Details for: MOCS1
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 40.3322
Cell Significance Index: -10.2300 - Cell Name: sebaceous gland cell (CL2000021)
Fold Change: 8.6411
Cell Significance Index: 11.1800 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 2.5823
Cell Significance Index: -10.1900 - Cell Name: microcirculation associated smooth muscle cell (CL0008035)
Fold Change: 1.6096
Cell Significance Index: 13.5200 - Cell Name: pro-B cell (CL0000826)
Fold Change: 0.8919
Cell Significance Index: 9.5900 - Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: 0.8914
Cell Significance Index: 6.0400 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.7584
Cell Significance Index: 75.0200 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.6904
Cell Significance Index: 41.4500 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.6634
Cell Significance Index: 598.9700 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.5594
Cell Significance Index: 60.8500 - Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
Fold Change: 0.5094
Cell Significance Index: 3.1400 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.4232
Cell Significance Index: 68.8300 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.4055
Cell Significance Index: 77.1700 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.3948
Cell Significance Index: 11.3800 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.3187
Cell Significance Index: 8.5400 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.3149
Cell Significance Index: 21.7800 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2877
Cell Significance Index: 13.0400 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2377
Cell Significance Index: 5.1500 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.2014
Cell Significance Index: 10.4600 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.1743
Cell Significance Index: 34.9600 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1407
Cell Significance Index: 27.9200 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.1256
Cell Significance Index: 9.6400 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.1093
Cell Significance Index: 2.8100 - Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 0.1039
Cell Significance Index: 1.7500 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.0899
Cell Significance Index: 16.2000 - Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.0792
Cell Significance Index: 1.9800 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0770
Cell Significance Index: 1.6400 - Cell Name: subcutaneous adipocyte (CL0002521)
Fold Change: 0.0689
Cell Significance Index: 0.3000 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0682
Cell Significance Index: 5.0800 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0627
Cell Significance Index: 22.5000 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.0579
Cell Significance Index: 7.4200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0487
Cell Significance Index: 91.6500 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0477
Cell Significance Index: 32.9600 - Cell Name: adipocyte of breast (CL0002617)
Fold Change: 0.0457
Cell Significance Index: 0.5700 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0326
Cell Significance Index: 44.3600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0282
Cell Significance Index: 43.4700 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.0216
Cell Significance Index: 11.7900 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0057
Cell Significance Index: 10.4200 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: 0.0040
Cell Significance Index: 0.0600 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.0037
Cell Significance Index: 0.4600 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0011
Cell Significance Index: 0.4900 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0004
Cell Significance Index: -0.0200 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0062
Cell Significance Index: -2.8300 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0072
Cell Significance Index: -4.5500 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0075
Cell Significance Index: -5.5200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0116
Cell Significance Index: -8.7600 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0131
Cell Significance Index: -9.7200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.0140
Cell Significance Index: -1.9200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0160
Cell Significance Index: -2.7400 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0168
Cell Significance Index: -2.4400 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0171
Cell Significance Index: -9.6300 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0256
Cell Significance Index: -7.3700 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0260
Cell Significance Index: -2.9800 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0353
Cell Significance Index: -1.2400 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0401
Cell Significance Index: -4.1000 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0505
Cell Significance Index: -3.5700 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0531
Cell Significance Index: -6.1900 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0536
Cell Significance Index: -1.4300 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0537
Cell Significance Index: -11.3100 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0658
Cell Significance Index: -4.1500 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.0667
Cell Significance Index: -4.0900 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0709
Cell Significance Index: -9.1700 - Cell Name: perivascular cell (CL4033054)
Fold Change: -0.0758
Cell Significance Index: -0.3500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.0760
Cell Significance Index: -2.4400 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.0873
Cell Significance Index: -9.0900 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.0932
Cell Significance Index: -4.7100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.0943
Cell Significance Index: -5.2900 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.0958
Cell Significance Index: -1.5200 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1065
Cell Significance Index: -5.5500 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1140
Cell Significance Index: -7.0100 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1149
Cell Significance Index: -9.1000 - Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.1165
Cell Significance Index: -1.7200 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1179
Cell Significance Index: -7.9300 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1303
Cell Significance Index: -2.1800 - Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.1337
Cell Significance Index: -1.9200 - Cell Name: myometrial cell (CL0002366)
Fold Change: -0.1337
Cell Significance Index: -1.5400 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1384
Cell Significance Index: -3.6400 - Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.1402
Cell Significance Index: -3.4200 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.1463
Cell Significance Index: -6.4700 - Cell Name: BEST4+ enteroycte (CL4030026)
Fold Change: -0.1480
Cell Significance Index: -2.2300 - Cell Name: preadipocyte (CL0002334)
Fold Change: -0.1486
Cell Significance Index: -2.9000 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1495
Cell Significance Index: -7.0300 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1586
Cell Significance Index: -3.3200 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1600
Cell Significance Index: -8.4000 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1707
Cell Significance Index: -6.4700 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1753
Cell Significance Index: -4.9000 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.1814
Cell Significance Index: -1.6700 - Cell Name: mural cell (CL0008034)
Fold Change: -0.1832
Cell Significance Index: -2.2300 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.1915
Cell Significance Index: -6.1000 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.1919
Cell Significance Index: -6.6700 - Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.1964
Cell Significance Index: -6.8800 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.2068
Cell Significance Index: -4.3900 - Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.2188
Cell Significance Index: -3.2300 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.2201
Cell Significance Index: -5.9900 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2309
Cell Significance Index: -7.5600 - Cell Name: corneal epithelial cell (CL0000575)
Fold Change: -0.2339
Cell Significance Index: -3.3300 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2441
Cell Significance Index: -8.9600 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.2548
Cell Significance Index: -7.2700 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.2585
Cell Significance Index: -7.4100 - Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -0.2615
Cell Significance Index: -6.3400
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 1623249781
Symbol: MOCS1_HUMAN
Name: Molybdenum cofactor biosynthesis protein 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9731530
Title: Mutations in a polycistronic nuclear gene associated with molybdenum cofactor deficiency.
PubMed ID: 9731530
DOI: 10.1038/1706
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 14574404
Title: The DNA sequence and analysis of human chromosome 6.
PubMed ID: 14574404
DOI: 10.1038/nature02055
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10917590
Title: Diverse splicing mechanisms fuse the evolutionarily conserved bicistronic MOCS1A and MOCS1B open reading frames.
PubMed ID: 10917590
PubMed ID: 11891227
Title: Functionality of alternative splice forms of the first enzymes involved in human molybdenum cofactor biosynthesis.
PubMed ID: 11891227
PubMed ID: 12208140
Title: The bicistronic MOCS1 gene has alternative start codons on two mutually exclusive exons.
PubMed ID: 12208140
PubMed ID: 15180982
Title: Characterization of MOCS1A, an oxygen-sensitive iron-sulfur protein involved in human molybdenum cofactor biosynthesis.
PubMed ID: 15180982
PubMed ID: 19608861
Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.
PubMed ID: 19608861
PubMed ID: 23627491
Title: Identification of a cyclic nucleotide as a cryptic intermediate in molybdenum cofactor biosynthesis.
PubMed ID: 23627491
DOI: 10.1021/ja401781t
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 25697423
Title: C-Terminal glycine-gated radical initiation by GTP 3',8-cyclase in the molybdenum cofactor biosynthesis.
PubMed ID: 25697423
DOI: 10.1021/ja512997j
PubMed ID: 9921896
Title: Genomic structure and mutational spectrum of the bicistronic MOCS1 gene defective in molybdenum cofactor deficiency type A.
PubMed ID: 9921896
PubMed ID: 12754701
Title: Mutations in the molybdenum cofactor biosynthetic genes MOCS1, MOCS2, and GEPH.
PubMed ID: 12754701
DOI: 10.1002/humu.10223
PubMed ID: 16021469
Title: Ten novel mutations in the molybdenum cofactor genes MOCS1 and MOCS2 and in vitro characterization of a MOCS2 mutation that abolishes the binding ability of molybdopterin synthase.
PubMed ID: 16021469
Sequence Information:
- Length: 636
- Mass: 70105
- Checksum: 6774A563BAC42120
- Sequence:
MAARPLSRML RRLLRSSARS CSSGAPVTQP CPGESARAAS EEVSRRRQFL REHAAPFSAF LTDSFGRQHS YLRISLTEKC NLRCQYCMPE EGVPLTPKAN LLTTEEILTL ARLFVKEGID KIRLTGGEPL IRPDVVDIVA QLQRLEGLRT IGVTTNGINL ARLLPQLQKA GLSAINISLD TLVPAKFEFI VRRKGFHKVM EGIHKAIELG YNPVKVNCVV MRGLNEDELL DFAALTEGLP LDVRFIEYMP FDGNKWNFKK MVSYKEMLDT VRQQWPELEK VPEEESSTAK AFKIPGFQGQ ISFITSMSEH FCGTCNRLRI TADGNLKVCL FGNSEVSLRD HLRAGASEQE LLRIIGAAVG RKKRQHAGMF SISQMKNRPM ILIELFLMFP NSPPANPSIF SWDPLHVQGL RPRMSFSSQV ATLWKGCRVP QTPPLAQQRL GSGSFQRHYT SRADSDANSK CLSPGSWASA APSGPQLTSE QLTHVDSEGR AAMVDVGRKP DTERVAVASA VVLLGPVAFK LVQQNQLKKG DALVVAQLAG VQAAKVTSQL IPLCHHVALS HIQVQLELDS TRHAVKIQAS CRARGPTGVE MEALTSAAVA ALTLYDMCKA VSRDIVLEEI KLISKTGGQR GDFHRA
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.