Details for: SCGB2A1

Gene ID: 4246

Symbol: SCGB2A1

Ensembl ID: ENSG00000124939

Description: secretoglobin family 2A member 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 37.0743
    Cell Significance Index: 478.9900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 8.0321
    Cell Significance Index: 185.5700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.0621
    Cell Significance Index: -9.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.9501
    Cell Significance Index: 1611.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.5499
    Cell Significance Index: 212.8500
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.3853
    Cell Significance Index: 27.0900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.1219
    Cell Significance Index: 52.3100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8235
    Cell Significance Index: 743.5900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7576
    Cell Significance Index: 34.3400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7126
    Cell Significance Index: 42.7800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6707
    Cell Significance Index: 14.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6343
    Cell Significance Index: 69.0000
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.5907
    Cell Significance Index: 4.7000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4915
    Cell Significance Index: 79.9500
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.3013
    Cell Significance Index: 4.1800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2983
    Cell Significance Index: 56.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2743
    Cell Significance Index: 18.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2481
    Cell Significance Index: 32.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1644
    Cell Significance Index: 16.2600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1113
    Cell Significance Index: 12.9700
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.0848
    Cell Significance Index: 0.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0378
    Cell Significance Index: 21.3400
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.0352
    Cell Significance Index: 0.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0328
    Cell Significance Index: 1.5400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.0226
    Cell Significance Index: 0.2400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0052
    Cell Significance Index: 0.9300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0013
    Cell Significance Index: 0.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0003
    Cell Significance Index: -0.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0026
    Cell Significance Index: -0.1600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0041
    Cell Significance Index: -0.1700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0074
    Cell Significance Index: -0.1900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0078
    Cell Significance Index: -0.1200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0082
    Cell Significance Index: -0.2300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0088
    Cell Significance Index: -0.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0128
    Cell Significance Index: -0.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0138
    Cell Significance Index: -26.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0182
    Cell Significance Index: -1.1500
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0238
    Cell Significance Index: -0.3100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0275
    Cell Significance Index: -20.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0325
    Cell Significance Index: -20.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0334
    Cell Significance Index: -7.0400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0388
    Cell Significance Index: -0.5300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0390
    Cell Significance Index: -29.5100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0507
    Cell Significance Index: -8.6600
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0524
    Cell Significance Index: -0.7900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0529
    Cell Significance Index: -0.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0536
    Cell Significance Index: -24.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0775
    Cell Significance Index: -1.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0863
    Cell Significance Index: -8.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0934
    Cell Significance Index: -26.8800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0959
    Cell Significance Index: -11.7900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0969
    Cell Significance Index: -3.4100
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: -0.1067
    Cell Significance Index: -0.5600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1205
    Cell Significance Index: -2.5000
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: -0.1258
    Cell Significance Index: -0.0900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1277
    Cell Significance Index: -25.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1290
    Cell Significance Index: -25.6000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1565
    Cell Significance Index: -17.9300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1586
    Cell Significance Index: -23.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1612
    Cell Significance Index: -4.0300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1742
    Cell Significance Index: -19.8900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2161
    Cell Significance Index: -6.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2403
    Cell Significance Index: -17.9100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2517
    Cell Significance Index: -26.2100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.2572
    Cell Significance Index: -4.0800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2734
    Cell Significance Index: -21.6500
  • Cell Name: contractile cell (CL0000183)
    Fold Change: -0.3211
    Cell Significance Index: -0.6200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3801
    Cell Significance Index: -23.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3818
    Cell Significance Index: -25.6700
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.4151
    Cell Significance Index: -4.0600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4184
    Cell Significance Index: -15.3600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4379
    Cell Significance Index: -11.9200
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.4460
    Cell Significance Index: -4.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5929
    Cell Significance Index: -30.8000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6055
    Cell Significance Index: -33.9800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.6274
    Cell Significance Index: -32.9400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6420
    Cell Significance Index: -22.3100
  • Cell Name: Merkel cell (CL0000242)
    Fold Change: -0.6936
    Cell Significance Index: -0.4200
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: -0.7059
    Cell Significance Index: -5.0800
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.7171
    Cell Significance Index: -17.9100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.7208
    Cell Significance Index: -25.2500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7526
    Cell Significance Index: -24.6400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7580
    Cell Significance Index: -33.5300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.7632
    Cell Significance Index: -22.4800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7875
    Cell Significance Index: -25.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.8108
    Cell Significance Index: -21.6500
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.8545
    Cell Significance Index: -9.0800
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.8636
    Cell Significance Index: -9.3500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.8726
    Cell Significance Index: -9.2100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8849
    Cell Significance Index: -33.5100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -0.9014
    Cell Significance Index: -18.8000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9020
    Cell Significance Index: -24.1700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.9030
    Cell Significance Index: -25.7700
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: -0.9352
    Cell Significance Index: -8.5900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.9561
    Cell Significance Index: -25.5800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9600
    Cell Significance Index: -27.5200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.9823
    Cell Significance Index: -25.8300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.9842
    Cell Significance Index: -24.5500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.9849
    Cell Significance Index: -23.6200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -1.0005
    Cell Significance Index: -24.9500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cellular Expression:** SCGB2A1 is significantly expressed in glandular epithelial cells, enteroendocrine cells, and other cell types, suggesting its involvement in tissue-specific functions. 2. **Androgen Receptor Signaling:** SCGB2A1 is implicated in the androgen receptor signaling pathway, which is essential for the development and maintenance of male reproductive tissues. 3. **Immune Regulation:** The gene is also expressed in conventional dendritic cells, type A enteroendocrine cells, and other immune cells, indicating its role in immune modulation and regulation. 4. **Protein Structure:** The Mammaglobin-B protein, encoded by SCGB2A1, belongs to the secretoglobin family of proteins, characterized by a unique structure and function. **Pathways and Functions:** 1. **Androgen Receptor Signaling Pathway:** SCGB2A1 is involved in the androgen receptor signaling pathway, which regulates the expression of target genes involved in male reproductive development and maintenance. 2. **Immune Regulation:** The gene plays a role in immune modulation, particularly in the regulation of dendritic cell function and the development of enteroendocrine cells. 3. **Cellular Differentiation:** SCGB2A1 is involved in the differentiation of glandular epithelial cells and other cell types, highlighting its role in tissue-specific functions. 4. **Protein-Protein Interactions:** The Mammaglobin-B protein interacts with other proteins, including androgen receptors, to regulate gene expression and cellular processes. **Clinical Significance:** 1. **Cancer Research:** SCGB2A1 has been implicated in the development and progression of various cancers, including prostate cancer, where it may serve as a biomarker for disease diagnosis and prognosis. 2. **Androgen Receptor Abnormalities:** Abnormalities in the androgen receptor signaling pathway, including SCGB2A1, have been linked to male infertility and other androgen-related disorders. 3. **Immune Disorders:** The gene's involvement in immune regulation suggests its potential role in the development of immune-related disorders, such as autoimmune diseases and immunodeficiencies. 4. **Therapeutic Applications:** Further research on SCGB2A1 may lead to the development of novel therapeutic strategies targeting this gene for the treatment of diseases associated with androgen receptor signaling and immune regulation. In conclusion, SCGB2A1 is a multifunctional gene that plays a crucial role in androgen receptor signaling, immune regulation, and cellular differentiation. Further research on this gene is essential for understanding its clinical significance and potential therapeutic applications.

Genular Protein ID: 2417914605

Symbol: SG2A1_HUMAN

Name: Mammaglobin-B

UniProtKB Accession Codes:

O75556

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 GO 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9806831

Title: Identification of mammaglobin B, a novel member of the uteroglobin gene family.

PubMed ID: 9806831

DOI: 10.1006/geno.1998.5539

PubMed ID: 10066439

Title: Lipophilins: human peptides homologous to rat prostatein.

PubMed ID: 10066439

DOI: 10.1006/bbrc.1999.0274

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9504814

Title: Establishment of the human reflex tear two-dimensional polyacrylamide gel electrophoresis reference map: new proteins of potential diagnostic value.

PubMed ID: 9504814

DOI: 10.1002/elps.1150181516

PubMed ID: 9720917

Title: Lipophilin, a novel heterodimeric protein of human tears.

PubMed ID: 9720917

DOI: 10.1016/s0014-5793(98)00852-7

PubMed ID: 25946035

Title: Human basal tear peptidome characterization by CID, HCD, and ETD followed by in silico and in vitro analyses for antimicrobial peptide identification.

PubMed ID: 25946035

DOI: 10.1021/acs.jproteome.5b00179

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

Sequence Information:

  • Length: 95
  • Mass: 10884
  • Checksum: 0719738289F89F8D
  • Sequence:
    • MKLLMVLMLA ALLLHCYADS GCKLLEDMVE KTINSDISIP EYKELLQEFI DSDAAAEAMG 
KFKQCFLNQS HRTLKNFGLM MHTVYDSIWC NMKSN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.