Details for: MOCS1

Gene ID: 4337

Symbol: MOCS1

Ensembl ID: ENSG00000124615

Description: molybdenum cofactor synthesis 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 40.3322
    Cell Significance Index: -10.2300
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 8.6411
    Cell Significance Index: 11.1800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.5823
    Cell Significance Index: -10.1900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 1.6096
    Cell Significance Index: 13.5200
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.8919
    Cell Significance Index: 9.5900
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.8914
    Cell Significance Index: 6.0400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7584
    Cell Significance Index: 75.0200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6904
    Cell Significance Index: 41.4500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6634
    Cell Significance Index: 598.9700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5594
    Cell Significance Index: 60.8500
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.5094
    Cell Significance Index: 3.1400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4232
    Cell Significance Index: 68.8300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4055
    Cell Significance Index: 77.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3948
    Cell Significance Index: 11.3800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3187
    Cell Significance Index: 8.5400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3149
    Cell Significance Index: 21.7800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2877
    Cell Significance Index: 13.0400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2377
    Cell Significance Index: 5.1500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2014
    Cell Significance Index: 10.4600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1743
    Cell Significance Index: 34.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1407
    Cell Significance Index: 27.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1256
    Cell Significance Index: 9.6400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.1093
    Cell Significance Index: 2.8100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.1039
    Cell Significance Index: 1.7500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0899
    Cell Significance Index: 16.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0792
    Cell Significance Index: 1.9800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0770
    Cell Significance Index: 1.6400
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 0.0689
    Cell Significance Index: 0.3000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0682
    Cell Significance Index: 5.0800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0627
    Cell Significance Index: 22.5000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0579
    Cell Significance Index: 7.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0487
    Cell Significance Index: 91.6500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0477
    Cell Significance Index: 32.9600
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.0457
    Cell Significance Index: 0.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0326
    Cell Significance Index: 44.3600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0282
    Cell Significance Index: 43.4700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0216
    Cell Significance Index: 11.7900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0057
    Cell Significance Index: 10.4200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.0040
    Cell Significance Index: 0.0600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0037
    Cell Significance Index: 0.4600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0011
    Cell Significance Index: 0.4900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0004
    Cell Significance Index: -0.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0062
    Cell Significance Index: -2.8300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0072
    Cell Significance Index: -4.5500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0075
    Cell Significance Index: -5.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0116
    Cell Significance Index: -8.7600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0131
    Cell Significance Index: -9.7200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0140
    Cell Significance Index: -1.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0160
    Cell Significance Index: -2.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0168
    Cell Significance Index: -2.4400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0171
    Cell Significance Index: -9.6300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0256
    Cell Significance Index: -7.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0260
    Cell Significance Index: -2.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0353
    Cell Significance Index: -1.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0401
    Cell Significance Index: -4.1000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0505
    Cell Significance Index: -3.5700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0531
    Cell Significance Index: -6.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0536
    Cell Significance Index: -1.4300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0537
    Cell Significance Index: -11.3100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0658
    Cell Significance Index: -4.1500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0667
    Cell Significance Index: -4.0900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0709
    Cell Significance Index: -9.1700
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0758
    Cell Significance Index: -0.3500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0760
    Cell Significance Index: -2.4400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0873
    Cell Significance Index: -9.0900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0932
    Cell Significance Index: -4.7100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0943
    Cell Significance Index: -5.2900
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0958
    Cell Significance Index: -1.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1065
    Cell Significance Index: -5.5500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1140
    Cell Significance Index: -7.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1149
    Cell Significance Index: -9.1000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.1165
    Cell Significance Index: -1.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1179
    Cell Significance Index: -7.9300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1303
    Cell Significance Index: -2.1800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1337
    Cell Significance Index: -1.9200
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: -0.1337
    Cell Significance Index: -1.5400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1384
    Cell Significance Index: -3.6400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.1402
    Cell Significance Index: -3.4200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1463
    Cell Significance Index: -6.4700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1480
    Cell Significance Index: -2.2300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1486
    Cell Significance Index: -2.9000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1495
    Cell Significance Index: -7.0300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1586
    Cell Significance Index: -3.3200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1600
    Cell Significance Index: -8.4000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1707
    Cell Significance Index: -6.4700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1753
    Cell Significance Index: -4.9000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1814
    Cell Significance Index: -1.6700
  • Cell Name: mural cell (CL0008034)
    Fold Change: -0.1832
    Cell Significance Index: -2.2300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1915
    Cell Significance Index: -6.1000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1919
    Cell Significance Index: -6.6700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1964
    Cell Significance Index: -6.8800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2068
    Cell Significance Index: -4.3900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2188
    Cell Significance Index: -3.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2201
    Cell Significance Index: -5.9900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2309
    Cell Significance Index: -7.5600
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2339
    Cell Significance Index: -3.3300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2441
    Cell Significance Index: -8.9600
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2548
    Cell Significance Index: -7.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2585
    Cell Significance Index: -7.4100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2615
    Cell Significance Index: -6.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Molybdenum cofactor biosynthesis:** MOCS1 is involved in the biosynthesis of molybdenum cofactors, which are essential for the functioning of several enzymes. 2. **Tissue-specific expression:** MOCS1 is significantly expressed in various tissues, including the kidney, heart, brain, and intestinal epithelial cells. 3. **Cellular localization:** The MOCS1 protein is localized to the cytosol and nucleus, suggesting its involvement in both metabolic and regulatory processes. 4. **Interactions with other molecules:** MOCS1 interacts with various molecules, including S-adenosyl-l-methionine, GTP, and metal ions, indicating its role in complex metabolic pathways. **Pathways and Functions:** 1. **Molybdenum cofactor biosynthesis:** MOCS1 is involved in the biosynthesis of molybdenum cofactors, which are essential for the functioning of several enzymes, including: * Cystathionine beta-synthase (CBS): involved in one-carbon metabolism and homocysteine metabolism. * Aldehyde oxidase (AOX): involved in the metabolism of aldehydes and the detoxification of xenobiotics. * xanthine oxidase (XO): involved in the metabolism of purines and the production of reactive oxygen species. 2. **Metabolism of vitamins and cofactors:** MOCS1 is involved in the metabolism of vitamins and cofactors, including: * One-carbon metabolism: MOCS1 is required for the biosynthesis of molybdenum cofactors, which are essential for one-carbon metabolism. * Vitamin B12 metabolism: MOCS1 is involved in the metabolism of vitamin B12, which is essential for the functioning of several enzymes. 3. **Detoxification processes:** MOCS1 is involved in the detoxification of xenobiotics, including: * Aldehydes: MOCS1 is involved in the metabolism of aldehydes, which are toxic compounds that can damage cellular components. * Heavy metals: MOCS1 is involved in the detoxification of heavy metals, which can be toxic to cells. **Clinical Significance:** 1. **Neurological disorders:** Abnormal expression or mutations in MOCS1 have been implicated in several neurological disorders, including: * Autism spectrum disorder (ASD): MOCS1 mutations have been identified in individuals with ASD. * Epilepsy: MOCS1 mutations have been identified in individuals with epilepsy. 2. **Metabolic disorders:** MOCS1 mutations have been implicated in several metabolic disorders, including: * One-carbon metabolism disorders: MOCS1 mutations can lead to disorders of one-carbon metabolism, including homocystinuria and methylmalonic acidemia. * Vitamin B12 deficiency: MOCS1 mutations can lead to vitamin B12 deficiency, which can cause neurological and hematological disorders. 3. **Cancer:** MOCS1 has been implicated in the development and progression of several types of cancer, including: * Colorectal cancer: MOCS1 mutations have been identified in individuals with colorectal cancer. * Breast cancer: MOCS1 mutations have been identified in individuals with breast cancer. In conclusion, MOCS1 is a critical gene involved in the biosynthesis of molybdenum cofactors, which are essential for various metabolic pathways. Abnormal expression or mutations in MOCS1 have been implicated in several diseases, highlighting the importance of this gene in maintaining cellular homeostasis. Further research is needed to fully elucidate the role of MOCS1 in human health and disease.

Genular Protein ID: 1623249781

Symbol: MOCS1_HUMAN

Name: Molybdenum cofactor biosynthesis protein 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9731530

Title: Mutations in a polycistronic nuclear gene associated with molybdenum cofactor deficiency.

PubMed ID: 9731530

DOI: 10.1038/1706

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10917590

Title: Diverse splicing mechanisms fuse the evolutionarily conserved bicistronic MOCS1A and MOCS1B open reading frames.

PubMed ID: 10917590

DOI: 10.1017/s1355838200000182

PubMed ID: 11891227

Title: Functionality of alternative splice forms of the first enzymes involved in human molybdenum cofactor biosynthesis.

PubMed ID: 11891227

DOI: 10.1074/jbc.m200947200

PubMed ID: 12208140

Title: The bicistronic MOCS1 gene has alternative start codons on two mutually exclusive exons.

PubMed ID: 12208140

DOI: 10.1016/s1096-7192(02)00100-2

PubMed ID: 15180982

Title: Characterization of MOCS1A, an oxygen-sensitive iron-sulfur protein involved in human molybdenum cofactor biosynthesis.

PubMed ID: 15180982

DOI: 10.1074/jbc.m313398200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 23627491

Title: Identification of a cyclic nucleotide as a cryptic intermediate in molybdenum cofactor biosynthesis.

PubMed ID: 23627491

DOI: 10.1021/ja401781t

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25697423

Title: C-Terminal glycine-gated radical initiation by GTP 3',8-cyclase in the molybdenum cofactor biosynthesis.

PubMed ID: 25697423

DOI: 10.1021/ja512997j

PubMed ID: 9921896

Title: Genomic structure and mutational spectrum of the bicistronic MOCS1 gene defective in molybdenum cofactor deficiency type A.

PubMed ID: 9921896

DOI: 10.1007/s004390050884

PubMed ID: 12754701

Title: Mutations in the molybdenum cofactor biosynthetic genes MOCS1, MOCS2, and GEPH.

PubMed ID: 12754701

DOI: 10.1002/humu.10223

PubMed ID: 16021469

Title: Ten novel mutations in the molybdenum cofactor genes MOCS1 and MOCS2 and in vitro characterization of a MOCS2 mutation that abolishes the binding ability of molybdopterin synthase.

PubMed ID: 16021469

DOI: 10.1007/s00439-005-1341-9

Sequence Information:

  • Length: 636
  • Mass: 70105
  • Checksum: 6774A563BAC42120
  • Sequence:
  • MAARPLSRML RRLLRSSARS CSSGAPVTQP CPGESARAAS EEVSRRRQFL REHAAPFSAF 
    LTDSFGRQHS YLRISLTEKC NLRCQYCMPE EGVPLTPKAN LLTTEEILTL ARLFVKEGID 
    KIRLTGGEPL IRPDVVDIVA QLQRLEGLRT IGVTTNGINL ARLLPQLQKA GLSAINISLD 
    TLVPAKFEFI VRRKGFHKVM EGIHKAIELG YNPVKVNCVV MRGLNEDELL DFAALTEGLP 
    LDVRFIEYMP FDGNKWNFKK MVSYKEMLDT VRQQWPELEK VPEEESSTAK AFKIPGFQGQ 
    ISFITSMSEH FCGTCNRLRI TADGNLKVCL FGNSEVSLRD HLRAGASEQE LLRIIGAAVG 
    RKKRQHAGMF SISQMKNRPM ILIELFLMFP NSPPANPSIF SWDPLHVQGL RPRMSFSSQV 
    ATLWKGCRVP QTPPLAQQRL GSGSFQRHYT SRADSDANSK CLSPGSWASA APSGPQLTSE 
    QLTHVDSEGR AAMVDVGRKP DTERVAVASA VVLLGPVAFK LVQQNQLKKG DALVVAQLAG 
    VQAAKVTSQL IPLCHHVALS HIQVQLELDS TRHAVKIQAS CRARGPTGVE MEALTSAAVA 
    ALTLYDMCKA VSRDIVLEEI KLISKTGGQR GDFHRA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.