Details for: MGAT1

Gene ID: 4245

Symbol: MGAT1

Ensembl ID: ENSG00000131446

Description: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 251.2453
    Cell Significance Index: -39.0800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 153.5226
    Cell Significance Index: -38.9400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 103.1120
    Cell Significance Index: -41.8900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 99.5080
    Cell Significance Index: -46.9800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 89.6410
    Cell Significance Index: -46.1100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 70.1020
    Cell Significance Index: -47.0400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 44.1585
    Cell Significance Index: -42.1600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.4376
    Cell Significance Index: -42.4600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.5767
    Cell Significance Index: -36.3700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 12.2636
    Cell Significance Index: -26.8400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.9976
    Cell Significance Index: -36.8500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 11.0490
    Cell Significance Index: -43.6000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.2420
    Cell Significance Index: 59.9200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.7087
    Cell Significance Index: 315.6700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.1490
    Cell Significance Index: 30.6800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.1292
    Cell Significance Index: 19.9600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1151
    Cell Significance Index: 121.2900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.1071
    Cell Significance Index: 30.1400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.0848
    Cell Significance Index: 9.9900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.0260
    Cell Significance Index: 29.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.9702
    Cell Significance Index: 45.2400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9258
    Cell Significance Index: 55.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8591
    Cell Significance Index: 154.8700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7846
    Cell Significance Index: 40.8700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.7453
    Cell Significance Index: 102.3500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6897
    Cell Significance Index: 32.4200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5982
    Cell Significance Index: 118.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5963
    Cell Significance Index: 73.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5746
    Cell Significance Index: 39.7400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.5744
    Cell Significance Index: 29.8400
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.5601
    Cell Significance Index: 3.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4818
    Cell Significance Index: 31.0800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.4768
    Cell Significance Index: 12.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4359
    Cell Significance Index: 43.1200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4009
    Cell Significance Index: 177.2400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3950
    Cell Significance Index: 215.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3867
    Cell Significance Index: 73.5900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3817
    Cell Significance Index: 24.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3781
    Cell Significance Index: 75.8500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3357
    Cell Significance Index: 57.3300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.3248
    Cell Significance Index: 9.5400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2425
    Cell Significance Index: 18.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2149
    Cell Significance Index: 15.2000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2118
    Cell Significance Index: 75.9700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1940
    Cell Significance Index: 8.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1854
    Cell Significance Index: 23.9500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1820
    Cell Significance Index: 2.1700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1626
    Cell Significance Index: 19.1700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1200
    Cell Significance Index: 15.3800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0937
    Cell Significance Index: 2.7000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0821
    Cell Significance Index: 74.1000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0658
    Cell Significance Index: 45.5000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0181
    Cell Significance Index: 1.8500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0058
    Cell Significance Index: 10.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0034
    Cell Significance Index: -2.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0153
    Cell Significance Index: -11.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0180
    Cell Significance Index: -33.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0185
    Cell Significance Index: -28.5000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0228
    Cell Significance Index: -14.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0304
    Cell Significance Index: -41.3800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0349
    Cell Significance Index: -21.7700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0360
    Cell Significance Index: -26.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0452
    Cell Significance Index: -0.9800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0553
    Cell Significance Index: -0.9300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0613
    Cell Significance Index: -34.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0763
    Cell Significance Index: -34.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0825
    Cell Significance Index: -13.4100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1273
    Cell Significance Index: -26.8100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1281
    Cell Significance Index: -36.8600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1715
    Cell Significance Index: -19.6500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.1818
    Cell Significance Index: -2.6200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1969
    Cell Significance Index: -6.9200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2045
    Cell Significance Index: -29.7300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2344
    Cell Significance Index: -5.8600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3090
    Cell Significance Index: -35.2800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3370
    Cell Significance Index: -25.8600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4001
    Cell Significance Index: -41.6600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.4014
    Cell Significance Index: -10.7600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.4074
    Cell Significance Index: -13.0500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4158
    Cell Significance Index: -14.4500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4204
    Cell Significance Index: -8.9500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4448
    Cell Significance Index: -9.3100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4523
    Cell Significance Index: -12.6400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4919
    Cell Significance Index: -24.8600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5043
    Cell Significance Index: -28.3000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5065
    Cell Significance Index: -31.1300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5290
    Cell Significance Index: -13.9100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5368
    Cell Significance Index: -42.5100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5382
    Cell Significance Index: -36.1900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.5572
    Cell Significance Index: -6.3300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5709
    Cell Significance Index: -5.9100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5989
    Cell Significance Index: -15.3000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.6285
    Cell Significance Index: -14.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6460
    Cell Significance Index: -33.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7397
    Cell Significance Index: -45.3500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7825
    Cell Significance Index: -34.6100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.8053
    Cell Significance Index: -15.7200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.8218
    Cell Significance Index: -4.9700
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8382
    Cell Significance Index: -24.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8407
    Cell Significance Index: -11.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MGAT1 is a member of the glycosyltransferase family, specifically involved in the transfer of mannose residues to asparagine residues in glycoproteins. This enzyme is composed of two subunits, which are crucial for its enzymatic activity. MGAT1 is primarily expressed in cells of the immune system, including monocytes, macrophages, and endothelial cells. Its expression is also found in non-immune cells, such as lung epithelial cells and Kupffer cells. **Pathways and Functions:** MGAT1 is involved in several key pathways, including: 1. **N-glycan biosynthesis:** MGAT1 is essential for the synthesis of N-glycans, which are attached to asparagine residues in glycoproteins. These glycans play a crucial role in protein stability, folding, and cell surface presentation. 2. **Viral protein maturation:** MGAT1 is involved in the maturation of viral proteins, such as the spike protein of SARS-CoV-2. This process is critical for viral entry and infection. 3. **Immune response regulation:** MGAT1 has been shown to regulate immune responses in different cell types, including monocytes and macrophages. Its expression is induced in response to inflammatory stimuli, suggesting a role in the modulation of immune responses. 4. **Endoplasmic reticulum-golgi intermediate compartment (ER-GIC) membrane:** MGAT1 is localized to the ER-GIC membrane, where it interacts with other glycosyltransferases and chaperones to regulate N-glycan biosynthesis. **Clinical Significance:** MGAT1 has been implicated in various infectious diseases, including: 1. **SARS-CoV-2 infection:** MGAT1 has been shown to play a critical role in the maturation of the SARS-CoV-2 spike protein, which is essential for viral entry and infection. 2. **Infectious diseases:** MGAT1 has been implicated in the regulation of immune responses in different infectious diseases, including tuberculosis and malaria. 3. **Cancer:** MGAT1 has been shown to be overexpressed in certain types of cancer, suggesting a potential role in tumorigenesis and cancer progression. 4. **Neurological disorders:** MGAT1 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, MGAT1 is a complex enzyme involved in the glycosylation process of glycoproteins, particularly those destined for the cell surface. Its expression is critical in the immune system, where it regulates immune responses and modulates the maturation of viral proteins. The clinical significance of MGAT1 is evident in various infectious diseases, cancer, and neurological disorders, highlighting the need for further research into its role in human disease.

Genular Protein ID: 4240377978

Symbol: MGAT1_HUMAN

Name: Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

UniProtKB Accession Codes:

P26572 A8K404 B3KRU8 D3DWR1 Q6IBE3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChEBI 7 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 1 EMBL 14 Ensembl 5 ExpressionAtlas 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 15 Rhea 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1702225

Title: Cloning and expression of N-acetylglucosaminyltransferase I, the medial Golgi transferase that initiates complex N-linked carbohydrate formation.

PubMed ID: 1702225

DOI: 10.1073/pnas.87.24.9948

PubMed ID: 1827260

Title: Organization and localization to chromosome 5 of the human UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I gene.

PubMed ID: 1827260

DOI: 10.1016/s0006-291x(05)80227-x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20378551

Title: Golgi N-glycosyltransferases form both homo- and heterodimeric enzyme complexes in live cells.

PubMed ID: 20378551

DOI: 10.1074/jbc.m110.103184

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 30983867

Title: Identification of IFITM3 and MGAT1 as novel interaction partners of BRI3 by yeast two-hybrid screening.

PubMed ID: 30983867

DOI: 10.3906/biy-1805-47

Sequence Information:

  • Length: 445
  • Mass: 50878
  • Checksum: 13402302ED69C302
  • Sequence:
    • MLKKQSAGLV LWGAILFVAW NALLLLFFWT RPAPGRPPSV SALDGDPASL TREVIRLAQD 
AEVELERQRG LLQQIGDALS SQRGRVPTAA PPAQPRVPVT PAPAVIPILV IACDRSTVRR 
CLDKLLHYRP SAELFPIIVS QDCGHEETAQ AIASYGSAVT HIRQPDLSSI AVPPDHRKFQ 
GYYKIARHYR WALGQVFRQF RFPAAVVVED DLEVAPDFFE YFRATYPLLK ADPSLWCVSA 
WNDNGKEQMV DASRPELLYR TDFFPGLGWL LLAELWAELE PKWPKAFWDD WMRRPEQRQG 
RACIRPEISR TMTFGRKGVS HGQFFDQHLK FIKLNQQFVH FTQLDLSYLQ REAYDRDFLA 
RVYGAPQLQV EKVRTNDRKE LGEVRVQYTG RDSFKAFAKA LGVMDDLKSG VPRAGYRGIV 
TFQFRGRRVH LAPPLTWEGY DPSWN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.