Details for: MAP3K4

Gene ID: 4216

Symbol: MAP3K4

Ensembl ID: ENSG00000085511

Description: mitogen-activated protein kinase kinase kinase 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 259.4744
    Cell Significance Index: -40.3600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 159.6730
    Cell Significance Index: -40.5000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 87.6044
    Cell Significance Index: -41.3600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 83.1985
    Cell Significance Index: -33.8000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 61.6597
    Cell Significance Index: -41.3800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 35.4546
    Cell Significance Index: -33.8500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 33.8536
    Cell Significance Index: -41.7400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 14.5883
    Cell Significance Index: -39.0800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.6512
    Cell Significance Index: -42.0300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.1931
    Cell Significance Index: -20.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.3400
    Cell Significance Index: 131.3100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.9014
    Cell Significance Index: 381.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.7024
    Cell Significance Index: 337.8400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.5709
    Cell Significance Index: 120.5500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3068
    Cell Significance Index: 17.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.3068
    Cell Significance Index: 87.8700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.2884
    Cell Significance Index: 20.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2553
    Cell Significance Index: 1133.4600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.1440
    Cell Significance Index: 410.3300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0237
    Cell Significance Index: 28.6100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8533
    Cell Significance Index: 138.7800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.8515
    Cell Significance Index: 92.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.8338
    Cell Significance Index: 51.2500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7739
    Cell Significance Index: 535.2400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.7414
    Cell Significance Index: 14.4700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.7249
    Cell Significance Index: 84.4800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7224
    Cell Significance Index: 43.3700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.6677
    Cell Significance Index: 19.1400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.5079
    Cell Significance Index: 12.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4660
    Cell Significance Index: 64.0000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4401
    Cell Significance Index: 19.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4004
    Cell Significance Index: 11.5400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3909
    Cell Significance Index: 17.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3837
    Cell Significance Index: 19.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3727
    Cell Significance Index: 9.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3687
    Cell Significance Index: 13.9600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3562
    Cell Significance Index: 24.6400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.3132
    Cell Significance Index: 3.8800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2964
    Cell Significance Index: 53.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2642
    Cell Significance Index: 32.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2076
    Cell Significance Index: 113.3800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1774
    Cell Significance Index: 78.4300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1680
    Cell Significance Index: 316.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1539
    Cell Significance Index: 4.1100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1424
    Cell Significance Index: 2.4400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1285
    Cell Significance Index: 5.9900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1202
    Cell Significance Index: 6.0800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1105
    Cell Significance Index: 10.9400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1043
    Cell Significance Index: 66.2500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0894
    Cell Significance Index: 137.7000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0790
    Cell Significance Index: 145.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0563
    Cell Significance Index: 76.5700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0559
    Cell Significance Index: 25.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0500
    Cell Significance Index: 9.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0023
    Cell Significance Index: 0.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0229
    Cell Significance Index: -16.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0260
    Cell Significance Index: -3.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0369
    Cell Significance Index: -27.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0502
    Cell Significance Index: -37.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0657
    Cell Significance Index: -2.3100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0668
    Cell Significance Index: -37.6800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0741
    Cell Significance Index: -46.3000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0822
    Cell Significance Index: -14.0300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1100
    Cell Significance Index: -7.7800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1168
    Cell Significance Index: -14.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1179
    Cell Significance Index: -5.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1247
    Cell Significance Index: -35.8900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1298
    Cell Significance Index: -6.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1607
    Cell Significance Index: -10.1300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1827
    Cell Significance Index: -3.9000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1916
    Cell Significance Index: -4.0800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1981
    Cell Significance Index: -12.7800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2033
    Cell Significance Index: -26.2600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2085
    Cell Significance Index: -43.9100
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2107
    Cell Significance Index: -3.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2132
    Cell Significance Index: -21.7800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2275
    Cell Significance Index: -11.9500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2506
    Cell Significance Index: -26.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2852
    Cell Significance Index: -21.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3086
    Cell Significance Index: -35.3600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3386
    Cell Significance Index: -4.8700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3699
    Cell Significance Index: -8.1000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4098
    Cell Significance Index: -6.0500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4202
    Cell Significance Index: -11.9900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4274
    Cell Significance Index: -33.8500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4933
    Cell Significance Index: -10.4700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5290
    Cell Significance Index: -17.3200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5405
    Cell Significance Index: -6.7400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.5507
    Cell Significance Index: -14.9900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6025
    Cell Significance Index: -19.1900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6107
    Cell Significance Index: -7.2800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6527
    Cell Significance Index: -17.4900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.6532
    Cell Significance Index: -40.0500
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6585
    Cell Significance Index: -13.0200
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.7353
    Cell Significance Index: -9.2800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7437
    Cell Significance Index: -14.9300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7557
    Cell Significance Index: -26.2600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.7891
    Cell Significance Index: -20.7500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.8435
    Cell Significance Index: -29.5500
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.8472
    Cell Significance Index: -24.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MAP3K4 is a serine/threonine kinase that belongs to the MAP3K family, which is known for its involvement in the regulation of various cellular processes. This kinase exhibits a unique structure, comprising three catalytic domains and a regulatory domain, allowing it to interact with multiple signaling pathways. The expression of MAP3K4 is widespread, with significant levels detected in germ cells, cortical interneurons, and corneal epithelial cells, suggesting its critical role in these cell types. **Pathways and Functions:** MAP3K4 is involved in multiple signaling pathways, including the MAPK cascade, which plays a crucial role in cell proliferation, differentiation, and apoptosis. Specifically, MAP3K4 phosphorylates and activates downstream kinases, such as JNK and p38 MAPK, leading to the regulation of gene expression and cell survival. Additionally, MAP3K4 is implicated in the regulation of telomerase activity, telomere capping, and telomere maintenance, highlighting its role in maintaining genome stability. The kinase also interacts with other signaling molecules, such as metal ions and ATP-binding proteins, further underscoring its complex regulatory mechanisms. **Clinical Significance:** The dysregulation of MAP3K4 has been implicated in various diseases, including cancer, where it can contribute to tumorigenesis and tumor progression. Furthermore, the kinase's involvement in telomere maintenance and genome stability suggests its potential role in age-related diseases, such as telomere shortening and premature aging. In the context of the immune system, MAP3K4 may play a role in regulating immune responses, particularly in the context of germ cell development and cortical interneuron function. However, further research is needed to fully elucidate the kinase's role in immune-related disorders. **Conclusion:** In conclusion, MAP3K4 is a multifunctional kinase that plays critical roles in various cellular processes, including signal transduction, gene expression, and cell differentiation. Its widespread expression in different cell types highlights its importance in maintaining cellular homeostasis. Further research is necessary to fully elucidate the kinase's role in immune-related disorders and to explore its therapeutic potential in the treatment of diseases associated with its dysregulation. **Recommendations:** 1. Further investigation into the kinase's role in immune-related disorders, particularly in the context of germ cell development and cortical interneuron function. 2. Elucidation of the kinase's regulatory mechanisms, including its interactions with metal ions and ATP-binding proteins. 3. Exploration of the kinase's therapeutic potential in the treatment of diseases associated with its dysregulation, such as cancer and age-related disorders. **Future Directions:** Future studies should focus on the following: 1. Investigating the kinase's role in regulating immune responses, particularly in the context of cancer and autoimmune diseases. 2. Elucidating the kinase's interactions with other signaling molecules, including metal ions and ATP-binding proteins. 3. Developing therapeutic strategies targeting MAP3K4 to treat diseases associated with its dysregulation. By further exploring the functions and regulatory mechanisms of MAP3K4, researchers can gain a deeper understanding of the kinase's role in maintaining cellular homeostasis and developing novel therapeutic strategies for the treatment of diseases associated with its dysregulation.

Genular Protein ID: 1958634124

Symbol: M3K4_HUMAN

Name: Mitogen-activated protein kinase kinase kinase 4

UniProtKB Accession Codes:

Q9Y6R4 A6H8W0 B7ZLD3 B9EG75 Q5VTT8 Q5VTT9 Q92612 Q9H408

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CPTAC 2 CTD 1 CarbonylDB 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 3 EMBL 10 Ensembl 2 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 4 Rhea 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9305639

Title: A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways.

PubMed ID: 9305639

DOI: 10.1093/emboj/16.16.4973

PubMed ID: 9039502

Title: Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.

PubMed ID: 9039502

DOI: 10.1093/dnares/3.5.321

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12052864

Title: Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding.

PubMed ID: 12052864

DOI: 10.1128/mcb.22.13.4544-4555.2002

PubMed ID: 15262978

Title: The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal kinase activation by Axin and dishevelled through distinct mechanisms.

PubMed ID: 15262978

DOI: 10.1074/jbc.m404598200

PubMed ID: 16157600

Title: MEKK4 is an effector of the embryonic TRAF4 for JNK activation.

PubMed ID: 16157600

DOI: 10.1074/jbc.c500260200

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20221403

Title: Phosphorylation of human tristetraprolin in response to its interaction with the Cbl interacting protein CIN85.

PubMed ID: 20221403

DOI: 10.1371/journal.pone.0009588

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 1608
  • Mass: 181685
  • Checksum: C22294914945EA91
  • Sequence:
    • MREAAAALVP PPAFAVTPAA AMEEPPPPPP PPPPPPEPET ESEPECCLAA RQEGTLGDSA 
CKSPESDLED FSDETNTENL YGTSPPSTPR QMKRMSTKHQ RNNVGRPASR SNLKEKMNAP 
NQPPHKDTGK TVENVEEYSY KQEKKIRAAL RTTERDRKKN VQCSFMLDSV GGSLPKKSIP 
DVDLNKPYLS LGCSNAKLPV SVPMPIARPA RQTSRTDCPA DRLKFFETLR LLLKLTSVSK 
KKDREQRGQE NTSGFWLNRS NELIWLELQA WHAGRTINDQ DFFLYTARQA IPDIINEILT 
FKVDYGSFAF VRDRAGFNGT SVEGQCKATP GTKIVGYSTH HEHLQRQRVS FEQVKRIMEL 
LEYIEALYPS LQALQKDYEK YAAKDFQDRV QALCLWLNIT KDLNQKLRIM GTVLGIKNLS 
DIGWPVFEIP SPRPSKGNEP EYEGDDTEGE LKELESSTDE SEEEQISDPR VPEIRQPIDN 
SFDIQSRDCI SKKLERLESE DDSLGWGAPD WSTEAGFSRH CLTSIYRPFV DKALKQMGLR 
KLILRLHKLM DGSLQRARIA LVKNDRPVEF SEFPDPMWGS DYVQLSRTPP SSEEKCSAVS 
WEELKAMDLP SFEPAFLVLC RVLLNVIHEC LKLRLEQRPA GEPSLLSIKQ LVRECKEVLK 
GGLLMKQYYQ FMLQEVLEDL EKPDCNIDAF EEDLHKMLMV YFDYMRSWIQ MLQQLPQASH 
SLKNLLEEEW NFTKEITHYI RGGEAQAGKL FCDIAGMLLK STGSFLEFGL QESCAEFWTS 
ADDSSASDEI RRSVIEISRA LKELFHEARE RASKALGFAK MLRKDLEIAA EFRLSAPVRD 
LLDVLKSKQY VKVQIPGLEN LQMFVPDTLA EEKSIILQLL NAAAGKDCSK DSDDVLIDAY 
LLLTKHGDRA RDSEDSWGTW EAQPVKVVPQ VETVDTLRSM QVDNLLLVVM QSAHLTIQRK 
AFQQSIEGLM TLCQEQTSSQ PVIAKALQQL KNDALELCNR ISNAIDRVDH MFTSEFDAEV 
DESESVTLQQ YYREAMIQGY NFGFEYHKEV VRLMSGEFRQ KIGDKYISFA RKWMNYVLTK 
CESGRGTRPR WATQGFDFLQ AIEPAFISAL PEDDFLSLQA LMNECIGHVI GKPHSPVTGL 
YLAIHRNSPR PMKVPRCHSD PPNPHLIIPT PEGFSTRSMP SDARSHGSPA AAAAAAAAAV 
AASRPSPSGG DSVLPKSISS AHDTRGSSVP ENDRLASIAA ELQFRSLSRH SSPTEERDEP 
AYPRGDSSGS TRRSWELRTL ISQSKDTASK LGPIEAIQKS VRLFEEKRYR EMRRKNIIGQ 
VCDTPKSYDN VMHVGLRKVT FKWQRGNKIG EGQYGKVYTC ISVDTGELMA MKEIRFQPND 
HKTIKETADE LKIFEGIKHP NLVRYFGVEL HREEMYIFME YCDEGTLEEV SRLGLQEHVI 
RLYSKQITIA INVLHEHGIV HRDIKGANIF LTSSGLIKLG DFGCSVKLKN NAQTMPGEVN 
STLGTAAYMA PEVITRAKGE GHGRAADIWS LGCVVIEMVT GKRPWHEYEH NFQIMYKVGM 
GHKPPIPERL SPEGKDFLSH CLESDPKMRW TASQLLDHSF VKVCTDEE

Genular Protein ID: 2253829729

Symbol: Q9P1M2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9P1M2

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 2 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 544
  • Mass: 62067
  • Checksum: E55CB8CF9E3055A7
  • Sequence:
    • MFTSEFDAEV DESESVTLQQ YYREAMIQGY NFGFEYHKEV VRLMSGEFRQ KIGDKYISFA 
RKWMNYVLTK CESGRGTRPR WATQGFDFLQ AIEPAFISAL PEDDFLSLQA LMNECIGHVI 
GKPHSPVTAI HRNSPRPMKV PRCHSDPPNP HLIIPTPEGF RGSSVPENDR LASIAAELQF 
RSLSRHSSPT EERDEPAYPR GDSSGSTRRS WELRTLISQS KDTASKLGPI EAIQKSVRLF 
EEKRYREMRR KNIIGQVCDT PKSYDNVMHV GLRKVTFKWQ RGNKIGEGQY GKVYTCISVD 
TGELMAMKEI RFQPNDHKTI KETADELKIF EGIKHPNLVR YFGVELHREE MYIFMEYCDE 
GTLEDVSRLG LQEHVIRLYS KQITIAINVL HEHGIVHRDI KGANIFLTSS GLIKLGDFGC 
SVKLKNNAQT MPGEVNSTLG TAAYMAPEVI TRAKGEGHGR AADIWSLGCV VIEMVTGKRP 
WHEYEHNFQI MYKVGMGHKP PIPERLSPEG KDFLSHCLES DPKMRWTASQ LLDHSFVKVC 
TDEE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.