.4%PRS 60.8%
-
CSI 0.9rCSI 3.7%PRS 61.5%
-
CSI 0.9rCSI 1.9%PRS 52.7%
-
CSI 1.0rCSI 1.5%PRS 66.8%
-
CSI 1.0rCSI 0.8%PRS 63.1%
-
CSI 1.0rCSI 2.9%PRS 82.3%
-
CSI 1.0rCSI 1.2%PRS 71.5%
-
CSI 1.0rCSI 1.3%PRS 64.2%
-
CSI 1.1rCSI 1.5%PRS 78.4%
-
CSI 1.1rCSI 3.0%PRS 58.0%
-
CSI 1.1rCSI 5.4%PRS 75.2%
-
CSI 1.1rCSI 2.0%PRS 70.7%
-
CSI 1.2rCSI 2.5%PRS 75.0%
-
CSI 1.2rCSI 3.5%PRS 52.1%
-
CSI 1.2rCSI 1.7%PRS 55.8%
-
CSI 1.2rCSI 1.0%PRS 66.9%
-
CSI 1.2rCSI 2.9%PRS 66.2%
-
CSI 1.2rCSI 3.2%PRS 66.0%
-
CSI 1.3rCSI 1.9%PRS 58.8%
-
CSI 1.3rCSI 2.8%PRS 50.2%
-
CSI 1.3rCSI 4.3%PRS 47.6%
-
CSI 1.3rCSI 1.9%PRS 74.2%
-
CSI 1.4rCSI 3.3%PRS 69.8%
-
CSI 1.4rCSI 2.0%PRS 52.0%
-
CSI 1.4rCSI 2.8%PRS 60.2%
-
CSI 1.4rCSI 2.5%PRS 55.6%
-
CSI 1.4rCSI 2.0%PRS 67.5%
-
CSI 1.4rCSI 1.8%PRS 59.2%
-
CSI 1.5rCSI 2.4%PRS 52.0%
-
CSI 1.5rCSI 3.6%PRS 80.1%
-
CSI 1.5rCSI 2.4%PRS 54.9%
-
CSI 1.5rCSI 4.4%PRS 60.4%
-
CSI 1.6rCSI 3.9%PRS 55.9%
-
CSI 1.6rCSI 4.3%PRS 51.6%
-
CSI 1.6rCSI 2.5%PRS 69.9%
-
CSI 1.6rCSI 6.4%PRS 82.3%
-
CSI 1.6rCSI 2.2%PRS 62.9%
-
CSI 1.6rCSI 2.4%PRS 67.4%
-
CSI 1.7rCSI 4.0%PRS 63.2%
-
CSI 1.7rCSI 1.5%PRS 71.4%
-
CSI 1.7rCSI 2.6%PRS 71.6%
-
CSI 1.7rCSI 2.2%PRS 54.8%
-
CSI 1.7rCSI 1.7%PRS 55.9%
-
CSI 1.8rCSI 1.8%PRS 68.3%
-
CSI 1.8rCSI 4.6%PRS 57.5%
-
CSI 1.8rCSI 5.6%PRS 59.5%
-
CSI 1.8rCSI 1.8%PRS 53.2%
-
CSI 1.9rCSI 1.7%PRS 77.1%
-
CSI 1.9rCSI 2.0%PRS 60.5%
-
CSI 1.9rCSI 4.7%PRS 61.0%
-
CSI 1.9rCSI 2.3%PRS 43.9%
-
CSI 1.9rCSI 3.3%PRS 52.6%
-
CSI 1.9rCSI 2.1%PRS 62.1%
-
CSI 1.9rCSI 1.5%PRS 68.1%
-
CSI 2.0rCSI 3.4%PRS 59.3%
-
CSI 2.0rCSI 5.1%PRS 59.9%
-
CSI 2.0rCSI 4.3%PRS 70.5%
-
CSI 2.0rCSI 1.8%PRS 50.4%
-
CSI 2.0rCSI 1.9%PRS 81.8%
-
CSI 2.1rCSI 7.7%PRS 54.4%
-
CSI 2.1rCSI 5.4%PRS 62.2%
-
CSI 2.1rCSI 3.8%PRS 54.2%
-
CSI 2.1rCSI 4.7%PRS 44.9%
-
CSI 2.1rCSI 2.2%PRS 62.8%
-
CSI 2.2rCSI 4.5%PRS 59.6%
-
CSI 2.2rCSI 2.5%PRS 70.1%
-
CSI 2.2rCSI 2.4%PRS 66.3%
-
CSI 2.2rCSI 3.6%PRS 67.7%
-
CSI 2.2rCSI 5.0%PRS 62.4%
-
CSI 2.2rCSI 3.4%PRS 63.2%
-
CSI 2.2rCSI 8.4%PRS 44.9%
-
CSI 2.2rCSI 3.6%PRS 59.2%
-
CSI 2.3rCSI 45.9%PRS 53.2%
-
CSI 2.3rCSI 55.3%PRS 44.0%
-
CSI 2.3rCSI 46.8%PRS 54.6%
-
CSI 2.3rCSI 4.7%PRS 41.7%
-
CSI 2.3rCSI 11.0%PRS 62.4%
-
CSI 2.3rCSI 3.7%PRS 66.7%
-
CSI 2.3rCSI 2.2%PRS 63.1%
-
CSI 2.3rCSI 1.8%PRS 64.6%
-
CSI 2.4rCSI 2.0%PRS 67.6%
-
CSI 2.4rCSI 4.2%PRS 61.6%
-
CSI 2.4rCSI 9.4%PRS 39.1%
-
CSI 2.4rCSI 2.7%PRS 78.8%
-
CSI 2.4rCSI 57.6%PRS 43.2%
-
CSI 2.5rCSI 2.5%PRS 65.2%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1958634124
Symbol: M3K4_HUMAN
Name: Mitogen-activated protein kinase kinase kinase 4
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9305639
Title: A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways.
PubMed ID: 9305639
PubMed ID: 9039502
Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.
PubMed ID: 9039502
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12052864
Title: Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding.
PubMed ID: 12052864
PubMed ID: 15262978
Title: The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms.
PubMed ID: 15262978
PubMed ID: 16157600
Title: MEKK4 is an effector of the embryonic TRAF4 for JNK activation.
PubMed ID: 16157600
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 19369195
Title: Large-scale proteomics analysis of the human kinome.
PubMed ID: 19369195
PubMed ID: 19690332
Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
PubMed ID: 19690332
PubMed ID: 20221403
Title: Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85.
PubMed ID: 20221403
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 17344846
Title: Patterns of somatic mutation in human cancer genomes.
PubMed ID: 17344846
DOI: 10.1038/nature05610
Sequence Information:
- Length: 1608
- Mass: 181685
- Checksum: C22294914945EA91
- Sequence:
MREAAAALVP PPAFAVTPAA AMEEPPPPPP PPPPPPEPET ESEPECCLAA RQEGTLGDSA CKSPESDLED FSDETNTENL YGTSPPSTPR QMKRMSTKHQ RNNVGRPASR SNLKEKMNAP NQPPHKDTGK TVENVEEYSY KQEKKIRAAL RTTERDRKKN VQCSFMLDSV GGSLPKKSIP DVDLNKPYLS LGCSNAKLPV SVPMPIARPA RQTSRTDCPA DRLKFFETLR LLLKLTSVSK KKDREQRGQE NTSGFWLNRS NELIWLELQA WHAGRTINDQ DFFLYTARQA IPDIINEILT FKVDYGSFAF VRDRAGFNGT SVEGQCKATP GTKIVGYSTH HEHLQRQRVS FEQVKRIMEL LEYIEALYPS LQALQKDYEK YAAKDFQDRV QALCLWLNIT KDLNQKLRIM GTVLGIKNLS DIGWPVFEIP SPRPSKGNEP EYEGDDTEGE LKELESSTDE SEEEQISDPR VPEIRQPIDN SFDIQSRDCI SKKLERLESE DDSLGWGAPD WSTEAGFSRH CLTSIYRPFV DKALKQMGLR KLILRLHKLM DGSLQRARIA LVKNDRPVEF SEFPDPMWGS DYVQLSRTPP SSEEKCSAVS WEELKAMDLP SFEPAFLVLC RVLLNVIHEC LKLRLEQRPA GEPSLLSIKQ LVRECKEVLK GGLLMKQYYQ FMLQEVLEDL EKPDCNIDAF EEDLHKMLMV YFDYMRSWIQ MLQQLPQASH SLKNLLEEEW NFTKEITHYI RGGEAQAGKL FCDIAGMLLK STGSFLEFGL QESCAEFWTS ADDSSASDEI RRSVIEISRA LKELFHEARE RASKALGFAK MLRKDLEIAA EFRLSAPVRD LLDVLKSKQY VKVQIPGLEN LQMFVPDTLA EEKSIILQLL NAAAGKDCSK DSDDVLIDAY LLLTKHGDRA RDSEDSWGTW EAQPVKVVPQ VETVDTLRSM QVDNLLLVVM QSAHLTIQRK AFQQSIEGLM TLCQEQTSSQ PVIAKALQQL KNDALELCNR ISNAIDRVDH MFTSEFDAEV DESESVTLQQ YYREAMIQGY NFGFEYHKEV VRLMSGEFRQ KIGDKYISFA RKWMNYVLTK CESGRGTRPR WATQGFDFLQ AIEPAFISAL PEDDFLSLQA LMNECIGHVI GKPHSPVTGL YLAIHRNSPR PMKVPRCHSD PPNPHLIIPT PEGFSTRSMP SDARSHGSPA AAAAAAAAAV AASRPSPSGG DSVLPKSISS AHDTRGSSVP ENDRLASIAA ELQFRSLSRH SSPTEERDEP AYPRGDSSGS TRRSWELRTL ISQSKDTASK LGPIEAIQKS VRLFEEKRYR EMRRKNIIGQ VCDTPKSYDN VMHVGLRKVT FKWQRGNKIG EGQYGKVYTC ISVDTGELMA MKEIRFQPND HKTIKETADE LKIFEGIKHP NLVRYFGVEL HREEMYIFME YCDEGTLEEV SRLGLQEHVI RLYSKQITIA INVLHEHGIV HRDIKGANIF LTSSGLIKLG DFGCSVKLKN NAQTMPGEVN STLGTAAYMA PEVITRAKGE GHGRAADIWS LGCVVIEMVT GKRPWHEYEH NFQIMYKVGM GHKPPIPERL SPEGKDFLSH CLESDPKMRW TASQLLDHSF VKVCTDEE
Genular Protein ID: 2253829729
Symbol: Q9P1M2_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 544
- Mass: 62067
- Checksum: E55CB8CF9E3055A7
- Sequence:
MFTSEFDAEV DESESVTLQQ YYREAMIQGY NFGFEYHKEV VRLMSGEFRQ KIGDKYISFA RKWMNYVLTK CESGRGTRPR WATQGFDFLQ AIEPAFISAL PEDDFLSLQA LMNECIGHVI GKPHSPVTAI HRNSPRPMKV PRCHSDPPNP HLIIPTPEGF RGSSVPENDR LASIAAELQF RSLSRHSSPT EERDEPAYPR GDSSGSTRRS WELRTLISQS KDTASKLGPI EAIQKSVRLF EEKRYREMRR KNIIGQVCDT PKSYDNVMHV GLRKVTFKWQ RGNKIGEGQY GKVYTCISVD TGELMAMKEI RFQPNDHKTI KETADELKIF EGIKHPNLVR YFGVELHREE MYIFMEYCDE GTLEDVSRLG LQEHVIRLYS KQITIAINVL HEHGIVHRDI KGANIFLTSS GLIKLGDFGC SVKLKNNAQT MPGEVNSTLG TAAYMAPEVI TRAKGEGHGR AADIWSLGCV VIEMVTGKRP WHEYEHNFQI MYKVGMGHKP PIPERLSPEG KDFLSHCLES DPKMRWTASQ LLDHSFVKVC TDEE