Details for: MTAP

Gene ID: 4507

Symbol: MTAP

Ensembl ID: ENSG00000099810

Description: methylthioadenosine phosphorylase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 203.3171
    Cell Significance Index: -31.6300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 120.5827
    Cell Significance Index: -30.5900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 66.7411
    Cell Significance Index: -31.5100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 56.1467
    Cell Significance Index: -22.8100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 27.0934
    Cell Significance Index: -33.4100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 24.2578
    Cell Significance Index: -23.1600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.3178
    Cell Significance Index: -27.6400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 8.5237
    Cell Significance Index: -33.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 3.1695
    Cell Significance Index: 313.5300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.1800
    Cell Significance Index: 122.3300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.7660
    Cell Significance Index: 287.2200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.7353
    Cell Significance Index: 202.2300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.7306
    Cell Significance Index: 47.1100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.4049
    Cell Significance Index: 37.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2013
    Cell Significance Index: 130.6700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1872
    Cell Significance Index: 1071.9700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.1299
    Cell Significance Index: 10.4100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9040
    Cell Significance Index: 46.9600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.8761
    Cell Significance Index: 44.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.8255
    Cell Significance Index: 148.8100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7633
    Cell Significance Index: 93.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7505
    Cell Significance Index: 57.6000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5026
    Cell Significance Index: 274.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4687
    Cell Significance Index: 22.0300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.4668
    Cell Significance Index: 32.2800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4446
    Cell Significance Index: 61.0600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4048
    Cell Significance Index: 24.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3898
    Cell Significance Index: 17.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.3797
    Cell Significance Index: 76.1600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.2738
    Cell Significance Index: 10.3700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2662
    Cell Significance Index: 117.6800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2584
    Cell Significance Index: 12.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2326
    Cell Significance Index: 83.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2175
    Cell Significance Index: 9.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2095
    Cell Significance Index: 6.0400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1833
    Cell Significance Index: 11.8300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1239
    Cell Significance Index: 1.6900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1004
    Cell Significance Index: 2.6800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0861
    Cell Significance Index: 16.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0738
    Cell Significance Index: 9.4600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0656
    Cell Significance Index: 11.2000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0365
    Cell Significance Index: 1.2700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0018
    Cell Significance Index: -0.1300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0077
    Cell Significance Index: -1.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0120
    Cell Significance Index: -8.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0125
    Cell Significance Index: -7.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0167
    Cell Significance Index: -31.4500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0237
    Cell Significance Index: -17.5900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0265
    Cell Significance Index: -20.0700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0273
    Cell Significance Index: -50.3400
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0324
    Cell Significance Index: -49.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0372
    Cell Significance Index: -50.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0405
    Cell Significance Index: -25.7000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0412
    Cell Significance Index: -23.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0744
    Cell Significance Index: -33.7500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0768
    Cell Significance Index: -7.8400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0808
    Cell Significance Index: -1.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0860
    Cell Significance Index: -18.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0999
    Cell Significance Index: -28.7400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1129
    Cell Significance Index: -12.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1280
    Cell Significance Index: -9.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1345
    Cell Significance Index: -26.7000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1658
    Cell Significance Index: -3.4400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1661
    Cell Significance Index: -19.5900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1738
    Cell Significance Index: -1.0500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1739
    Cell Significance Index: -2.9100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1785
    Cell Significance Index: -20.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1798
    Cell Significance Index: -11.3300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2016
    Cell Significance Index: -29.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2133
    Cell Significance Index: -11.1100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2240
    Cell Significance Index: -7.1800
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2442
    Cell Significance Index: -3.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2835
    Cell Significance Index: -22.4600
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.2994
    Cell Significance Index: -3.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3028
    Cell Significance Index: -10.6400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3196
    Cell Significance Index: -7.6700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3262
    Cell Significance Index: -33.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3761
    Cell Significance Index: -23.0600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3775
    Cell Significance Index: -11.1200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.3992
    Cell Significance Index: -9.9800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.4004
    Cell Significance Index: -11.1900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.4525
    Cell Significance Index: -12.9700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4736
    Cell Significance Index: -12.1000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4865
    Cell Significance Index: -32.7100
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4905
    Cell Significance Index: -7.3500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.5160
    Cell Significance Index: -11.1800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5203
    Cell Significance Index: -12.0200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5511
    Cell Significance Index: -14.4900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5592
    Cell Significance Index: -29.3600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.6136
    Cell Significance Index: -13.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6160
    Cell Significance Index: -18.0900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.7091
    Cell Significance Index: -12.2600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7166
    Cell Significance Index: -15.6900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.7199
    Cell Significance Index: -14.0500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.7253
    Cell Significance Index: -19.4000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.7321
    Cell Significance Index: -23.3200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.7551
    Cell Significance Index: -27.7200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.7906
    Cell Significance Index: -25.8900
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.7918
    Cell Significance Index: -4.9200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7964
    Cell Significance Index: -16.6700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** MTAP is a member of the adenine phosphoribosyltransferase family, characterized by its ability to catalyze the conversion of methylthioadenosine into methionine. The enzyme exhibits a high degree of specificity, with a preference for methylthioadenosine as its substrate. MTAP is also notable for its involvement in various cellular processes, including: 1. **Methionine salvage pathway**: MTAP plays a central role in this pathway, which allows cells to recycle methionine from methylthioadenosine, thereby conserving this essential amino acid. 2. **Interleukin-12 signaling**: MTAP is involved in the signaling cascade initiated by interleukin-12 (IL-12), a cytokine that regulates immune responses. 3. **Cytokine signaling**: MTAP is also expressed in cells that respond to cytokines, such as IL-12, indicating its role in modulating immune responses. **Pathways and Functions** MTAP is involved in several key pathways, including: 1. **Methionine salvage pathway**: MTAP facilitates the conversion of methylthioadenosine into methionine, allowing cells to recycle this essential amino acid. 2. **Interleukin-12 signaling**: MTAP is involved in the signaling cascade initiated by IL-12, which regulates immune responses and cell-mediated immunity. 3. **Cytokine signaling**: MTAP is expressed in cells that respond to cytokines, such as IL-12, indicating its role in modulating immune responses. 4. **Metabolism of sulfur-containing compounds**: MTAP is involved in the metabolism of sulfur-containing compounds, including L-methionine and S-methyl-5-thioadenosine. **Clinical Significance** MTAP's involvement in immune responses and cellular metabolism makes it a potential target for therapeutic interventions. Dysregulation of MTAP has been implicated in various diseases, including: 1. **Autoimmune disorders**: MTAP's role in regulating immune responses makes it a potential target for therapies aimed at modulating autoimmune disease. 2. **Cancer**: MTAP's involvement in the methionine salvage pathway and its expression in cancer cells make it a potential target for cancer therapies. 3. **Neurological disorders**: MTAP's expression in neurons and its involvement in cytokine signaling make it a potential target for therapies aimed at modulating neuroinflammation. In conclusion, MTAP is a crucial enzyme involved in the metabolism of sulfur-containing compounds and plays a vital role in regulating immune responses. Its dysregulation has been implicated in various diseases, making it a potential target for therapeutic interventions. Further research is needed to fully elucidate the role of MTAP in human disease and to explore its therapeutic potential.

Genular Protein ID: 3044981147

Symbol: MTAP_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q13126 I2G7M5 I2G7M6 I2G7M7 I2G7M8 I2G7M9 I2G7N0 Q5T3P3 Q9H010

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EC 1 EMBL 20 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 18 PDBsum 18 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 1 SABIO-RK 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7604019

Title: Construction of a 2.8-megabase yeast artificial chromosome contig and cloning of the human methylthioadenosine phosphorylase gene from the tumor suppressor region on 9p21.

PubMed ID: 7604019

DOI: 10.1073/pnas.92.14.6489

PubMed ID: 8650244

Title: Genomic cloning of methylthioadenosine phosphorylase: a purine metabolic enzyme deficient in multiple different cancers.

PubMed ID: 8650244

DOI: 10.1073/pnas.93.12.6203

PubMed ID: 22464254

Title: Primate genome gain and loss: a bone dysplasia, muscular dystrophy, and bone cancer syndrome resulting from mutated retroviral-derived MTAP transcripts.

PubMed ID: 22464254

DOI: 10.1016/j.ajhg.2012.02.024

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3091600

Title: Purification and characterization of 5'-deoxy-5'-methylthioadenosine phosphorylase from human placenta.

PubMed ID: 3091600

DOI: 10.1016/s0021-9258(18)67242-4

PubMed ID: 8687427

Title: Purification and characterization of recombinant human 5'-methylthioadenosine phosphorylase: definite identification of coding cDNA.

PubMed ID: 8687427

DOI: 10.1006/bbrc.1996.0926

PubMed ID: 11895909

Title: Methylthioadenosine phosphorylase gene deletions are common in osteosarcoma.

PubMed ID: 11895909

PubMed ID: 17912432

Title: Methylthioadenosine phosphorylase deficiency in Japanese osteosarcoma patients.

PubMed ID: 17912432

PubMed ID: 19097084

Title: Direct and tumor microenvironment mediated influences of 5'-deoxy-5'-(methylthio)adenosine on tumor progression of malignant melanoma.

PubMed ID: 19097084

DOI: 10.1002/jcb.21984

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21412930

Title: Downregulation of methylthioadenosine phosphorylase by homozygous deletion in gastric carcinoma.

PubMed ID: 21412930

DOI: 10.1002/gcc.20867

PubMed ID: 10404592

Title: The structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase at 1.7-A resolution provides insights into substrate binding and catalysis.

PubMed ID: 10404592

DOI: 10.1016/s0969-2126(99)80084-7

PubMed ID: 15122881

Title: Structural comparison of MTA phosphorylase and MTA/AdoHcy nucleosidase explains substrate preferences and identifies regions exploitable for inhibitor design.

PubMed ID: 15122881

DOI: 10.1021/bi035492h

PubMed ID: 14705926

Title: Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A.

PubMed ID: 14705926

DOI: 10.1021/bi0358420

PubMed ID: 20934997

Title: The impact of human leukocyte antigen (HLA) micropolymorphism on ligand specificity within the HLA-B*41 allotypic family.

PubMed ID: 20934997

DOI: 10.3324/haematol.2010.030924

Sequence Information:

  • Length: 283
  • Mass: 31236
  • Checksum: 3B34C565EB5B99DA
  • Sequence:
    • MASGTTTTAV KIGIIGGTGL DDPEILEGRT EKYVDTPFGK PSDALILGKI KNVDCVLLAR 
HGRQHTIMPS KVNYQANIWA LKEEGCTHVI VTTACGSLRE EIQPGDIVII DQFIDRTTMR 
PQSFYDGSHS CARGVCHIPM AEPFCPKTRE VLIETAKKLG LRCHSKGTMV TIEGPRFSSR 
AESFMFRTWG ADVINMTTVP EVVLAKEAGI CYASIAMATD YDCWKEHEEA VSVDRVLKTL 
KENANKAKSL LLTTIPQIGS TEWSETLHNL KNMAQFSVLL PRH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.